Published in Cancer Sci on February 17, 2011
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Cellular levels of 8-oxoguanine in either DNA or the nucleotide pool play pivotal roles in carcinogenesis and survival of cancer cells. Int J Mol Sci (2014) 0.99
8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair. J Clin Invest (2012) 0.98
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Pivotal role of inosine triphosphate pyrophosphatase in maintaining genome stability and the prevention of apoptosis in human cells. PLoS One (2012) 0.89
Mammalian MutY homolog (MYH or MUTYH) protects cells from oxidative DNA damage. DNA Repair (Amst) (2013) 0.88
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Genome-wide profiling of 8-oxoguanine reveals its association with spatial positioning in nucleus. DNA Res (2014) 0.80
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Human MutY homolog induces apoptosis in etoposide-treated HEK293 cells. Oncol Lett (2012) 0.77
MUTYH mediates the toxicity of combined DNA 6-thioguanine and UVA radiation. Oncotarget (2015) 0.76
Distinct functional consequences of MUTYH variants associated with colorectal cancer: Damaged DNA affinity, glycosylase activity and interaction with PCNA and Hus1. DNA Repair (Amst) (2015) 0.76
Polymorphism and protein expression of MUTYH gene for risk of rheumatoid arthritis. BMC Musculoskelet Disord (2017) 0.75
Base Excision Repair of N(6)-Deoxyadenosine Adducts of 1,3-Butadiene. Biochemistry (2016) 0.75
Pro-Oxidant Role of Silibinin in DMBA/TPA Induced Skin Cancer: 1H NMR Metabolomic and Biochemical Study. PLoS One (2016) 0.75
MUTYH promotes oxidative microglial activation and inherited retinal degeneration. JCI Insight (2016) 0.75
Regulation of MUTYH, a DNA Repair Enzyme, in Renal Proximal Tubular Epithelial Cells. Oxid Med Cell Longev (2015) 0.75
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Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy. Proc Natl Acad Sci U S A (2006) 2.26
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APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination. J Exp Med (2007) 1.70
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Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs. EMBO J (2008) 1.53
DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1. Cancer Cell (2010) 1.52
Narrow-band UVB induces more carcinogenic skin tumors than broad-band UVB through the formation of cyclobutane pyrimidine dimer. J Invest Dermatol (2007) 1.52
Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancer. Oncogene (2003) 1.47
Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. PLoS One (2009) 1.46
XRCC1 interactions with multiple DNA glycosylases: a model for its recruitment to base excision repair. DNA Repair (Amst) (2005) 1.42
Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferation. EMBO J (2005) 1.41
Suberoylanilide hydroxamic acid (SAHA) induces apoptosis or autophagy-associated cell death in chondrosarcoma cell lines. Anticancer Res (2008) 1.38
The dopamine D1 receptor is a critical mediator for cocaine-induced gene expression. J Neurochem (2002) 1.34
MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis. Cancer Res (2007) 1.30
An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress. J Biol Chem (2003) 1.30
The oxidized deoxynucleoside triphosphate pool is a significant contributor to genetic instability in mismatch repair-deficient cells. Mol Cell Biol (2004) 1.29
Mutator phenotype of MUTYH-null mouse embryonic stem cells. J Biol Chem (2003) 1.19
8-Oxoguanine formation induced by chronic UVB exposure makes Ogg1 knockout mice susceptible to skin carcinogenesis. Cancer Res (2005) 1.15
Accumulation of 8-oxoguanine in the cellular DNA and the alteration of the OGG1 expression during ischemia-reperfusion injury in the rat kidney. DNA Repair (Amst) (2003) 1.14
Significance of error-avoiding mechanisms for oxidative DNA damage in carcinogenesis. Cancer Sci (2007) 1.11
Growth retardation and dyslymphopoiesis accompanied by G2/M arrest in APEX2-null mice. Blood (2004) 1.06
A genome-wide distribution of 8-oxoguanine correlates with the preferred regions for recombination and single nucleotide polymorphism in the human genome. Genome Res (2006) 1.06
RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS. DNA Repair (Amst) (2007) 1.05
Hematopoietic tissue-specific expression of mouse Neil3 for endonuclease VIII-like protein. J Biochem (2005) 1.03
Replication-associated repair of adenine:8-oxoguanine mispairs by MYH. Curr Biol (2002) 1.02
A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1. J Biol Chem (2001) 1.02
Expression of 8-oxoguanine DNA glycosylase is reduced and associated with neurofibrillary tangles in Alzheimer's disease brain. Acta Neuropathol (2002) 1.02
MUTYH prevents OGG1 or APEX1 from inappropriately processing its substrate or reaction product with its C-terminal domain. Nucleic Acids Res (2004) 1.01
Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates. J Biol Chem (2004) 1.01
A role for oxidized DNA precursors in Huntington's disease-like striatal neurodegeneration. PLoS Genet (2008) 1.01
A functional analysis of the DNA glycosylase activity of mouse MUTYH protein excising 2-hydroxyadenine opposite guanine in DNA. Nucleic Acids Res (2005) 1.00
Therapeutic approach to neurodegenerative diseases by medical gases: focusing on redox signaling and related antioxidant enzymes. Oxid Med Cell Longev (2012) 0.98
8-Oxoguanine DNA glycosylase (OGG1) deficiency increases susceptibility to obesity and metabolic dysfunction. PLoS One (2012) 0.98
8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair. J Clin Invest (2012) 0.98
Quantitative analysis of oxidized guanine, 8-oxoguanine, in mitochondrial DNA by immunofluorescence method. Methods Mol Biol (2009) 0.97
Expression of adipose differentiation-related protein (ADRP) is conjointly regulated by PU.1 and AP-1 in macrophages. J Biochem (2005) 0.97
Characterization of the genomic structure and expression of the mouse Apex2 gene. Genomics (2003) 0.95
Up-regulation of hMUTYH, a DNA repair enzyme, in the mitochondria of substantia nigra in Parkinson's disease. Acta Neuropathol (2006) 0.95
Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson's disease and related neurodegenerative disorders. Acta Neuropathol (2004) 0.95
Novel role of neuronal Ca2+ sensor-1 as a survival factor up-regulated in injured neurons. J Cell Biol (2006) 0.95
Futile short-patch DNA base excision repair of adenine:8-oxoguanine mispair. Nucleic Acids Res (2004) 0.95
Oxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell death. DNA Repair (Amst) (2007) 0.95
FosB is essential for the enhancement of stress tolerance and antagonizes locomotor sensitization by ΔFosB. Biol Psychiatry (2011) 0.94
Impairment of mitochondrial DNA repair enzymes against accumulation of 8-oxo-guanine in the spinal motor neurons of amyotrophic lateral sclerosis. Acta Neuropathol (2002) 0.93
Targeted disruption of one allele of the Y-box binding protein-1 (YB-1) gene in mouse embryonic stem cells and increased sensitivity to cisplatin and mitomycin C. Cancer Sci (2004) 0.93
NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals. Nucleic Acids Res (2010) 0.92
Mouse RS21-C6 is a mammalian 2'-deoxycytidine 5'-triphosphate pyrophosphohydrolase that prefers 5-iodocytosine. FEBS J (2009) 0.91
MTH1, an oxidized purine nucleoside triphosphatase, suppresses the accumulation of oxidative damage of nucleic acids in the hippocampal microglia during kainate-induced excitotoxicity. J Neurosci (2006) 0.91
Adenine DNA glycosylase activity of 14 human MutY homolog (MUTYH) variant proteins found in patients with colorectal polyposis and cancer. Hum Mutat (2010) 0.90
Identification and characterization of two forms of mouse MUTYH proteins encoded by alternatively spliced transcripts. Nucleic Acids Res (2004) 0.90
Mutagenic target for hydroxyl radicals generated in Escherichia coli mutant deficient in Mn- and Fe- superoxide dismutases and Fur, a repressor for iron-uptake systems. DNA Repair (Amst) (2002) 0.90
A comparative immunohistochemistry of O6-methylguanine-DNA methyltransferase and p53 in diffusely infiltrating astrocytomas. Neuropathology (2003) 0.90
Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis. Am J Pathol (2006) 0.88
Identification and biochemical characterization of a novel transcription elongation factor, Elongin A3. J Biol Chem (2002) 0.87
In vitro development of mouse embryonic stem cells lacking JNK/stress-activated protein kinase-associated protein 1 (JSAP1) scaffold protein revealed its requirement during early embryonic neurogenesis. J Biol Chem (2003) 0.87
Deficient expression of O(6)-methylguanine-DNA methyltransferase combined with mismatch-repair proteins hMLH1 and hMSH2 is related to poor prognosis in human biliary tract carcinoma. Ann Surg Oncol (2002) 0.86
The human HYMAI/PLAGL1 differentially methylated region acts as an imprint control region in mice. Genomics (2006) 0.86
ITPA protein, an enzyme that eliminates deaminated purine nucleoside triphosphates in cells. Mutat Res (2010) 0.86
Antagonistic regulation of cell-matrix adhesion by FosB and DeltaFosB/Delta2DeltaFosB encoded by alternatively spliced forms of fosB transcripts. Mol Biol Cell (2008) 0.86
NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest. Nucleic Acids Res (2010) 0.86
Apurinic/apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge. J Immunol (2011) 0.85
Characterization of the structure and expression of mouse Itpa gene and its related sequences in the mouse genome. DNA Res (2005) 0.85
Contribution of estrogen receptor alpha to oncogenic K-Ras-mediated NIH3T3 cell transformation and its implication for escape from senescence by modulating the p53 pathway. J Biol Chem (2002) 0.85
Cancer-related PRUNE2 protein is associated with nucleotides and is highly expressed in mature nerve tissues. J Mol Neurosci (2011) 0.85
A novel Nudix hydrolase for oxidized purine nucleoside triphosphates encoded by ORFYLR151c (PCD1 gene) in Saccharomyces cerevisiae. Nucleic Acids Res (2004) 0.85
Oral 'hydrogen water' induces neuroprotective ghrelin secretion in mice. Sci Rep (2013) 0.85
Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity. J Clin Invest (2016) 0.85
Altered expression of MUTYH and an increase in 8-hydroxydeoxyguanosine are early events in ulcerative colitis-associated carcinogenesis. J Pathol (2009) 0.84
fosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior. Neuropsychopharmacology (2012) 0.84
MutT homolog-1 attenuates oxidative DNA damage and delays photoreceptor cell death in inherited retinal degeneration. Am J Pathol (2012) 0.83
Neonatal ventral hippocampal lesions produce an elevation of DeltaFosB-like protein(s) in the rodent neocortex. Neuropsychopharmacology (2006) 0.83
Mammalian elongin A is not essential for cell viability but is required for proper cell cycle progression with limited alteration of gene expression. J Biol Chem (2003) 0.83
Impaired spermatogenesis and elevated spontaneous tumorigenesis in xeroderma pigmentosum group A gene (Xpa)-deficient mice. DNA Repair (Amst) (2008) 0.83
Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia. Glia (2014) 0.83
Accumulation of 8-oxo-deoxyguanosine in cardiovascular tissues with the development of hypertension. DNA Repair (Amst) (2007) 0.82
Crystallization and preliminary X-ray analysis of human MTH1 complexed with two oxidized nucleotides, 8-oxo-dGMP and 2-oxo-dATP. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.82
GDNF promotes neurite outgrowth and upregulates galectin-1 through the RET/PI3K signaling in cultured adult rat dorsal root ganglion neurons. Neurochem Int (2013) 0.82
Defense mechanism to oxidative DNA damage in glial cells. Neuropathology (2004) 0.81
Probing the substrate recognition mechanism of the human MTH1 protein by nucleotide analogs. J Mol Biol (2004) 0.81
Some flavonoids and DHEA-S prevent the cis-effect of expanded CTG repeats in a stable PC12 cell transformant. Biochem Pharmacol (2004) 0.80
Altered gene expression profiles and higher frequency of spontaneous DNA strand breaks in APEX2-null thymus. DNA Repair (Amst) (2008) 0.80
FosB gene products trigger cell proliferation and morphological alteration with an increased expression of a novel processed form of galectin-1 in the rat 3Y1 embryo cell line. J Biochem (2002) 0.80
Increased expression of versican in the inflammatory response to UVB- and reactive oxygen species-induced skin tumorigenesis. Am J Pathol (2011) 0.80
Silencing of SNX1 by siRNA stimulates the ligand-induced endocytosis of EGFR and increases EGFR phosphorylation in gefitinib-resistant human lung cancer cell lines. Int J Oncol (2012) 0.80
Therapeutic effects of hydrogen in animal models of Parkinson's disease. Parkinsons Dis (2011) 0.79
Angiotensin I-converting enzyme gene polymorphism modifies the smoking-cancer association: the Hisayama Study. Eur J Cancer Prev (2006) 0.79
Neuroendocrine phenotypes in a boy with 5q14 deletion syndrome implicate the regulatory roles of myocyte-specific enhancer factor 2C in the postnatal hypothalamus. Eur J Med Genet (2013) 0.79
A comprehensive screening system for damaged nucleotide-binding proteins. Mutat Res (2010) 0.79
Mice heterozygous for the xanthine oxidoreductase gene facilitate lipid accumulation in adipocytes. Arterioscler Thromb Vasc Biol (2013) 0.79
Skin tumours induced by narrowband UVB have higher frequency of p53 mutations than tumours induced by broadband UVB independent of Ogg1 genotype. Mutagenesis (2012) 0.79
Regulation of the neuronal fate by DeltaFosB and its downstream target, galectin-1. Curr Drug Targets (2005) 0.79
Recognition of nucleotide analogs containing the 7,8-dihydro-8-oxo structure by the human MTH1 protein. J Biochem (2006) 0.78
Clozapine-, but not haloperidol-, induced increases in deltaFosB-like immunoreactivity are completely blocked in the striatum of mice lacking D3 dopamine receptors. Eur J Neurosci (2004) 0.78
Crystallization and preliminary X-ray analysis of human MTH1 with a homogeneous N-terminus. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.77
8-Chloro-dGTP, a hypochlorous acid-modified nucleotide, is hydrolyzed by hMTH1, the human MutT homolog. FEBS Lett (2002) 0.77
Nucleotides function as endogenous chemical sensors for oxidative stress signaling. J Clin Biochem Nutr (2010) 0.77
Characterization of galectin-1-positive cells in the mouse hippocampus. Neuroreport (2014) 0.77
Oxidative stress-induced tumorigenesis in the small intestines of DNA repair-deficient mice. Health Phys (2011) 0.76
Construction and characterization of a cell line deficient in repair of mitochondrial, but not nuclear, oxidative DNA damage. Methods Mol Biol (2009) 0.76