Systemic elimination of de novo capsid protein synthesis from replication-competent AAV contamination in the liver.

PubWeight™: 0.82‹?›

🔗 View Article (PMC 3081442)

Published in Hum Gene Ther on March 23, 2011

Authors

Hui Lu1, Guang Qu, Xiao Yang, Ruian Xu, Weidong Xiao

Author Affiliations

1: Sol Sherry Thrombosis Research Center, Department of Microbiology and Immunology, Temple University, Philadelphia, PA 19140, USA.

Articles cited by this

The microRNA Registry. Nucleic Acids Res (2004) 29.45

Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response. Nat Med (2006) 13.51

Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial. Lancet (2009) 6.71

Dystrophin immunity in Duchenne's muscular dystrophy. N Engl J Med (2010) 4.28

Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virus. Proc Natl Acad Sci U S A (1997) 3.84

Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy. Proc Natl Acad Sci U S A (2009) 3.58

Recombinant adeno-associated virus: formulation challenges and strategies for a gene therapy vector. Curr Opin Drug Discov Devel (2003) 1.65

Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors. J Clin Invest (2009) 1.54

Cellular immune response to cryptic epitopes during therapeutic gene transfer. Proc Natl Acad Sci U S A (2009) 1.53

Naturally occurring singleton residues in AAV capsid impact vector performance and illustrate structural constraints. Gene Ther (2009) 1.42

Tailoring the AAV vector capsid for gene therapy. Gene Ther (2008) 1.41

Identification and elimination of replication-competent adeno-associated virus (AAV) that can arise by nonhomologous recombination during AAV vector production. J Virol (1997) 1.35

Adeno-associated virus capsid structure drives CD4-dependent CD8+ T cell response to vector encoded proteins. J Immunol (2009) 1.28

Large-scale adeno-associated viral vector production using a herpesvirus-based system enables manufacturing for clinical studies. Hum Gene Ther (2009) 1.26

Producing recombinant adeno-associated virus in foster cells: overcoming production limitations using a baculovirus-insect cell expression strategy. Hum Gene Ther (2009) 1.24

New developments in the generation of Ad-free, high-titer rAAV gene therapy vectors. Nat Med (1997) 1.21

Complete correction of hemophilia A with adeno-associated viral vectors containing a full-size expression cassette. Hum Gene Ther (2008) 1.13

Selective Rep-Cap gene amplification as a mechanism for high-titer recombinant AAV production from stable cell lines. Mol Ther (2000) 1.12

Undetectable transcription of cap in a clinical AAV vector: implications for preformed capsid in immune responses. Mol Ther (2008) 1.11

Characterization of wild-type adeno-associated virus type 2-like particles generated during recombinant viral vector production and strategies for their elimination. J Virol (1998) 1.06

Intron splicing-mediated expression of AAV Rep and Cap genes and production of AAV vectors in insect cells. Mol Ther (2008) 1.04

Enhanced factor VIII heavy chain for gene therapy of hemophilia A. Mol Ther (2009) 0.99

Cytotoxic-T-lymphocyte-mediated elimination of target cells transduced with engineered adeno-associated virus type 2 vector in vivo. J Virol (2009) 0.97

High-throughput screening and biophysical interrogation of hepatotropic AAV. Mol Ther (2008) 0.95

Feasibility of generating adeno-associated virus packaging cell lines containing inducible adenovirus helper genes. J Virol (2002) 0.84

Identification of the murine AAVrh32.33 capsid-specific CD8+ T cell epitopes. J Gene Med (2009) 0.83

Herpesvirus-based infectious titering of recombinant adeno-associated viral vectors. Mol Ther (2005) 0.82

Articles by these authors

Cross-packaging of a single adeno-associated virus (AAV) type 2 vector genome into multiple AAV serotypes enables transduction with broad specificity. J Virol (2002) 5.82

A novel 5-enolpyruvoylshikimate-3-phosphate (EPSP) synthase transgene for glyphosate resistance stimulates growth and fecundity in weedy rice (Oryza sativa) without herbicide. New Phytol (2013) 3.44

Reversal of blindness in animal models of leber congenital amaurosis using optimized AAV2-mediated gene transfer. Mol Ther (2008) 3.28

Transforming growth factor-beta-regulated miR-24 promotes skeletal muscle differentiation. Nucleic Acids Res (2008) 2.44

Complete viral RNA genome sequencing of ultra-low copy samples by sequence-independent amplification. Nucleic Acids Res (2012) 2.19

Endothelial Smad4 maintains cerebrovascular integrity by activating N-cadherin through cooperation with Notch. Dev Cell (2011) 2.17

Quantitative measurement of interocular suppression in anisometropic amblyopia: a case-control study. Ophthalmology (2013) 2.17

Ultrasonography for detection of disc displacement of temporomandibular joint: a systematic review and meta-analysis. J Oral Maxillofac Surg (2012) 2.06

Vector-virus mutualism accelerates population increase of an invasive whitefly. PLoS One (2007) 1.91

The structure and pharmacological functions of coumarins and their derivatives. Curr Med Chem (2009) 1.74

Characterization of genome integrity for oversized recombinant AAV vector. Mol Ther (2009) 1.71

Recombinant adeno-associated virus: formulation challenges and strategies for a gene therapy vector. Curr Opin Drug Discov Devel (2003) 1.65

Predictive power progesterone combined with beta human chorionic gonadotropin measurements in the outcome of threatened miscarriage. Arch Gynecol Obstet (2010) 1.64

Targeted disruption of Smad4 in cardiomyocytes results in cardiac hypertrophy and heart failure. Circ Res (2005) 1.62

Safety and efficacy of factor IX gene transfer to skeletal muscle in murine and canine hemophilia B models by adeno-associated viral vector serotype 1. Blood (2003) 1.62

Developmental control of histone mRNA and dSLBP synthesis during Drosophila embryogenesis and the role of dSLBP in histone mRNA 3' end processing in vivo. Mol Cell Biol (2002) 1.59

Production of lantipeptides in Escherichia coli. J Am Chem Soc (2010) 1.56

Generation and characterization of chimeric recombinant AAV vectors. Mol Ther (2003) 1.54

In vitro and in vivo anticancer activity of a novel puerarin nanosuspension against colon cancer, with high efficacy and low toxicity. Int J Pharm (2012) 1.54

Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1. Nat Cell Biol (2008) 1.51

Aryl Hydrocarbon Receptor Activation Down-Regulates IL-7 and Reduces Inflammation in a Mouse Model of DSS-Induced Colitis. Dig Dis Sci (2015) 1.50

Long non-coding RNA HNF1A-AS1 regulates proliferation and migration in oesophageal adenocarcinoma cells. Gut (2013) 1.48

Smad4-mediated TGF-beta signaling in tumorigenesis. Int J Biol Sci (2010) 1.47

Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an alpha-smooth muscle actin-Cre transgenic mouse. Respir Res (2007) 1.46

Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. Cell Res (2013) 1.46

Potential uses of microRNA in lung cancer diagnosis, prognosis, and therapy. Curr Cancer Drug Targets (2009) 1.46

Rituximab, cyclophosphamide-fractionated, vincristine, doxorubicin and dexamethasone alternating with rituximab, methotrexate and cytarabine overcomes risk features associated with inferior outcomes in treatment of newly diagnosed, high-risk diffuse large B-cell lymphoma. Leuk Lymphoma (2013) 1.45

The hepatitis B virus X protein disrupts innate immunity by downregulating mitochondrial antiviral signaling protein. J Immunol (2010) 1.44

Targeted disruption of Smad4 in mouse epidermis results in failure of hair follicle cycling and formation of skin tumors. Cancer Res (2005) 1.43

Squamous cell carcinoma and mammary abscess formation through squamous metaplasia in Smad4/Dpc4 conditional knockout mice. Development (2003) 1.43

Selective antegrade cerebral perfusion attenuating the TLR4/NF-κB pathway during deep hypothermia circulatory arrest in a pig model. Cardiology (2014) 1.40

Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway. J Clin Invest (2009) 1.39

Altered contractile phenotypes of intestinal smooth muscle in mice deficient in myosin phosphatase target subunit 1. Gastroenterology (2013) 1.38

Smad4 is required for maintaining normal murine postnatal bone homeostasis. J Cell Sci (2007) 1.37

Hepatitis B virus X protein modulates oncogene Yes-associated protein by CREB to promote growth of hepatoma cells. Hepatology (2012) 1.34

miR-148a promoted cell proliferation by targeting p27 in gastric cancer cells. Int J Biol Sci (2011) 1.33

WASH inhibits autophagy through suppression of Beclin 1 ubiquitination. EMBO J (2013) 1.32

Mouse embryonic head as a site for hematopoietic stem cell development. Cell Stem Cell (2012) 1.31

Characterization of unique small RNA populations from rice grain. PLoS One (2008) 1.31

Mice lacking NKT cells but with a complete complement of CD8+ T-cells are not protected against the metabolic abnormalities of diet-induced obesity. PLoS One (2011) 1.30

Essential role of endothelial Smad4 in vascular remodeling and integrity. Mol Cell Biol (2007) 1.29

Characterization of tissue tropism determinants of adeno-associated virus type 1. J Virol (2003) 1.29

BMP4 Signaling Acts via dual-specificity phosphatase 9 to control ERK activity in mouse embryonic stem cells. Cell Stem Cell (2012) 1.29

Smad4 is required for the normal organization of the cartilage growth plate. Dev Biol (2005) 1.29

HBsAg and HBx knocked into the p21 locus causes hepatocellular carcinoma in mice. Hepatology (2004) 1.28

Cardiomyocyte overexpression of miR-27b induces cardiac hypertrophy and dysfunction in mice. Cell Res (2011) 1.26

Functional screening for miRNAs targeting Smad4 identified miR-199a as a negative regulator of TGF-β signalling pathway. Nucleic Acids Res (2012) 1.24

Dendritic cells promote macrophage infiltration and comprise a substantial proportion of obesity-associated increases in CD11c+ cells in adipose tissue and liver. Diabetes (2012) 1.22

Identification of factors that contribute to recombinant AAV2 particle aggregation and methods to prevent its occurrence during vector purification and formulation. Mol Ther (2005) 1.22

Constitutive stabilization of ß-catenin in the dental mesenchyme leads to excessive dentin and cementum formation. Biochem Biophys Res Commun (2011) 1.20

Essential role of Smad4 in maintaining cardiomyocyte proliferation during murine embryonic heart development. Dev Biol (2007) 1.20

Improved hepatic gene transfer by using an adeno-associated virus serotype 5 vector. J Virol (2002) 1.19

Grb-2-associated binder 1 (Gab1) regulates postnatal ischemic and VEGF-induced angiogenesis through the protein kinase A-endothelial NOS pathway. Proc Natl Acad Sci U S A (2011) 1.17

Intracellular viral processing, not single-stranded DNA accumulation, is crucial for recombinant adeno-associated virus transduction. J Virol (2004) 1.17

Overexpression of soluble TRAIL induces apoptosis in human lung adenocarcinoma and inhibits growth of tumor xenografts in nude mice. Cancer Res (2005) 1.15

IL-17 induces autoantibody overproduction and peripheral blood mononuclear cell overexpression of IL-6 in lupus nephritis patients. Chin Med J (Engl) (2003) 1.15

ATHLATES: accurate typing of human leukocyte antigen through exome sequencing. Nucleic Acids Res (2013) 1.13

Complete correction of hemophilia A with adeno-associated viral vectors containing a full-size expression cassette. Hum Gene Ther (2008) 1.13

Ion sensing in the RCK1 domain of BK channels. Proc Natl Acad Sci U S A (2010) 1.13

PTEN deficiency causes dyschondroplasia in mice by enhanced hypoxia-inducible factor 1alpha signaling and endoplasmic reticulum stress. Development (2008) 1.13

Loss of enteral nutrition in a mouse model results in intestinal epithelial barrier dysfunction. Ann N Y Acad Sci (2012) 1.13

Existence of transient functional double-stranded DNA intermediates during recombinant AAV transduction. Proc Natl Acad Sci U S A (2007) 1.12

Antiangiogenic therapy enhances the efficacy of transcatheter arterial embolization for hepatocellular carcinomas. Int J Cancer (2007) 1.12

PACT is a negative regulator of p53 and essential for cell growth and embryonic development. Proc Natl Acad Sci U S A (2007) 1.12

Undetectable transcription of cap in a clinical AAV vector: implications for preformed capsid in immune responses. Mol Ther (2008) 1.11

Potential of DNMT and its Epigenetic Regulation for Lung Cancer Therapy. Curr Genomics (2009) 1.11

Effect of TGF-beta/Smad signaling pathway on lung myofibroblast differentiation. Acta Pharmacol Sin (2007) 1.10

Identification of genes differentially expressed in cauliflower associated with resistance to Xanthomonas campestris pv. campestris. Mol Biol Rep (2010) 1.10

Akt-p53-miR-365-cyclin D1/cdc25A axis contributes to gastric tumorigenesis induced by PTEN deficiency. Nat Commun (2013) 1.09

miR-21 promotes keratinocyte migration and re-epithelialization during wound healing. Int J Biol Sci (2011) 1.08

High-throughput DNA sequence data compression. Brief Bioinform (2013) 1.07

Synergistic function of Smad4 and PTEN in suppressing forestomach squamous cell carcinoma in the mouse. Cancer Res (2006) 1.06

Native molecular state of adeno-associated viral vectors revealed by single-molecule sequencing. Hum Gene Ther (2011) 1.05

Gene therapy for colon cancer by adeno-associated viral vector-mediated transfer of survivin Cys84Ala mutant. Gastroenterology (2005) 1.05

rAAV-mediated stable expression of heme oxygenase-1 in stellate cells: a new approach to attenuate liver fibrosis in rats. Hepatology (2005) 1.04

Suppression of lung tumor growth and metastasis in mice by adeno-associated virus-mediated expression of vasostatin. Clin Cancer Res (2008) 1.04

The enhancing effects of the light chain on heavy chain secretion in split delivery of factor VIII gene. Mol Ther (2007) 1.03

SOCS3 promotes TLR4 response in macrophages by feedback inhibiting TGF-beta1/Smad3 signaling. Mol Immunol (2007) 1.03

Disruption of Smad4 in odontoblasts causes multiple keratocystic odontogenic tumors and tooth malformation in mice. Mol Cell Biol (2009) 1.02

Adeno-associated virus vectors serotype 2 induce prolonged proliferation of capsid-specific CD8+ T cells in mice. Mol Ther (2010) 1.02

Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS. Nucleic Acids Res (2006) 1.01

Effect of social support on psychological-stress-induced anxiety and depressive symptoms in patients receiving peritoneal dialysis. J Psychosom Res (2008) 1.01

Identification of mesenchymal stem cells in aorta-gonad-mesonephros and yolk sac of human embryos. Blood (2007) 1.01

VlincRNAs controlled by retroviral elements are a hallmark of pluripotency and cancer. Genome Biol (2013) 1.00

Elevated neutrophil to lymphocyte ratio predicts overall and cardiovascular mortality in maintenance peritoneal dialysis patients. Int Urol Nephrol (2012) 1.00

Involvement of miR-20a in promoting gastric cancer progression by targeting early growth response 2 (EGR2). Int J Mol Sci (2013) 0.99

GM-CSF contributes to aortic aneurysms resulting from SMAD3 deficiency. J Clin Invest (2013) 0.99

Enhanced factor VIII heavy chain for gene therapy of hemophilia A. Mol Ther (2009) 0.99

Expression of growth differentiation factor 15 is positively correlated with histopathological malignant grade and in vitro cell proliferation in oral squamous cell carcinoma. Oral Oncol (2008) 0.99

Transforming growth factor β-regulated microRNA-29a promotes angiogenesis through targeting the phosphatase and tensin homolog in endothelium. J Biol Chem (2013) 0.99

Osteoblastic Wnts differentially regulate bone remodeling and the maintenance of bone marrow mesenchymal stem cells. Bone (2013) 0.98

Hepatitis B virus X protein and the estrogen receptor variant lacking exon 5 inhibit estrogen receptor signaling in hepatoma cells. Nucleic Acids Res (2006) 0.98

Accelerated re-epithelialization in Dpr2-deficient mice is associated with enhanced response to TGFbeta signaling. J Cell Sci (2008) 0.98

Performance of hybrids between weedy rice and insect-resistant transgenic rice under field experiments: implication for environmental biosafety assessment. J Integr Plant Biol (2009) 0.97

Insights on biology and pathology of HIF-1α/-2α, TGFβ/BMP, Wnt/β-catenin, and NF-κB pathways in osteoarthritis. Curr Pharm Des (2012) 0.96

Chondrocyte-specific Smad4 gene conditional knockout results in hearing loss and inner ear malformation in mice. Dev Dyn (2009) 0.96

Bone morphogenetic protein-2: a potential regulator in scleral remodeling. Mol Vis (2008) 0.96

Anti-TNF-alpha therapies in systemic lupus erythematosus. J Biomed Biotechnol (2010) 0.96