Published in Microb Biotechnol on November 01, 2008
Improving the stability and catalyst lifetime of the halogenase RebH by directed evolution. Chembiochem (2014) 0.82
A broad range of themes in Microbial Biotechnology. Microb Biotechnol (2009) 0.75
VMD: visual molecular dynamics. J Mol Graph (1996) 117.02
Scalable molecular dynamics with NAMD. J Comput Chem (2005) 59.49
All-atom empirical potential for molecular modeling and dynamics studies of proteins. J Phys Chem B (1998) 54.00
Canonical dynamics: Equilibrium phase-space distributions. Phys Rev A Gen Phys (1985) 26.82
Amino acid preferences for specific locations at the ends of alpha helices. Science (1988) 8.29
A rapid method for localized mutagenesis of yeast genes. Yeast (1992) 7.79
Cation-pi interactions in structural biology. Proc Natl Acad Sci U S A (1999) 6.88
Factors enhancing protein thermostability. Protein Eng (2000) 3.25
Crystal structure of glucoamylase from Aspergillus awamori var. X100 to 2.2-A resolution. J Biol Chem (1992) 1.12
Commodity scale production of sugars from starches. Curr Opin Microbiol (1999) 1.10
Comparison of various types of hydrogen bonds involving aromatic amino acids. J Am Chem Soc (2002) 1.00
Protein engineering to improve the thermostability of glucoamylase from Aspergillus awamori based on molecular dynamics simulations. Protein Eng (2003) 0.94
Refined crystal structures of glucoamylase from Aspergillus awamori var. X100. J Mol Biol (1994) 0.92
Stabilization of Aspergillus awamori glucoamylase by proline substitution and combining stabilizing mutations. Protein Eng (1998) 0.91
Effect on thermostability and catalytic activity of introducing disulfide bonds into Aspergillus awamori glucoamylase. Protein Eng (1998) 0.86
Thermosensitive mutants of Aspergillus awamori glucoamylase by random mutagenesis: inactivation kinetics and structural interpretation. Protein Eng (1994) 0.85
Crystallographic complexes of glucoamylase with maltooligosaccharide analogs: relationship of stereochemical distortions at the nonreducing end to the catalytic mechanism. Biochemistry (1996) 0.85
Increased thermostability of Asn182 --> Ala mutant Aspergillus awamori glucoamylase. Biotechnol Bioeng (1994) 0.83
Identification and elimination by site-directed mutagenesis of thermolabile aspartyl bonds in Aspergillus awamori glucoamylase. Protein Eng (1995) 0.81
Improving operating performance of glucoamylase by mutagenesis. Curr Opin Biotechnol (1999) 0.80
Effect of introducing proline residues on the stability of Aspergillus awamori. Protein Eng (1997) 0.79
Effect of replacing helical glycine residues with alanines on reversible and irreversible stability and production of Aspergillus awamori glucoamylase. Protein Eng (1996) 0.78
The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements. Nat Biotechnol (2006) 30.90
Genome-wide atlas of gene expression in the adult mouse brain. Nature (2006) 28.02
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell (2011) 11.44
The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models. Nat Biotechnol (2010) 7.08
FaST linear mixed models for genome-wide association studies. Nat Methods (2011) 6.52
The complete genome sequence of Francisella tularensis, the causative agent of tularemia. Nat Genet (2005) 6.22
Increasing hospital admission rates for urological complications after transrectal ultrasound guided prostate biopsy. J Urol (2010) 6.01
Genomic alterations in cultured human embryonic stem cells. Nat Genet (2005) 3.89
Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Mol Cell (2011) 3.78
Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy. Biochim Biophys Acta (2006) 3.10
Trajectory of performance status and symptom scores for patients with cancer during the last six months of life. J Clin Oncol (2011) 3.05
Human embryonic stem cells have a unique epigenetic signature. Genome Res (2006) 2.89
An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells. Immunity (2011) 2.77
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev (2012) 2.70
Structure and function of a transcriptional network activated by the MAPK Hog1. Nat Genet (2008) 2.67
Binding of blood proteins to carbon nanotubes reduces cytotoxicity. Proc Natl Acad Sci U S A (2011) 2.66
Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14. Nat Med (2010) 2.58
Increasing hospital admission rates for urological complications after transrectal ultrasound guided prostate biopsy. J Urol (2013) 2.53
Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation. Nat Med (2005) 2.46
Anatomical traits associated with absorption and mycorrhizal colonization are linked to root branch order in twenty-three Chinese temperate tree species. New Phytol (2008) 2.43
Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo. J Neurosci (2012) 2.35
Proliferation of prenatal ultrasonography. CMAJ (2010) 2.33
IScore: a risk score to predict death early after hospitalization for an acute ischemic stroke. Circulation (2011) 2.29
Inhibition of hemangiogenesis and lymphangiogenesis after normal-risk corneal transplantation by neutralizing VEGF promotes graft survival. Invest Ophthalmol Vis Sci (2004) 2.27
Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice. PLoS Genet (2012) 2.19
A document clustering and ranking system for exploring MEDLINE citations. J Am Med Inform Assoc (2007) 2.18
Corneal immunity is mediated by heterogeneous population of antigen-presenting cells. J Leukoc Biol (2003) 2.08
Common genetic variants of the human uromodulin gene regulate transcription and predict plasma uric acid levels. Kidney Int (2013) 2.05
The corneal stroma is endowed with a significant number of resident dendritic cells. Invest Ophthalmol Vis Sci (2003) 2.05
Cellular uptake, intracellular trafficking, and cytotoxicity of nanomaterials. Small (2011) 2.00
Bis(acetato-κO)[1,2-bis-(2-pyridylmeth-oxy)benzene-κN,O,O',N']copper(II) monohydrate. Acta Crystallogr Sect E Struct Rep Online (2010) 1.94
Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2. PLoS One (2011) 1.93
The chemistrode: a droplet-based microfluidic device for stimulation and recording with high temporal, spatial, and chemical resolution. Proc Natl Acad Sci U S A (2008) 1.90
A novel GATA6 mutation in patients with tetralogy of Fallot or atrial septal defect. J Hum Genet (2010) 1.89
Molecular signatures of tissue-specific microvascular endothelial cell heterogeneity in organ maintenance and regeneration. Dev Cell (2013) 1.89
Comparison of adenoviruses from species B, C, E, and F after intravenous delivery. Mol Ther (2007) 1.88
Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival. Proc Natl Acad Sci U S A (2010) 1.85
Brn3a-expressing retinal ganglion cells project specifically to thalamocortical and collicular visual pathways. J Neurosci (2005) 1.81
Novel characterization of MHC class II-negative population of resident corneal Langerhans cell-type dendritic cells. Invest Ophthalmol Vis Sci (2002) 1.80
Evolution of multi-drug resistant hepatitis B virus during sequential therapy. Hepatology (2006) 1.76
Addiction related alteration in resting-state brain connectivity. Neuroimage (2009) 1.76
Karyotypic stability, genotyping, differentiation, feeder-free maintenance, and gene expression sampling in three human embryonic stem cell lines derived prior to August 9, 2001. Stem Cells Dev (2004) 1.75
A subset of methylated CpG sites differentiate psoriatic from normal skin. J Invest Dermatol (2011) 1.73
A cryptographic approach to securely share and query genomic sequences. IEEE Trans Inf Technol Biomed (2008) 1.71
Imaging MALDI mass spectrometry using an oscillating capillary nebulizer matrix coating system and its application to analysis of lipids in brain from a mouse model of Tay-Sachs/Sandhoff disease. Anal Chem (2008) 1.69
Exercise and the metabolic syndrome with weight regain. J Appl Physiol (1985) (2010) 1.66
Structural basis for the modular recognition of single-stranded RNA by PPR proteins. Nature (2013) 1.66
Population based study of long-term rates of surgery for urinary incontinence after radical prostatectomy for prostate cancer. J Urol (2012) 1.66
A new group B adenovirus receptor is expressed at high levels on human stem and tumor cells. J Virol (2006) 1.65
Qualification of embryonal carcinoma 2102Ep as a reference for human embryonic stem cell research. Stem Cells (2007) 1.62
Neuropathologies in transgenic mice expressing human immunodeficiency virus type 1 Tat protein under the regulation of the astrocyte-specific glial fibrillary acidic protein promoter and doxycycline. Am J Pathol (2003) 1.62
catena-Poly[[bis-(nitrato-κO)copper(II)]-bis-[μ-1,4-bis-(pyridin-3-ylmeth-oxy)benzene-κN:N']]. Acta Crystallogr Sect E Struct Rep Online (2011) 1.61
The lexical constituency model: some implications of research on Chinese for general theories of reading. Psychol Rev (2005) 1.61
T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) mediates natural killer cell suppression in chronic hepatitis B. J Hepatol (2010) 1.60
Noninvasive evaluation of coronary distensibility in older adults: a feasibility study with MR angiography. Radiology (2011) 1.60
A targeted neuroglial reporter line generated by homologous recombination in human embryonic stem cells. Stem Cells (2009) 1.59
Assessing self-renewal and differentiation in human embryonic stem cell lines. Stem Cells (2005) 1.58
A key commitment step in erythropoiesis is synchronized with the cell cycle clock through mutual inhibition between PU.1 and S-phase progression. PLoS Biol (2010) 1.58
Identification of a Kir3.4 mutation in congenital long QT syndrome. Am J Hum Genet (2010) 1.57
Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility. Proc Natl Acad Sci U S A (2013) 1.57
The coexistence of superconductivity and topological order in the Bi₂Se₃ thin films. Science (2012) 1.56
Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO(2) nanoparticles. Toxicology (2008) 1.56
Changes in sexual problems over time in women with and without early-stage breast cancer. Menopause (2010) 1.56
Semantic Similarity and Relatedness between Clinical Terms: An Experimental Study. AMIA Annu Symp Proc (2010) 1.56
Efficacy of contrast-enhanced US and magnetic microbubbles targeted to vascular cell adhesion molecule-1 for molecular imaging of atherosclerosis. Radiology (2011) 1.55
Structure of C3PO and mechanism of human RISC activation. Nat Struct Mol Biol (2011) 1.55
Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase. J Biol Chem (2003) 1.54
Mutations in the AXIN1 gene in advanced prostate cancer. Eur Urol (2008) 1.53
Exome sequencing and unrelated findings in the context of complex disease research: ethical and clinical implications. Discov Med (2011) 1.52
Impact of metabolic syndrome on benign prostatic hyperplasia in elderly Chinese men. Urol Int (2014) 1.51
Analysis of epithelial and mesenchymal markers in ovarian cancer reveals phenotypic heterogeneity and plasticity. PLoS One (2011) 1.50
Inhibition of CD26 in human cord blood CD34+ cells enhances their engraftment of nonobese diabetic/severe combined immunodeficiency mice. Stem Cells Dev (2007) 1.50
Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia. Brain Res (2009) 1.49
Targeted genomic sequencing identifies PRRT2 mutations as a cause of paroxysmal kinesigenic choreoathetosis. J Med Genet (2011) 1.49
Surface chemistry and aspect ratio mediated cellular uptake of Au nanorods. Biomaterials (2010) 1.48
An HLA-DRB1-coded signal transduction ligand facilitates inflammatory arthritis: a new mechanism of autoimmunity. J Immunol (2012) 1.48
Targeting heat shock proteins on cancer cells: selection, characterization, and cell-penetrating properties of a peptidic GRP78 ligand. Biochemistry (2006) 1.48
A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. Diabetes (2012) 1.47
Symptom burden and performance status in a population-based cohort of ambulatory cancer patients. Cancer (2010) 1.47
Effect of botulinum toxin type A on transforming growth factor beta1 in fibroblasts derived from hypertrophic scar: a preliminary report. Aesthetic Plast Surg (2009) 1.46
Preparation and evaluation of self-microemulsifying drug delivery system of oridonin. Int J Pharm (2007) 1.46
Candidate pathway-based genome-wide association studies identify novel associations of genomic variants in the complement system associated with coronary artery disease. Circ Cardiovasc Genet (2014) 1.45
The sphingolipid long-chain base-Pkh1/2-Ypk1/2 signaling pathway regulates eisosome assembly and turnover. J Biol Chem (2008) 1.45
Behavioral response of tilapia (Oreochromis niloticus) to acute ammonia stress monitored by computer vision. J Zhejiang Univ Sci B (2005) 1.45
High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling. J Neurochem (2010) 1.43
Human embryonic stem cells have enhanced repair of multiple forms of DNA damage. Stem Cells (2008) 1.43
Alterations in corneal stromal dendritic cell phenotype and distribution in inflammation. Arch Ophthalmol (2003) 1.43
Structural basis and binding properties of the second bromodomain of Brd4 with acetylated histone tails. Biochemistry (2008) 1.43
The association of the palliative performance scale and hazard of death in an ambulatory cancer population. J Palliat Med (2012) 1.41
Effects of breast cancer surgery and surgical side effects on body image over time. Breast Cancer Res Treat (2010) 1.41
[1,2-Bis(2-pyridyl-meth-oxy)benzene-κN,O,O',N']bis-(nitrato-κO)copper(II). Acta Crystallogr Sect E Struct Rep Online (2010) 1.41
Endogenous Nkx2.2+/Olig2+ oligodendrocyte precursor cells fail to remyelinate the demyelinated adult rat spinal cord in the absence of astrocytes. Exp Neurol (2005) 1.41
Activated androgen receptor downregulates E-cadherin gene expression and promotes tumor metastasis. Mol Cell Biol (2008) 1.41
Relevance of the direct pathway of sensitization in corneal transplantation is dictated by the graft bed microenvironment. J Immunol (2004) 1.40
MUS81 promotes common fragile site expression. Nat Cell Biol (2013) 1.40
Selective targeting of gold nanorods at the mitochondria of cancer cells: implications for cancer therapy. Nano Lett (2010) 1.40
[Idiopathic CD4+ T-lymphocytopenia in a child with disseminated cryptococcosis]. Zhonghua Er Ke Za Zhi (2005) 1.39
Coronary plaque characterization of nonculprit or nontarget lesions assessed by analysis of in vivo intracoronary ultrasound radio-frequency data. Chin Med J (Engl) (2009) 1.39
Mutations in PRRT2 result in paroxysmal dyskinesias with marked variability in clinical expression. J Med Genet (2011) 1.38