PDCD4 nuclear loss inversely correlates with miR-21 levels in colon carcinogenesis.

PubWeight™: 1.28‹?› | Rank: Top 10%

🔗 View Article (PMID 21279518)

Published in Virchows Arch on January 29, 2011

Authors

Matteo Fassan1, Marco Pizzi, Luciano Giacomelli, Claudia Mescoli, Kathrin Ludwig, Salvatore Pucciarelli, Massimo Rugge

Author Affiliations

1: Department of Medical Diagnostic Sciences & Special Therapies, Surgical Pathology & Cytopathology Unit, University of Padua-Italy, Padua, Italy.

Articles citing this

Serum miR-21 as a diagnostic and prognostic biomarker in colorectal cancer. J Natl Cancer Inst (2013) 4.03

The role of microRNAs in cancers of the upper gastrointestinal tract. Nat Rev Gastroenterol Hepatol (2012) 1.17

CD44 variant 9 expression in primary early gastric cancer as a predictive marker for recurrence. Br J Cancer (2013) 1.13

miR-21 Is a Promising Novel Biomarker for Lymph Node Metastasis in Patients with Gastric Cancer. Gastroenterol Res Pract (2012) 1.07

Serum miR-21, miR-29a, and miR-125b Are Promising Biomarkers for the Early Detection of Colorectal Neoplasia. Clin Cancer Res (2015) 1.03

Serum microRNA-21 levels are related to tumor size in gastric cancer patients but cannot predict prognosis. Oncol Lett (2013) 1.00

MicroRNA profiles in familial and sporadic medullary thyroid carcinoma: preliminary relationships with RET status and outcome. Thyroid (2012) 0.96

MicroRNAs as growth regulators, their function and biomarker status in colorectal cancer. Oncotarget (2016) 0.94

PDCD4/miR-21 dysregulation in inflammatory bowel disease-associated carcinogenesis. Virchows Arch (2012) 0.93

Epigenetic regulation of miR-21 in colorectal cancer: ITGB4 as a novel miR-21 target and a three-gene network (miR-21-ITGΒ4-PDCD4) as predictor of metastatic tumor potential. Epigenetics (2013) 0.91

Essential role of NADPH oxidase-dependent reactive oxygen species generation in regulating microRNA-21 expression and function in prostate cancer. Antioxid Redox Signal (2013) 0.88

Implications of microRNAs in colorectal cancer development, diagnosis, prognosis, and therapeutics. Front Genet (2011) 0.88

miRNAs in precancerous lesions of the gastrointestinal tract. World J Gastroenterol (2011) 0.86

The critical roles of miR-21 in anti-cancer effects of curcumin. Ann Transl Med (2015) 0.83

MicroRNA-21 regulates biological behavior by inducing EMT in human cholangiocarcinoma. Int J Clin Exp Pathol (2015) 0.82

Possible roles of mmu-miR-141 in the endometrium of mice in early pregnancy following embryo implantation. PLoS One (2013) 0.82

MicroRNA MIR21 and T Cells in Colorectal Cancer. Cancer Immunol Res (2015) 0.82

Role of deregulated microRNAs in non-small cell lung cancer progression using fresh-frozen and formalin-fixed, paraffin-embedded samples. Oncol Lett (2015) 0.81

Sweating the small stuff: microRNAs and genetic changes define pancreatic cancer. Pancreas (2013) 0.81

Effect of microRNA-21 on the proliferation of human degenerated nucleus pulposus by targeting programmed cell death 4. Braz J Med Biol Res (2016) 0.79

PDCD4 expression in thyroid neoplasia. Virchows Arch (2012) 0.78

Stromal Expression of MicroRNA-21 in Advanced Colorectal Cancer Patients with Distant Metastases. J Pathol Transl Med (2016) 0.76

Cell Density-Dependent Upregulation of PDCD4 in Keratinocytes and Its Implications for Epidermal Homeostasis and Repair. Int J Mol Sci (2015) 0.76

Hexavalent chromium induces malignant transformation of human lung bronchial epithelial cells via ROS-dependent activation of miR-21-PDCD4 signaling. Oncotarget (2016) 0.76

Antisense oligonucleotides against microRNA-21 reduced the proliferation and migration of human colon carcinoma cells. Cancer Cell Int (2015) 0.76

Different types of cell cycle- and apoptosis-related gene expressions alter in corticosteroid-, vincristine-, and melphalan-resistant u-266 multiple myeloma cell lines. Turk J Haematol (2014) 0.75

What influences preneoplastic colorectal lesion recurrence? Oncotarget (2016) 0.75

Programmed cell death 4 mechanism of action: the model to be updated? Cell Cycle (2017) 0.75

Quercetin inhibits Cr(VI)-induced malignant cell transformation by targeting miR-21-PDCD4 signaling pathway. Oncotarget (2016) 0.75

A novel aromatic mutagen, 5-amino-6-hydroxy-8H-benzo[6,7]azepino[5,4,3-de]quinolin-7-one (ABAQ), induces colonic preneoplastic lesions in mice. Toxicol Rep (2014) 0.75

The role of tumour suppressor PDCD4 in beta cell death in hypoxia. PLoS One (2017) 0.75

Articles cited by this

Cancer statistics, 2009. CA Cancer J Clin (2009) 83.57

Genetic alterations during colorectal-tumor development. N Engl J Med (1988) 26.82

ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia (2004) 17.08

Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression. Proc Natl Acad Sci U S A (2004) 9.42

Colorectal cancer. Lancet (2010) 8.36

S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. Science (2006) 5.94

Cancer screening in the United States, 2010: a review of current American Cancer Society guidelines and issues in cancer screening. CA Cancer J Clin (2010) 4.76

Role of the serrated pathway in colorectal cancer pathogenesis. Gastroenterology (2010) 4.25

Transcriptome profile of human colorectal adenomas. Mol Cancer Res (2007) 3.82

MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets. J Pathol (2009) 3.29

Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biol (2007) 2.70

A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A. Mol Cell Biol (2004) 2.38

Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis. Cancer Res (2005) 2.30

Involvement of programmed cell death 4 in transforming growth factor-beta1-induced apoptosis in human hepatocellular carcinoma. Oncogene (2006) 2.10

Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis. J Pathol (2003) 2.04

Loss of programmed cell death 4 expression marks adenoma-carcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancer. Cancer (2007) 1.94

Locked nucleic acid in situ hybridization analysis of miR-21 expression during colorectal cancer development. Clin Cancer Res (2009) 1.70

Induction of PDCD4 tumor suppressor gene expression by RAR agonists, antiestrogen and HER-2/neu antagonist in breast cancer cells. Evidence for a role in apoptosis. Oncogene (2004) 1.63

Dysregulation of the annexin family protein family is associated with prostate cancer progression. Am J Pathol (2003) 1.60

Downregulation of tumor suppressor Pdcd4 promotes invasion and activates both beta-catenin/Tcf and AP-1-dependent transcription in colon carcinoma cells. Oncogene (2007) 1.49

Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1). Am J Physiol Cell Physiol (2004) 1.49

Transformation suppressor protein Pdcd4 interferes with JNK-mediated phosphorylation of c-Jun and recruitment of the coactivator p300 by c-Jun. Oncogene (2004) 1.47

Mutational analysis of the DEAD-box RNA helicase eIF4AII characterizes its interaction with transformation suppressor Pdcd4 and eIF4GI. RNA (2005) 1.40

Application of cDNA microarrays to generate a molecular taxonomy capable of distinguishing between colon cancer and normal colon. Oncogene (2002) 1.39

Programmed cell death 4 loss increases tumor cell invasion and is regulated by miR-21 in oral squamous cell carcinoma. Mol Cancer (2010) 1.37

siRNA-mediated knockdown of Pdcd4 expression causes upregulation of p21(Waf1/Cip1) expression. Oncogene (2008) 1.36

The transformation suppressor protein Pdcd4 shuttles between nucleus and cytoplasm and binds RNA. Oncogene (2003) 1.35

Pdcd4, a colon cancer prognostic that is regulated by a microRNA. Crit Rev Oncol Hematol (2009) 1.34

Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis. Am J Pathol (2008) 1.26

Suppression of programmed cell death 4 (PDCD4) protein expression by BCR-ABL-regulated engagement of the mTOR/p70 S6 kinase pathway. J Biol Chem (2008) 1.21

Progress and challenges in colorectal cancer screening and surveillance. Gastroenterology (2010) 1.19

MicroRNA expression profiling in human Barrett's carcinogenesis. Int J Cancer (2011) 1.17

Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody. Pathol Int (1999) 1.07

Biomarkers in gastroenterology: between hope and hype comes histopathology. Am J Gastroenterol (2009) 1.02

Programmed cell death 4 protein in esophageal cancer. Oncol Rep (2010) 1.01

Early cellular events in colorectal carcinogenesis. Colorectal Dis (2002) 0.95

Bronchopulmonary carcinoid: phenotype and long-term outcome in a single-institution series of Italian patients. Clin Cancer Res (2008) 0.94

Does colonoscopy work? J Natl Compr Canc Netw (2010) 0.91

Programmed cell death 4 (PDCD4) expression during multistep Barrett's carcinogenesis. J Clin Pathol (2010) 0.88

Reducing the incidence and mortality of colon cancer: mass screening and colonoscopic polypectomy. Gastroenterol Clin North Am (2008) 0.87

Articles by these authors

Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data. Lancet Oncol (2010) 5.65

A randomized study on 1-week versus 4-week prophylaxis for venous thromboembolism after laparoscopic surgery for colorectal cancer. Ann Surg (2014) 3.43

MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets. J Pathol (2009) 3.29

A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis. Gastroenterology (2004) 2.70

Consensus statements for management of Barrett's dysplasia and early-stage esophageal adenocarcinoma, based on a Delphi process. Gastroenterology (2012) 2.68

Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. Cell (2005) 2.66

Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms. Gastroenterology (2008) 2.63

Galectin-3-expression analysis in the surgical selection of follicular thyroid nodules with indeterminate fine-needle aspiration cytology: a prospective multicentre study. Lancet Oncol (2008) 2.32

HP-NAP inhibits the growth of bladder cancer in mice by activating a cytotoxic Th1 response. Cancer Immunol Immunother (2011) 2.16

cT3N0 rectal cancer: potential overtreatment with preoperative chemoradiotherapy is warranted. J Clin Oncol (2008) 1.93

Gastritis staging in clinical practice: the OLGA staging system. Gut (2006) 1.90

Liver transplantation for the treatment of moderately or well-differentiated hepatocellular carcinoma. Ann Surg (2004) 1.88

Liver biopsy sampling in chronic viral hepatitis. Semin Liver Dis (2004) 1.66

Pro- and anti-inflammatory cytokines gene polymorphisms and Helicobacter pylori infection: interactions influence outcome. Cytokine (2004) 1.65

Prediction of lymph node status in superficial esophageal carcinoma. Ann Surg Oncol (2008) 1.62

Quantification of serum levels of pepsinogens and gastrin to assess eradication of Helicobacter pylori. Clin Gastroenterol Hepatol (2010) 1.58

Barrett's epithelium after antireflux surgery. J Gastrointest Surg (2005) 1.52

Clinical usefulness of gastric-juice analysis in 2007: the stone that the builders rejected has become the cornerstone. Gastrointest Endosc (2007) 1.51

Helicobacter pylori-negative gastritis: prevalence and risk factors. Am J Gastroenterol (2012) 1.51

Definition of Barrett's esophagus dysplasia: are we speaking the same language? World J Surg (2015) 1.50

Liver steatosis in children with chronic hepatitis C. Am J Gastroenterol (2006) 1.46

Waist-to-hip ratio, but not body mass index, is associated with an increased risk of Barrett's esophagus in white men. Clin Gastroenterol Hepatol (2012) 1.41

Helicobacter pylori eradication: are we really all equal? A controlled study in native and immigrant population. Intern Emerg Med (2010) 1.40

Impact of microRNAs on regulatory networks and pathways in human colorectal carcinogenesis and development of metastasis. BMC Genomics (2013) 1.39

Staging gastritis: an international proposal. Gastroenterology (2005) 1.29

Liver tumorigenicity promoted by microRNA-221 in a mouse transgenic model. Hepatology (2012) 1.23

MicroRNA expression profiling of male breast cancer. Breast Cancer Res (2009) 1.22

Biomechanical comparison of expandable cages for vertebral body replacement in the thoracolumbar spine. Spine (Phila Pa 1976) (2004) 1.21

Molecular characteristics in papillary thyroid cancers (PTCs) with no 131I uptake. Clin Endocrinol (Oxf) (2007) 1.20

Rationale in diagnosis and screening of atrophic gastritis with stomach-specific plasma biomarkers. Scand J Gastroenterol (2012) 1.18

Donor livers with steatosis are safe to use in hepatitis C virus-positive recipients. Liver Transpl (2009) 1.18

MicroRNA expression profiling in human Barrett's carcinogenesis. Int J Cancer (2011) 1.17

M30 neoepitope expression in epithelial cancer: quantification of apoptosis in circulating tumor cells by CellSearch analysis. Clin Cancer Res (2010) 1.17

Management of gastric polyps: an endoscopy-based approach. Clin Gastroenterol Hepatol (2013) 1.15

The hyaluronic acid receptor CD44 coordinates normal and metaplastic gastric epithelial progenitor cell proliferation. J Biol Chem (2013) 1.14

Fibrosis in chronic hepatitis C acquired in infancy: is it only a matter of time? Am J Gastroenterol (2003) 1.12

Relationship between tumor and plasma levels of hTERT mRNA in patients with colorectal cancer: implications for monitoring of neoplastic disease. Clin Cancer Res (2008) 1.11

Neck emergency due to parathyroid adenoma bleeding: a case report. J Med Case Rep (2009) 1.10

Protein kinase CK2 inhibition down modulates the NF-κB and STAT3 survival pathways, enhances the cellular proteotoxic stress and synergistically boosts the cytotoxic effect of bortezomib on multiple myeloma and mantle cell lymphoma cells. PLoS One (2013) 1.10

Oxidative DNA damage correlates with cell immortalization and mir-92 expression in hepatocellular carcinoma. BMC Cancer (2012) 1.07

The potential of restaging in the prediction of pathologic response after preoperative chemoradiotherapy for rectal cancer. Ann Surg Oncol (2006) 1.07

Prospective assessment of imaging after preoperative chemoradiotherapy for rectal cancer. Surgery (2010) 1.07

Two PMS2 mutations in a Turcot syndrome family with small bowel cancers. Am J Gastroenterol (2005) 1.05

Hepatoid adenocarcinoma of the colon: what should we target? Pathol Oncol Res (2011) 1.05

Operative link for gastritis assessment vs operative link on intestinal metaplasia assessment. World J Gastroenterol (2011) 1.03

Helicobacter pylori, inflammation, oxidative damage and gastric cancer: a morphological, biological and molecular pathway. Eur J Cancer Prev (2008) 1.02

Programmed cell death 4 protein in esophageal cancer. Oncol Rep (2010) 1.01

The HER2-miR125a5p/miR125b loop in gastric and esophageal carcinogenesis. Hum Pathol (2013) 1.00

Effects of blood group antigen-binding adhesin expression during Helicobacter pylori infection of Mongolian gerbils. J Infect Dis (2011) 0.99

Antibodies against synthetic deamidated gliadin peptides for celiac disease diagnosis and follow-up in children. Clin Chem (2008) 0.99

Early HER2 dysregulation in gastric and oesophageal carcinogenesis. Histopathology (2012) 0.98

The ubiquitin ligase Mindbomb 1 coordinates gastrointestinal secretory cell maturation. J Clin Invest (2013) 0.96

Nuclear expression of S100A4 calcium-binding protein increases cholangiocarcinoma invasiveness and metastasization. Hepatology (2011) 0.96

BRAF(K601E) mutation in a patient with a follicular thyroid carcinoma. Thyroid (2011) 0.96

MicroRNA profiles in familial and sporadic medullary thyroid carcinoma: preliminary relationships with RET status and outcome. Thyroid (2012) 0.96

Autoimmune atrophic gastritis--pathogenesis, pathology and management. Nat Rev Gastroenterol Hepatol (2013) 0.96

Combined RET and Ki-67 assessment in sporadic medullary thyroid carcinoma: a useful tool for patient risk stratification. Eur J Endocrinol (2011) 0.95

miRNAs in colon and rectal cancer: A consensus for their true clinical value. Clin Chim Acta (2010) 0.95

Anterior gradient 2 overexpression in lung adenocarcinoma. Appl Immunohistochem Mol Morphol (2012) 0.95

Tumor-associated macrophages as major source of APRIL in gastric MALT lymphoma. Blood (2011) 0.94

A haplotype of the methylenetetrahydrofolate reductase gene predicts poor tumor response in rectal cancer patients receiving preoperative chemoradiation. Pharmacogenet Genomics (2006) 0.94

Circulating cell-free DNA: a promising marker of pathologic tumor response in rectal cancer patients receiving preoperative chemoradiotherapy. Ann Surg Oncol (2011) 0.94

Bronchopulmonary carcinoid: phenotype and long-term outcome in a single-institution series of Italian patients. Clin Cancer Res (2008) 0.94

Rectal cancer neoadjuvant treatment in elderly patients. Anticancer Res (2006) 0.94

PDCD4/miR-21 dysregulation in inflammatory bowel disease-associated carcinogenesis. Virchows Arch (2012) 0.93

Helicobacter pylori CagA status, mucosal oxidative damage and gastritis phenotype: a potential pathway to cancer? Helicobacter (2003) 0.93

Anti-tumor activity of a miR-199-dependent oncolytic adenovirus. PLoS One (2013) 0.93

Nodal metastasis from locally advanced esophageal cancer: how neoadjuvant therapy modifies their frequency and distribution. Ann Surg Oncol (2011) 0.93

Expression of p53, p16INK4A, pRb, p21WAF1/CIP1, p27KIP1, cyclin D1, Ki-67 and HPV DNA in sinonasal endophytic Schneiderian (inverted) papilloma. Acta Otolaryngol (2009) 0.92

Pathogenesis of Helicobacter pylori infection. Helicobacter (2012) 0.92

Hepatic spleen nodules (HSN). Scand J Gastroenterol (2010) 0.92

Oxidative DNA damage in gastric cancer: CagA status and OGG1 gene polymorphism. Int J Cancer (2008) 0.91

Serological markers for gastric atrophy in asymptomatic patients infected with Helicobacter pylori. Am J Gastroenterol (2004) 0.91

Re: CDX2 homeotic gene expression in gastric noninvasive neoplasia. Am J Surg Pathol (2004) 0.91

microRNA-145 in Barrett's oesophagus: regulating BMP4 signalling via GATA6. Gut (2012) 0.91

Oxidative damage, pro-inflammatory cytokines, TGF-alpha and c-myc in chronic HCV-related hepatitis and cirrhosis. World J Gastroenterol (2006) 0.91

Oral-facial-digital syndrome type VI: is C5orf42 really the major gene? Hum Genet (2014) 0.90

Caustic ingestion and oesophageal cancer: intra- and peri-tumoral fibrosis is associated with a better prognosis. Eur J Cardiothorac Surg (2010) 0.89

BRAF in primary and recurrent papillary thyroid cancers: the relationship with (131)I and 2-[(18)F]fluoro-2-deoxy-D-glucose uptake ability. Eur J Endocrinol (2010) 0.89

Different hemodynamic patterns of alcoholic and viral endstage cirrhosis: analysis of explanted liver weight, degree of fibrosis and splanchnic Doppler parameters. Scand J Gastroenterol (2007) 0.89

Usefulness of serum pepsinogens in Helicobacter pylori chronic gastritis: relationship with inflammation, activity, and density of the bacterium. Dig Dis Sci (2006) 0.89