The hyaluronic acid receptor CD44 coordinates normal and metaplastic gastric epithelial progenitor cell proliferation.

PubWeight™: 1.14‹?› | Rank: Top 10%

🔗 View Article (PMC 3668764)

Published in J Biol Chem on April 15, 2013

Authors

Shradha S Khurana1, Terrence E Riehl, Benjamin D Moore, Matteo Fassan, Massimo Rugge, Judith Romero-Gallo, Jennifer Noto, Richard M Peek, William F Stenson, Jason C Mills

Author Affiliations

1: Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

Articles citing this

Stomach Organ and Cell Lineage Differentiation: from Embryogenesis to Adult Homeostasis. Cell Mol Gastroenterol Hepatol (2016) 1.46

Chronic tamoxifen use is associated with a decreased risk of intestinal metaplasia in human gastric epithelium. Dig Dis Sci (2013) 1.43

Reserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract. Sci Signal (2015) 1.15

Pathobiology of Helicobacter pylori-Induced Gastric Cancer. Gastroenterology (2015) 1.13

OCT1 is a determinant of synbindin-related ERK signalling with independent prognostic significance in gastric cancer. Gut (2014) 1.11

Expression of Activated Ras in Gastric Chief Cells of Mice Leads to the Full Spectrum of Metaplastic Lineage Transitions. Gastroenterology (2015) 1.04

CD44 plays a functional role in Helicobacter pylori-induced epithelial cell proliferation. PLoS Pathog (2015) 0.96

Gastric cancer stem cells in gastric carcinogenesis, progression, prevention and treatment. World J Gastroenterol (2014) 0.92

A novel human gastric primary cell culture system for modelling Helicobacter pylori infection in vitro. Gut (2014) 0.92

Chronic inflammation with Helicobacter pylori infection is implicated in CD44 overexpression through miR-328 suppression in the gastric mucosa. J Gastroenterol (2014) 0.91

The Role of CD44 in Disease Pathophysiology and Targeted Treatment. Front Immunol (2015) 0.91

Targeted Apoptosis of Parietal Cells is Insufficient to Induce Metaplasia in Stomach. Gastroenterology (2016) 0.90

The use of murine-derived fundic organoids in studies of gastric physiology. J Physiol (2015) 0.90

Wnt/β-catenin, an oncogenic pathway targeted by H. pylori in gastric carcinogenesis. Oncotarget (2015) 0.89

Hyaluronan, Inflammation, and Breast Cancer Progression. Front Immunol (2015) 0.87

Mesenchymal stem cells induce epithelial proliferation within the inflamed stomach. Am J Physiol Gastrointest Liver Physiol (2014) 0.81

NF-κB affects proliferation and invasiveness of breast cancer cells by regulating CD44 expression. PLoS One (2014) 0.80

Characterization of stem/progenitor cell cycle using murine circumvallate papilla taste bud organoid. Sci Rep (2015) 0.79

Murine Models of Gastric Corpus Preneoplasia. Cell Mol Gastroenterol Hepatol (2016) 0.79

Inhibition of interleukin-1beta-stimulated dedifferentiation of chondrocytes via controlled release of CrmA from hyaluronic acid-chitosan microspheres. BMC Musculoskelet Disord (2015) 0.78

Identification of alanyl aminopeptidase (CD13) as a surface marker for isolation of mature gastric zymogenic chief cells. Am J Physiol Gastrointest Liver Physiol (2015) 0.77

Gastric Metaplasia Induced by Helicobacter pylori Is Associated with Enhanced SOX9 Expression via Interleukin-1 Signaling. Infect Immun (2015) 0.77

Hepatocyte nuclear factor 4α is required for cell differentiation and homeostasis in the adult mouse gastric epithelium. Am J Physiol Gastrointest Liver Physiol (2016) 0.77

Intestine-specific homeobox (ISX) induces intestinal metaplasia and cell proliferation to contribute to gastric carcinogenesis. J Gastroenterol (2016) 0.76

A reciprocal regulatory circuit between CD44 and FGFR2 via c-myc controls gastric cancer cell growth. Oncotarget (2016) 0.76

Clinicopathological and prognostic significance of cancer stem cell markers CD44 and CD133 in patients with gastric cancer: A comprehensive meta-analysis with 4729 patients involved. Medicine (Baltimore) (2016) 0.75

A single transcription factor is sufficient to induce and maintain secretory cell architecture. Genes Dev (2017) 0.75

Initiation and Maintenance of Gastric Cancer: A Focus on CD44 Variant Isoforms and Cancer Stem Cells. Cell Mol Gastroenterol Hepatol (2017) 0.75

The homing receptor CD44 is involved in the progression of precancerous gastric lesions in patients infected with Helicobacter pylori and in development of mucous metaplasia in mice. Cancer Lett (2015) 0.75

Regulation of Gastric Metaplasia, Dysplasia, and Neoplasia by Bone Morphogenetic Protein Signaling. Cell Mol Gastroenterol Hepatol (2017) 0.75

Hyaluronic acid in digestive cancers. J Cancer Res Clin Oncol (2016) 0.75

CD44 variant isoform 9 emerges in response to injury and contributes to the regeneration of the gastric epithelium. J Pathol (2017) 0.75

Articles cited by this

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer (2010) 90.16

Bmi1 is expressed in vivo in intestinal stem cells. Nat Genet (2008) 10.22

Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell (2010) 7.25

CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis. Breast Cancer Res (2006) 6.35

Inflammation, atrophy, and gastric cancer. J Clin Invest (2007) 4.29

Identification of gastric cancer stem cells using the cell surface marker CD44. Stem Cells (2009) 4.08

The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor. Cell (2012) 3.91

CD44: structure, function, and association with the malignant process. Adv Cancer Res (1997) 3.66

Carcinogenesis of Helicobacter pylori. Gastroenterology (2007) 3.63

CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth. Cancer Cell (2011) 3.41

CD44 is of functional importance for colorectal cancer stem cells. Clin Cancer Res (2008) 3.40

Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer. Gastroenterology (2000) 2.99

Helicobacter pylori eradication and gastric cancer: when is the horse out of the barn? Am J Gastroenterol (2009) 2.89

Heparanase, hyaluronan, and CD44 in cancers: a breast carcinoma perspective. Cancer Res (2006) 2.61

The epidemiology of gastric cancer. Gastric Cancer (2002) 2.58

STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells. Stem Cells (2009) 2.46

Dynamics of epithelial cells in the corpus of the mouse stomach. I. Identification of proliferative cell types and pinpointing of the stem cell. Anat Rec (1993) 2.41

A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo. Oncogene (2006) 2.37

Breast cancer stem cell markers CD44, CD24 and ALDH1: expression distribution within intrinsic molecular subtype. J Clin Pathol (2011) 2.33

Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia. Cancer Cell (2012) 2.16

The maturation of mucus-secreting gastric epithelial progenitors into digestive-enzyme secreting zymogenic cells requires Mist1. Development (2007) 2.14

Mature chief cells are cryptic progenitors for metaplasia in the stomach. Gastroenterology (2010) 2.02

STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells. Oncogene (2004) 1.96

Molecular characterization of mouse gastric epithelial progenitor cells. Proc Natl Acad Sci U S A (2002) 1.94

A molecular signature of gastric metaplasia arising in response to acute parietal cell loss. Gastroenterology (2007) 1.88

A central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma. Cancer Discov (2012) 1.87

Helicobacter pylori recurrence in developed and developing countries: meta-analysis of 13C-urea breath test follow-up after eradication. Helicobacter (2008) 1.83

De-novo expression of CD44 and survival in gastric cancer. Lancet (1993) 1.75

Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3. Cancer Res (2006) 1.69

Patterns of gastric atrophy in intestinal type gastric carcinoma. Cancer (2002) 1.69

Prognostic significance of the cancer stem cell markers CD133, CD44, and CD166 in colorectal cancer. Cancer Invest (2009) 1.68

Tamoxifen induces rapid, reversible atrophy, and metaplasia in mouse stomach. Gastroenterology (2011) 1.65

Gene expression profiling of metaplastic lineages identifies CDH17 as a prognostic marker in early stage gastric cancer. Gastroenterology (2010) 1.64

Heregulin-mediated ErbB2-ERK signaling activates hyaluronan synthases leading to CD44-dependent ovarian tumor cell growth and migration. J Biol Chem (2007) 1.57

Loss of parietal cell expression of Sonic hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells. Gastroenterology (2009) 1.55

Helicobacter pylori and gastric adenocarcinoma. Clin Microbiol Infect (2009) 1.53

The gastric epithelial progenitor cell niche and differentiation of the zymogenic (chief) cell lineage. Dev Biol (2008) 1.53

Spasmolytic polypeptide expressing metaplasia to preneoplasia in H. felis-infected mice. Gastroenterology (2004) 1.52

Helicobacter pylori attaches to NeuAc alpha 2,3Gal beta 1,4 glycoconjugates produced in the stomach of transgenic mice lacking parietal cells. Mol Cell (1999) 1.51

Dynamics of epithelial cells in the corpus of the mouse stomach. II. Outward migration of pit cells. Anat Rec (1993) 1.47

Acetylation and activation of STAT3 mediated by nuclear translocation of CD44. J Cell Biol (2009) 1.47

Gastric epithelial stem cells. Gastroenterology (2010) 1.39

Bone morphogenetic protein signaling regulates gastric epithelial cell development and proliferation in mice. Gastroenterology (2010) 1.38

CD44 can be activated to function as an hyaluronic acid receptor in normal murine T cells. Eur J Immunol (1992) 1.37

The transcription factor MIST1 is a novel human gastric chief cell marker whose expression is lost in metaplasia, dysplasia, and carcinoma. Am J Pathol (2010) 1.37

CD44+ slow-cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesis. Cancer Sci (2009) 1.32

Ménétrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach. J Clin Invest (2007) 1.31

Helicobacter pylori cytotoxin-associated gene A activates the signal transducer and activator of transcription 3 pathway in vitro and in vivo. Cancer Res (2009) 1.28

Spasmolytic polypeptide-expressing metaplasia and intestinal metaplasia: time for reevaluation of metaplasias and the origins of gastric cancer. Gastroenterology (2010) 1.28

Stat3 activation in urothelial stem cells leads to direct progression to invasive bladder cancer. Cancer Res (2012) 1.25

MEK/ERK inhibitor U0126 affects in vitro and in vivo growth of embryonal rhabdomyosarcoma. Mol Cancer Ther (2009) 1.17

Effect of Helicobacter pylori eradication on gastric carcinogenesis. Lab Invest (2008) 1.14

Ras/Erk MAPK signaling in epidermal homeostasis and neoplasia. Cell Cycle (2007) 1.13

Expression of cell adhesion molecule CD44 in gastric adenocarcinoma and its prognostic importance. World J Gastroenterol (2008) 1.08

Current molecular markers for gastric progenitor cells and gastric cancer stem cells. J Gastroenterol (2011) 1.05

Acid increases proliferation via ERK and p38 MAPK-mediated increases in cyclooxygenase-2 in Barrett's adenocarcinoma cells. Am J Physiol Gastrointest Liver Physiol (2004) 1.04

Overexpression of transforming growth factor-alpha alters differentiation of gastric cell lineages. Dig Dis Sci (1996) 1.03

Differentiation of the gastric mucosa. II. Role of gastrin in gastric epithelial cell proliferation and maturation. Am J Physiol Gastrointest Liver Physiol (2006) 1.01

Expression of the cell adhesion molecule CD44 in gastric adenocarcinomas. Hum Pathol (1994) 1.00

Epidermal growth factor-regulated activation of Rac GTPase enhances CD44 cleavage by metalloproteinase disintegrin ADAM10. Biochem J (2006) 1.00

Natural history of gastric cancer after Helicobacter pylori eradication in Japan: after endoscopic resection, after treatment of the general population, and naturally. Helicobacter (2006) 0.98

Knockdown of STAT3 expression by RNAi suppresses growth and induces apoptosis and differentiation in glioblastoma stem cells. Int J Oncol (2010) 0.96

Abnormal functional and morphological regulation of the gastric mucosa in histamine H2 receptor-deficient mice. J Clin Invest (2000) 0.96

Altered expression of a putative progenitor cell marker DCAMKL1 in the rat gastric mucosa in regeneration, metaplasia and dysplasia. BMC Gastroenterol (2010) 0.95

Expression of CD44 and its variants on gastric epithelial cells of patients with Helicobacter pylori colonisation. Gut (1996) 0.95

Expression of CD44 variants in gastric carcinoma with or without Epstein-Barr virus. Int J Cancer (1997) 0.94

EGFR mutation up-regulates EGR1 expression through the ERK pathway. Anticancer Res (2009) 0.90

Oxyntic atrophy, metaplasia, and gastric cancer. Prog Mol Biol Transl Sci (2010) 0.87

Systemic activation of K-ras rapidly induces gastric hyperplasia and metaplasia in mice. Am J Cancer Res (2011) 0.87

EGFR is involved in control of gastric cell proliferation through activation of MAPK and Src signalling pathways in early-weaned rats. Cell Prolif (2011) 0.87

Stimulation of neoplastic mouse lung cell proliferation by alveolar macrophage-derived, insulin-like growth factor-1 can be blocked by inhibiting MEK and PI3K activation. Mol Cancer (2011) 0.84

Hyaluronic acid regulates normal intestinal and colonic growth in mice. Am J Physiol Gastrointest Liver Physiol (2012) 0.84

Clinicopathologic significance of putative stem cell markers, CD44 and nestin, in gastric adenocarcinoma. Int J Clin Exp Pathol (2011) 0.82

Evaluation of CD44 transcription variants in human digestive tract carcinomas and normal tissues. Int J Cancer (1996) 0.82

Gastric stem cells: an update. Keio J Med (2003) 0.81

Oncogenic CagA promotes gastric cancer risk via activating ERK signaling pathways: a nested case-control study. PLoS One (2011) 0.80

Lack of histamine alters gastric mucosal morphology: comparison of histidine decarboxylase-deficient and mast cell-deficient mice. Am J Physiol Gastrointest Liver Physiol (2004) 0.80

Epidermal growth factor influences cell proliferation, glycoproteins, and lipase activity in human fetal stomach. Gastroenterology (1997) 0.78

The MEK inhibitor, PD98059, reduces survival but does not block acute myeloid leukemia blast maturation in vitro. Eur J Haematol (2000) 0.78

Epithelial cell proliferation is promoted by the histamine H(3) receptor agonist (R)-alpha-methylhistamine throughout the rat gastrointestinal tract. Eur J Pharmacol (2006) 0.77

Articles by these authors

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity. Nature (2008) 8.22

Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury. Proc Natl Acad Sci U S A (2004) 5.89

Helicobacter pylori: gastric cancer and beyond. Nat Rev Cancer (2010) 4.64

Micro-RNA profiling in kidney and bladder cancers. Urol Oncol (2007) 4.35

Activation of beta-catenin by carcinogenic Helicobacter pylori. Proc Natl Acad Sci U S A (2005) 3.52

Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE). Nat Biotechnol (2008) 3.43

Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin Microbiol Rev (2010) 3.41

MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets. J Pathol (2009) 3.29

Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple intestinal neoplasia mice. Stem Cells (2007) 3.13

Celecoxib versus naproxen and diclofenac in osteoarthritis patients: SUCCESS-I Study. Am J Med (2006) 2.87

A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis. Gastroenterology (2004) 2.70

Consensus statements for management of Barrett's dysplasia and early-stage esophageal adenocarcinoma, based on a Delphi process. Gastroenterology (2012) 2.68

Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. Cell (2005) 2.66

Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms. Gastroenterology (2008) 2.63

Inflammation and intestinal metaplasia of the distal esophagus are associated with alterations in the microbiome. Gastroenterology (2009) 2.55

Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury. J Clin Invest (2007) 2.55

Molecular properties of adult mouse gastric and intestinal epithelial progenitors in their niches. J Biol Chem (2006) 2.49

Molecular features of adult mouse small intestinal epithelial progenitors. Proc Natl Acad Sci U S A (2003) 2.33

Galectin-3-expression analysis in the surgical selection of follicular thyroid nodules with indeterminate fine-needle aspiration cytology: a prospective multicentre study. Lancet Oncol (2008) 2.32

Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice. Gastroenterology (2009) 2.22

HP-NAP inhibits the growth of bladder cancer in mice by activating a cytotoxic Th1 response. Cancer Immunol Immunother (2011) 2.16

Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism. J Clin Invest (2011) 2.16

The maturation of mucus-secreting gastric epithelial progenitors into digestive-enzyme secreting zymogenic cells requires Mist1. Development (2007) 2.14

Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium. Cell (2013) 2.10

Regulation of gastric carcinogenesis by Helicobacter pylori virulence factors. Cancer Res (2008) 2.08

Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk. Gut (2011) 2.08

Mature chief cells are cryptic progenitors for metaplasia in the stomach. Gastroenterology (2010) 2.02

Helicobacter pylori protein-specific antibodies and risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev (2013) 2.01

Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin. Cancer Res (2003) 2.00

Reactive hemophagocytic syndrome complicating the treatment of inflammatory bowel disease. Inflamm Bowel Dis (2006) 1.96

Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemia. Gastroenterology (2003) 1.96

Inhibition of indoleamine 2,3-dioxygenase augments trinitrobenzene sulfonic acid colitis in mice. Gastroenterology (2003) 1.91

Regulation of colonic epithelial repair in mice by Toll-like receptors and hyaluronic acid. Gastroenterology (2009) 1.89

Doublecortin and CaM kinase-like-1 and leucine-rich-repeat-containing G-protein-coupled receptor mark quiescent and cycling intestinal stem cells, respectively. Stem Cells (2009) 1.89

Liver transplantation for the treatment of moderately or well-differentiated hepatocellular carcinoma. Ann Surg (2004) 1.88

A molecular signature of gastric metaplasia arising in response to acute parietal cell loss. Gastroenterology (2007) 1.88

Functional plasticity in the type IV secretion system of Helicobacter pylori. PLoS Pathog (2013) 1.84

Helicobacter pylori flagellin evades toll-like receptor 5-mediated innate immunity. J Infect Dis (2004) 1.83

Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms and gastric cancer: a meta-analysis. Cancer Epidemiol Biomarkers Prev (2006) 1.69

GATA2 functions at multiple steps in hemangioblast development and differentiation. Development (2006) 1.69

Liver biopsy sampling in chronic viral hepatitis. Semin Liver Dis (2004) 1.66

Pro- and anti-inflammatory cytokines gene polymorphisms and Helicobacter pylori infection: interactions influence outcome. Cytokine (2004) 1.65

Tamoxifen induces rapid, reversible atrophy, and metaplasia in mouse stomach. Gastroenterology (2011) 1.65

Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-beta peptide catabolism. J Neurosci (2006) 1.65

Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination. EMBO Rep (2009) 1.63

Prediction of lymph node status in superficial esophageal carcinoma. Ann Surg Oncol (2008) 1.62

Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer. Cancer Res (2004) 1.62

Phytosterols that are naturally present in commercial corn oil significantly reduce cholesterol absorption in humans. Am J Clin Nutr (2002) 1.60

Helicobacter pylori induces up-regulation of the epidermal growth factor receptor in AGS gastric epithelial cells. J Infect Dis (2007) 1.60

Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation. J Clin Invest (2004) 1.59

Quantification of serum levels of pepsinogens and gastrin to assess eradication of Helicobacter pylori. Clin Gastroenterol Hepatol (2010) 1.58

DNA qualification workflow for next generation sequencing of histopathological samples. PLoS One (2013) 1.57

Helicobacter pylori perturbs iron trafficking in the epithelium to grow on the cell surface. PLoS Pathog (2011) 1.57

Apobec-1 protects intestine from radiation injury through posttranscriptional regulation of cyclooxygenase-2 expression. Gastroenterology (2004) 1.56

The gastric epithelial progenitor cell niche and differentiation of the zymogenic (chief) cell lineage. Dev Biol (2008) 1.53

Barrett's epithelium after antireflux surgery. J Gastrointest Surg (2005) 1.52

Bone morphogenetic protein 4 signaling regulates epithelial renewal in the urinary tract in response to uropathogenic infection. Cell Host Microbe (2009) 1.51

Helicobacter pylori-negative gastritis: prevalence and risk factors. Am J Gastroenterol (2012) 1.51

Clinical usefulness of gastric-juice analysis in 2007: the stone that the builders rejected has become the cornerstone. Gastrointest Endosc (2007) 1.51

Definition of Barrett's esophagus dysplasia: are we speaking the same language? World J Surg (2015) 1.50

Safety of celecoxib in patients with ulcerative colitis in remission: a randomized, placebo-controlled, pilot study. Clin Gastroenterol Hepatol (2006) 1.49

Host response to Helicobacter pylori infection before initiation of the adaptive immune response. FEMS Immunol Med Microbiol (2007) 1.49

Human and Helicobacter pylori coevolution shapes the risk of gastric disease. Proc Natl Acad Sci U S A (2014) 1.48

Liver steatosis in children with chronic hepatitis C. Am J Gastroenterol (2006) 1.46

Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humans. J Clin Invest (2012) 1.45

Regulation of p53 tumor suppressor by Helicobacter pylori in gastric epithelial cells. Gastroenterology (2010) 1.45

Effects of trace components of dietary fat on cholesterol metabolism: phytosterols, oxysterols, and squalene. Nutr Rev (2002) 1.43

Chronic tamoxifen use is associated with a decreased risk of intestinal metaplasia in human gastric epithelium. Dig Dis Sci (2013) 1.43

Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancer. BMC Genomics (2009) 1.42

Waist-to-hip ratio, but not body mass index, is associated with an increased risk of Barrett's esophagus in white men. Clin Gastroenterol Hepatol (2012) 1.41

Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA. Gastroenterology (2011) 1.41

Helicobacter pylori dysregulation of gastric epithelial tight junctions by urease-mediated myosin II activation. Gastroenterology (2008) 1.41

Helicobacter pylori eradication: are we really all equal? A controlled study in native and immigrant population. Intern Emerg Med (2010) 1.40

Impact of microRNAs on regulatory networks and pathways in human colorectal carcinogenesis and development of metastasis. BMC Genomics (2013) 1.39

XBP1 controls maturation of gastric zymogenic cells by induction of MIST1 and expansion of the rough endoplasmic reticulum. Gastroenterology (2010) 1.37

The transcription factor MIST1 is a novel human gastric chief cell marker whose expression is lost in metaplasia, dysplasia, and carcinoma. Am J Pathol (2010) 1.37

The impact of parietal cells on Helicobacter pylori tropism and host pathology: an analysis using gnotobiotic normal and transgenic mice. Proc Natl Acad Sci U S A (2003) 1.36

An antimetastatic role for decorin in breast cancer. Am J Pathol (2008) 1.34

Helicobacter pylori strain-selective induction of matrix metalloproteinase-7 in vitro and within gastric mucosa. Gastroenterology (2003) 1.34

Targeted next-generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas. J Pathol (2014) 1.33

Interaction of Helicobacter pylori with gastric epithelial cells is mediated by the p53 protein family. Gastroenterology (2008) 1.33

Molecular typing of lung adenocarcinoma on cytological samples using a multigene next generation sequencing panel. PLoS One (2013) 1.32

Helicobacter pylori regulates cellular migration and apoptosis by activation of phosphatidylinositol 3-kinase signaling. J Infect Dis (2009) 1.29