Rectal epithelial cell mitosis and expression of macrophage migration inhibitory factor are increased 3 years after Roux-en-Y gastric bypass (RYGB) for morbid obesity: implications for long-term neoplastic risk following RYGB.

PubWeight™: 0.83‹?›

🔗 View Article (PMID 21303912)

Published in Gut on February 08, 2011

Authors

Prashant Kant1, Anita Sainsbury, Karen R Reed, Stephen G Pollard, Nigel Scott, Alan R Clarke, P Louise Coletta, Mark A Hull

Author Affiliations

1: Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, St James's University Hospital, Leeds LS9 7TF, UK.

Articles by these authors

Crypt stem cells as the cells-of-origin of intestinal cancer. Nature (2008) 11.66

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev (2004) 5.66

Myc deletion rescues Apc deficiency in the small intestine. Nature (2007) 5.42

Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin. Gastroenterology (2004) 3.39

Rates of circumferential resection margin involvement vary between surgeons and predict outcomes in rectal cancer surgery. Ann Surg (2002) 2.89

Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. Mol Cell Biol (2006) 2.83

Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice. Science (2002) 2.73

Ablation of beta1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation. J Cell Biol (2005) 2.33

Xylan-regulated delivery of human keratinocyte growth factor-2 to the inflamed colon by the human anaerobic commensal bacterium Bacteroides ovatus. Gut (2009) 2.32

Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposis. Gut (2010) 2.23

Increased risk of colorectal cancer after obesity surgery. Ann Surg (2013) 2.17

Alemtuzumab induction in renal transplantation permits safe steroid avoidance with tacrolimus monotherapy: a randomized controlled trial. Transplantation (2013) 2.06

Macrophage migration inhibitory factor promotes intestinal tumorigenesis. Gastroenterology (2005) 2.05

Aspirin in the chemoprevention of colorectal neoplasia: an overview. Cancer Prev Res (Phila) (2011) 2.03

The modern abdominoperineal excision: the next challenge after total mesorectal excision. Ann Surg (2005) 2.03

Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. Proc Natl Acad Sci U S A (2006) 1.93

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Dev Cell (2010) 1.79

WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis. Hum Mol Genet (2002) 1.70

Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine. J Biol Chem (2005) 1.62

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation. Nat Genet (2008) 1.50

Deficiency of Mbd2 suppresses intestinal tumorigenesis. Nat Genet (2003) 1.44

Matricellular protein SPARCL1 regulates tumor microenvironment-dependent endothelial cell heterogeneity in colorectal carcinoma. J Clin Invest (2016) 1.43

Outcomes in right liver lobe transplantation: a matched pair analysis. Transpl Int (2008) 1.40

Colorectal surgery performance. HESteria or hype? BMJ (2011) 1.38

Lkb1 deficiency causes prostate neoplasia in the mouse. Cancer Res (2008) 1.32

Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis. Proc Natl Acad Sci U S A (2003) 1.29

Surgical strategy for cystic diseases of the liver in a western hepatobiliary center. World J Surg (2002) 1.28

Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism. Gastroenterology (2009) 1.25

Mechanisms of disease: methyl-binding domain proteins as potential therapeutic targets in cancer. Nat Clin Pract Oncol (2007) 1.24

K-ras and Wnt signaling synergize to accelerate prostate tumorigenesis in the mouse. Cancer Res (2009) 1.24

PPARdelta status and Apc-mediated tumourigenesis in the mouse intestine. Oncogene (2004) 1.24

Apc deficiency predisposes to renal carcinoma in the mouse. Oncogene (2005) 1.23

Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss. Cancer Res (2010) 1.21

Indomethacin induces differential expression of beta-catenin, gamma-catenin and T-cell factor target genes in human colorectal cancer cells. Carcinogenesis (2002) 1.20

Excess body weight and obesity--the link with gastrointestinal and hepatobiliary cancer. Nat Rev Gastroenterol Hepatol (2011) 1.18

Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine. PLoS One (2009) 1.18

Aspirin activates the NF-kappaB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer. Carcinogenesis (2006) 1.16

Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo. PLoS Genet (2010) 1.16

Lymphodepletion in the ApcMin/+ mouse model of intestinal tumorigenesis. Blood (2003) 1.14

Liver transplantation following donation after cardiac death: an analysis using matched pairs. Liver Transpl (2009) 1.13

Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin. Cancer Res (2009) 1.10

Continuous transversus abdominis plane block for renal transplant recipients. Anesth Analg (2009) 1.10

Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy. Cancer Res (2005) 1.08

Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency. Oncogene (2002) 1.08

MiR-26b is down-regulated in carcinoma-associated fibroblasts from ER-positive breast cancers leading to enhanced cell migration and invasion. J Pathol (2013) 1.07

Lkb1 and Pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladder. PLoS One (2011) 1.06

B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver. Proc Natl Acad Sci U S A (2008) 1.06

Loss of Indian Hedgehog activates multiple aspects of a wound healing response in the mouse intestine. Gastroenterology (2010) 1.05

Donor risk index and MELD interactions in predicting long-term graft survival: a single-centre experience. Transplantation (2009) 1.04

Effects of Wnt3A and mechanical load on cartilage chondrocyte homeostasis. Arthritis Res Ther (2011) 1.01

Evidence and research in rectal cancer. Radiother Oncol (2008) 1.00

Early FDG PET response assessment of preoperative radiochemotherapy in locally advanced rectal cancer: correlation with long-term outcome. Eur J Nucl Med Mol Imaging (2012) 0.99

FGFR1-induced epithelial to mesenchymal transition through MAPK/PLCγ/COX-2-mediated mechanisms. PLoS One (2012) 0.98

Bile duct strictures after hepatobiliary surgery: assessment with MR cholangiography. Radiology (2004) 0.98

A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine. BMC Cancer (2008) 0.97

Vascular access survival in children and young adults receiving long-term hemodialysis. Am J Kidney Dis (2005) 0.97

Deficiency of Mbd2 attenuates Wnt signaling. Mol Cell Biol (2008) 0.97

Origin and maintenance of the intestinal cancer stem cell. Mol Carcinog (2011) 0.97

β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells. Gut (2011) 0.96

Effect of eicosapentaenoic acid on E-type prostaglandin synthesis and EP4 receptor signaling in human colorectal cancer cells. Neoplasia (2010) 0.95

The Roles of the Methyl-CpG Binding Proteins in Cancer. Genes Cancer (2011) 0.94

The effect of the selective cyclooxygenase-2 inhibitor rofecoxib on human colorectal cancer liver metastases. Gastroenterology (2003) 0.94

The wt1-heterozygous mouse; a model to study the development of glomerular sclerosis. J Pathol (2003) 0.94

Increased morbidity in overweight and obese liver transplant recipients: a single-center experience of 1325 patients from the United Kingdom. Liver Transpl (2013) 0.93

p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium. EMBO Mol Med (2010) 0.91

PTEN loss and KRAS activation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine. J Pathol (2014) 0.91

Gene manipulation through the use of small interfering RNA (siRNA): from in vitro to in vivo applications. Adv Drug Deliv Rev (2007) 0.91

Interstitial cell cyclooxygenase-2 expression is associated with increased angiogenesis in human sporadic colorectal adenomas. J Pathol (2002) 0.89

Brca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cells. Oncogene (2005) 0.89

New approaches for modelling cancer mechanisms in the mouse. J Pathol (2005) 0.89

MBD4 deficiency does not increase mutation or accelerate tumorigenesis in mice lacking MMR. Oncogene (2004) 0.89

Xanthogranulomatous cholecystitis: a European and global perspective. HPB (Oxford) (2013) 0.87

Oxaliplatin plus dual inhibition of thymidilate synthase during preoperative pelvic radiotherapy for locally advanced rectal carcinoma: long-term outcome. Int J Radiat Oncol Biol Phys (2010) 0.87

Increased colorectal epithelial cell proliferation and crypt fission associated with obesity and roux-en-Y gastric bypass. Cancer Epidemiol Biomarkers Prev (2008) 0.87

What are the best routes to effectively model human colorectal cancer? Mol Oncol (2013) 0.86

A randomized controlled trial of eicosapentaenoic acid and/or aspirin for colorectal adenoma prevention during colonoscopic surveillance in the NHS Bowel Cancer Screening Programme (The seAFOod Polyp Prevention Trial): study protocol for a randomized controlled trial. Trials (2013) 0.86

Aspirin users attending for NHS bowel cancer screening have less colorectal neoplasia: chemoprevention or false-positive faecal occult blood testing? Digestion (2012) 0.86

PTEN loss and KRAS activation cooperate in murine biliary tract malignancies. J Pathol (2013) 0.86

Apoptosis and mutation in the murine small intestine: loss of Mlh1- and Pms2-dependent apoptosis leads to increased mutation in vivo. DNA Repair (Amst) (2003) 0.86

Emergency subtotal hepatectomy: a new concept for acetaminophen-induced acute liver failure: temporary hepatic support by auxiliary orthotopic liver transplantation enables long-term success. Ann Surg (2008) 0.85

Evidence for a crucial role of paneth cells in mediating the intestinal response to injury. Stem Cells (2013) 0.84

A combined liver-pancreas en-bloc transplant in a patient with cystic fibrosis. Transplantation (2005) 0.84

DNA damage-induced apoptosis: insights from the mouse. Biochim Biophys Acta (2004) 0.84

Conditional disruption of Axin1 leads to development of liver tumors in mice. Gastroenterology (2012) 0.84

Efficient infection and persistence of a herpesvirus saimiri-based gene delivery vector into human tumor xenografts and multicellular spheroid cultures. Cancer Gene Ther (2005) 0.84

Absence of p53 in Clara cells favours multinucleation and loss of cell cycle arrest. BMC Cell Biol (2002) 0.84

Brg1 is required for stem cell maintenance in the murine intestinal epithelium in a tissue-specific manner. Stem Cells (2013) 0.83

A study of indefinite for dysplasia in Barrett's oesophagus: reproducibility of diagnosis, clinical outcomes and predicting progression with AMACR (alpha-methylacyl-CoA-racemase). Histopathology (2010) 0.83