Published in Gastroenterology on September 06, 2012
β-Catenin Signaling and Roles in Liver Homeostasis, Injury, and Tumorigenesis. Gastroenterology (2015) 1.20
Virus associated malignancies: the role of viral hepatitis in hepatocellular carcinoma. Semin Cancer Biol (2014) 1.04
AXIN1 and AXIN2 variants in gastrointestinal cancers. Cancer Lett (2014) 0.88
WNT-3A regulates an Axin1/NRF2 complex that regulates antioxidant metabolism in hepatocytes. Antioxid Redox Signal (2014) 0.85
Apc and p53 interaction in DNA damage and genomic instability in hepatocytes. Oncogene (2014) 0.81
Aberrant regulation of Wnt signaling in hepatocellular carcinoma. World J Gastroenterol (2016) 0.76
Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers. Gut (2016) 0.76
Vitamin D receptor is a novel transcriptional regulator for Axin1. J Steroid Biochem Mol Biol (2016) 0.75
Blocking Wnt Secretion Reduces Growth of Hepatocellular Carcinoma Cell Lines Mostly Independent of β-Catenin Signaling. Neoplasia (2016) 0.75
An AXIN2 Mutant Allele Associated With Predisposition to Colorectal Neoplasia Has Context-Dependent Effects on AXIN2 Protein Function. Neoplasia (2015) 0.75
Hippo signaling interactions with Wnt/β-catenin and Notch signaling repress liver tumorigenesis. J Clin Invest (2016) 0.75
Crypt stem cells as the cells-of-origin of intestinal cancer. Nature (2008) 11.66
Inherited variants of MYH associated with somatic G:C-->T:A mutations in colorectal tumors. Nat Genet (2002) 7.00
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev (2004) 5.66
Myc deletion rescues Apc deficiency in the small intestine. Nature (2007) 5.42
Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin. Gastroenterology (2004) 3.39
Morphologic changes in the peritoneal membrane of patients with renal disease. J Am Soc Nephrol (2002) 3.33
The future of the TNM staging system in colorectal cancer: time for a debate? Lancet Oncol (2007) 2.94
Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. Mol Cell Biol (2006) 2.83
Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice. Science (2002) 2.73
Functional and molecular characterisation of mammary side population cells. Breast Cancer Res (2002) 2.63
Biallelic germline mutations in MYH predispose to multiple colorectal adenoma and somatic G:C-->T:A mutations. Hum Mol Genet (2002) 2.48
Review of the pathological results of 2660 appendicectomy specimens. J Gastroenterol (2006) 2.41
Ablation of beta1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation. J Cell Biol (2005) 2.33
Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex. EMBO J (2003) 2.33
Morphologic predictors of lymph node status in rectal cancer with use of high-spatial-resolution MR imaging with histopathologic comparison. Radiology (2003) 2.24
The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk. Nat Med (2005) 2.01
Protein kinase B/Akt acts via glycogen synthase kinase 3 to regulate recycling of alpha v beta 3 and alpha 5 beta 1 integrins. Mol Cell Biol (2004) 1.93
Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. Proc Natl Acad Sci U S A (2006) 1.93
A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules. J Cell Biol (2004) 1.90
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Dev Cell (2010) 1.79
Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. J Cell Biol (2007) 1.77
WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis. Hum Mol Genet (2002) 1.70
A new transcription factor that regulates TNF-alpha gene expression, LITAF, is increased in intestinal tissues from patients with CD and UC. Inflamm Bowel Dis (2006) 1.69
CD4+CD25+FOXP3+ regulatory T cells suppress anti-tumor immune responses in patients with colorectal cancer. PLoS One (2006) 1.68
Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine. J Biol Chem (2005) 1.62
The natural course of peritoneal membrane biology during peritoneal dialysis. Kidney Int Suppl (2003) 1.58
Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation. Nat Genet (2008) 1.50
Pelvic examination of asymptomatic women - attitudes and clinical practice. Aust Fam Physician (2008) 1.49
Identification of the Axin and Frat binding region of glycogen synthase kinase-3. J Biol Chem (2001) 1.49
Contribution of the ABC transporters Bcrp1 and Mdr1a/1b to the side population phenotype in mammary gland and bone marrow of mice. Stem Cells (2005) 1.46
Deficiency of Mbd2 suppresses intestinal tumorigenesis. Nat Genet (2003) 1.44
Matricellular protein SPARCL1 regulates tumor microenvironment-dependent endothelial cell heterogeneity in colorectal carcinoma. J Clin Invest (2016) 1.43
High-resolution MRI of the anatomy important in total mesorectal excision of the rectum. AJR Am J Roentgenol (2004) 1.42
Darzi review. Managers put faith in Darzi's clinical vision. Health Serv J (2008) 1.39
The faith, activity, and nutrition (FAN) program: design of a participatory research intervention to increase physical activity and improve dietary habits in African American churches. Contemp Clin Trials (2010) 1.37
Lkb1 deficiency causes prostate neoplasia in the mouse. Cancer Res (2008) 1.32
Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis. Proc Natl Acad Sci U S A (2003) 1.29
The Faith, Activity, and Nutrition program: a randomized controlled trial in African-American churches. Am J Prev Med (2013) 1.26
The regulation of glycogen synthase kinase-3 nuclear export by Frat/GBP. J Biol Chem (2002) 1.25
Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism. Gastroenterology (2009) 1.25
Mechanisms of disease: methyl-binding domain proteins as potential therapeutic targets in cancer. Nat Clin Pract Oncol (2007) 1.24
K-ras and Wnt signaling synergize to accelerate prostate tumorigenesis in the mouse. Cancer Res (2009) 1.24
PPARdelta status and Apc-mediated tumourigenesis in the mouse intestine. Oncogene (2004) 1.24
Apc deficiency predisposes to renal carcinoma in the mouse. Oncogene (2005) 1.23
Dietary energy availability affects primary and metastatic breast cancer and metformin efficacy. Breast Cancer Res Treat (2009) 1.23
Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss. Cancer Res (2010) 1.21
Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine. PLoS One (2009) 1.18
Aspirin activates the NF-kappaB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer. Carcinogenesis (2006) 1.16
Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo. PLoS Genet (2010) 1.16
Collagenous sprue: a clinicopathologic study of 12 cases. Am J Surg Pathol (2009) 1.13
Dishevelled (Dvl-2) activates canonical Wnt signalling in the absence of cytoplasmic puncta. J Cell Sci (2005) 1.12
Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin. Cancer Res (2009) 1.10
Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy. Cancer Res (2005) 1.08
Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency. Oncogene (2002) 1.08
Lkb1 and Pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladder. PLoS One (2011) 1.06
B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver. Proc Natl Acad Sci U S A (2008) 1.06
Loss of Indian Hedgehog activates multiple aspects of a wound healing response in the mouse intestine. Gastroenterology (2010) 1.05
Shared decision making and decision aids - a literature review. Aust Fam Physician (2006) 1.05
Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathway. Sci Signal (2014) 1.01
Effects of Wnt3A and mechanical load on cartilage chondrocyte homeostasis. Arthritis Res Ther (2011) 1.01
Extensive telomere erosion in the initiation of colorectal adenomas and its association with chromosomal instability. J Natl Cancer Inst (2013) 0.98
Double-blind placebo-controlled trial of fluoxetine in smoking cessation treatment including nicotine patch and cognitive-behavioral group therapy. Am J Addict (2005) 0.98
Three-dimensional hierarchical plasmonic nano-architecture enhanced surface-enhanced Raman scattering immunosensor for cancer biomarker detection in blood plasma. ACS Nano (2013) 0.98
A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine. BMC Cancer (2008) 0.97
Origin and maintenance of the intestinal cancer stem cell. Mol Carcinog (2011) 0.97
Deficiency of Mbd2 attenuates Wnt signaling. Mol Cell Biol (2008) 0.97
The potential for targeting oncogenic WNT/beta-catenin signaling in therapy. Curr Drug Targets (2008) 0.97
Toward a quantitative understanding of the Wnt/β-catenin pathway through simulation and experiment. Wiley Interdiscip Rev Syst Biol Med (2013) 0.96
Peritoneal dialysis: changes to the structure of the peritoneal membrane and potential for biocompatible solutions. Kidney Int Suppl (2003) 0.96
Identification and quantification of a new family of peptide endocannabinoids (Pepcans) showing negative allosteric modulation at CB1 receptors. J Biol Chem (2012) 0.96
The Roles of the Methyl-CpG Binding Proteins in Cancer. Genes Cancer (2011) 0.94
The wt1-heterozygous mouse; a model to study the development of glomerular sclerosis. J Pathol (2003) 0.94
Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans. Dev Biol (2007) 0.94
Telemedicine for rural cancer care in North Queensland: bringing cancer care home. Aust J Rural Health (2012) 0.93
A prospective study of the accuracy and concordance between in-situ and postfixation measurements of colorectal polyp size and their potential impact upon surveillance. Eur J Gastroenterol Hepatol (2013) 0.93
Cardiac-specific, inducible ClC-3 gene deletion eliminates native volume-sensitive chloride channels and produces myocardial hypertrophy in adult mice. J Mol Cell Cardiol (2009) 0.92
p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium. EMBO Mol Med (2010) 0.91
PTEN loss and KRAS activation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine. J Pathol (2014) 0.91
Gene manipulation through the use of small interfering RNA (siRNA): from in vitro to in vivo applications. Adv Drug Deliv Rev (2007) 0.91
Targeting peptide termini, a novel immunoaffinity approach to reduce complexity in mass spectrometric protein identification. Mol Cell Proteomics (2010) 0.90
MBD4 deficiency does not increase mutation or accelerate tumorigenesis in mice lacking MMR. Oncogene (2004) 0.89
Brca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cells. Oncogene (2005) 0.89
New approaches for modelling cancer mechanisms in the mouse. J Pathol (2005) 0.89
What are the best routes to effectively model human colorectal cancer? Mol Oncol (2013) 0.86
Medical students seeking medical help: a qualitative study. Med Teach (2010) 0.86
PTEN loss and KRAS activation cooperate in murine biliary tract malignancies. J Pathol (2013) 0.86
A randomized trial of nicotine enemas for active ulcerative colitis. Clin Gastroenterol Hepatol (2005) 0.86
Cardiac-specific overexpression of the human short CLC-3 chloride channel isoform in mice. Clin Exp Pharmacol Physiol (2008) 0.86
Apoptosis and mutation in the murine small intestine: loss of Mlh1- and Pms2-dependent apoptosis leads to increased mutation in vivo. DNA Repair (Amst) (2003) 0.86
Optimal selection of epitopes for TXP-immunoaffinity mass spectrometry. Algorithms Mol Biol (2010) 0.85
Integrating service-learning into an MPH curriculum for future public health practitioners: strengthening community-campus partnerships. J Public Health Manag Pract (2011) 0.85