Published in J Pharmacol Exp Ther on February 08, 2011
A double-blind randomized controlled trial of N-acetylcysteine in cannabis-dependent adolescents. Am J Psychiatry (2012) 2.03
The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research. Psychopharmacology (Berl) (2013) 2.01
Thinking outside the cleft to understand synaptic activity: contribution of the cystine-glutamate antiporter (System xc-) to normal and pathological glutamatergic signaling. Pharmacol Rev (2012) 1.21
Ceftriaxone prevents the induction of cocaine sensitization and produces enduring attenuation of cue- and cocaine-primed reinstatement of cocaine-seeking. Behav Brain Res (2011) 1.16
Nicotine self-administration and reinstatement of nicotine-seeking in male and female rats. Drug Alcohol Depend (2011) 1.13
Potential role of N-acetylcysteine in the management of substance use disorders. CNS Drugs (2014) 1.04
Astrocytic dysfunction and addiction: consequences of impaired glutamate homeostasis. Neuroscientist (2014) 0.99
Oxidative stress and cerebral endothelial cells: regulation of the blood-brain-barrier and antioxidant based interventions. Biochim Biophys Acta (2011) 0.98
Effect of fenfluramine on reinstatement of food seeking in female and male rats: implications for the predictive validity of the reinstatement model. Psychopharmacology (Berl) (2011) 0.98
Rapid, transient synaptic plasticity in addiction. Neuropharmacology (2013) 0.98
Morphine induces redox-based changes in global DNA methylation and retrotransposon transcription by inhibition of excitatory amino acid transporter type 3-mediated cysteine uptake. Mol Pharmacol (2014) 0.97
N-acetylcysteine decreased nicotine self-administration and cue-induced reinstatement of nicotine seeking in rats: comparison with the effects of N-acetylcysteine on food responding and food seeking. Psychopharmacology (Berl) (2012) 0.96
Dysregulation of dopamine and glutamate release in the prefrontal cortex and nucleus accumbens following methamphetamine self-administration and during reinstatement in rats. Neuropsychopharmacology (2013) 0.94
A double-blind placebo-controlled trial of N-acetylcysteine in the treatment of cocaine dependence. Am J Addict (2013) 0.94
Achieving cannabis cessation -- evaluating N-acetylcysteine treatment (ACCENT): design and implementation of a multi-site, randomized controlled study in the National Institute on Drug Abuse Clinical Trials Network. Contemp Clin Trials (2014) 0.92
The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis. Pharmacol Rev (2016) 0.86
Chronic modafinil effects on drug-seeking following methamphetamine self-administration in rats. Int J Neuropsychopharmacol (2011) 0.84
The effects of N-Acetylcysteine on frontostriatal resting-state functional connectivity, withdrawal symptoms and smoking abstinence: A double-blind, placebo-controlled fMRI pilot study. Drug Alcohol Depend (2015) 0.84
Future pharmacological treatments for substance use disorders. Br J Clin Pharmacol (2014) 0.83
Ceftriaxone and cefazolin attenuate the cue-primed reinstatement of alcohol-seeking. Front Pharmacol (2015) 0.82
Glutamate Transporter GLT-1 as a Therapeutic Target for Substance Use Disorders. CNS Neurol Disord Drug Targets (2015) 0.80
Redox-based epigenetic status in drug addiction: a potential contributor to gene priming and a mechanistic rationale for metabolic intervention. Front Neurosci (2015) 0.80
Enhanced extinction of cocaine seeking in brain-derived neurotrophic factor Val66Met knock-in mice. Eur J Neurosci (2012) 0.80
An open-label pilot trial of N-acetylcysteine and varenicline in adult cigarette smokers. Am J Drug Alcohol Abuse (2014) 0.77
Genetic variation in the alpha synuclein gene (SNCA) is associated with BOLD response to alcohol cues. J Stud Alcohol Drugs (2013) 0.77
Glutathione and redox signaling in substance abuse. Biomed Pharmacother (2014) 0.76
Chronic N-acetylcysteine after cocaine self-administration produces enduring reductions in drug-seeking. Neuropsychopharmacology (2012) 0.76
Ceftriaxone attenuates cocaine relapse after abstinence through modulation of nucleus accumbens AMPA subunit expression. Eur Neuropsychopharmacol (2015) 0.76
N-acetylcysteine amide (AD4) reduces cocaine-induced reinstatement. Psychopharmacology (Berl) (2016) 0.75
S-Glutathionylation and Redox Protein Signaling in Drug Addiction. Prog Mol Biol Transl Sci (2015) 0.75
Toward early estimation and treatment of addiction vulnerability: radial arm maze and N-acetyl cysteine before cocaine sensitization or nicotine self-administration in neonatal ventral hippocampal lesion rats. Psychopharmacology (Berl) (2016) 0.75
Behavioral History of Withdrawal Influences Regulation of Cocaine Seeking by Glutamate Re-Uptake. PLoS One (2016) 0.75
Hypothesizing that, A Pro-Dopamine Regulator (KB220Z) Should Optimize, but Not Hyper-Activate the Activity of Trace Amine-Associated Receptor 1 (TAAR-1) and Induce Anti-Craving of Psychostimulants in the Long-Term. J Reward Defic Syndr Addict Sci (2016) 0.75
Acquisition, Maintenance and Relapse-Like Alcohol Drinking: Lessons from the UChB Rat Line. Front Behav Neurosci (2017) 0.75
Glutamate transport: a new bench to bedside mechanism for treating drug abuse. Int J Neuropsychopharmacol (2017) 0.75
N-Acetylcysteine reduces cocaine-cue attentional bias and differentially alters cocaine self-administration based on dosing order. Drug Alcohol Depend (2017) 0.75
The reinstatement model of drug relapse: history, methodology and major findings. Psychopharmacology (Berl) (2002) 9.90
Neural mechanisms of extinction learning and retrieval. Neuropsychopharmacology (2007) 7.57
Context, ambiguity, and unlearning: sources of relapse after behavioral extinction. Biol Psychiatry (2002) 6.67
The glutamate homeostasis hypothesis of addiction. Nat Rev Neurosci (2009) 5.97
Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear. Arch Gen Psychiatry (2004) 5.26
Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior. J Neurosci (2003) 5.20
Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse. Nat Neurosci (2003) 4.63
N-Acetylcysteine reverses cocaine-induced metaplasticity. Nat Neurosci (2009) 3.49
Effects of D-cycloserine on extinction: translation from preclinical to clinical work. Biol Psychiatry (2006) 3.45
The origin and neuronal function of in vivo nonsynaptic glutamate. J Neurosci (2002) 3.40
Fos protein expression and cocaine-seeking behavior in rats after exposure to a cocaine self-administration environment. J Neurosci (2000) 2.86
Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour. Nature (2003) 2.86
Different neural substrates mediate cocaine seeking after abstinence versus extinction training: a critical role for the dorsolateral caudate-putamen. J Neurosci (2006) 2.51
Repeated N-acetylcysteine administration alters plasticity-dependent effects of cocaine. J Neurosci (2007) 2.35
Cue reactivity and cue reactivity interventions in drug dependence. NIDA Res Monogr (1993) 2.23
Is cocaine desire reduced by N-acetylcysteine? Am J Psychiatry (2007) 2.08
Reversing cocaine-induced synaptic potentiation provides enduring protection from relapse. Proc Natl Acad Sci U S A (2010) 1.94
N-acetylcysteine reduces extinction responding and induces enduring reductions in cue- and heroin-induced drug-seeking. Biol Psychiatry (2007) 1.90
An open-label trial of N-acetylcysteine for the treatment of cocaine dependence: a pilot study. Prog Neuropsychopharmacol Biol Psychiatry (2006) 1.82
Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine seeking. J Neurosci (2010) 1.76
Environments as cues to smoke: implications for human extinction-based research and treatment. Exp Clin Psychopharmacol (2006) 1.74
The group II metabotropic glutamate receptor agonist, LY379268, inhibits both cocaine- and food-seeking behavior in rats. Psychopharmacology (Berl) (2006) 1.74
Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking. Behav Brain Res (2009) 1.73
The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice. J Neurochem (2003) 1.67
Regulation of drug-taking and -seeking behaviors by neuroadaptations in the mesolimbic dopamine system. Neuropharmacology (2004) 1.54
Blunted cystine-glutamate antiporter function in the nucleus accumbens promotes cocaine-induced drug seeking. Neuroscience (2008) 1.52
Repeated N-acetyl cysteine reduces cocaine seeking in rodents and craving in cocaine-dependent humans. Neuropsychopharmacology (2010) 1.36
Fos and glutamate AMPA receptor subunit coexpression associated with cue-elicited cocaine-seeking behavior in abstinent rats. Neuroscience (2007) 1.28
N-acetyl cysteine-induced blockade of cocaine-induced reinstatement. Ann N Y Acad Sci (2003) 1.26
Forced abstinence model of relapse to study pharmacological treatments of substance use disorder. Curr Drug Abuse Rev (2009) 1.11
Extinction training regulates tyrosine hydroxylase during withdrawal from cocaine self-administration. J Neurosci (2001) 1.10
Anti-relapse medications: preclinical models for drug addiction treatment. Pharmacol Ther (2009) 1.08
Methamphetamine craving induced in an online virtual reality environment. Pharmacol Biochem Behav (2010) 1.07
Cue-exposure therapy to decrease alcohol craving in virtual environment. Cyberpsychol Behav (2007) 1.02
Internal cue exposure and the treatment of substance use disorders: lessons from the treatment of panic disorder. J Anxiety Disord (2004) 1.01
Cue exposure therapy for the treatment of opiate addiction: results of a randomized controlled clinical trial. Psychother Psychosom (2007) 0.99
Impairment in consolidation of learned place preference following dopaminergic neurotoxicity in mice is ameliorated by N-acetylcysteine but not D1 and D2 dopamine receptor agonists. Neuropsychopharmacology (2006) 0.90
Antidepressant-like effects of N-acetyl-L-cysteine in rats. Behav Pharmacol (2008) 0.85
Effect of N-acetyl cysteine against aluminium-induced cognitive dysfunction and oxidative damage in rats. Basic Clin Pharmacol Toxicol (2009) 0.85
Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior. J Neurosci (2003) 5.20
Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse. Nat Neurosci (2003) 4.63
Extinction circuits for fear and addiction overlap in prefrontal cortex. Learn Mem (2009) 3.62
N-Acetylcysteine reverses cocaine-induced metaplasticity. Nat Neurosci (2009) 3.49
The origin and neuronal function of in vivo nonsynaptic glutamate. J Neurosci (2002) 3.40
The role of the dorsomedial prefrontal cortex, basolateral amygdala, and dorsal hippocampus in contextual reinstatement of cocaine seeking in rats. Neuropsychopharmacology (2005) 3.28
Infralimbic prefrontal cortex is responsible for inhibiting cocaine seeking in extinguished rats. J Neurosci (2008) 3.20
Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking. J Neurosci (2005) 3.08
Limbic and motor circuitry underlying footshock-induced reinstatement of cocaine-seeking behavior. J Neurosci (2004) 2.87
Selective inactivation of the dorsomedial prefrontal cortex and the basolateral amygdala attenuates conditioned-cued reinstatement of extinguished cocaine-seeking behavior in rats. Psychopharmacology (Berl) (2002) 2.79
Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking. Biol Psychiatry (2010) 2.60
Activator of G protein signaling 3: a gatekeeper of cocaine sensitization and drug seeking. Neuron (2004) 2.57
Different neural substrates mediate cocaine seeking after abstinence versus extinction training: a critical role for the dorsolateral caudate-putamen. J Neurosci (2006) 2.51
Harnessing neuroplasticity for clinical applications. Brain (2011) 2.45
Altered dendritic spine plasticity in cocaine-withdrawn rats. J Neurosci (2009) 2.44
Drug wanting: behavioral sensitization and relapse to drug-seeking behavior. Pharmacol Rev (2011) 2.30
Differential involvement of the core and shell subregions of the nucleus accumbens in conditioned cue-induced reinstatement of cocaine seeking in rats. Psychopharmacology (Berl) (2004) 2.29
Glutamate release in the nucleus accumbens core is necessary for heroin seeking. J Neurosci (2008) 2.25
Homer2 is necessary for EtOH-induced neuroplasticity. J Neurosci (2005) 2.17
The role of cystine-glutamate exchange in nicotine dependence in rats and humans. Biol Psychiatry (2008) 2.08
Is cocaine desire reduced by N-acetylcysteine? Am J Psychiatry (2007) 2.08
A BDNF infusion into the medial prefrontal cortex suppresses cocaine seeking in rats. Eur J Neurosci (2007) 2.00
Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase. Mol Cell (2009) 1.94
Reversing cocaine-induced synaptic potentiation provides enduring protection from relapse. Proc Natl Acad Sci U S A (2010) 1.94
N-acetylcysteine reduces extinction responding and induces enduring reductions in cue- and heroin-induced drug-seeking. Biol Psychiatry (2007) 1.90
Differential involvement of orbitofrontal cortex subregions in conditioned cue-induced and cocaine-primed reinstatement of cocaine seeking in rats. J Neurosci (2004) 1.87
Cocaine increases actin cycling: effects in the reinstatement model of drug seeking. J Neurosci (2006) 1.86
Cystine/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation. J Neurosci (2006) 1.85
Homer proteins regulate sensitivity to cocaine. Neuron (2004) 1.83
An open-label trial of N-acetylcysteine for the treatment of cocaine dependence: a pilot study. Prog Neuropsychopharmacol Biol Psychiatry (2006) 1.82
Relapse induced by cues predicting cocaine depends on rapid, transient synaptic potentiation. Neuron (2013) 1.78
Ethanol exposure decreases glutamate uptake in the nucleus accumbens. Alcohol Clin Exp Res (2005) 1.77
Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine seeking. J Neurosci (2010) 1.76
The group II metabotropic glutamate receptor agonist, LY379268, inhibits both cocaine- and food-seeking behavior in rats. Psychopharmacology (Berl) (2006) 1.74
Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens. J Pharmacol Exp Ther (2002) 1.70
Potentiation of cue-induced reinstatement of cocaine-seeking in rats by the anxiogenic drug yohimbine. Behav Brain Res (2006) 1.69
A silent synapse-based mechanism for cocaine-induced locomotor sensitization. J Neurosci (2011) 1.68
Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking. Eur J Neurosci (2009) 1.67
The infralimbic cortex regulates the consolidation of extinction after cocaine self-administration. Learn Mem (2010) 1.66
The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities. Antioxid Redox Signal (2012) 1.64
Optogenetic inhibition of cocaine seeking in rats. Addict Biol (2012) 1.64
Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine. J Pharmacol Exp Ther (2002) 1.59
Glutamate and reinstatement. Curr Opin Pharmacol (2009) 1.59
Contributions of prolonged contingent and noncontingent cocaine exposure to enhanced reinstatement of cocaine seeking in rats. Psychopharmacology (Berl) (2006) 1.58
Extended access to cocaine self-administration enhances drug-primed reinstatement but not behavioral sensitization. J Pharmacol Exp Ther (2007) 1.58
A single intra-PFC infusion of BDNF prevents cocaine-induced alterations in extracellular glutamate within the nucleus accumbens. J Neurosci (2009) 1.54
Regulation of extracellular glutamate in the prefrontal cortex: focus on the cystine glutamate exchanger and group I metabotropic glutamate receptors. J Pharmacol Exp Ther (2005) 1.47
Extended methamphetamine self-administration in rats results in a selective reduction of dopamine transporter levels in the prefrontal cortex and dorsal striatum not accompanied by marked monoaminergic depletion. J Pharmacol Exp Ther (2009) 1.43
Translating glutamate: from pathophysiology to treatment. Sci Transl Med (2011) 1.42
Cocaine-induced reinstatement requires endogenous stimulation of mu-opioid receptors in the ventral pallidum. J Neurosci (2005) 1.41
Neural circuit competition in cocaine-seeking: roles of the infralimbic cortex and nucleus accumbens shell. Eur J Neurosci (2012) 1.39
Glutamatergic medications for the treatment of drug and behavioral addictions. Pharmacol Biochem Behav (2011) 1.38
Homer proteins: implications for neuropsychiatric disorders. Curr Opin Neurobiol (2006) 1.38
Cocaine-induced adaptations in D1 and D2 accumbens projection neurons (a dichotomy not necessarily synonymous with direct and indirect pathways). Curr Opin Neurobiol (2013) 1.36
Basolateral amygdala inactivation abolishes conditioned stimulus- and heroin-induced reinstatement of extinguished heroin-seeking behavior in rats. Psychopharmacology (Berl) (2002) 1.33
Reinstatement of nicotine seeking is mediated by glutamatergic plasticity. Proc Natl Acad Sci U S A (2013) 1.33
Using glutamate homeostasis as a target for treating addictive disorders. Behav Pharmacol (2010) 1.31
Ceftriaxone normalizes nucleus accumbens synaptic transmission, glutamate transport, and export following cocaine self-administration and extinction training. J Neurosci (2012) 1.29
Heroin relapse requires long-term potentiation-like plasticity mediated by NMDA2b-containing receptors. Proc Natl Acad Sci U S A (2011) 1.29
Selective inactivation of the ventral hippocampus attenuates cue-induced and cocaine-primed reinstatement of drug-seeking in rats. Neurobiol Learn Mem (2007) 1.28
The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine. Biol Psychiatry (2011) 1.28
The role of the basolateral amygdala in stimulus-reward memory and extinction memory consolidation and in subsequent conditioned cued reinstatement of cocaine seeking. Eur J Neurosci (2006) 1.27
Group II metabotropic glutamate receptors (mGlu2/3) in drug addiction. Eur J Pharmacol (2010) 1.27
Plasma progesterone levels and cocaine-seeking in freely cycling female rats across the estrous cycle. Drug Alcohol Depend (2007) 1.27
N-acetyl cysteine-induced blockade of cocaine-induced reinstatement. Ann N Y Acad Sci (2003) 1.26
Loss of object recognition memory produced by extended access to methamphetamine self-administration is reversed by positive allosteric modulation of metabotropic glutamate receptor 5. Neuropsychopharmacology (2010) 1.25
Potentiation of cocaine-primed reinstatement of drug seeking in female rats during estrus. Psychopharmacology (Berl) (2005) 1.24
GABA transmission in the nucleus accumbens is altered after withdrawal from repeated cocaine. J Neurosci (2003) 1.23
Opposing roles for the ventral prefrontal cortex and the basolateral amygdala on the spontaneous recovery of cocaine-seeking in rats. Psychopharmacology (Berl) (2007) 1.21
Development of an alcohol deprivation and escalation effect in C57BL/6J mice. Alcohol Clin Exp Res (2006) 1.21
Attenuation of cocaine-seeking by progesterone treatment in female rats. Psychoneuroendocrinology (2008) 1.21
Chronic ethanol consumption by C57BL/6 mice promotes tolerance to its interoceptive cues and increases extracellular dopamine, an effect blocked by naltrexone. Alcohol Clin Exp Res (2003) 1.20
Automated quantification of dendritic spine density and spine head diameter in medium spiny neurons of the nucleus accumbens. Brain Struct Funct (2008) 1.20
Modafinil effects on reinstatement of methamphetamine seeking in a rat model of relapse. Psychopharmacology (Berl) (2010) 1.19
Homer isoforms differentially regulate cocaine-induced neuroplasticity. Neuropsychopharmacology (2006) 1.18
Role of the prefrontal cortex and nucleus accumbens in reinstating methamphetamine seeking. Eur J Neurosci (2010) 1.17
NMDA receptor blockade in the basolateral amygdala disrupts consolidation of stimulus-reward memory and extinction learning during reinstatement of cocaine-seeking in an animal model of relapse. Neurobiol Learn Mem (2007) 1.17
Inactivation of the bed nucleus of the stria terminalis in an animal model of relapse: effects on conditioned cue-induced reinstatement and its enhancement by yohimbine. Psychopharmacology (Berl) (2010) 1.16
Impoverished rearing environment alters metabotropic glutamate receptor expression and function in the prefrontal cortex. Neuropsychopharmacology (2004) 1.15
Homer1 proteins and AMPA receptors modulate cocaine-induced behavioural plasticity. Eur J Neurosci (2003) 1.14
Nicotine self-administration and reinstatement of nicotine-seeking in male and female rats. Drug Alcohol Depend (2011) 1.13
Enhancement of cue-induced reinstatement of cocaine-seeking in rats by yohimbine: sex differences and the role of the estrous cycle. Psychopharmacology (Berl) (2011) 1.12
Sex differences in escalation of methamphetamine self-administration: cognitive and motivational consequences in rats. Psychopharmacology (Berl) (2012) 1.12
Forebrain astroglial plasticity is induced following withdrawal from repeated cocaine administration. Eur J Neurosci (2003) 1.12
Synaptic glutamate spillover due to impaired glutamate uptake mediates heroin relapse. J Neurosci (2014) 1.12
Influence of sex and estrous cyclicity on conditioned cue-induced reinstatement of cocaine-seeking behavior in rats. Psychopharmacology (Berl) (2005) 1.12
Optogenetic evidence that pallidal projections, not nigral projections, from the nucleus accumbens core are necessary for reinstating cocaine seeking. J Neurosci (2013) 1.12
A comparison of the effects of different operant training experiences and dietary restriction on the reinstatement of cocaine-seeking in rats. Pharmacol Biochem Behav (2007) 1.10
Yohimbine stress potentiates conditioned cue-induced reinstatement of heroin-seeking in rats. Behav Brain Res (2009) 1.09
Methamphetamine self-administration produces attentional set-shifting deficits and alters prefrontal cortical neurophysiology in rats. Biol Psychiatry (2010) 1.08
Distinct roles for different Homer1 isoforms in behaviors and associated prefrontal cortex function. J Neurosci (2005) 1.08
Aripiprazole blocks reinstatement of cocaine seeking in an animal model of relapse. Biol Psychiatry (2006) 1.08
Anti-relapse medications: preclinical models for drug addiction treatment. Pharmacol Ther (2009) 1.08