Published in J Exp Biol on March 01, 2011
Emerging roles of aquaporins in relation to the physiology of blood-feeding arthropods. J Comp Physiol B (2014) 0.83
Diapause, signal and molecular characteristics of overwintering Chilo suppressalis (Insecta: Lepidoptera: Pyralidae). Sci Rep (2013) 0.78
The physiological role of fat body and muscle tissues in response to cold stress in the tropical cockroach Gromphadorhina coquereliana. PLoS One (2017) 0.75
Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans. Proc Natl Acad Sci U S A (2004) 3.52
Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections. Nat Rev Microbiol (2011) 2.68
Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nat Chem Biol (2012) 2.40
Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans. Antimicrob Agents Chemother (2005) 2.35
Heterogeneity of mycolactones produced by clinical isolates of Mycobacterium ulcerans: implications for virulence. Infect Immun (2003) 2.08
Globally distributed mycobacterial fish pathogens produce a novel plasmid-encoded toxic macrolide, mycolactone F. Infect Immun (2006) 1.91
A newly discovered mycobacterial pathogen isolated from laboratory colonies of Xenopus species with lethal infections produces a novel form of mycolactone, the Mycobacterium ulcerans macrolide toxin. Infect Immun (2005) 1.73
A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents. J Antimicrob Chemother (2008) 1.58
Acyl-phosphates initiate membrane phospholipid synthesis in Gram-positive pathogens. Mol Cell (2006) 1.56
Synthesis and evaluation of nitrofuranylamides as novel antituberculosis agents. J Med Chem (2004) 1.55
Methods for acquisition and assignment of multidimensional high-resolution magic angle spinning NMR of whole cell bacteria. Anal Chem (2005) 1.46
Defining "rural" for veterans' health care planning. J Rural Health (2010) 1.43
Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis. Chem Biol (2007) 1.35
Acyl carrier protein is a cellular target for the antibacterial action of the pantothenamide class of pantothenate antimetabolites. J Biol Chem (2004) 1.33
Novel acyl phosphate mimics that target PlsY, an essential acyltransferase in gram-positive bacteria. ChemMedChem (2008) 1.31
Novel inhibitors of an emerging target in Mycobacterium tuberculosis; substituted thiazolidinones as inhibitors of dTDP-rhamnose synthesis. Bioorg Med Chem Lett (2003) 1.25
Validation of molecular docking programs for virtual screening against dihydropteroate synthase. J Chem Inf Model (2009) 1.19
Structure-activity relationships and enzyme inhibition of pantothenamide-type pantothenate kinase inhibitors. Bioorg Med Chem (2005) 1.19
Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity. Mol Pharmacol (2004) 1.18
A pantothenate kinase from Staphylococcus aureus refractory to feedback regulation by coenzyme A. J Biol Chem (2004) 1.17
Synthesis and evaluation of cyclic secondary amine substituted phenyl and benzyl nitrofuranyl amides as novel antituberculosis agents. J Med Chem (2005) 1.15
N-substituted 3-acetyltetramic acid derivatives as antibacterial agents. J Med Chem (2008) 1.14
Catalysis and sulfa drug resistance in dihydropteroate synthase. Science (2012) 1.14
A statistical framework to evaluate virtual screening. BMC Bioinformatics (2009) 1.14
Crystal structure of 7,8-dihydropteroate synthase from Bacillus anthracis: mechanism and novel inhibitor design. Structure (2004) 1.13
Biomechanical evaluation of an injectable calcium phosphate cement for vertebroplasty. Spine (Phila Pa 1976) (2002) 1.12
Detection of Mycolactone A/B in Mycobacterium ulcerans-Infected Human Tissue. PLoS Negl Trop Dis (2010) 1.11
Discovery of novel isoxazolines as anti-tuberculosis agents. Bioorg Med Chem Lett (2007) 1.11
Continuous up-regulation of heat shock proteins in larvae, but not adults, of a polar insect. Proc Natl Acad Sci U S A (2006) 1.11
Dehydration-induced cross tolerance of Belgica antarctica larvae to cold and heat is facilitated by trehalose accumulation. Comp Biochem Physiol A Mol Integr Physiol (2008) 1.10
Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase . Biochemistry (2010) 1.09
Nitrofurans as novel anti-tuberculosis agents: identification, development and evaluation. Curr Top Med Chem (2007) 1.09
Rapid cold-hardening protects Drosophila melanogaster from cold-induced apoptosis. Apoptosis (2007) 1.08
Cryoprotection by urea in a terrestrially hibernating frog. J Exp Biol (2005) 1.08
Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated. PLoS One (2013) 1.07
The structure-activity relationship of urea derivatives as anti-tuberculosis agents. Bioorg Med Chem (2011) 1.07
Carcinoma of sigmoid colon following urinary diversion: a case report and review of literature. World J Surg Oncol (2004) 1.06
Evaluation of analogs of reutericyclin as prospective candidates for treatment of staphylococcal skin infections. Antimicrob Agents Chemother (2009) 1.06
Topology and active site of PlsY: the bacterial acylphosphate:glycerol-3-phosphate acyltransferase. J Biol Chem (2007) 1.05
Structural studies of pterin-based inhibitors of dihydropteroate synthase. J Med Chem (2010) 1.04
Design, synthesis, and evaluation of novel ethambutol analogues. Bioorg Med Chem Lett (2008) 1.03
Crystal structure of the anthrax drug target, Bacillus anthracis dihydrofolate reductase. J Med Chem (2007) 1.01
The structure of the pantothenate kinase.ADP.pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites. J Biol Chem (2004) 1.01
Antitubercular nitrofuran isoxazolines with improved pharmacokinetic properties. Bioorg Med Chem (2012) 1.00
Pharmacokinetically-guided lead optimization of nitrofuranylamide anti-tuberculosis agents. AAPS J (2008) 1.00
Dehydration, rehydration, and overhydration alter patterns of gene expression in the Antarctic midge, Belgica antarctica. J Comp Physiol B (2009) 1.00
Synthesis of new and potent analogues of anti-tuberculosis agent 5-nitro-furan-2-carboxylic acid 4-(4-benzyl-piperazin-1-yl)-benzylamide with improved bioavailability. Bioorg Med Chem Lett (2006) 1.00
Aquaporins play a role in desiccation and freeze tolerance in larvae of the goldenrod gall fly, Eurosta solidaginis. J Exp Biol (2008) 0.99
Cryoprotective dehydration and the resistance to inoculative freezing in the Antarctic midge, Belgica antarctica. J Exp Biol (2008) 0.99
Screening a library of 1600 adamantyl ureas for anti-Mycobacterium tuberculosis activity in vitro and for better physical chemical properties for bioavailability. Bioorg Med Chem (2012) 0.97
Hibernation physiology, freezing adaptation and extreme freeze tolerance in a northern population of the wood frog. J Exp Biol (2013) 0.97
The membrane as a target for controlling hypervirulent Clostridium difficile infections. J Antimicrob Chemother (2012) 0.96
Discovery of non-carbohydrate inhibitors of aminoglycoside-modifying enzymes. Bioorg Med Chem (2005) 0.96
A rapid approach to lipid profiling of mycobacteria using 2D HSQC NMR maps. J Lipid Res (2007) 0.95
Reutericyclin and related analogues kill stationary phase Clostridium difficile at achievable colonic concentrations. J Antimicrob Chemother (2011) 0.94
Diagnostic accuracy of the Barr and Blethyn radiological scoring systems for childhood constipation assessed using colonic transit time as the gold standard. Pediatr Radiol (2009) 0.94
Crystal structure of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase•dihydropteroate synthase bifunctional enzyme from Francisella tularensis. PLoS One (2010) 0.94
A simple in vitro PK/PD model system to determine time-kill curves of drugs against Mycobacteria. Tuberculosis (Edinb) (2009) 0.93
Design, synthesis and anti-tuberculosis activity of 1-adamantyl-3-heteroaryl ureas with improved in vitro pharmacokinetic properties. Bioorg Med Chem (2013) 0.93
Gene expression changes governing extreme dehydration tolerance in an Antarctic insect. Proc Natl Acad Sci U S A (2012) 0.93
Metabolic depression induced by urea in organs of the wood frog, Rana sylvatica: effects of season and temperature. J Exp Zool A Ecol Genet Physiol (2008) 0.92
Physiological ecology of overwintering in hatchling turtles. J Exp Zool A Ecol Genet Physiol (2008) 0.92
Antibacterial and antitubercular activity of fosmidomycin, FR900098, and their lipophilic analogs. Bioorg Med Chem Lett (2011) 0.91
Analysis of Mycobacterium species for the presence of a macrolide toxin, mycolactone. Infect Immun (2004) 0.91
Genome-wide expression profiling of the response to ciclopirox olamine in Candida albicans. J Antimicrob Chemother (2005) 0.91
Geographic variation in energy storage and physiological responses to freezing in the gray treefrogs Hyla versicolor and H. chrysoscelis. J Exp Biol (2003) 0.90
Biopharmaceutics, pharmacokinetics and pharmacodynamics of antituberculosis drugs. Curr Med Chem (2008) 0.90
Avoidance and tolerance of freezing in ectothermic vertebrates. J Exp Biol (2013) 0.90
Identification of triazinoindol-benzimidazolones as nanomolar inhibitors of the Mycobacterium tuberculosis enzyme TDP-6-deoxy-d-xylo-4-hexopyranosid-4-ulose 3,5-epimerase (RmlC). Bioorg Med Chem (2009) 0.90
Quantitative structure-activity relationship studies on nitrofuranyl anti-tubercular agents. Bioorg Med Chem (2008) 0.90
Osmotic and metabolic responses to dehydration and urea-loading in a dormant, terrestrially hibernating frog. J Comp Physiol B (2007) 0.89
Discovery, synthesis, and biological evaluation of piperidinol analogs with anti-tuberculosis activity. Bioorg Med Chem (2009) 0.89
Calcium signaling mediates cold sensing in insect tissues. Proc Natl Acad Sci U S A (2013) 0.89
Metabolomics reveals unique and shared metabolic changes in response to heat shock, freezing and desiccation in the Antarctic midge, Belgica antarctica. J Insect Physiol (2008) 0.88
Mechanisms to reduce dehydration stress in larvae of the Antarctic midge, Belgica antarctica. J Insect Physiol (2007) 0.87
Synthesis, optimization and structure-activity relationships of 3,5-disubstituted isoxazolines as new anti-tuberculosis agents. Eur J Med Chem (2008) 0.87
Do older rural and urban veterans experience different rates of unplanned readmission to VA and non-VA hospitals? J Rural Health (2009) 0.87
High resistance to oxidative damage in the Antarctic midge Belgica antarctica, and developmentally linked expression of genes encoding superoxide dismutase, catalase and heat shock proteins. Insect Biochem Mol Biol (2008) 0.87
Preservation of reproductive behaviors during modest cooling: rapid cold-hardening fine-tunes organismal response. J Exp Biol (2004) 0.87
Mild desiccation rapidly increases freeze tolerance of the goldenrod gall fly, Eurosta solidaginis: evidence for drought-induced rapid cold-hardening. J Exp Biol (2012) 0.87
Increased dietary cholesterol enhances cold tolerance in Drosophila melanogaster. Cryo Letters (2007) 0.86
Functional characterization of an aquaporin in the Antarctic midge Belgica antarctica. J Insect Physiol (2011) 0.86
Postfreeze reduction of locomotor endurance in the freeze-tolerant wood frog, Rana sylvatica. Physiol Biochem Zool (2003) 0.85
Rapid cold-hardening in larvae of the Antarctic midge Belgica antarctica: cellular cold-sensing and a role for calcium. Am J Physiol Regul Integr Comp Physiol (2008) 0.84
Potentiation of azole antifungals by 2-adamantanamine. Antimicrob Agents Chemother (2013) 0.84
In vitro pharmacokinetic/pharmacodynamic models in anti-infective drug development: focus on TB. Future Med Chem (2010) 0.84
Slow dehydration promotes desiccation and freeze tolerance in the Antarctic midge Belgica antarctica. J Exp Biol (2007) 0.84
Cuticular lipids and desiccation resistance in overwintering larvae of the goldenrod gall fly, Eurosta solidaginis (Diptera: Tephritidae). Comp Biochem Physiol B Biochem Mol Biol (2004) 0.83
Detecting freeze injury and seasonal cold-hardening of cells and tissues in the gall fly larvae, Eurosta solidaginis (Diptera: Tephritidae) using fluorescent vital dyes. J Insect Physiol (2003) 0.83
A screen for and validation of prodrug antimicrobials. Antimicrob Agents Chemother (2013) 0.83
Solid-phase synthesis and biological evaluation of a uridinyl branched peptide urea library. Bioorg Med Chem Lett (2007) 0.83
The limited role of microbiological culture and sensitivity in the management of superficial soft tissue abscesses. ScientificWorldJournal (2006) 0.82
Distinct contractile and cytoskeletal protein patterns in the Antarctic midge are elicited by desiccation and rehydration. Proteomics (2009) 0.82
Metabolic activation of CaMKII by coenzyme A. Mol Cell (2013) 0.82
Synthesis of bi-substrate state mimics of dihydropteroate synthase as potential inhibitors and molecular probes. Bioorg Med Chem (2010) 0.82
Rapid cold-hardening blocks cold-induced apoptosis by inhibiting the activation of pro-caspases in the flesh fly Sarcophaga crassipalpis. Apoptosis (2011) 0.82
Function and immuno-localization of aquaporins in the Antarctic midge Belgica antarctica. J Insect Physiol (2011) 0.82
Solid-phase synthesis of a thymidinyl dipeptide urea library. J Comb Chem (2007) 0.81
Structure-based design of novel pyrimido[4,5-c]pyridazine derivatives as dihydropteroate synthase inhibitors with increased affinity. ChemMedChem (2012) 0.81