Published in J Biol Chem on November 17, 2004
The antibiotic CJ-15,801 is an antimetabolite that hijacks and then inhibits CoA biosynthesis. Chem Biol (2012) 1.53
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Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated. PLoS One (2013) 1.07
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Crystal structure of a type III pantothenate kinase: insight into the mechanism of an essential coenzyme A biosynthetic enzyme universally distributed in bacteria. J Bacteriol (2006) 0.97
The human malaria parasite Plasmodium falciparum is not dependent on host coenzyme A biosynthesis. J Biol Chem (2009) 0.97
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Pantethine rescues phosphopantothenoylcysteine synthetase and phosphopantothenoylcysteine decarboxylase deficiency in Escherichia coli but not in Pseudomonas aeruginosa. J Bacteriol (2011) 0.95
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Pantothenate kinase from the thermoacidophilic archaeon Picrophilus torridus. J Bacteriol (2010) 0.83
The type III pantothenate kinase encoded by coaX is essential for growth of Bacillus anthracis. J Bacteriol (2008) 0.81
A detailed biochemical characterization of phosphopantothenate synthetase, a novel enzyme involved in coenzyme A biosynthesis in the Archaea. Extremophiles (2012) 0.80
Exploring structural motifs necessary for substrate binding in the active site of Escherichia coli pantothenate kinase. Bioorg Med Chem (2014) 0.79
Trapping of intermediates with substrate analog HBOCoA in the polymerizations catalyzed by class III polyhydroxybutyrate (PHB) synthase from Allochromatium vinosum. ACS Chem Biol (2015) 0.78
Induction of Neuron-Specific Degradation of Coenzyme A Models Pantothenate Kinase-Associated Neurodegeneration by Reducing Motor Coordination in Mice. PLoS One (2015) 0.78
Combination of pantothenamides with vanin inhibitors as a novel antibiotic strategy against gram-positive bacteria. Antimicrob Agents Chemother (2013) 0.78
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Antimicrobial activity of pantothenol against staphylococci possessing a prokaryotic type II pantothenate kinase. Microbes Environ (2014) 0.75
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Biosynthesis of Pantothenic Acid and Coenzyme A. Ecosal Plus (2007) 0.75
XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum. J Cell Biol (2004) 4.03
Membrane lipid homeostasis in bacteria. Nat Rev Microbiol (2008) 3.88
The structural biology of type II fatty acid biosynthesis. Annu Rev Biochem (2005) 3.69
Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans. Proc Natl Acad Sci U S A (2004) 3.52
Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections. Nat Rev Microbiol (2011) 2.68
Coenzyme A: back in action. Prog Lipid Res (2005) 2.62
Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nat Chem Biol (2012) 2.40
Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans. Antimicrob Agents Chemother (2005) 2.35
Cofactor-induced conformational rearrangements establish a catalytically competent active site and a proton relay conduit in FabG. Structure (2004) 2.20
Heterogeneity of mycolactones produced by clinical isolates of Mycobacterium ulcerans: implications for virulence. Infect Immun (2003) 2.08
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis. EMBO J (2011) 2.08
Two aerobic pathways for the formation of unsaturated fatty acids in Pseudomonas aeruginosa. Mol Microbiol (2006) 2.05
Inhibiting bacterial fatty acid synthesis. J Biol Chem (2006) 2.03
Globally distributed mycobacterial fish pathogens produce a novel plasmid-encoded toxic macrolide, mycolactone F. Infect Immun (2006) 1.91
The Claisen condensation in biology. Nat Prod Rep (2002) 1.88
Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis. J Biol Chem (2007) 1.88
Prediction of mechanisms of action of antibacterial compounds by gene expression profiling. Antimicrob Agents Chemother (2004) 1.88
Hypothalamic malonyl-CoA as a mediator of feeding behavior. Proc Natl Acad Sci U S A (2003) 1.82
A newly discovered mycobacterial pathogen isolated from laboratory colonies of Xenopus species with lethal infections produces a novel form of mycolactone, the Mycobacterium ulcerans macrolide toxin. Infect Immun (2005) 1.73
Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors. Proc Natl Acad Sci U S A (2011) 1.72
Forty years of bacterial fatty acid synthesis. Biochem Biophys Res Commun (2002) 1.70
Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport. EMBO J (2002) 1.66
Incorporation of extracellular fatty acids by a fatty acid kinase-dependent pathway in Staphylococcus aureus. Mol Microbiol (2014) 1.63
Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake. Proc Natl Acad Sci U S A (2007) 1.61
The structure of (3R)-hydroxyacyl-acyl carrier protein dehydratase (FabZ) from Pseudomonas aeruginosa. J Biol Chem (2004) 1.58
A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents. J Antimicrob Chemother (2008) 1.58
ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulum. J Cell Sci (2009) 1.57
Acyl-phosphates initiate membrane phospholipid synthesis in Gram-positive pathogens. Mol Cell (2006) 1.56
Synthesis and evaluation of nitrofuranylamides as novel antituberculosis agents. J Med Chem (2004) 1.55
Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation. J Biol Chem (2012) 1.49
Product diversity and regulation of type II fatty acid synthases. Biochem Cell Biol (2004) 1.49
Characterization of Streptococcus pneumoniae enoyl-(acyl-carrier protein) reductase (FabK). Biochem J (2003) 1.48
Methods for acquisition and assignment of multidimensional high-resolution magic angle spinning NMR of whole cell bacteria. Anal Chem (2005) 1.46
The FabR (YijC) transcription factor regulates unsaturated fatty acid biosynthesis in Escherichia coli. J Biol Chem (2002) 1.44
Crystal structures of the Dab homology domains of mouse disabled 1 and 2. J Biol Chem (2003) 1.43
Defining "rural" for veterans' health care planning. J Rural Health (2010) 1.43
Bacterial lipids: metabolism and membrane homeostasis. Prog Lipid Res (2013) 1.42
Transcriptional regulation of fatty acid biosynthesis in Streptococcus pneumoniae. Mol Microbiol (2006) 1.39
Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway. Mol Cell (2011) 1.38
Differential effects of central fructose and glucose on hypothalamic malonyl-CoA and food intake. Proc Natl Acad Sci U S A (2008) 1.38
Key residues responsible for acyl carrier protein and beta-ketoacyl-acyl carrier protein reductase (FabG) interaction. J Biol Chem (2003) 1.36
The solution structure of acyl carrier protein from Mycobacterium tuberculosis. J Biol Chem (2002) 1.36
Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis. Chem Biol (2007) 1.35
Early embryonic lethality in mice with targeted deletion of the CTP:phosphocholine cytidylyltransferase alpha gene (Pcyt1a). Mol Cell Biol (2005) 1.34
Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery? Curr Opin Microbiol (2011) 1.34
Acyl carrier protein is a cellular target for the antibacterial action of the pantothenamide class of pantothenate antimetabolites. J Biol Chem (2004) 1.33
A new mechanism for anaerobic unsaturated fatty acid formation in Streptococcus pneumoniae. J Biol Chem (2002) 1.33
Fatty acid biosynthesis as a target for novel antibacterials. Curr Opin Investig Drugs (2004) 1.33
Phospholipid biosynthesis program underlying membrane expansion during B-lymphocyte differentiation. J Biol Chem (2007) 1.33
Coupling of fatty acid and phospholipid synthesis in Bacillus subtilis. J Bacteriol (2007) 1.32
Novel acyl phosphate mimics that target PlsY, an essential acyltransferase in gram-positive bacteria. ChemMedChem (2008) 1.31
Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine. Proc Natl Acad Sci U S A (2007) 1.29
Membrane phospholipid synthesis and endoplasmic reticulum function. J Lipid Res (2008) 1.29
Phosphatidylcholine and the CDP-choline cycle. Biochim Biophys Acta (2012) 1.28
A role for hypothalamic malonyl-CoA in the control of food intake. J Biol Chem (2005) 1.28
The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase. J Lipid Res (2003) 1.27
Pantothenate kinase 1 is required to support the metabolic transition from the fed to the fasted state. PLoS One (2010) 1.26
Regulation of hypothalamic malonyl-CoA by central glucose and leptin. Proc Natl Acad Sci U S A (2007) 1.26
Novel inhibitors of an emerging target in Mycobacterium tuberculosis; substituted thiazolidinones as inhibitors of dTDP-rhamnose synthesis. Bioorg Med Chem Lett (2003) 1.25
Inhibition of hypothalamic fatty acid synthase triggers rapid activation of fatty acid oxidation in skeletal muscle. Proc Natl Acad Sci U S A (2005) 1.25
Membrane disruption by antimicrobial fatty acids releases low-molecular-weight proteins from Staphylococcus aureus. J Bacteriol (2012) 1.24
PPARalpha controls the intracellular coenzyme A concentration via regulation of PANK1alpha gene expression. J Lipid Res (2003) 1.23
Thematic review series: Glycerolipids. Acyltransferases in bacterial glycerophospholipid synthesis. J Lipid Res (2008) 1.22
Role of feedback regulation of pantothenate kinase (CoaA) in control of coenzyme A levels in Escherichia coli. J Bacteriol (2003) 1.21
Transcriptional regulation in bacterial membrane lipid synthesis. J Lipid Res (2008) 1.21
The murine pantothenate kinase (Pank1) gene encodes two differentially regulated pantothenate kinase isozymes. Gene (2002) 1.20
Validation of molecular docking programs for virtual screening against dihydropteroate synthase. J Chem Inf Model (2009) 1.19
Structure-activity relationships and enzyme inhibition of pantothenamide-type pantothenate kinase inhibitors. Bioorg Med Chem (2005) 1.19
Structure of the type III pantothenate kinase from Bacillus anthracis at 2.0 A resolution: implications for coenzyme A-dependent redox biology. Biochemistry (2007) 1.19
Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity. Mol Pharmacol (2004) 1.18
Biochemical properties of human pantothenate kinase 2 isoforms and mutations linked to pantothenate kinase-associated neurodegeneration. J Biol Chem (2005) 1.18
Serum opacity factor, a streptococcal virulence factor that binds to apolipoproteins A-I and A-II and disrupts high density lipoprotein structure. J Biol Chem (2006) 1.16