Published in Eur J Cancer on February 23, 2011
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The multifactorial role of leptin in driving the breast cancer microenvironment. Nat Rev Endocrinol (2011) 1.21
Metabolic syndrome and triple-negative breast cancer: a new paradigm. Int J Breast Cancer (2011) 1.10
Design and development of a peptide-based adiponectin receptor agonist for cancer treatment. BMC Biotechnol (2011) 1.09
Oncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cells. Biochim Biophys Acta (2012) 1.08
Leptin receptor maintains cancer stem-like properties in triple negative breast cancer cells. Endocr Relat Cancer (2013) 1.06
Leptin signaling and circuits in puberty and fertility. Cell Mol Life Sci (2012) 1.01
Glioblastoma-derived leptin induces tube formation and growth of endothelial cells: comparison with VEGF effects. BMC Cancer (2011) 0.97
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Leptin's Pro-Angiogenic Signature in Breast Cancer. Cancers (Basel) (2013) 0.92
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The balance between leptin and adiponectin in the control of carcinogenesis - focus on mammary tumorigenesis. Biochimie (2012) 0.88
Leptin signaling enhances cell invasion and promotes the metastasis of human pancreatic cancer via increasing MMP-13 production. Oncotarget (2015) 0.87
Tumour expression of leptin is associated with chemotherapy resistance and therapy-independent prognosis in gastro-oesophageal adenocarcinomas. Br J Cancer (2014) 0.86
Honokiol activates LKB1-miR-34a axis and antagonizes the oncogenic actions of leptin in breast cancer. Oncotarget (2015) 0.85
A novel leptin antagonist peptide inhibits breast cancer growth in vitro and in vivo. J Cell Mol Med (2015) 0.84
The Multifaceted Mechanism of Leptin Signaling within Tumor Microenvironment in Driving Breast Cancer Growth and Progression. Front Oncol (2014) 0.84
Integral role of PTP1B in adiponectin-mediated inhibition of oncogenic actions of leptin in breast carcinogenesis. Neoplasia (2013) 0.83
Leptin-mediated regulation of ICAM-1 is Rho/ROCK dependent and enhances gastric cancer cell migration. Br J Cancer (2014) 0.83
Leptin and Adiponectin Modulate the Self-renewal of Normal Human Breast Epithelial Stem Cells. Cancer Prev Res (Phila) (2015) 0.82
Reciprocal Inhibitory Interactions Between the Reward-Related Effects of Leptin and Cocaine. Neuropsychopharmacology (2015) 0.82
Leptin signaling molecular actions and drug target in hepatocellular carcinoma. Drug Des Devel Ther (2014) 0.79
Exploring leptin antagonism in ophthalmic cell models. PLoS One (2013) 0.78
n-3 polyunsaturated fatty acids and mechanisms to mitigate inflammatory paracrine signaling in obesity-associated breast cancer. Nutrients (2014) 0.78
The adipokine leptin mediates muscle- and liver-derived IGF-1 in aged mice. Exp Gerontol (2015) 0.78
Development of second generation peptides modulating cellular adiponectin receptor responses. Front Chem (2014) 0.77
NILCO biomarkers in breast cancer from Chinese patients. BMC Cancer (2014) 0.77
Adipocyte activation of cancer stem cell signaling in breast cancer. World J Biol Chem (2015) 0.77
Metabolic syndrome in breast cancer. Gland Surg (2013) 0.76
Nanoparticle-linked antagonist for leptin signaling inhibition in breast cancer. World J Clin Oncol (2017) 0.76
Epithelial-mesenchymal transition and its regulators are major targets of triple-negative breast cancer. Cell Adh Migr (2013) 0.76
Leptin signaling and cancer chemoresistance: Perspectives. World J Clin Oncol (2017) 0.75
Designer Leptin Receptor Antagonist Allo-aca Inhibits VEGF Effects in Ophthalmic Neoangiogenesis Models. Front Mol Biosci (2016) 0.75
The molecular mechanism of action of superactive human leptin antagonist (SHLA) and quadruple leptin mutein Lan-2 on human ovarian epithelial cell lines. Cancer Chemother Pharmacol (2016) 0.75
Leptin influences estrogen metabolism and increases DNA adduct formation in breast cancer cells. Cancer Biol Med (2016) 0.75
Leptin and cancer. J Cell Physiol (2006) 2.88
Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli. Clin Cancer Res (2006) 2.41
Distinct Epidemiology and Clinical Consequence of Classic Versus Rare EGFR Mutations in Lung Adenocarcinoma. J Thorac Oncol (2015) 2.17
Amyloid-beta peptide (Abeta) neurotoxicity is modulated by the rate of peptide aggregation: Abeta dimers and trimers correlate with neurotoxicity. J Neurosci (2008) 1.86
miR-20b modulates VEGF expression by targeting HIF-1 alpha and STAT3 in MCF-7 breast cancer cells. J Cell Physiol (2010) 1.74
INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent. J Biol Chem (2002) 1.71
Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family. J Biol Chem (2001) 1.57
Paracrine regulation of mammalian oocyte maturation and male germ cell survival. Proc Natl Acad Sci U S A (2004) 1.55
Proteoglycans and tumor progression: Janus-faced molecules with contradictory functions in cancer. Semin Cancer Biol (2002) 1.35
Leptin interferes with the effects of the antiestrogen ICI 182,780 in MCF-7 breast cancer cells. Clin Cancer Res (2004) 1.20
Nuclear insulin receptor substrate 1 interacts with estrogen receptor alpha at ERE promoters. Oncogene (2004) 1.18
Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation. J Biol Chem (2003) 1.14
Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity. J Biol Chem (2005) 1.14
Designer antibacterial peptides kill fluoroquinolone-resistant clinical isolates. J Med Chem (2005) 1.13
Chromatin remodeling and modification during HIV-1 Tat-activated transcription. Curr HIV Res (2003) 1.12
Lymphoepithelioma-like carcinoma of the breast: not Epstein-Barr virus-, but human papilloma virus-positive. Hum Pathol (2008) 1.11
Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge. J Biol Chem (2006) 1.10
Role of the IGF-I receptor in the regulation of cell-cell adhesion: implications in cancer development and progression. J Cell Physiol (2003) 1.09
Design and development of a peptide-based adiponectin receptor agonist for cancer treatment. BMC Biotechnol (2011) 1.09
Tumor cell and carcinoma-associated fibroblast interaction regulates matrix metalloproteinases and their inhibitors in oral squamous cell carcinoma. Exp Cell Res (2012) 1.09
Functional significance of type 1 insulin-like growth factor-mediated nuclear translocation of the insulin receptor substrate-1 and beta-catenin. J Biol Chem (2005) 1.08
Decorin-TGFβ axis in hepatic fibrosis and cirrhosis. J Histochem Cytochem (2012) 1.08
The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors. J Biol Chem (2008) 1.06
Alternative stabilities of a proline-rich antibacterial peptide in vitro and in vivo. Protein Sci (2008) 1.05
Overexpression of the obesity hormone leptin in human colorectal cancer. J Clin Pathol (2007) 1.04
Alzheimer disease beta-amyloid activity mimics cholesterol oxidase. J Clin Invest (2005) 1.04
Estrogen receptor-alpha regulates the degradation of insulin receptor substrates 1 and 2 in breast cancer cells. Oncogene (2003) 1.04
R3(BDelta23 27)R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7: in vitro and in vivo characterization. J Biol Chem (2007) 1.03
Relaxin-3: improved synthesis strategy and demonstration of its high-affinity interaction with the relaxin receptor LGR7 both in vitro and in vivo. Biochemistry (2006) 1.03
The human insulin superfamily of polypeptide hormones. Vitam Horm (2009) 1.02
Ablation of the decorin gene enhances experimental hepatic fibrosis and impairs hepatic healing in mice. Lab Invest (2010) 1.02
Proline-rich antimicrobial peptides: potential therapeutics against antibiotic-resistant bacteria. Amino Acids (2014) 1.01
Leptin/HER2 crosstalk in breast cancer: in vitro study and preliminary in vivo analysis. BMC Cancer (2008) 1.01
Claudin-4 differentiates biliary tract cancers from hepatocellular carcinomas. Mod Pathol (2006) 1.00
Expression of angiogenic regulators, VEGF and leptin, is regulated by the EGF/PI3K/STAT3 pathway in colorectal cancer cells. J Cell Physiol (2009) 0.99
Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3. J Biol Chem (2005) 0.99
Tumor-produced, active interleukin-1β regulates gene expression in carcinoma-associated fibroblasts. Exp Cell Res (2011) 0.99
Leptin and its receptor are overexpressed in brain tumors and correlate with the degree of malignancy. Brain Pathol (2009) 0.99
Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production. Proc Natl Acad Sci U S A (2013) 0.98
Modulation of hippocampal theta oscillations and spatial memory by relaxin-3 neurons of the nucleus incertus. Learn Mem (2009) 0.98
Expression of ERalpha, ERbeta and Ki-67 in primary tumors and lymph node metastases in breast cancer. Oncol Rep (2004) 0.97
Glioblastoma-derived leptin induces tube formation and growth of endothelial cells: comparison with VEGF effects. BMC Cancer (2011) 0.97
Syndecan-1 and FGF-2, but not FGF receptor-1, share a common transport route and co-localize with heparanase in the nuclei of mesenchymal tumor cells. PLoS One (2009) 0.97
Placental protein 13 (galectin-13) has decreased placental expression but increased shedding and maternal serum concentrations in patients presenting with preterm pre-eclampsia and HELLP syndrome. Virchows Arch (2008) 0.96
Insulin-like growth factor 1 differentially regulates estrogen receptor-dependent transcription at estrogen response element and AP-1 sites in breast cancer cells. J Biol Chem (2006) 0.96
Crosstalk between IGF signaling and steroid hormone receptors in breast cancer. Curr Pharm Des (2007) 0.95
Insulin-dependent leptin expression in breast cancer cells. Cancer Res (2008) 0.95
Molecular characteristics of fibrolamellar hepatocellular carcinoma. Pathol Oncol Res (2012) 0.95
Curcumin targets fibroblast-tumor cell interactions in oral squamous cell carcinoma. Exp Cell Res (2012) 0.95
Insights into interactions between the alpha-helical region of the salmon calcitonin antagonists and the human calcitonin receptor using photoaffinity labeling. J Biol Chem (2005) 0.94
Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide 3. J Biol Chem (2006) 0.94
The designer proline-rich antibacterial peptide A3-APO is effective against systemic Escherichia coli infections in different mouse models. Int J Antimicrob Agents (2009) 0.93
Expression of nuclear insulin receptor substrate 1 in breast cancer. J Clin Pathol (2006) 0.93
Site-specific conjugation of a lanthanide chelator and its effects on the chemical synthesis and receptor binding affinity of human relaxin-2 hormone. Biochem Biophys Res Commun (2012) 0.93
Genome-wide screening of genes regulated by DNA methylation in colon cancer development. PLoS One (2012) 0.92
Defining the LGR8 residues involved in binding insulin-like peptide 3. Mol Endocrinol (2007) 0.92
INSL3/RXFP2 signaling in testicular descent. Ann N Y Acad Sci (2009) 0.92
Endoscopic diagnosis of cytomegalovirus infection of upper gastrointestinal tract in solid organ transplant recipients: Hungarian single-center experience. Clin Transplant (2004) 0.92
Dimeric structures of alpha-synuclein bind preferentially to lipid membranes. Biochim Biophys Acta (2008) 0.92
Inhibition of HIV-1 virus replication using small soluble Tat peptides. Virology (2005) 0.92
Serum levels of angiogenic factors and their prognostic relevance in bladder cancer. Pathol Oncol Res (2008) 0.92
Quantitative and qualitative alterations of heparan sulfate in fibrogenic liver diseases and hepatocellular cancer. J Histochem Cytochem (2010) 0.92
Amphipathic alpha-helical peptide, HP (2-20), and its analogues derived from Helicobacter pylori: pore formation mechanism in various lipid compositions. Biochim Biophys Acta (2007) 0.92
Scope and limitations of the designer proline-rich antibacterial peptide dimer, A3-APO, alone or in synergy with conventional antibiotics. Peptides (2008) 0.91
Obesity hormone leptin induces growth and interferes with the cytotoxic effects of 5-fluorouracil in colorectal tumor stem cells. Endocr Relat Cancer (2010) 0.91
An immunohistochemical study of colon adenomas and carcinomas: E-cadherin, Syndecan-1, Ets-1. Pathol Oncol Res (2009) 0.91
TP53 and p16INK4A, but not H-KI-Ras, are involved in tumorigenesis and progression of pleomorphic adenomas. J Cell Physiol (2006) 0.91
A structural core within apolipoprotein C-II amyloid fibrils identified using hydrogen exchange and proteolysis. J Mol Biol (2006) 0.91
Solid-phase synthesis of europium-labeled human INSL3 as a novel probe for the study of ligand-receptor interactions. Bioconjug Chem (2008) 0.91
Agrin, a novel basement membrane component in human and rat liver, accumulates in cirrhosis and hepatocellular carcinoma. Lab Invest (2006) 0.91
Amyloid-beta as a "difficult sequence" in solid phase peptide synthesis. Protein Pept Lett (2004) 0.91
Use of a temporary "solubilizing" peptide tag for the Fmoc solid-phase synthesis of human insulin glargine via use of regioselective disulfide bond formation. Bioconjug Chem (2009) 0.91
Specific syndecan-1 domains regulate mesenchymal tumor cell adhesion, motility and migration. PLoS One (2011) 0.90
Peptide-based leptin receptor antagonists for cancer treatment and appetite regulation. Biopolymers (2011) 0.90
Claudins and tricellulin in fibrolamellar hepatocellular carcinoma. Virchows Arch (2011) 0.90
Metal effects on the membrane interactions of amyloid-beta peptides. Eur Biophys J (2008) 0.90
Design, synthesis, and characterization of a single-chain peptide antagonist for the relaxin-3 receptor RXFP3. J Am Chem Soc (2011) 0.90
Changes of cell adhesion and extracellular matrix (ECM) components in cervical intraepithelial neoplasia. Pathol Oncol Res (2005) 0.90
IGF-I receptor, cell-cell adhesion, tumour development and progression. J Mol Histol (2004) 0.90
Analogs of insulin-like peptide 3 (INSL3) B-chain are LGR8 antagonists in vitro and in vivo. J Biol Chem (2006) 0.90
Agrin and CD34 immunohistochemistry for the discrimination of benign versus malignant hepatocellular lesions. Am J Surg Pathol (2009) 0.90
Decorin interferes with platelet-derived growth factor receptor signaling in experimental hepatocarcinogenesis. FEBS J (2013) 0.89
Marked increase of CYP24A1 mRNA level in hepatocellular carcinoma cell lines following vitamin D administration. Anticancer Res (2012) 0.89
Development of a pharmacologically improved peptide agonist of the leptin receptor. Biochim Biophys Acta (2008) 0.89
Comparison of the expression of agrin, a basement membrane heparan sulfate proteoglycan, in cholangiocarcinoma and hepatocellular carcinoma. Hum Pathol (2007) 0.89
Synthesis, conformation, and activity of human insulin-like peptide 5 (INSL5). Chembiochem (2008) 0.89
Retinoic acid mediates degradation of IRS-1 by the ubiquitin-proteasome pathway, via a PKC-dependant mechanism. Oncogene (2004) 0.89