Elevated invasive potential of glioblastoma stem cells.

The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance. EMBO Mol Med (2013) 1.59

Glioma cancer stem cells secrete Gremlin1 to promote their maintenance within the tumor hierarchy. Genes Dev (2014) 1.57

Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulation. PLoS Biol (2012) 1.29

CD44+/CD24- ovarian cancer cells demonstrate cancer stem cell properties and correlate to survival. Clin Exp Metastasis (2012) 1.18

Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity. Genes Dev (2012) 1.15

Laminin alpha 2 enables glioblastoma stem cell growth. Ann Neurol (2012) 1.13

Therapeutic targeting of constitutive PARP activation compromises stem cell phenotype and survival of glioblastoma-initiating cells. Cell Death Differ (2013) 1.12

EphA2 promotes infiltrative invasion of glioma stem cells in vivo through cross-talk with Akt and regulates stem cell properties. Oncogene (2014) 1.08

Interleukins in glioblastoma pathophysiology: implications for therapy. Br J Pharmacol (2013) 1.07

Astrocytes enhance the invasion potential of glioblastoma stem-like cells. PLoS One (2013) 1.06

Cancer stem cell contribution to glioblastoma invasiveness. Stem Cell Res Ther (2013) 0.98

Brain tumor stem cell multipotency correlates with nanog expression and extent of passaging in human glioblastoma xenografts. Oncotarget (2013) 0.96

The malignant social network: cell-cell adhesion and communication in cancer stem cells. Cell Adh Migr (2012) 0.96

The role of glioma stem cells in chemotherapy resistance and glioblastoma multiforme recurrence. Expert Rev Neurother (2015) 0.96

Twisted tango: brain tumor neurovascular interactions. Nat Neurosci (2011) 0.95

A CDC20-APC/SOX2 Signaling Axis Regulates Human Glioblastoma Stem-like Cells. Cell Rep (2015) 0.94

KITENIN promotes glioma invasiveness and progression, associated with the induction of EMT and stemness markers. Oncotarget (2015) 0.93

Molecular biology of gliomas: present and future challenges. Transl Med UniSa (2014) 0.92

Unique biology of gliomas: challenges and opportunities. Trends Neurosci (2012) 0.87

Human glioma-initiating cells show a distinct immature phenotype resembling but not identical to NG2 glia. J Neuropathol Exp Neurol (2013) 0.87

Intercellular cooperation and competition in brain cancers: lessons from Drosophila and human studies. Stem Cells Transl Med (2014) 0.86

Cisplatin-selected resistance is associated with increased motility and stem-like properties via activation of STAT3/Snail axis in atypical teratoid/rhabdoid tumor cells. Oncotarget (2015) 0.86

Aptamer identification of brain tumor-initiating cells. Cancer Res (2013) 0.86

Effect of the JAK2/STAT3 inhibitor SAR317461 on human glioblastoma tumorspheres. J Transl Med (2015) 0.86

Cellular-based immunotherapies for patients with glioblastoma multiforme. Clin Dev Immunol (2012) 0.84

Extracellular Matrix Properties Regulate the Migratory Response of Glioblastoma Stem Cells in Three-Dimensional Culture. Tissue Eng Part A (2015) 0.81

Stemness of the CT-2A Immunocompetent Mouse Brain Tumor Model: Characterization In Vitro. J Cancer (2012) 0.80

L1CAM and its cell-surface mutants: new mechanisms and effects relevant to the physiology and pathology of neural cells. J Neurochem (2012) 0.80

Antiproliferative and apoptosis-inducing activity of schisandrin B against human glioma cells. Cancer Cell Int (2015) 0.80

EphrinB2 drives perivascular invasion and proliferation of glioblastoma stem-like cells. Elife (2016) 0.78

MicroRNA-101 inhibits proliferation, migration and invasion of human glioblastoma by targeting SOX9. Oncotarget (2016) 0.78

Na⁺/K⁺-ATPase β2-subunit (AMOG) expression abrogates invasion of glioblastoma-derived brain tumor-initiating cells. Neuro Oncol (2013) 0.78

Unlocking the promise of oncolytic virotherapy in glioma: combination with chemotherapy to enhance efficacy. Ther Deliv (2015) 0.78

Establishment and Characterization of a Tumor Stem Cell-Based Glioblastoma Invasion Model. PLoS One (2016) 0.78

Forkhead Box M1 Is Essential for Nuclear Localization of Glioma-associated Oncogene Homolog 1 in Glioblastoma Multiforme Cells by Promoting Importin-7 Expression. J Biol Chem (2015) 0.78

Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells. Mol Cancer (2015) 0.78

IKK/NF-κB signaling contributes to glioblastoma stem cell maintenance. Oncotarget (2016) 0.78

miR128-1 inhibits the growth of glioblastoma multiforme and glioma stem-like cells via targeting BMI1 and E2F3. Oncotarget (2016) 0.77

Proportional upregulation of CD97 isoforms in glioblastoma and glioblastoma-derived brain tumor initiating cells. PLoS One (2015) 0.77

Serum-Induced Differentiation of Glioblastoma Neurospheres Leads to Enhanced Migration/Invasion Capacity That Is Associated with Increased MMP9. PLoS One (2015) 0.76

Comparison of L1 expression and secretion in glioblastoma and neuroblastoma cells. Oncol Lett (2012) 0.76

A Short Region of Connexin43 Reduces Human Glioma Stem Cell Migration, Invasion, and Survival through Src, PTEN, and FAK. Stem Cell Reports (2017) 0.75

The CDC20-APC/SOX2 signaling axis: An achilles' heel for glioblastoma. Mol Cell Oncol (2015) 0.75

Time-Frequency Analysis of Peptide Microarray Data: Application to Brain Cancer Immunosignatures. Cancer Inform (2015) 0.75

Adult neurogenesis and glial oncogenesis: when the process fails. Biomed Res Int (2014) 0.75

Brain Cancer Stem Cells in Adults and Children: Cell Biology and Therapeutic Implications. Neurotherapeutics (2017) 0.75

Molecular and Microenvironmental Determinants of Glioma Stem-Like Cell Survival and Invasion. Front Oncol (2017) 0.75

Blocking epithelial-to-mesenchymal transition in glioblastoma with a sextet of repurposed drugs: the EIS regimen. Oncotarget (2017) 0.75

PNIPAAm-co-Jeffamine(®) (PNJ) scaffolds as in vitro models for niche enrichment of glioblastoma stem-like cells. Biomaterials (2017) 0.75

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med (2005) 74.55

Identification of human brain tumour initiating cells. Nature (2004) 38.87

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature (2006) 27.91

Malignant gliomas in adults. N Engl J Med (2008) 20.54

Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev (2007) 17.20

Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell (2006) 15.16

Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res (2004) 14.73

Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci U S A (2003) 10.56

Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol Cancer (2006) 8.50

Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res (2006) 6.77

Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell (2009) 5.81

PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. Cell Stem Cell (2009) 4.94

Neural recognition molecules of the immunoglobulin superfamily: signaling transducers of axon guidance and neuronal migration. Nat Neurosci (2007) 4.06

Targeting cancer stem cells through L1CAM suppresses glioma growth. Cancer Res (2008) 2.97

Glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via vascular endothelial growth factor and stromal-derived factor 1. Cancer Res (2009) 2.80

L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers. J Cell Biol (2005) 2.39

microRNA-146b inhibits glioma cell migration and invasion by targeting MMPs. Brain Res (2009) 1.76

Potential therapeutic implications of cancer stem cells in glioblastoma. Biochem Pharmacol (2010) 1.60

Mesenchymal differentiation of glioblastoma stem cells. Cell Death Differ (2008) 1.48

L1 and NCAM adhesion molecules as signaling coreceptors in neuronal migration and process outgrowth. Curr Opin Neurobiol (2008) 1.41

L1 cell adhesion molecule (L1CAM) in invasive tumors. Cancer Lett (2009) 1.25

L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells. Gynecol Oncol (2006) 1.25

The cleavage of semaphorin 3C induced by ADAMTS1 promotes cell migration. J Biol Chem (2009) 1.15

L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1. EMBO J (2011) 1.10

Medical oncology: treatment and management of malignant gliomas. Nat Rev Clin Oncol (2010) 0.94

alpha5-integrin is crucial for L1CAM-mediated chemoresistance in pancreatic adenocarcinoma. Int J Oncol (2009) 0.87

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature (2006) 27.91

The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation. Nat Genet (2005) 17.07

Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. J Clin Oncol (2007) 12.62

Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma. Clin Cancer Res (2007) 9.21

Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res (2006) 6.77

Genome-scale RNAi screen for host factors required for HIV replication. Cell Host Microbe (2008) 6.24

The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med (2005) 5.95

Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell (2009) 5.81

Making a tumour's bed: glioblastoma stem cells and the vascular niche. Nat Rev Cancer (2007) 4.54

Distinct requirements for Ras oncogenesis in human versus mouse cells. Genes Dev (2002) 4.30

Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis. J Clin Oncol (2008) 3.84

Integrin alpha 6 regulates glioblastoma stem cells. Cell Stem Cell (2010) 3.82

Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell (2004) 3.63

The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype. Cell Cycle (2009) 3.55

Regulation of HIF-1alpha stability through S-nitrosylation. Mol Cell (2007) 3.50

An improved comorbidity index for outcome analyses among dialysis patients. Kidney Int (2009) 3.32

Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth. Cell (2013) 3.32

Notch promotes radioresistance of glioma stem cells. Stem Cells (2010) 3.07

Targeting cancer stem cells through L1CAM suppresses glioma growth. Cancer Res (2008) 2.97

Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration. Circ Res (2007) 2.91

Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation. Blood (2005) 2.76

HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. Nat Med (2003) 2.62

Recent advances in the treatment of malignant astrocytoma. J Clin Oncol (2006) 2.55

BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development (2004) 2.50

Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. Mol Cell Biol (2004) 2.49

HIF induces human embryonic stem cell markers in cancer cells. Cancer Res (2011) 2.46

c-Myc is required for maintenance of glioma cancer stem cells. PLoS One (2008) 2.41

Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells. Cancer Cell (2013) 2.38

Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration. Sci Signal (2010) 2.36

The multifaceted role of periostin in tumorigenesis. Cell Mol Life Sci (2009) 2.35

Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan. J Clin Oncol (2008) 2.32

Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake. Nat Neurosci (2013) 2.30

Catalytic generation of N2O3 by the concerted nitrite reductase and anhydrase activity of hemoglobin. Nat Chem Biol (2007) 2.30

Targeted photothermal ablation of murine melanomas with melanocyte-stimulating hormone analog-conjugated hollow gold nanospheres. Clin Cancer Res (2009) 2.22

Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth. J Exp Med (2012) 2.21

Phase II trial of temozolomide in patients with progressive low-grade glioma. J Clin Oncol (2003) 2.16

Influence of anchoring ligands and particle size on the colloidal stability and in vivo biodistribution of polyethylene glycol-coated gold nanoparticles in tumor-xenografted mice. Biomaterials (2009) 2.13

Brain cancer stem cells display preferential sensitivity to Akt inhibition. Stem Cells (2008) 2.12

Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3. Cancer Cell (2011) 2.04

Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT. Sci Transl Med (2011) 2.03

Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation. Genes Dev (2008) 2.00

Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth. Stem Cells (2009) 1.97

Molecularly targeted therapy for malignant glioma. Cancer (2007) 1.96

Phase II study of imatinib mesylate plus hydroxyurea in adults with recurrent glioblastoma multiforme. J Clin Oncol (2005) 1.85

Histone deacetylase activities are required for innate immune cell control of Th1 but not Th2 effector cell function. Blood (2006) 1.77

Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2. Cell (2011) 1.77

A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth. Mol Carcinog (2007) 1.74

Targeting transcription factor NFkappaB: comparative analysis of proteasome and IKK inhibitors. Cell Cycle (2009) 1.74

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo. J Exp Med (2013) 1.71

Photoacoustic imaging of living mouse brain vasculature using hollow gold nanospheres. Biomaterials (2009) 1.70

Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition. Mol Cancer Ther (2005) 1.66

Biology of glioma cancer stem cells. Mol Cells (2009) 1.64

Cancer stem cells in gliomas: identifying and understanding the apex cell in cancer's hierarchy. Glia (2011) 1.63

Phase 1 trial of gefitinib plus sirolimus in adults with recurrent malignant glioma. Clin Cancer Res (2006) 1.63

Receptor-mediated transcytosis: a mechanism for active extravascular transport of nanoparticles in solid tumors. J Control Release (2012) 1.61

Potential therapeutic implications of cancer stem cells in glioblastoma. Biochem Pharmacol (2010) 1.60

Tumor site-specific silencing of NF-kappaB p65 by targeted hollow gold nanosphere-mediated photothermal transfection. Cancer Res (2010) 1.60

Phase II trial of bevacizumab and erlotinib in patients with recurrent malignant glioma. Neuro Oncol (2010) 1.59

Concerted nitric oxide formation and release from the simultaneous reactions of nitrite with deoxy- and oxyhemoglobin. J Biol Chem (2007) 1.57

Informed consent in pediatric surgery: Do parents understand the risks? Arch Otolaryngol Head Neck Surg (2010) 1.55

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities. J Biol Chem (2003) 1.54

Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma. J Clin Oncol (2009) 1.53

Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma. J Clin Oncol (2002) 1.50

LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease. Proc Natl Acad Sci U S A (2006) 1.50

Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells. Nat Cell Biol (2011) 1.49

GW112, a novel antiapoptotic protein that promotes tumor growth. Cancer Res (2004) 1.49

Deadly teamwork: neural cancer stem cells and the tumor microenvironment. Cell Stem Cell (2011) 1.49

MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants. Antimicrob Agents Chemother (2012) 1.48

Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation. Genes Dev (2004) 1.47

New treatment strategies for malignant gliomas. Expert Rev Anticancer Ther (2006) 1.47

Cancer stem cells in glioblastoma--molecular signaling and therapeutic targeting. Protein Cell (2010) 1.45

Effects of photoacoustic imaging and photothermal ablation therapy mediated by targeted hollow gold nanospheres in an orthotopic mouse xenograft model of glioma. Cancer Res (2011) 1.45

Copper sulfide nanoparticles for photothermal ablation of tumor cells. Nanomedicine (Lond) (2010) 1.42

Apoptotic caspases regulate induction of iPSCs from human fibroblasts. Cell Stem Cell (2010) 1.37

Bevacizumab plus irinotecan in recurrent WHO grade 3 malignant gliomas. Clin Cancer Res (2008) 1.35