Cross-linking of both Fc gamma RI and Fc gamma RII induces secretion of tumor necrosis factor by human monocytes, requiring high affinity Fc-Fc gamma R interactions. Functional activation of Fc gamma RII by treatment with proteases or neuraminidase.

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Published in J Immunol on February 15, 1990

Authors

J M Debets1, J G Van de Winkel, J L Ceuppens, I E Dieteren, W A Buurman

Author Affiliations

1: Department of Surgery, University of Limburg, Maastricht, The Netherlands.

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