PubRank

Jurg Tschopp

Author PubWeight™ 102.31‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The inflammasomes. Cell 2010 19.37
2 The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature 2008 9.01
3 Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival. Cell 2006 4.63
4 The NLRP3 inflammasome: a sensor for metabolic danger? Science 2010 4.33
5 Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome. J Clin Invest 2002 4.14
6 Quantitative proteomics reveals subset-specific viral recognition in dendritic cells. Immunity 2010 4.03
7 The inflammasome: an integrated view. Immunol Rev 2011 3.52
8 Malarial hemozoin is a Nalp3 inflammasome activating danger signal. PLoS One 2009 2.93
9 Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity. Nat Med 2011 2.82
10 Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation. J Biol Chem 2011 2.81
11 Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1. Immunity 2012 2.57
12 Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex. Cell 2007 2.48
13 Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome. Gut 2010 2.42
14 Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome. Proc Natl Acad Sci U S A 2009 2.42
15 Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity 2013 2.39
16 Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4. PLoS Pathog 2010 2.33
17 The NLRP3 inflammasome promotes renal inflammation and contributes to CKD. J Am Soc Nephrol 2010 2.04
18 Regulation of interleukin-1- and lipopolysaccharide-induced NF-kappaB activation by alternative splicing of MyD88. Curr Biol 2002 1.95
19 NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis. Inflamm Bowel Dis 2010 1.84
20 Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome. Gastroenterology 2010 1.83
21 PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling. Mol Cell 2012 1.71
22 Histones trigger sterile inflammation by activating the NLRP3 inflammasome. Eur J Immunol 2013 1.65
23 MyD88S, a splice variant of MyD88, differentially modulates NF-kappaB- and AP-1-dependent gene expression. FEBS Lett 2003 1.59
24 Smac mimetics and TNFalpha: a dangerous liaison? Cell 2007 1.53
25 Cellular FLIP (long form) regulates CD8+ T cell activation through caspase-8-dependent NF-kappa B activation. J Immunol 2005 1.51
26 Inflammatory role of ASC in antigen-induced arthritis is independent of caspase-1, NALP-3, and IPAF. J Immunol 2009 1.50
27 Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis. J Immunol 2010 1.48
28 TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma. J Immunol 2004 1.47
29 Identification of a new murine tumor necrosis factor receptor locus that contains two novel murine receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Biol Chem 2002 1.29
30 Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes. J Exp Med 2013 1.21
31 TLR3 and Rig-like receptor on myeloid dendritic cells and Rig-like receptor on human NK cells are both mandatory for production of IFN-gamma in response to double-stranded RNA. J Immunol 2010 1.13
32 Chemotherapy enhances TNF-related apoptosis-inducing ligand DISC assembly in HT29 human colon cancer cells. Oncogene 2003 1.12
33 Cutting edge: cyclic polypeptide and aminoglycoside antibiotics trigger IL-1β secretion by activating the NLRP3 inflammasome. J Immunol 2011 1.09
34 Neutrophil-derived APRIL concentrated in tumor lesions by proteoglycans correlates with human B-cell lymphoma aggressiveness. Blood 2007 1.08
35 Contribution of TIR domain-containing adapter inducing IFN-beta-mediated IL-18 release to LPS-induced liver injury in mice. J Hepatol 2009 0.99
36 Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis. Proc Natl Acad Sci U S A 2012 0.95
37 TNF-alpha-dependent loss of IKKbeta-deficient myeloid progenitors triggers a cytokine loop culminating in granulocytosis. Proc Natl Acad Sci U S A 2011 0.90
38 IRF-3 partners Bax in a viral-induced dance macabre. EMBO J 2010 0.89
39 Antiviral antibodies target adenovirus to phagolysosomes and amplify the innate immune response. J Immunol 2009 0.89
40 Cells with defective p53-p21-pRb pathway are susceptible to apoptosis induced by p84N5 via caspase-6. Cancer Res 2007 0.88
41 IL-4 potentiates activated T cell apoptosis via an IL-2-dependent mechanism. J Immunol 2003 0.88