Quantitative proteomics reveals subset-specific viral recognition in dendritic cells.

PubWeight™: 4.03‹?› | Rank: Top 1%

🔗 View Article (PMID 20171123)

Published in Immunity on February 18, 2010

Authors

Christian A Luber1, Jürgen Cox, Henning Lauterbach, Ben Fancke, Matthias Selbach, Jurg Tschopp, Shizuo Akira, Marian Wiegand, Hubertus Hochrein, Meredith O'Keeffe, Matthias Mann

Author Affiliations

1: Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany.

Articles citing this

(truncated to the top 100)

Accurate proteome-wide label-free quantification by delayed normalization and maximal peptide ratio extraction, termed MaxLFQ. Mol Cell Proteomics (2014) 5.09

The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu Rev Immunol (2013) 4.75

Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens. J Exp Med (2010) 4.17

Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha}+ dendritic cells. J Exp Med (2011) 4.02

Cross-presentation by dendritic cells. Nat Rev Immunol (2012) 3.95

Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells. J Exp Med (2010) 3.84

Decoding signalling networks by mass spectrometry-based proteomics. Nat Rev Mol Cell Biol (2010) 3.78

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. EMBO J (2012) 3.70

Comparative proteomic analysis of eleven common cell lines reveals ubiquitous but varying expression of most proteins. Mol Cell Proteomics (2012) 3.57

Dendritic cell and macrophage heterogeneity in vivo. Immunity (2011) 3.41

Plasmacytoid dendritic cells: recent progress and open questions. Annu Rev Immunol (2011) 3.32

Mass spectrometry-based proteomics in cell biology. J Cell Biol (2010) 2.66

β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments. Nat Cell Biol (2013) 2.52

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity. Cell (2016) 2.28

Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC. J Exp Med (2010) 2.26

Systems biology in immunology: a computational modeling perspective. Annu Rev Immunol (2011) 2.15

1D and 2D annotation enrichment: a statistical method integrating quantitative proteomics with complementary high-throughput data. BMC Bioinformatics (2012) 1.99

Use of stable isotope labeling by amino acids in cell culture as a spike-in standard in quantitative proteomics. Nat Protoc (2011) 1.99

Studying the mononuclear phagocyte system in the molecular age. Nat Rev Immunol (2011) 1.93

Analysis of high accuracy, quantitative proteomics data in the MaxQB database. Mol Cell Proteomics (2012) 1.81

Proteomics on an Orbitrap benchtop mass spectrometer using all-ion fragmentation. Mol Cell Proteomics (2010) 1.71

Extensive quantitative remodeling of the proteome between normal colon tissue and adenocarcinoma. Mol Syst Biol (2012) 1.54

C9orf72 FTLD/ALS-associated Gly-Ala dipeptide repeat proteins cause neuronal toxicity and Unc119 sequestration. Acta Neuropathol (2014) 1.48

Found in translation: the human equivalent of mouse CD8+ dendritic cells. J Exp Med (2010) 1.45

A "proteomic ruler" for protein copy number and concentration estimation without spike-in standards. Mol Cell Proteomics (2014) 1.39

Dendritic cells in antifungal immunity and vaccine design. Cell Host Microbe (2012) 1.35

Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets. J Clin Invest (2011) 1.33

Hematopoietic-specific targeting of influenza A virus reveals replication requirements for induction of antiviral immune responses. Proc Natl Acad Sci U S A (2012) 1.29

Interplay between innate immunity and negative-strand RNA viruses: towards a rational model. Microbiol Mol Biol Rev (2011) 1.22

Quantitative subcellular proteome and secretome profiling of influenza A virus-infected human primary macrophages. PLoS Pathog (2011) 1.22

Proteomics pipeline for biomarker discovery of laser capture microdissected breast cancer tissue. J Mammary Gland Biol Neoplasia (2012) 1.22

The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells. Nat Immunol (2013) 1.22

Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. Nat Commun (2014) 1.19

Systems biology approaches to new vaccine development. Curr Opin Immunol (2011) 1.17

A proteomic characterization of factors enriched at nascent DNA molecules. Cell Rep (2013) 1.15

Sequestration by IFIT1 impairs translation of 2'O-unmethylated capped RNA. PLoS Pathog (2013) 1.14

Label-free quantification and shotgun analysis of complex proteomes by one-dimensional SDS-PAGE/NanoLC-MS: evaluation for the large scale analysis of inflammatory human endothelial cells. Mol Cell Proteomics (2012) 1.14

Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming. EMBO J (2014) 1.12

Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus. Proc Natl Acad Sci U S A (2013) 1.10

A proteomic chronology of gene expression through the cell cycle in human myeloid leukemia cells. Elife (2014) 1.10

Accurate protein complex retrieval by affinity enrichment mass spectrometry (AE-MS) rather than affinity purification mass spectrometry (AP-MS). Mol Cell Proteomics (2014) 1.07

Open source libraries and frameworks for biological data visualisation: a guide for developers. Proteomics (2015) 1.00

Global phosphoproteomics reveals crosstalk between Bcr-Abl and negative feedback mechanisms controlling Src signaling. Sci Signal (2011) 0.99

RIG-I like receptors in antiviral immunity and therapeutic applications. Viruses (2011) 0.99

Orchestration of secretory protein folding by ER chaperones. Biochim Biophys Acta (2013) 0.98

CD74-dependent deregulation of the tumor suppressor scribble in human epithelial and breast cancer cells. Neoplasia (2013) 0.97

Novel murine dendritic cell lines: a powerful auxiliary tool for dendritic cell research. Front Immunol (2012) 0.97

Type I interferon drives dendritic cell apoptosis via multiple BH3-only proteins following activation by PolyIC in vivo. PLoS One (2011) 0.97

E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal (2014) 0.96

Comparison of membrane proteins of Mycobacterium tuberculosis H37Rv and H37Ra strains. BMC Microbiol (2011) 0.96

Human and Mouse Mononuclear Phagocyte Networks: A Tale of Two Species? Front Immunol (2015) 0.95

Lymph-node resident CD8α+ dendritic cells capture antigens from migratory malaria sporozoites and induce CD8+ T cell responses. PLoS Pathog (2015) 0.94

The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation. EMBO J (2013) 0.94

RNA helicase signaling is critical for type i interferon production and protection against Rift Valley fever virus during mucosal challenge. J Virol (2013) 0.92

Mass spectrometry analysis and quantitation of peptides presented on the MHC II molecules of mouse spleen dendritic cells. J Proteome Res (2011) 0.91

Into the intracellular logistics of cross-presentation. Front Immunol (2012) 0.90

YBX1/YB-1 induces partial EMT and tumourigenicity through secretion of angiogenic factors into the extracellular microenvironment. Oncotarget (2015) 0.90

Defining Mononuclear Phagocyte Subset Homology Across Several Distant Warm-Blooded Vertebrates Through Comparative Transcriptomics. Front Immunol (2015) 0.89

Systems biology approaches to dissect mammalian innate immunity. Curr Opin Immunol (2010) 0.89

Segmentation of precursor mass range using "tiling" approach increases peptide identifications for MS1-based label-free quantification. Anal Chem (2013) 0.88

Sensing and control of bluetongue virus infection in epithelial cells via RIG-I and MDA5 helicases. J Virol (2012) 0.88

Single-cell systems-level analysis of human Toll-like receptor activation defines a chemokine signature in patients with systemic lupus erythematosus. J Allergy Clin Immunol (2015) 0.88

Type B coxsackieviruses and their interactions with the innate and adaptive immune systems. Future Microbiol (2010) 0.87

IPS-1 signaling has a nonredundant role in mediating antiviral responses and the clearance of respiratory syncytial virus. J Immunol (2012) 0.86

Lymphoid organ-resident dendritic cells exhibit unique transcriptional fingerprints based on subset and site. PLoS One (2011) 0.86

Quantitative proteome profiling of lymph node-positive vs. -negative colorectal carcinomas pinpoints MX1 as a marker for lymph node metastasis. Int J Cancer (2014) 0.86

Strategy for identifying dendritic cell-processed CD4+ T cell epitopes from the HIV gag p24 protein. PLoS One (2012) 0.86

A major role for TLR8 in the recognition of vaccinia viral DNA by murine pDC? Proc Natl Acad Sci U S A (2010) 0.85

Differential roles of lung dendritic cell subsets against respiratory virus infection. Immune Netw (2014) 0.85

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers. Mol Cell Proteomics (2013) 0.84

Wild-type coxsackievirus infection dramatically alters the abundance, heterogeneity, and immunostimulatory capacity of conventional dendritic cells in vivo. Virology (2012) 0.84

A quantitative proteomic approach for detecting protein profiles of activated human myeloid dendritic cells. J Immunol Methods (2011) 0.84

Global secretome characterization of herpes simplex virus 1-infected human primary macrophages. J Virol (2012) 0.83

The Aeromonas salmonicida subsp. salmonicida exoproteome: determination of the complete repertoire of Type-Three Secretion System effectors and identification of other virulence factors. Proteome Sci (2013) 0.83

Current strategies and findings in clinically relevant post-translational modification-specific proteomics. Expert Rev Proteomics (2015) 0.83

Enterovirus-infected β-cells induce distinct response patterns in BDCA1+ and BDCA3+ human dendritic cells. PLoS One (2015) 0.82

Elution profile analysis of SDS-induced subcomplexes by quantitative mass spectrometry. Mol Cell Proteomics (2014) 0.82

The Aeromonas salmonicida subsp. salmonicida exoproteome: global analysis, moonlighting proteins and putative antigens for vaccination against furunculosis. Proteome Sci (2013) 0.81

Bacteria evade immune recognition via TLR13 and binding of their 23S rRNA by MLS antibiotics by the same mechanisms. Oncoimmunology (2013) 0.81

Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo. Mol Cell Proteomics (2015) 0.81

Actin activates Pseudomonas aeruginosa ExoY nucleotidyl cyclase toxin and ExoY-like effector domains from MARTX toxins. Nat Commun (2016) 0.80

Adaptive immunity to fungi. Cold Spring Harb Perspect Med (2014) 0.80

Thogoto virus infection induces sustained type I interferon responses that depend on RIG-I-like helicase signaling of conventional dendritic cells. J Virol (2010) 0.79

Complement regulates conventional DC-mediated NK-cell activation by inducing TGF-β1 in Gr-1+ myeloid cells. Eur J Immunol (2012) 0.79

Importance of host cell arginine uptake in Francisella phagosomal escape and ribosomal protein amounts. Mol Cell Proteomics (2015) 0.79

Uncovering immobilized trypsin digestion features from large-scale proteome data generated by high-resolution mass spectrometry. J Chromatogr A (2014) 0.79

A Quantitative Proteomic Analysis of Hemogenic Endothelium Reveals Differential Regulation of Hematopoiesis by SOX17. Stem Cell Reports (2015) 0.79

Metabolic remodeling in moderate synchronous versus dyssynchronous pacing-induced heart failure: integrated metabolomics and proteomics study. PLoS One (2015) 0.79

Human papillomavirus type 16 viral load is decreased following a therapeutic vaccination. Cancer Immunol Immunother (2016) 0.79

The anticancer drug AUY922 generates a proteomics fingerprint that is highly conserved among structurally diverse Hsp90 inhibitors. J Proteome Res (2013) 0.79

Evolutionary acquisition of cysteines determines FOXO paralog-specific redox signaling. Antioxid Redox Signal (2015) 0.79

Proteomic Analysis of the Ubiquitin Landscape in the Drosophila Embryonic Nervous System and the Adult Photoreceptor Cells. PLoS One (2015) 0.79

Caspase-8 and FLIP regulate RIG-I/MDA5-induced innate immune host responses to picornaviruses. Future Virol (2012) 0.79

Dendritic cell subsets digested: RNA sensing makes the difference! Immunity (2010) 0.78

RhoGEF12 controls cardiac remodeling by integrating G protein- and integrin-dependent signaling cascades. J Exp Med (2013) 0.78

Investigation of Yersinia pestis Laboratory Adaptation through a Combined Genomics and Proteomics Approach. PLoS One (2015) 0.78

The lectin Siglec-G inhibits dendritic cell cross-presentation by impairing MHC class I-peptide complex formation. Nat Immunol (2016) 0.78

Spleen-resident CD4+ and CD4- CD8α- dendritic cell subsets differ in their ability to prime invariant natural killer T lymphocytes. PLoS One (2011) 0.77

Molecular T cell biology -- basic and translational challenges in the twenty-first century. Front Immunol (2011) 0.77

Quantitative proteomics identify DAB2 as a cardiac developmental regulator that inhibits WNT/β-catenin signaling. Proc Natl Acad Sci U S A (2016) 0.77

Articles by these authors

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nat Biotechnol (2008) 38.00

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature (2002) 37.66

Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol Cell Proteomics (2002) 30.58

Mass spectrometry-based proteomics. Nature (2003) 28.94

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol (2004) 26.12

Toll-like receptors. Annu Rev Immunol (2001) 26.06

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol (2010) 24.08

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature (2006) 22.65

Global quantification of mammalian gene expression control. Nature (2011) 22.36

Pattern recognition receptors and inflammation. Cell (2010) 21.05

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell (2006) 20.92

Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science (2009) 20.49

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

The inflammasomes. Cell (2010) 19.37

miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. Genes Dev (2002) 19.24

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol (2005) 18.32

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science (2003) 17.57

Universal sample preparation method for proteome analysis. Nat Methods (2009) 16.88

In-gel digestion for mass spectrometric characterization of proteins and proteomes. Nat Protoc (2006) 16.56

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science (2004) 16.26

5'-Triphosphate RNA is the ligand for RIG-I. Science (2006) 15.78

Andromeda: a peptide search engine integrated into the MaxQuant environment. J Proteome Res (2011) 14.82

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science (2004) 14.80

Stop and go extraction tips for matrix-assisted laser desorption/ionization, nanoelectrospray, and LC/MS sample pretreatment in proteomics. Anal Chem (2003) 13.58

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol (2002) 13.10

Toll-like receptors in innate immunity. Int Immunol (2005) 12.24

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature (2008) 11.39

Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity (2011) 11.15

Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips. Nat Protoc (2007) 10.71

Exponentially modified protein abundance index (emPAI) for estimation of absolute protein amount in proteomics by the number of sequenced peptides per protein. Mol Cell Proteomics (2005) 10.67

Parts per million mass accuracy on an Orbitrap mass spectrometer via lock mass injection into a C-trap. Mol Cell Proteomics (2005) 10.60

Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast. Nature (2008) 10.28

The minimum information about a proteomics experiment (MIAPE). Nat Biotechnol (2007) 10.24

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature (2006) 9.77

Innate immune recognition of viral infection. Nat Immunol (2006) 9.59

Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature (2004) 9.40

Cell type-specific involvement of RIG-I in antiviral response. Immunity (2005) 9.37

Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol (2005) 9.17

TLR signaling pathways. Semin Immunol (2004) 9.08

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature (2008) 9.01

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J Exp Med (2008) 9.00

TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature (2007) 8.87

Proteomic characterization of the human centrosome by protein correlation profiling. Nature (2003) 8.74

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal (2010) 8.61

TLR signaling. Semin Immunol (2007) 8.16

A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat Immunol (2005) 7.94

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol (2008) 7.87

Mass spectrometry-based proteomics turns quantitative. Nat Chem Biol (2005) 7.52

ER stress triggers apoptosis by activating BH3-only protein Bim. Cell (2007) 7.50

Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med (2003) 7.38

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat Cell Biol (2009) 7.35

Nucleolar proteome dynamics. Nature (2005) 7.32

Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med (2003) 7.26

Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat Med (2007) 7.25

Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J Virol (2007) 7.18

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med (2005) 7.18

Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. J Immunol (2002) 7.07

Innate immunity to virus infection. Immunol Rev (2009) 7.04

Directed proteomic analysis of the human nucleolus. Curr Biol (2002) 7.04

Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics. Proc Natl Acad Sci U S A (2003) 6.87

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell (2003) 6.77

Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4. Cell (2007) 6.62

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation. Nat Cell Biol (2009) 6.62

Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med (2007) 6.52

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest (2002) 6.48

Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology (2004) 6.47

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature (2008) 6.40

Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell (2008) 6.37

Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature (2002) 6.26

Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol (2005) 6.13

Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. Immunity (2006) 5.98

Toll-like receptor and RIG-I-like receptor signaling. Ann N Y Acad Sci (2008) 5.95

Pathogen recognition by the innate immune system. Int Rev Immunol (2011) 5.76

Large-scale proteomic analysis of the human spliceosome. Genome Res (2002) 5.75

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature (2005) 5.72

Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol (2004) 5.71

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Proc Natl Acad Sci U S A (2006) 5.70

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity (2009) 5.70

Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med (2006) 5.63

Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc Natl Acad Sci U S A (2004) 5.58

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev (2005) 5.56

Analysis of the Plasmodium falciparum proteome by high-accuracy mass spectrometry. Nature (2002) 5.48

Deep proteome and transcriptome mapping of a human cancer cell line. Mol Syst Biol (2011) 5.48

Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol (2002) 5.48

Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat Immunol (2002) 5.41

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell (2008) 5.38

Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics. Nat Biotechnol (2004) 5.22

A practical recipe for stable isotope labeling by amino acids in cell culture (SILAC). Nat Protoc (2006) 5.21

The roles of TLRs, RLRs and NLRs in pathogen recognition. Int Immunol (2009) 5.21

Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nat Immunol (2007) 5.20

Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. J Biol Chem (2006) 5.11

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat Immunol (2008) 5.10

Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway. Mol Cell Proteomics (2005) 5.07

Higher-energy C-trap dissociation for peptide modification analysis. Nat Methods (2007) 5.04

SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function. Cell (2008) 5.02

Essential role of IPS-1 in innate immune responses against RNA viruses. J Exp Med (2006) 5.01

TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol (2003) 4.94