Published in Clin Orthop Relat Res on October 01, 2011
Hydrogel design for cartilage tissue engineering: a case study with hyaluronic acid. Biomaterials (2011) 1.40
High mesenchymal stem cell seeding densities in hyaluronic acid hydrogels produce engineered cartilage with native tissue properties. Acta Biomater (2012) 1.12
Transient exposure to TGF-β3 improves the functional chondrogenesis of MSC-laden hyaluronic acid hydrogels. J Mech Behav Biomed Mater (2012) 0.99
Dynamic compressive loading enhances cartilage matrix synthesis and distribution and suppresses hypertrophy in hMSC-laden hyaluronic acid hydrogels. Tissue Eng Part A (2011) 0.98
Translating stem cell therapies: the role of companion animals in regenerative medicine. Wound Repair Regen (2013) 0.91
Stem cell therapies for knee cartilage repair: the current status of preclinical and clinical studies. Am J Sports Med (2013) 0.88
Age associated communication between cells and matrix: a potential impact on stem cell-based tissue regeneration strategies. Organogenesis (2014) 0.87
Altering the architecture of tissue engineered hypertrophic cartilaginous grafts facilitates vascularisation and accelerates mineralisation. PLoS One (2014) 0.81
The influence of IL-10 and TNFα on chondrogenesis of human mesenchymal stromal cells in three-dimensional cultures. Int J Mol Sci (2014) 0.78
Glucocorticoid receptor antagonist and siRNA prevent senescence of human bone marrow mesenchymal stromal cells in vitro. Cell Tissue Res (2013) 0.77
Delivering heparin-binding insulin-like growth factor 1 with self-assembling peptide hydrogels. Tissue Eng Part A (2014) 0.77
A comparison of self-assembly and hydrogel encapsulation as a means to engineer functional cartilaginous grafts using culture expanded chondrocytes. Tissue Eng Part C Methods (2013) 0.77
Changes in Chondrogenic Progenitor Populations Associated with Aging and Osteoarthritis. Cartilage (2015) 0.75
Anatomic Mesenchymal Stem Cell-Based Engineered Cartilage Constructs for Biologic Total Joint Replacement. Tissue Eng Part A (2016) 0.75
The determination of hydroxyproline. J Biol Chem (1950) 20.59
Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta (1986) 13.69
Determination of hydroxyproline. Clin Chim Acta (1967) 7.28
Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells. Bone (2003) 4.61
Functional tissue engineering of articular cartilage through dynamic loading of chondrocyte-seeded agarose gels. J Biomech Eng (2000) 4.22
Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy. J Cell Mol Med (2004) 4.16
Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies. Mech Ageing Dev (2007) 4.02
Autologous chondrocyte implantation compared with microfracture in the knee. A randomized trial. J Bone Joint Surg Am (2004) 3.59
Chondrogenic differentiation and functional maturation of bovine mesenchymal stem cells in long-term agarose culture. Osteoarthritis Cartilage (2005) 3.47
Microfracture: surgical technique and rehabilitation to treat chondral defects. Clin Orthop Relat Res (2001) 3.45
Controlled degradation and mechanical behavior of photopolymerized hyaluronic acid networks. Biomacromolecules (2005) 3.44
The significance of the fine structure of articular cartilage. J Bone Joint Surg Br (1968) 3.13
Chondrogenic differentiation of mesenchymal stem cells from bone marrow: differentiation-dependent gene expression of matrix components. Exp Cell Res (2001) 3.06
Compressive properties and function-composition relationships of developing bovine articular cartilage. J Orthop Res (2001) 2.51
Reduced chondrogenic and adipogenic activity of mesenchymal stem cells from patients with advanced osteoarthritis. Arthritis Rheum (2002) 2.20
Influence of three-dimensional hyaluronic acid microenvironments on mesenchymal stem cell chondrogenesis. Tissue Eng Part A (2009) 2.12
Development of synovial joints. Birth Defects Res C Embryo Today (2003) 2.00
Donor age and cell passage affects differentiation potential of murine bone marrow-derived stem cells. BMC Cell Biol (2008) 2.00
Tensile mechanical properties of bovine articular cartilage: variations with growth and relationships to collagen network components. J Orthop Res (2003) 1.87
Age related changes in human articular chondrocyte yield, proliferation and post-expansion chondrogenic capacity. Osteoarthritis Cartilage (2004) 1.84
Differential maturation and structure-function relationships in mesenchymal stem cell- and chondrocyte-seeded hydrogels. Tissue Eng Part A (2009) 1.81
Articular cartilage: a review and scanning electron microscope study. 1. The interterritorial fibrillar architecture. J Bone Joint Surg Br (1971) 1.66
The development of articular cartilage: I. The spatial and temporal patterns of collagen types. J Anat (1996) 1.63
Telomere erosion and senescence in human articular cartilage chondrocytes. J Gerontol A Biol Sci Med Sci (2001) 1.50
Transient exposure to transforming growth factor beta 3 improves the mechanical properties of mesenchymal stem cell-laden cartilage constructs in a density-dependent manner. Tissue Eng Part A (2009) 1.43
Macromer density influences mesenchymal stem cell chondrogenesis and maturation in photocrosslinked hyaluronic acid hydrogels. Osteoarthritis Cartilage (2009) 1.43
Chondrogenic potential of human adult mesenchymal stem cells is independent of age or osteoarthritis etiology. Stem Cells (2007) 1.39
Tensile properties of engineered cartilage formed from chondrocyte- and MSC-laden hydrogels. Osteoarthritis Cartilage (2008) 1.37
Age-related changes in the tensile properties of human articular cartilage: a comparative study between the femoral head of the hip joint and the talus of the ankle joint. Biochim Biophys Acta (1991) 1.35
Autologous chondrocyte implantation of the knee: multicenter experience and minimum 3-year follow-up. Clin J Sport Med (2001) 1.32
Age- and site-associated biomechanical weakening of human articular cartilage of the femoral condyle. Osteoarthritis Cartilage (2007) 1.27
Aged bovine chondrocytes display a diminished capacity to produce a collagen-rich, mechanically functional cartilage extracellular matrix. J Orthop Res (2005) 1.26
Long-term dynamic loading improves the mechanical properties of chondrogenic mesenchymal stem cell-laden hydrogel. Eur Cell Mater (2010) 1.25
Effect of aging on the pluripotential capacity of human CD105+ mesenchymal stem cells. Eur J Heart Fail (2006) 1.15
Evaluation of the complex transcriptional topography of mesenchymal stem cell chondrogenesis for cartilage tissue engineering. Tissue Eng Part A (2010) 1.14
In vitro generation of scaffold independent neocartilage. Clin Orthop Relat Res (2001) 1.13
Passaged adult chondrocytes can form engineered cartilage with functional mechanical properties: a canine model. Tissue Eng Part A (2010) 1.12
Age-related changes in the frequency of mesenchymal stem cells in the bone marrow of rats. Stem Cells Dev (2007) 1.11
Human mesenchymal stem cells derived from bone marrow display a better chondrogenic differentiation compared with other sources. Connect Tissue Res (2007) 1.11
Donor sex and age influence the chondrogenic potential of human femoral bone marrow stem cells. Osteoarthritis Cartilage (2010) 1.09
Patellofemoral joint biomechanics and tissue engineering. Clin Orthop Relat Res (2005) 1.09
Effects of age on the repair ability of mesenchymal stem cells in rabbit tendon. J Orthop Res (2005) 1.04
Impaired differentiation potential of human trabecular bone mesenchymal stromal cells from elderly patients. Cytotherapy (2009) 0.98
Nonlinear tensile properties of bovine articular cartilage and their variation with age and depth. J Biomech Eng (2004) 0.97
Cartilage mechanical response under dynamic compression at physiological stress levels following collagenase digestion. Ann Biomed Eng (2008) 0.97
Autologous chondrocyte implantation (ACI) for aged patients: development of the proper cell expansion conditions for possible therapeutic applications. Osteoarthritis Cartilage (2005) 0.93
Adult equine bone marrow stromal cells produce a cartilage-like ECM mechanically superior to animal-matched adult chondrocytes. Matrix Biol (2010) 0.91
The split-line pattern of the distal femur: A consideration in the orientation of autologous cartilage grafts. Arthroscopy (2002) 0.89
Mechanical behavior of articular cartilage after osteochondral autograft transfer in an ovine model. Am J Sports Med (2007) 0.87
Treatment options for articular cartilage defects of the knee. Orthop Nurs (2005) 0.84
Articular cartilage repair in the adolescent athlete: is autologous chondrocyte implantation the answer? Clin J Sport Med (2006) 0.79
The potential to improve cell infiltration in composite fiber-aligned electrospun scaffolds by the selective removal of sacrificial fibers. Biomaterials (2008) 2.44
Fabrication and characterization of six electrospun poly(alpha-hydroxy ester)-based fibrous scaffolds for tissue engineering applications. Acta Biomater (2006) 2.14
The effect of nanofiber alignment on the maturation of engineered meniscus constructs. Biomaterials (2007) 2.11
Transient exposure to transforming growth factor beta 3 under serum-free conditions enhances the biomechanical and biochemical maturation of tissue-engineered cartilage. Tissue Eng Part A (2008) 1.95
Mechanics of oriented electrospun nanofibrous scaffolds for annulus fibrosus tissue engineering. J Orthop Res (2007) 1.90
A paradigm for functional tissue engineering of articular cartilage via applied physiologic deformational loading. Ann Biomed Eng (2004) 1.89
Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus. Nat Mater (2009) 1.83
Differential maturation and structure-function relationships in mesenchymal stem cell- and chondrocyte-seeded hydrogels. Tissue Eng Part A (2009) 1.81
Anatomically shaped osteochondral constructs for articular cartilage repair. J Biomech (2003) 1.64
Cartilage tissue engineering: its potential and uses. Curr Opin Rheumatol (2006) 1.59
Coculture of human mesenchymal stem cells and articular chondrocytes reduces hypertrophy and enhances functional properties of engineered cartilage. Tissue Eng Part A (2011) 1.49
Tissue engineering for articular cartilage repair--the state of the art. Eur Cell Mater (2013) 1.48
Enhanced MSC chondrogenesis following delivery of TGF-β3 from alginate microspheres within hyaluronic acid hydrogels in vitro and in vivo. Biomaterials (2011) 1.43
Transient exposure to transforming growth factor beta 3 improves the mechanical properties of mesenchymal stem cell-laden cartilage constructs in a density-dependent manner. Tissue Eng Part A (2009) 1.43
A layered agarose approach to fabricate depth-dependent inhomogeneity in chondrocyte-seeded constructs. J Orthop Res (2005) 1.42
Hydrogel design for cartilage tissue engineering: a case study with hyaluronic acid. Biomaterials (2011) 1.40
Material properties in unconfined compression of human nucleus pulposus, injectable hyaluronic acid-based hydrogels and tissue engineering scaffolds. Eur Spine J (2007) 1.37
Tissue engineering and regenerative medicine: recent innovations and the transition to translation. Tissue Eng Part B Rev (2013) 1.34
The influence of degradation characteristics of hyaluronic acid hydrogels on in vitro neocartilage formation by mesenchymal stem cells. Biomaterials (2009) 1.32
Mechanics and mechanobiology of mesenchymal stem cell-based engineered cartilage. J Biomech (2009) 1.29
Cartilage interstitial fluid load support in unconfined compression following enzymatic digestion. J Biomech Eng (2004) 1.26
Long-term dynamic loading improves the mechanical properties of chondrogenic mesenchymal stem cell-laden hydrogel. Eur Cell Mater (2010) 1.25
Sacrificial nanofibrous composites provide instruction without impediment and enable functional tissue formation. Proc Natl Acad Sci U S A (2012) 1.23
Engineered disc-like angle-ply structures for intervertebral disc replacement. Spine (Phila Pa 1976) (2010) 1.19
ISSLS prize winner: integrating theoretical and experimental methods for functional tissue engineering of the annulus fibrosus. Spine (Phila Pa 1976) (2008) 1.19
Fabrication and modeling of dynamic multipolymer nanofibrous scaffolds. J Biomech Eng (2009) 1.19
The influence of an aligned nanofibrous topography on human mesenchymal stem cell fibrochondrogenesis. Biomaterials (2010) 1.18
Evaluation of the complex transcriptional topography of mesenchymal stem cell chondrogenesis for cartilage tissue engineering. Tissue Eng Part A (2010) 1.14
Differential behavior of auricular and articular chondrocytes in hyaluronic acid hydrogels. Tissue Eng Part A (2008) 1.14
Hydrogels that mimic developmentally relevant matrix and N-cadherin interactions enhance MSC chondrogenesis. Proc Natl Acad Sci U S A (2013) 1.12
Electrospinning of photocrosslinked and degradable fibrous scaffolds. J Biomed Mater Res A (2008) 1.12
High mesenchymal stem cell seeding densities in hyaluronic acid hydrogels produce engineered cartilage with native tissue properties. Acta Biomater (2012) 1.12
Homologous structure-function relationships between native fibrocartilage and tissue engineered from MSC-seeded nanofibrous scaffolds. Biomaterials (2010) 1.12
Mechanical design criteria for intervertebral disc tissue engineering. J Biomech (2010) 1.09
Mechano-topographic modulation of stem cell nuclear shape on nanofibrous scaffolds. Acta Biomater (2010) 1.07
Functional tissue engineering of chondral and osteochondral constructs. Biorheology (2004) 1.07
Acellular biomaterials: an evolving alternative to cell-based therapies. Sci Transl Med (2013) 1.05
Maturation state-dependent alterations in meniscus integration: implications for scaffold design and tissue engineering. Tissue Eng Part A (2010) 1.02
The influence of hyaluronic acid hydrogel crosslinking density and macromolecular diffusivity on human MSC chondrogenesis and hypertrophy. Biomaterials (2012) 1.02
Osteocyte viability and regulation of osteoblast function in a 3D trabecular bone explant under dynamic hydrostatic pressure. J Bone Miner Res (2004) 1.01
Dynamic tensile loading improves the functional properties of mesenchymal stem cell-laden nanofiber-based fibrocartilage. Tissue Eng Part A (2011) 1.01
Fiber stretch and reorientation modulates mesenchymal stem cell morphology and fibrous gene expression on oriented nanofibrous microenvironments. Ann Biomed Eng (2011) 1.00
Role of cell-associated matrix in the development of free-swelling and dynamically loaded chondrocyte-seeded agarose gels. Biorheology (2004) 1.00
An anisotropic nanofiber/microsphere composite with controlled release of biomolecules for fibrous tissue engineering. Biomaterials (2010) 1.00
Fiber-aligned polymer scaffolds for rotator cuff repair in a rat model. J Shoulder Elbow Surg (2012) 1.00
New directions in nanofibrous scaffolds for soft tissue engineering and regeneration. Expert Rev Med Devices (2009) 1.00
Transient exposure to TGF-β3 improves the functional chondrogenesis of MSC-laden hyaluronic acid hydrogels. J Mech Behav Biomed Mater (2012) 0.99
Dynamic compressive loading enhances cartilage matrix synthesis and distribution and suppresses hypertrophy in hMSC-laden hyaluronic acid hydrogels. Tissue Eng Part A (2011) 0.98
Dynamic culture enhances stem cell infiltration and modulates extracellular matrix production on aligned electrospun nanofibrous scaffolds. Acta Biomater (2010) 0.98
Nucleus pulposus cells synthesize a functional extracellular matrix and respond to inflammatory cytokine challenge following long-term agarose culture. Eur Cell Mater (2011) 0.97
Cartilage mechanical response under dynamic compression at physiological stress levels following collagenase digestion. Ann Biomed Eng (2008) 0.97
IL-1ra delivered from poly(lactic-co-glycolic acid) microspheres attenuates IL-1β-mediated degradation of nucleus pulposus in vitro. Arthritis Res Ther (2012) 0.96
Pathogenesis and prevention of posttraumatic osteoarthritis after intra-articular fracture. J Am Acad Orthop Surg (2014) 0.96
Biomaterials in the repair of sports injuries. Nat Mater (2012) 0.95
Cartilage repair and subchondral bone remodeling in response to focal lesions in a mini-pig model: implications for tissue engineering. Tissue Eng Part A (2014) 0.95
High-throughput screening for modulators of mesenchymal stem cell chondrogenesis. Ann Biomed Eng (2008) 0.94
Macro- to microscale strain transfer in fibrous tissues is heterogeneous and tissue-specific. Biophys J (2013) 0.93
Dynamic deformational loading results in selective application of mechanical stimulation in a layered, tissue-engineered cartilage construct. Biorheology (2006) 0.93
Porosity and cell preseeding influence electrospun scaffold maturation and meniscus integration in vitro. Tissue Eng Part A (2012) 0.93
The detrimental effects of systemic Ibuprofen delivery on tendon healing are time-dependent. Clin Orthop Relat Res (2014) 0.92
Low-serum media and dynamic deformational loading in tissue engineering of articular cartilage. Ann Biomed Eng (2008) 0.92
Multi-scale structural and tensile mechanical response of annulus fibrosus to osmotic loading. Ann Biomed Eng (2012) 0.91
Biomaterial-mediated delivery of degradative enzymes to improve meniscus integration and repair. Acta Biomater (2013) 0.90
Engineering of fiber-reinforced tissues with anisotropic biodegradable nanofibrous scaffolds. Conf Proc IEEE Eng Med Biol Soc (2006) 0.90
High-throughput screening of a small molecule library for promoters and inhibitors of mesenchymal stem cell osteogenic differentiation. Biotechnol Bioeng (2011) 0.89
Biaxial mechanics and inter-lamellar shearing of stem-cell seeded electrospun angle-ply laminates for annulus fibrosus tissue engineering. J Orthop Res (2013) 0.89
Growth factor supplementation improves native and engineered meniscus repair in vitro. Acta Biomater (2012) 0.88
Improved cartilage repair via in vitro pre-maturation of MSC-seeded hyaluronic acid hydrogels. Biomed Mater (2012) 0.87
Organized nanofibrous scaffolds that mimic the macroscopic and microscopic architecture of the knee meniscus. Acta Biomater (2012) 0.87
Sliding contact loading enhances the tensile properties of mesenchymal stem cell-seeded hydrogels. Eur Cell Mater (2012) 0.86
Modeling interlamellar interactions in angle-ply biologic laminates for annulus fibrosus tissue engineering. Biomech Model Mechanobiol (2011) 0.86
Fiber angle and aspect ratio influence the shear mechanics of oriented electrospun nanofibrous scaffolds. J Mech Behav Biomed Mater (2011) 0.85
Fabrication and evaluation of biomimetic-synthetic nanofibrous composites for soft tissue regeneration. Cell Tissue Res (2012) 0.84
The influence of fibrous elastomer structure and porosity on matrix organization. PLoS One (2010) 0.83
Duty Cycle of Deformational Loading Influences the Growth of Engineered Articular Cartilage. Cell Mol Bioeng (2009) 0.83
Population average T2 MRI maps reveal quantitative regional transformations in the degenerating rabbit intervertebral disc that vary by lumbar level. J Orthop Res (2014) 0.82
Meniscus tissue engineering on the nanoscale: from basic principles to clinical application. J Knee Surg (2009) 0.82
Hypoxic regulation of functional extracellular matrix elaboration by nucleus pulposus cells in long-term agarose culture. J Orthop Res (2015) 0.81
The effect of applied compressive loading on tissue-engineered cartilage constructs cultured with TGF-beta3. Conf Proc IEEE Eng Med Biol Soc (2006) 0.81
Biodegradable fibrous scaffolds with diverse properties by electrospinning candidates from a combinatorial macromer library. Acta Biomater (2009) 0.81
In vitro characterization of a stem-cell-seeded triple-interpenetrating-network hydrogel for functional regeneration of the nucleus pulposus. Tissue Eng Part A (2014) 0.80
Delayed fracture healing in growth differentiation factor 5-deficient mice: a pilot study. Clin Orthop Relat Res (2011) 0.80
Intervertebral Disc Degeneration in a Percutaneous Mouse Tail Injury Model. Am J Phys Med Rehabil (2017) 0.75
T1rho Magnetic Resonance Imaging at 3T Detects Knee Cartilage Changes After Viscosupplementation. Orthopedics (2015) 0.75
Starting with form, emerging with function: nanofibrous scaffolds for tissue engineering of orthopedic tissues. Nanomedicine (Lond) (2013) 0.75