OAT2 catalyses efflux of glutamate and uptake of orotic acid.

PubWeight™: 0.83‹?›

🔗 View Article (PMID 21446918)

Published in Biochem J on June 01, 2011

Authors

Christian Fork1, Tim Bauer, Stefan Golz, Andreas Geerts, Jessica Weiland, Domenico Del Turco, Edgar Schömig, Dirk Gründemann

Author Affiliations

1: Department of Pharmacology, University of Cologne, Gleueler Straße 24, 50931 Cologne, Germany.

Articles by these authors

Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science (2004) 15.91

Paraoxonase-1 is a major determinant of clopidogrel efficacy. Nat Med (2010) 3.32

Effects of low habitual cocoa intake on blood pressure and bioactive nitric oxide: a randomized controlled trial. JAMA (2007) 2.70

Discovery of the ergothioneine transporter. Proc Natl Acad Sci U S A (2005) 2.03

Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6. Neurobiol Dis (2006) 1.96

Pharmacokinetics of clopidogrel after administration of a high loading dose. Thromb Haemost (2004) 1.84

Impact of P-glycoprotein on clopidogrel absorption. Clin Pharmacol Ther (2006) 1.57

AnkyrinG is required to maintain axo-dendritic polarity in vivo. Proc Natl Acad Sci U S A (2009) 1.53

Effect of cocoa and tea intake on blood pressure: a meta-analysis. Arch Intern Med (2007) 1.43

Cloning and expression of cDNA for a luciferase from the marine copepod Metridia longa. A novel secreted bioluminescent reporter enzyme. J Biol Chem (2003) 1.42

IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system. Brain (2011) 1.37

Transgenic mice expressing mutant A53T human alpha-synuclein show neuronal dysfunction in the absence of aggregate formation. Mol Cell Neurosci (2003) 1.37

Acute and chronic cannabinoid treatment differentially affects recognition memory and social behavior in pubertal and adult rats. Addict Biol (2008) 1.35

Absorption, metabolization, and antiplatelet effects of 300-, 600-, and 900-mg loading doses of clopidogrel: results of the ISAR-CHOICE (Intracoronary Stenting and Antithrombotic Regimen: Choose Between 3 High Oral Doses for Immediate Clopidogrel Effect) Trial. Circulation (2005) 1.34

Simultaneous fitting of real-time PCR data with efficiency of amplification modeled as Gaussian function of target fluorescence. BMC Bioinformatics (2008) 1.25

TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex. J Cell Sci (2010) 1.25

Luteinizing hormone reduces the activity of the NPR2 guanylyl cyclase in mouse ovarian follicles, contributing to the cyclic GMP decrease that promotes resumption of meiosis in oocytes. Dev Biol (2012) 1.13

Coincident enrichment of phosphorylated IkappaBalpha, activated IKK, and phosphorylated p65 in the axon initial segment of neurons. Mol Cell Neurosci (2006) 1.11

Quantitation of azoles and echinocandins in compartments of peripheral blood by liquid chromatography-tandem mass spectrometry. Antimicrob Agents Chemother (2010) 1.07

Impaired bioavailability of clopidogrel in patients with a ST-segment elevation myocardial infarction. Thromb Res (2008) 1.07

Charcot-Marie-Tooth disease CMT4A: GDAP1 increases cellular glutathione and the mitochondrial membrane potential. Hum Mol Genet (2011) 1.07

3D-reconstruction and functional properties of GFP-positive and GFP-negative granule cells in the fascia dentata of the Thy1-GFP mouse. Hippocampus (2008) 1.06

Store-operated calcium entry modulates neuronal network activity in a model of chronic epilepsy. Exp Neurol (2011) 1.05

Myocardial transcriptome analysis of human arrhythmogenic right ventricular cardiomyopathy. Physiol Genomics (2011) 1.05

Interchange of aequorin and obelin bioluminescence color is determined by substitution of one active site residue of each photoprotein. FEBS Lett (2005) 1.00

Laser microdissection of immunolabeled astrocytes allows quantification of astrocytic gene expression. J Neurosci Methods (2004) 0.98

Intracellular concentrations of posaconazole in different compartments of peripheral blood. Antimicrob Agents Chemother (2010) 0.97

Induction of brain-derived neurotrophic factor in plaque-associated glial cells of aged APP23 transgenic mice. J Neurosci (2004) 0.97

A simple method for elimination of false positive results in RT-PCR. J Biochem Mol Biol (2002) 0.97

Dietary sources and antioxidant effects of ergothioneine. J Agric Food Chem (2007) 0.97

Dentate granule cells in reeler mutants and VLDLR and ApoER2 knockout mice. Exp Neurol (2002) 0.97

Novel mutations of the extraneuronal monoamine transporter gene in children and adolescents with obsessive-compulsive disorder. Int J Neuropsychopharmacol (2007) 0.96

Mechanism of Ca(v)1.2 channel modulation by the amino terminus of cardiac beta2-subunits. FASEB J (2007) 0.95

Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I. Proc Natl Acad Sci U S A (2004) 0.95

Thyroid hormone controls cone opsin expression in the retina of adult rodents. J Neurosci (2011) 0.94

Vessel ultrastructure in APP23 transgenic mice after passive anti-Abeta immunotherapy and subsequent intracerebral hemorrhage. Neurobiol Aging (2006) 0.94

Regulation of the spatial code for BDNF mRNA isoforms in the rat hippocampus following pilocarpine-treatment: a systematic analysis using laser microdissection and quantitative real-time PCR. Hippocampus (2013) 0.93

Lamina-specific distribution of Synaptopodin, an actin-associated molecule essential for the spine apparatus, in identified principal cell dendrites of the mouse hippocampus. J Comp Neurol (2005) 0.93

Determination of anandamide and other fatty acyl ethanolamides in human serum by electrospray tandem mass spectrometry. Anal Biochem (2006) 0.93

The constitutively active orphan G-protein-coupled receptor GPR39 protects from cell death by increasing secretion of pigment epithelium-derived growth factor. J Biol Chem (2008) 0.93

Quantification of layer-specific gene expression in the hippocampus: effective use of laser microdissection in combination with quantitative RT-PCR. J Neurosci Methods (2003) 0.93

Degeneration of the cerebellum in Huntington's disease (HD): possible relevance for the clinical picture and potential gateway to pathological mechanisms of the disease process. Brain Pathol (2012) 0.92

Impaired left-ventricular cardiac function in male GPR30-deficient mice. Mol Med Rep (2010) 0.91

A role for synaptopodin and the spine apparatus in hippocampal synaptic plasticity. Ann Anat (2007) 0.91

Chemosensory Ca2+ dynamics correlate with diverse behavioral phenotypes in human sperm. J Biol Chem (2011) 0.91

Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2). J Pharmacol Exp Ther (2003) 0.90

Associational sprouting in the mouse fascia dentata after entorhinal lesion in vitro. Brain Res (2003) 0.90

Downregulation of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) in human hepatocellular carcinoma and their prognostic significance. BMC Cancer (2012) 0.89

Unilateral entorhinal denervation leads to long-lasting dendritic alterations of mouse hippocampal granule cells. Exp Neurol (2011) 0.88

Fast set-up of doxycycline-inducible protein expression in human cell lines with a single plasmid based on Epstein-Barr virus replication and the simple tetracycline repressor. FEBS J (2007) 0.88

Decreased anxiety in mice lacking the organic cation transporter 3. J Neural Transm (Vienna) (2009) 0.88

Uptake of mIBG and catecholamines in noradrenaline- and organic cation transporter-expressing cells: potential use of corticosterone for a preferred uptake in neuroblastoma- and pheochromocytoma cells. Nucl Med Biol (2009) 0.88

VPA response in SMA is suppressed by the fatty acid translocase CD36. Hum Mol Genet (2012) 0.87

Role of neuronal KATP channels and extraneuronal monoamine transporter on norepinephrine overflow in a model of myocardial low flow ischemia. J Pharmacol Exp Ther (2004) 0.87

Human organic cation transporters 1 (SLC22A1), 2 (SLC22A2), and 3 (SLC22A3) as disposition pathways for fluoroquinolone antimicrobials. Antimicrob Agents Chemother (2013) 0.86

The carnitine transporter SLC22A5 is not a general drug transporter, but it efficiently translocates mildronate. Drug Metab Dispos (2008) 0.86

NADPH oxidase-4 maintains neuropathic pain after peripheral nerve injury. J Neurosci (2012) 0.86

Laser microdissection reveals regional and cellular differences in GFAP mRNA upregulation following brain injury, axonal denervation, and amyloid plaque deposition. Glia (2004) 0.86

Genetic variability of the extraneuronal monoamine transporter EMT (SLC22A3). J Hum Genet (2003) 0.85

In vivo role of cytochrome P450 2E1 and glutathione-S-transferase activity for acrylamide toxicokinetics in humans. Cancer Epidemiol Biomarkers Prev (2009) 0.85

Green-fluorescent protein from the bioluminescent jellyfish Clytia gregaria: cDNA cloning, expression, and characterization of novel recombinant protein. Photochem Photobiol Sci (2010) 0.85

Identification of the endogenous key substrates of the human organic cation transporter OCT2 and their implication in function of dopaminergic neurons. PLoS One (2007) 0.84

Structural reorganization of the dentate gyrus following entorhinal denervation: species differences between rat and mouse. Prog Brain Res (2007) 0.84

Interaction of Ethambutol with human organic cation transporters of the SLC22 family indicates potential for drug-drug interactions during antituberculosis therapy. Antimicrob Agents Chemother (2013) 0.84

Interaction of organic cation transporter 3 (SLC22A3) and amphetamine. J Neurochem (2010) 0.84

Are organic cation transporters capable of transporting prostaglandins? Naunyn Schmiedebergs Arch Pharmacol (2005) 0.83

The light-sensitive photoprotein berovin from the bioluminescent ctenophore Beroe abyssicola: a novel type of Ca(2+) -regulated photoprotein. FEBS J (2012) 0.83

The localisation of the extraneuronal monoamine transporter (EMT) in rat brain. J Neurochem (2004) 0.83

Essential role of the synaptic vesicle protein synapsin II in formalin-induced hyperalgesia and glutamate release in the spinal cord. Pain (2005) 0.83

Probing the substrate specificity of the ergothioneine transporter with methimazole, hercynine, and organic cations. Biochem Pharmacol (2007) 0.83

Pharmacological and kinetic characterization of adrenomedullin 1 and calcitonin gene-related peptide 1 receptor reporter cell lines. Mol Pharmacol (2008) 0.83

CNGA3: a target of spinal nitric oxide/cGMP signaling and modulator of inflammatory pain hypersensitivity. J Neurosci (2011) 0.82

Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells. Br J Pharmacol (2002) 0.82

Do activities of cytochrome P450 (CYP)3A, CYP2D6 and P-glycoprotein differ between healthy volunteers and HIV-infected patients? Antivir Ther (2010) 0.82

A novel giant peroxisomal superoxide dismutase motif-containing protein. Free Radic Biol Med (2010) 0.82

Evaluation of organic cation transporter 3 (SLC22A3) inhibition as a potential mechanism of antidepressant action. Pharmacol Res (2012) 0.81

The garlic ingredient diallyl sulfide inhibits cytochrome P450 2E1 dependent bioactivation of acrylamide to glycidamide. Toxicol Lett (2005) 0.81

A novel PDE2A reporter cell line: characterization of the cellular activity of PDE inhibitors. Mol Pharm (2009) 0.80