Published in J Biol Chem on October 28, 2003
A highly sensitive assay for monitoring the secretory pathway and ER stress. PLoS One (2007) 2.63
Engineered luciferase reporter from a deep sea shrimp utilizing a novel imidazopyrazinone substrate. ACS Chem Biol (2012) 2.53
Real-time detection and continuous monitoring of ER stress in vitro and in vivo by ES-TRAP: evidence for systemic, transient ER stress during endotoxemia. Nucleic Acids Res (2006) 1.55
Crystal structures of the luciferase and green fluorescent protein from Renilla reniformis. J Mol Biol (2007) 1.44
In vivo bioluminescent imaging (BLI): noninvasive visualization and interrogation of biological processes in living animals. Sensors (Basel) (2010) 1.33
Ultrasound-assisted nonviral gene transfer of AQP1 to the irradiated minipig parotid gland restores fluid secretion. Gene Ther (2015) 1.17
Alternative luciferase for monitoring bacterial cells under adverse conditions. Appl Environ Microbiol (2005) 1.06
Virologic escape during danoprevir (ITMN-191/RG7227) monotherapy is hepatitis C virus subtype dependent and associated with R155K substitution. Antimicrob Agents Chemother (2011) 1.06
A pathway sensor for genome-wide screens of intracellular proteolytic cleavage. Genome Biol (2008) 1.04
A real time Metridia luciferase based non-invasive reporter assay of mammalian cell viability and cytotoxicity via the β-actin promoter and enhancer. PLoS One (2012) 0.88
Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche. Development (2015) 0.88
Crystal structure of obelin after Ca2+-triggered bioluminescence suggests neutral coelenteramide as the primary excited state. Proc Natl Acad Sci U S A (2006) 0.86
Suppression of HPV-16 late L1 5'-splice site SD3632 by binding of hnRNP D proteins and hnRNP A2/B1 to upstream AUAGUA RNA motifs. Nucleic Acids Res (2013) 0.83
Expression, purification and characterization of the secreted luciferase of the copepod Metridia longa from Sf9 insect cells. Protein Expr Purif (2008) 0.81
A multisampling reporter system for monitoring microRNA activity in the same population of cells. J Biomed Biotechnol (2010) 0.80
Multiplexing bioluminescent and fluorescent reporters to monitor live cells. Curr Chem Genomics (2008) 0.80
Intercellular chaperone transmission via exosomes contributes to maintenance of protein homeostasis at the organismal level. Proc Natl Acad Sci U S A (2015) 0.79
Application of Gaussia luciferase in bicistronic and non-conventional secretion reporter constructs. BMC Biochem (2014) 0.78
Protein reporter bioassay systems for the phenotypic screening of candidate drugs: a mouse platform for anti-aging drug screening. Sensors (Basel) (2012) 0.77
The Expanding Toolbox of In Vivo Bioluminescent Imaging. Front Oncol (2016) 0.77
In vitro and in vivo activities of AIC292, a novel HIV-1 nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother (2013) 0.76
Quantification of dopaminergic neuron differentiation and neurotoxicity via a genetic reporter. Sci Rep (2016) 0.75
A puzzling homology: a brittle star using a putative cnidarian-type luciferase for bioluminescence. Open Biol (2017) 0.75
Substrate cooperativity in marine luciferases. PLoS One (2012) 0.75
Human cellular CYBA UTR sequences increase mRNA translation without affecting the half-life of recombinant RNA transcripts. Sci Rep (2016) 0.75
Highly active BRET-reporter based on yellow mutant of Renilla muelleri luciferase. Dokl Biochem Biophys (2013) 0.75
Discovery of the ergothioneine transporter. Proc Natl Acad Sci U S A (2005) 2.03
TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex. J Cell Sci (2010) 1.25
Charcot-Marie-Tooth disease CMT4A: GDAP1 increases cellular glutathione and the mitochondrial membrane potential. Hum Mol Genet (2011) 1.07
Store-operated calcium entry modulates neuronal network activity in a model of chronic epilepsy. Exp Neurol (2011) 1.05
Myocardial transcriptome analysis of human arrhythmogenic right ventricular cardiomyopathy. Physiol Genomics (2011) 1.05
Interchange of aequorin and obelin bioluminescence color is determined by substitution of one active site residue of each photoprotein. FEBS Lett (2005) 1.00
Obelin from the bioluminescent marine hydroid Obelia geniculata: cloning, expression, and comparison of some properties with those of other Ca2+-regulated photoproteins. Biochemistry (2002) 0.94
The constitutively active orphan G-protein-coupled receptor GPR39 protects from cell death by increasing secretion of pigment epithelium-derived growth factor. J Biol Chem (2008) 0.93
Impaired left-ventricular cardiac function in male GPR30-deficient mice. Mol Med Rep (2010) 0.91
Crystal structure of a Ca2+-discharged photoprotein: implications for mechanisms of the calcium trigger and bioluminescence. J Biol Chem (2004) 0.88
All three Ca2+-binding loops of photoproteins bind calcium ions: the crystal structures of calcium-loaded apo-aequorin and apo-obelin. Protein Sci (2005) 0.88
Coelenterazine-v ligated to Ca2+-triggered coelenterazine-binding protein is a stable and efficient substrate of the red-shifted mutant of Renilla muelleri luciferase. Anal Bioanal Chem (2010) 0.86
Crystal structure of coelenterazine-binding protein from Renilla muelleri at 1.7 A: why it is not a calcium-regulated photoprotein. Photochem Photobiol Sci (2008) 0.86
The carnitine transporter SLC22A5 is not a general drug transporter, but it efficiently translocates mildronate. Drug Metab Dispos (2008) 0.86
Crystal structure of obelin after Ca2+-triggered bioluminescence suggests neutral coelenteramide as the primary excited state. Proc Natl Acad Sci U S A (2006) 0.86
Green-fluorescent protein from the bioluminescent jellyfish Clytia gregaria: cDNA cloning, expression, and characterization of novel recombinant protein. Photochem Photobiol Sci (2010) 0.85
Violet bioluminescence and fast kinetics from W92F obelin: structure-based proposals for the bioluminescence triggering and the identification of the emitting species. Biochemistry (2003) 0.84
The light-sensitive photoprotein berovin from the bioluminescent ctenophore Beroe abyssicola: a novel type of Ca(2+) -regulated photoprotein. FEBS J (2012) 0.83
OAT2 catalyses efflux of glutamate and uptake of orotic acid. Biochem J (2011) 0.83
Pharmacological and kinetic characterization of adrenomedullin 1 and calcitonin gene-related peptide 1 receptor reporter cell lines. Mol Pharmacol (2008) 0.83
Probing the substrate specificity of the ergothioneine transporter with methimazole, hercynine, and organic cations. Biochem Pharmacol (2007) 0.83
A novel giant peroxisomal superoxide dismutase motif-containing protein. Free Radic Biol Med (2010) 0.82
High-active truncated luciferase of copepod Metridia longa. Biochem Biophys Res Commun (2011) 0.82
Protein-protein complexation in bioluminescence. Protein Cell (2012) 0.81
Expression, purification and characterization of the secreted luciferase of the copepod Metridia longa from Sf9 insect cells. Protein Expr Purif (2008) 0.81
Spectral tuning of obelin bioluminescence by mutations of Trp92. FEBS Lett (2003) 0.81
Atomic resolution structure of obelin: soaking with calcium enhances electron density of the second oxygen atom substituted at the C2-position of coelenterazine. Biochem Biophys Res Commun (2003) 0.80
A cell-based nitric oxide reporter assay useful for the identification and characterization of modulators of the nitric oxide/guanosine 3',5'-cyclic monophosphate pathway. Anal Biochem (2007) 0.80
NMR-derived topology of a GFP-photoprotein energy transfer complex. J Biol Chem (2010) 0.79
Green-fluorescent protein from the bioluminescent jellyfish Clytia gregaria is an obligate dimer and does not form a stable complex with the Ca(2+)-discharged photoprotein clytin. Biochemistry (2011) 0.79
Functional cell-based assays in microliter volumes for ultra-high throughput screening. Comb Chem High Throughput Screen (2008) 0.79
Coelenterazine-binding protein of Renilla muelleri: cDNA cloning, overexpression, and characterization as a substrate of luciferase. Photochem Photobiol Sci (2007) 0.79
Sex-dependent regulation of fibrosis and inflammation in human left ventricular remodelling under pressure overload. Eur J Heart Fail (2014) 0.78
Long-term levosimendan treatment improves systolic function and myocardial relaxation in mice with cardiomyocyte-specific disruption of the Serca2 gene. J Appl Physiol (1985) (2013) 0.78
Bioluminescent immunoassay of thyrotropin and thyroxine using obelin as a label. Anal Biochem (2004) 0.78
Preparation and X-ray crystallographic analysis of the Ca2+-discharged photoprotein obelin. Acta Crystallogr D Biol Crystallogr (2004) 0.77
Genomic profiling of developing cardiomyocytes from recombinant murine embryonic stem cells reveals regulation of transcription factor clusters. Physiol Genomics (2009) 0.77
Large-scale, high-throughput validation of short hairpin RNA sequences for RNA interference. J Biomol Screen (2006) 0.77
Violet and greenish photoprotein obelin mutants for reporter applications in dual-color assay. Anal Bioanal Chem (2008) 0.77
Oxygen activation of apo-obelin-coelenterazine complex. Chembiochem (2013) 0.77
Crystal structures of the F88Y obelin mutant before and after bioluminescence provide molecular insight into spectral tuning among hydromedusan photoproteins. FEBS J (2014) 0.77
Bioluminescent and spectroscopic properties of His-Trp-Tyr triad mutants of obelin and aequorin. Photochem Photobiol Sci (2013) 0.77
Spatial structure of the novel light-sensitive photoprotein berovin from the ctenophore Beroe abyssicola in the Ca(2+)-loaded apoprotein conformation state. Biochim Biophys Acta (2013) 0.76
Role of certain amino acid residues of the coelenterazine-binding cavity in bioluminescence of light-sensitive Ca(2+)-regulated photoprotein berovin. Photochem Photobiol Sci (2016) 0.76
Role of key residues of obelin in coelenterazine binding and conversion into 2-hydroperoxy adduct. J Photochem Photobiol B (2013) 0.76
Structure based mechanism of the Ca(2+)-induced release of coelenterazine from the Renilla binding protein. Proteins (2009) 0.76
The intrinsic fluorescence of apo-obelin and apo-aequorin and use of its quenching to characterize coelenterazine binding. FEBS Lett (2009) 0.76
Simultaneous bioluminescent immunoassay of serum total and IgG-bound prolactins. Anal Chem (2012) 0.75
Characterization of hydromedusan Ca(2+)-regulated photoproteins as a tool for measurement of Ca(2+)concentration. Anal Bioanal Chem (2014) 0.75
Bioluminescent detection probe for tick-borne encephalitis virus immunoassay. Anal Bioanal Chem (2015) 0.75
Bioluminescent properties of obelin and aequorin with novel coelenterazine analogues. Anal Bioanal Chem (2014) 0.75
Hydrogen-bond networks between the C-terminus and Arg from the first α-helix stabilize photoprotein molecules. Photochem Photobiol Sci (2014) 0.75
Ligand binding and conformational states of the photoprotein obelin. FEBS Lett (2012) 0.75
Simultaneous Genotyping of Four Single Nucleotide Polymorphisms Associated with Risk Factors of Hemostasis Disorders. Comb Chem High Throughput Screen (2015) 0.75
RNA aptamer against autoantibodies associated with multiple sclerosis and bioluminescent detection probe on its basis. Anal Chem (2014) 0.75
Picosecond fluorescence relaxation spectroscopy of the calcium-discharged photoproteins aequorin and obelin. Biochemistry (2009) 0.75
Recombinant Metridia luciferase isoforms: expression, refolding and applicability for in vitro assay. Photochem Photobiol Sci (2008) 0.75