Implication of snail in metabolic stress-induced necrosis.

Regulation of the protein stability of EMT transcription factors. Cell Adh Migr (2014) 0.88

Homeobox gene Dlx-2 is implicated in metabolic stress-induced necrosis. Mol Cancer (2011) 0.87

Hyperglycemia causes renal cell damage via CCN2-induced activation of the TrkA receptor: implications for diabetic nephropathy. Diabetes (2012) 0.82

Early growth response 1 regulates glucose deprivation-induced necrosis. Oncol Rep (2012) 0.80

The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol (2000) 21.15

Why do cancers have high aerobic glycolysis? Nat Rev Cancer (2004) 20.60

Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer (2007) 18.69

Autophagy in health and disease: a double-edged sword. Science (2004) 13.69

Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell (2006) 11.79

High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol (2005) 11.57

The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol (2002) 10.59

TGF-beta and epithelial-to-mesenchymal transitions. Oncogene (2005) 10.02

Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol (2004) 9.80

Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature (2005) 7.24

Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. Nature (2000) 6.70

Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev (2004) 6.08

Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes. J Exp Med (2000) 5.90

The transcriptional repressor Snail promotes mammary tumor recurrence. Cancer Cell (2005) 5.81

Snail blocks the cell cycle and confers resistance to cell death. Genes Dev (2004) 5.34

Necrotic death as a cell fate. Genes Dev (2006) 4.93

The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition. Mol Cell Biol (2001) 4.80

Cell death by necrosis: towards a molecular definition. Trends Biochem Sci (2006) 4.67

A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Nat Cell Biol (2006) 4.55

Correlation of Snail expression with histological grade and lymph node status in breast carcinomas. Oncogene (2002) 4.20

Mitochondrial mutations in cancer. Oncogene (2006) 3.86

Inflammation and necrosis promote tumour growth. Nat Rev Immunol (2004) 3.68

Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma. Am J Surg Pathol (2003) 3.66

Complex III releases superoxide to both sides of the inner mitochondrial membrane. J Biol Chem (2004) 3.59

Mitochondrial ROS-induced ROS release: an update and review. Biochim Biophys Acta (2006) 3.57

Role of autophagy in cancer: management of metabolic stress. Autophagy (2007) 3.40

Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells. Stem Cells (2009) 3.25

Opinion: What is the role of protein aggregation in neurodegeneration? Nat Rev Mol Cell Biol (2005) 3.18

Wnt-dependent regulation of the E-cadherin repressor snail. J Biol Chem (2005) 3.03

Transient and long-lasting openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes in mitochondrial calcein fluorescence. Biophys J (1999) 2.96

The use of 3-D cultures for high-throughput screening: the multicellular spheroid model. J Biomol Screen (2004) 2.94

Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress. Mol Cell Biol (2004) 2.80

Autophagy in cancer: good, bad, or both? Cancer Res (2006) 2.66

Metabolic catastrophe as a means to cancer cell death. J Cell Sci (2007) 2.58

Mitochondrial permeability transition: a common pathway to necrosis and apoptosis. Biochem Biophys Res Commun (2003) 2.58

Phosphorylation regulates the subcellular location and activity of the snail transcriptional repressor. Mol Cell Biol (2003) 2.46

Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation. Biochem J (2009) 2.35

Snail silencing effectively suppresses tumour growth and invasiveness. Oncogene (2006) 2.27

Glucose deprivation-induced oxidative stress in human tumor cells. A fundamental defect in metabolism? Ann N Y Acad Sci (2000) 2.25

Bioenergetics and the formation of mitochondrial reactive oxygen species. Trends Pharmacol Sci (2006) 2.22

Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells. Am J Pathol (2003) 2.18

uPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cells. J Cell Biol (2007) 2.11

3-D tumor model for in vitro evaluation of anticancer drugs. Mol Pharm (2008) 2.11

Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells. Carcinogenesis (2008) 2.05

VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail. Mol Cell Biol (2006) 2.03

Mitochondrial O2*- and H2O2 mediate glucose deprivation-induced stress in human cancer cells. J Biol Chem (2004) 1.94

Protein aggregation after transient cerebral ischemia. J Neurosci (2000) 1.79

Transcriptional repressor snail and progression of human hepatocellular carcinoma. Clin Cancer Res (2003) 1.79

Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: methylation of the E-cadherin promoter. Gastroenterology (2008) 1.78

Angiogenetic signaling through hypoxia: HMGB1: an angiogenetic switch molecule. Am J Pathol (2005) 1.75

Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis. Mol Cell Biol (2008) 1.68

Diversity of cell-mediated adhesions in breast cancer spheroids. Int J Oncol (2007) 1.49

Protein aggregation after focal brain ischemia and reperfusion. J Cereb Blood Flow Metab (2001) 1.45

Receptor for advanced glycation end products (RAGE) and its ligand, amphoterin are overexpressed and associated with prostate cancer development. Prostate (2005) 1.41

The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation. J Biol Chem (2009) 1.35

Protein aggregation and proteasome dysfunction after brain ischemia. Stroke (2007) 1.22

Mitochondria and cancer: is there a morphological connection? Oncogene (2006) 1.22

Cancer development induced by graded expression of Snail in mice. Hum Mol Genet (2005) 1.18

Overexpression of high mobility group box 1 in gastrointestinal stromal tumors with KIT mutation. Cancer Res (2003) 1.12

Microenvironmental regulation of proliferation in multicellular spheroids is mediated through differential expression of cyclin-dependent kinase inhibitors. Cancer Res (2004) 1.12

Necrosis and hypoxia in invasive breast carcinoma. Breast Cancer Res Treat (2003) 1.12

Role of extracellular signal-regulated kinase (ERK)1/2 in multicellular resistance to docetaxel in MCF-7 cells. Int J Oncol (2010) 0.91

Protein kinase C-ERK1/2 signal pathway switches glucose depletion-induced necrosis to apoptosis by regulating superoxide dismutases and suppressing reactive oxygen species production in A549 lung cancer cells. J Cell Physiol (2007) 0.89

Role of reactive oxygen species-dependent protein aggregation in metabolic stress-induced necrosis. Int J Oncol (2010) 0.87

New class of microRNA targets containing simultaneous 5'-UTR and 3'-UTR interaction sites. Genome Res (2009) 2.56

A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition. J Cell Biol (2011) 2.19

Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor. Aging Cell (2008) 2.09

Janus microspheres for a highly flexible and impregnable water-repelling interface. Angew Chem Int Ed Engl (2010) 2.07

p53 and microRNA-34 are suppressors of canonical Wnt signaling. Sci Signal (2011) 1.80

Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes. Mol Cell Biol (2003) 1.72

Development of a novel bone grafting material using autogenous teeth. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2010) 1.63

Sequence dependent exposure of mammary carcinoma cells to Taxotere and the MEK1/2 inhibitor U0126 causes enhanced cell killing in vitro. Cancer Biol Ther (2003) 1.61

Predictors of the response to gefitinib in refractory non-small cell lung cancer. Clin Cancer Res (2005) 1.51

Reversible SUMOylation of TBL1-TBLR1 regulates β-catenin-mediated Wnt signaling. Mol Cell (2011) 1.45

Slug, mammalian homologue gene of Drosophila escargot, promotes neuronal-differentiation through suppression of HEB/daughterless. Cell Cycle (2010) 1.41

Visfatin enhances ICAM-1 and VCAM-1 expression through ROS-dependent NF-kappaB activation in endothelial cells. Biochim Biophys Acta (2008) 1.41

Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes. Hepatology (2004) 1.40

Acute renal failure due to acute tubular necrosis caused by direct invasion of Orientia tsutsugamushi. J Clin Microbiol (2007) 1.34

The role of p38b MAPK in age-related modulation of intestinal stem cell proliferation and differentiation in Drosophila. Aging (Albany NY) (2009) 1.32

A rapid and transient ROS generation by cadmium triggers apoptosis via caspase-dependent pathway in HepG2 cells and this is inhibited through N-acetylcysteine-mediated catalase upregulation. Toxicol Appl Pharmacol (2005) 1.32

Polymorphism of the DNA repair gene XRCC1 and risk of primary lung cancer. Cancer Epidemiol Biomarkers Prev (2002) 1.28

Impaired D2 dopamine receptor function in mice lacking type 5 adenylyl cyclase. J Neurosci (2002) 1.26

Use of particulate dentin-plaster of Paris combination with/without platelet-rich plasma in the treatment of bone defects around implants. Int J Oral Maxillofac Implants (2002) 1.26

Bimetallic anilido-aldimine zinc complexes for epoxide/CO2 copolymerization. J Am Chem Soc (2005) 1.25

Endoplasmic reticulum stress-mediated autophagy/apoptosis induced by capsaicin (8-methyl-N-vanillyl-6-nonenamide) and dihydrocapsaicin is regulated by the extent of c-Jun NH2-terminal kinase/extracellular signal-regulated kinase activation in WI38 lung epithelial fibroblast cells. J Pharmacol Exp Ther (2009) 1.23

Snail1 is stabilized by O-GlcNAc modification in hyperglycaemic condition. EMBO J (2010) 1.23

Differences in classification of COPD group using COPD assessment test (CAT) or modified Medical Research Council (mMRC) dyspnea scores: a cross-sectional analyses. BMC Pulm Med (2013) 1.21

O-GlcNAc protein modification in cancer cells increases in response to glucose deprivation through glycogen degradation. J Biol Chem (2009) 1.21

Wnt/Snail signaling regulates cytochrome C oxidase and glucose metabolism. Cancer Res (2012) 1.19

Electroacupuncture preconditioning reduces cerebral ischemic injury via BDNF and SDF-1α in mice. BMC Complement Altern Med (2013) 1.18

Visfatin promotes angiogenesis by activation of extracellular signal-regulated kinase 1/2. Biochem Biophys Res Commun (2007) 1.17

The DRE/DREF transcriptional regulatory system: a master key for cell proliferation. Biochim Biophys Acta (2007) 1.17

The homeobox gene Caudal regulates constitutive local expression of antimicrobial peptide genes in Drosophila epithelia. Mol Cell Biol (2004) 1.15

Biosynthesis of polylactic acid and its copolymers using evolved propionate CoA transferase and PHA synthase. Biotechnol Bioeng (2010) 1.14

Blocking of p53-Snail binding, promoted by oncogenic K-Ras, recovers p53 expression and function. Neoplasia (2009) 1.13

Trends in the incidence of hospitalized acute myocardial infarction and stroke in Korea, 2006-2010. J Korean Med Sci (2013) 1.10

MiRNA-34 intrinsically links p53 tumor suppressor and Wnt signaling. Cell Cycle (2012) 1.10

Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1. FEBS Lett (2006) 1.08

Improved recombinant gene expression in CHO cells using matrix attachment regions. J Biotechnol (2004) 1.07

Effect of betulinic acid on anticancer drug-resistant colon cancer cells. Basic Clin Pharmacol Toxicol (2007) 1.07

Polymorphisms of the DNA repair gene xeroderma pigmentosum group A and risk of primary lung cancer. Cancer Epidemiol Biomarkers Prev (2002) 1.07

Electroacupuncture acutely improves cerebral blood flow and attenuates moderate ischemic injury via an endothelial mechanism in mice. PLoS One (2013) 1.07

Dichloromethane fraction of Cimicifuga heracleifolia decreases the level of melanin synthesis by activating the ERK or AKT signaling pathway in B16F10 cells. Exp Dermatol (2008) 1.07

Tetrandrine-induced cell cycle arrest and apoptosis in A549 human lung carcinoma cells. Int J Oncol (2002) 1.06

H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent. Mol Cancer Ther (2005) 1.06

17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines. Mol Cancer Ther (2007) 1.03

Lipid raft-dependent death receptor 5 (DR5) expression and activation are critical for ursodeoxycholic acid-induced apoptosis in gastric cancer cells. Carcinogenesis (2011) 1.02

Methyl jasmonate induces apoptosis through induction of Bax/Bcl-XS and activation of caspase-3 via ROS production in A549 cells. Oncol Rep (2004) 1.02

Characterization of newly established oral cancer cell lines derived from six squamous cell carcinoma and two mucoepidermoid carcinoma cells. Exp Mol Med (2005) 1.02

Histone deacetylase regulates high mobility group A2-targeting microRNAs in human cord blood-derived multipotent stem cell aging. Cell Mol Life Sci (2010) 1.01

Implication of intracellular ROS formation, caspase-3 activation and Egr-1 induction in platycodon D-induced apoptosis of U937 human leukemia cells. Biomed Pharmacother (2008) 1.01

Microvascular decompression for hemifacial spasm: analyses of operative complications in 1582 consecutive patients. Surg Neurol (2008) 1.00

Roles of cyclin-dependent kinase 8 and β-catenin in the oncogenesis and progression of gastric adenocarcinoma. Int J Oncol (2011) 1.00

p53 regulates nuclear GSK-3 levels through miR-34-mediated Axin2 suppression in colorectal cancer cells. Cell Cycle (2013) 1.00

Hybrid odontogenic tumor of calcifying odontogenic cyst and ameloblastic fibroma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2004) 0.99

Ursodeoxycholic acid switches oxaliplatin-induced necrosis to apoptosis by inhibiting reactive oxygen species production and activating p53-caspase 8 pathway in HepG2 hepatocellular carcinoma. Int J Cancer (2010) 0.99

Age-related upregulation of Drosophila caudal gene via NF-kappaB in the adult posterior midgut. Biochim Biophys Acta (2008) 0.99

Genistein sensitizes TRAIL-resistant human gastric adenocarcinoma AGS cells through activation of caspase-3. Cancer Lett (2007) 0.99

Clinical evaluations of OSTEON as a new alloplastic material in sinus bone grafting and its effect on bone healing. J Biomed Mater Res B Appl Biomater (2008) 0.99

Beta-sitosterol induces anti-proliferation and apoptosis in human leukemic U937 cells through activation of caspase-3 and induction of Bax/Bcl-2 ratio. Biol Pharm Bull (2007) 0.98

The protein phosphatase 1/2A inhibitor okadaic acid increases CREB and Elk-1 phosphorylation and c-fos expression in the rat striatum in vivo. J Neurochem (2004) 0.97

Protective effect of the phosphodiesterase III inhibitor cilostazol on amyloid β-induced cognitive deficits associated with decreased amyloid β accumulation. Biochem Biophys Res Commun (2011) 0.97

Induction of apoptosis by esculetin in human leukemia U937 cells through activation of JNK and ERK. Toxicol Appl Pharmacol (2007) 0.97

Curcumin induces apoptosis and inhibits prostaglandin E(2) production in synovial fibroblasts of patients with rheumatoid arthritis. Int J Mol Med (2007) 0.97

Colon cancer progression is driven by APEX1-mediated upregulation of Jagged. J Clin Invest (2013) 0.96

Ca2+/calmodulin-dependent protein phosphatase calcineurin mediates the expression of iNOS through IKK and NF-kappaB activity in LPS-stimulated mouse peritoneal macrophages and RAW 264.7 cells. Biochem Biophys Res Commun (2004) 0.96

Platycodin D induces apoptosis and decreases telomerase activity in human leukemia cells. Cancer Lett (2008) 0.96

Efficacy of gemcitabine in patients with non-small cell lung cancer according to promoter polymorphisms of the ribonucleotide reductase M1 gene. Clin Cancer Res (2008) 0.96

Resveratrol inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression in beta-amyloid-treated C6 glioma cells. Int J Mol Med (2006) 0.96

Induction of apoptosis and inhibition of telomerase activity by trichostatin A, a histone deacetylase inhibitor, in human leukemic U937 cells. Exp Mol Pathol (2006) 0.95

Capsaicin-induced apoptosis is regulated by endoplasmic reticulum stress- and calpain-mediated mitochondrial cell death pathways. Toxicology (2009) 0.95

Severe scrub typhus confirmed early via immunohistochemical staining. Am J Trop Med Hyg (2007) 0.95

The Traditional Herbal Medicine, Dangkwisoo-San, Prevents Cerebral Ischemic Injury through Nitric Oxide-Dependent Mechanisms. Evid Based Complement Alternat Med (2011) 0.95

Partial characterization and immunostimulatory effect of a novel polysaccharide-protein complex extracted from Phellinus linteus. Biosci Biotechnol Biochem (2006) 0.94

Biosynthesis of polyhydroxyalkanoates containing 2-hydroxybutyrate from unrelated carbon source by metabolically engineered Escherichia coli. Appl Microbiol Biotechnol (2011) 0.93

Hyperinsulinemic hypoglycemia due to diffuse nesidioblastosis in adults: a case report. World J Gastroenterol (2008) 0.93

Hyperplasia and spontaneous tumor development in the gynecologic system in mice lacking the BRCA1-Delta11 isoform. Mol Cell Biol (2006) 0.93

Nuclear localization signals of the E-cadherin transcriptional repressor Snail. Cells Tissues Organs (2007) 0.93

Cognitive improvement after long-term electrical stimulation of bilateral anterior thalamic nucleus in refractory epilepsy patients. Seizure (2011) 0.92

Fas (Apo-1/CD95) and Fas ligand interaction between gastric cancer cells and immune cells. J Gastroenterol Hepatol (2002) 0.92

Multicentric infarcted leiomyoadenomatoid tumor: a case report. Int J Clin Exp Pathol (2008) 0.92

Sulforaphane generates reactive oxygen species leading to mitochondrial perturbation for apoptosis in human leukemia U937 cells. Biomed Pharmacother (2008) 0.92

Induction of apoptosis in human colon cancer HCT-116 cells by anthocyanins through suppression of Akt and activation of p38-MAPK. Int J Oncol (2009) 0.92

Migration of human neural stem cells toward an intracranial glioma. Exp Mol Med (2008) 0.92

The aqueous extract from Artemisia capillaris Thunb. inhibits lipopolysaccharide-induced inflammatory response through preventing NF-kappaB activation in human hepatoma cell line and rat liver. Int J Mol Med (2004) 0.92

Resveratrol inhibits cell proliferation and induces apoptosis of human breast carcinoma MCF-7 cells. Oncol Rep (2004) 0.91

Role of extracellular signal-regulated kinase (ERK)1/2 in multicellular resistance to docetaxel in MCF-7 cells. Int J Oncol (2010) 0.91