Published in Trends Biochem Sci on October 01, 1990
Cyclin A is required at two points in the human cell cycle. EMBO J (1992) 7.96
A family of human cdc2-related protein kinases. EMBO J (1992) 4.96
Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function. EMBO J (1991) 4.59
Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites. EMBO J (1991) 4.24
Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. EMBO J (1992) 4.21
Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc Natl Acad Sci U S A (1996) 4.16
Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide. Proc Natl Acad Sci U S A (1991) 3.70
Cell cycle regulation of the human cdc2 gene. EMBO J (1992) 3.69
Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells. J Cell Biol (1992) 3.57
Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein. Mol Cell Biol (1993) 3.39
Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A. Proc Natl Acad Sci U S A (1992) 3.38
Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates. EMBO J (1991) 3.23
Redundant cyclin overexpression and gene amplification in breast cancer cells. Proc Natl Acad Sci U S A (1993) 2.85
Differential function and expression of Saccharomyces cerevisiae B-type cyclins in mitosis and meiosis. Mol Cell Biol (1993) 2.76
Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E. Mol Cell Biol (1993) 2.75
Activation of human cyclin-dependent kinases in vitro. Mol Biol Cell (1992) 2.68
A minimal cascade model for the mitotic oscillator involving cyclin and cdc2 kinase. Proc Natl Acad Sci U S A (1991) 2.68
Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes. Mol Biol Cell (1993) 2.57
NuMA: an unusually long coiled-coil related protein in the mammalian nucleus. J Cell Biol (1992) 2.33
p34cdc2-mediated phosphorylation at T124 inhibits nuclear import of SV-40 T antigen proteins. J Cell Biol (1991) 2.08
Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase. J Cell Biol (1994) 1.96
Transforming growth factor beta effects on expression of G1 cyclins and cyclin-dependent protein kinases. Proc Natl Acad Sci U S A (1993) 1.89
The NIMA protein kinase is hyperphosphorylated and activated downstream of p34cdc2/cyclin B: coordination of two mitosis promoting kinases. EMBO J (1995) 1.73
SCP2: a major protein component of the axial elements of synaptonemal complexes of the rat. Nucleic Acids Res (1998) 1.68
A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4. Mol Cell Biol (1994) 1.62
cDNA cloning of the HMGI-C phosphoprotein, a nuclear protein associated with neoplastic and undifferentiated phenotypes. Nucleic Acids Res (1991) 1.56
A connection between pre-mRNA splicing and the cell cycle in fission yeast: cdc28+ is allelic with prp8+ and encodes an RNA-dependent ATPase/helicase. Mol Biol Cell (1996) 1.55
Interaction between the Cig1 and Cig2 B-type cyclins in the fission yeast cell cycle. Mol Cell Biol (1994) 1.50
Analysis of wild-type and mutant p21WAF-1 gene activities. Mol Cell Biol (1996) 1.47
The molecular anatomy of caldesmon. Biochem J (1991) 1.46
KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases. Proc Natl Acad Sci U S A (1994) 1.45
Cyclin A- and cyclin B-dependent protein kinases are regulated by different mechanisms in Xenopus egg extracts. EMBO J (1992) 1.41
E1A induces phosphorylation of the retinoblastoma protein independently of direct physical association between the E1A and retinoblastoma products. Mol Cell Biol (1991) 1.41
Disassembly of in vitro formed lamin head-to-tail polymers by CDC2 kinase. EMBO J (1991) 1.38
Inhibition of cAMP-dependent protein kinase plays a key role in the induction of mitosis and nuclear envelope breakdown in mammalian cells. EMBO J (1991) 1.38
Interaction of the interferon-induced PKR protein kinase with inhibitory proteins P58IPK and vaccinia virus K3L is mediated by unique domains: implications for kinase regulation. Mol Cell Biol (1996) 1.37
Cloning of a D-type cyclin from murine erythroleukemia cells. Proc Natl Acad Sci U S A (1992) 1.35
Mitotic destruction of the cell cycle regulated NIMA protein kinase of Aspergillus nidulans is required for mitotic exit. EMBO J (1995) 1.34
Characterization of the fission yeast mcs2 cyclin and its associated protein kinase activity. EMBO J (1993) 1.31
Isolation of Drosophila cyclin D, a protein expressed in the morphogenetic furrow before entry into S phase. Proc Natl Acad Sci U S A (1996) 1.30
Two S-phase checkpoint systems, one involving the function of both BIME and Tyr15 phosphorylation of p34cdc2, inhibit NIMA and prevent premature mitosis. EMBO J (1996) 1.27
Cell cycle regulation in Aspergillus by two protein kinases. Biochem J (1996) 1.22
Cell cycle control, checkpoint mechanisms, and genotoxic stress. Environ Health Perspect (1999) 1.22
The G2/M DNA damage checkpoint inhibits mitosis through Tyr15 phosphorylation of p34cdc2 in Aspergillus nidulans. EMBO J (1997) 1.19
Alteration of cell cycle kinase complexes in human papillomavirus E6- and E7-expressing fibroblasts precedes neoplastic transformation. J Virol (1996) 1.18
A three-dimensional model of the Cdc2 protein kinase: localization of cyclin- and Suc1-binding regions and phosphorylation sites. Mol Cell Biol (1993) 1.08
SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells. Mol Cell Biol (1993) 1.08
Temporal regulation of cyclin A-p107 and p33cdk2 complexes binding to a human thymidine kinase promoter element important for G1-S phase transcriptional regulation. Proc Natl Acad Sci U S A (1993) 1.08
p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A. Mol Cell Biol (1996) 1.08
Cell cycle-regulated degradation of Xenopus cyclin B2 requires binding to p34cdc2. Mol Biol Cell (1994) 1.03
Evidence for the induction of casein kinase II in bovine lymphocytes transformed by the intracellular protozoan parasite Theileria parva. EMBO J (1993) 1.02
The c-mos gene product is required for cyclin B accumulation during meiosis of mouse eggs. Proc Natl Acad Sci U S A (1991) 1.02
Mutations at sites involved in Suc1 binding inactivate Cdc2. Mol Cell Biol (1991) 1.01
Association between histology grade, expression of HsMCM2, and cyclin A in human invasive breast carcinomas. J Clin Pathol (2003) 1.01
p21WAF1 expression by an activator of protein kinase C is regulated mainly at the post-transcriptional level in cells lacking p53: important role of RNA stabilization. Biochem J (1999) 0.99
p63cdc13, a B-type cyclin, is associated with both the nucleolar and chromatin domains of the fission yeast nucleus. Mol Biol Cell (1993) 0.93
Interleukin-1 activates a novel protein kinase that phosphorylates the epidermal-growth-factor receptor peptide T669. Biochem J (1994) 0.92
CyclinPred: a SVM-based method for predicting cyclin protein sequences. PLoS One (2008) 0.89
CDK/CCN and CDKI alterations for cancer prognosis and therapeutic predictivity. Biomed Res Int (2014) 0.88
Transforming growth factor beta 1 (TGF beta 1) reduces cellular levels of p34cdc2, and this effect is abrogated by adenovirus independently of the E1A-associated pRB binding activity. Mol Biol Cell (1992) 0.87
Nucleotide sequence of a Trypanosoma cruzi cDNA encoding a protein homologous to mammalian EF1 gamma. Nucleic Acids Res (1993) 0.82
LAMMER Kinase LkhA plays multiple roles in the vegetative growth and asexual and sexual development of Aspergillus nidulans. PLoS One (2013) 0.81
Activation of a histone H1 kinase by tyrosine phosphorylation in v-src-transformed fibroblasts. EMBO J (1993) 0.80
Understanding and modulating cyclin-dependent kinase inhibitor specificity: molecular modeling and biochemical evaluation of pyrazolopyrimidinones as CDK2/cyclin A and CDK4/cyclin D1 inhibitors. J Comput Aided Mol Des (2005) 0.79
Peptides containing cyclin/Cdk-nuclear localization signal motifs derived from viral initiator proteins bind to DNA when unphosphorylated. J Virol (2002) 0.79
A novel nuclear inhibitor I-92 regulates DNA binding activity of octamer binding protein p92 during the cell cycle. Nucleic Acids Res (1991) 0.78
Nucleotide sequence of a rabbit cDNA encoding elongation factor 1 gamma. Nucleic Acids Res (1992) 0.76
Role of LM23 in cell proliferation and apoptosis and its expression during the testis development. Asian J Androl (2013) 0.75
δEF1 upregulates CDK4 transcription via the E2-box element on the CDK4 promoter. Exp Ther Med (2013) 0.75