Published in Proc Natl Acad Sci U S A on March 01, 1994
Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains. FASEB J (2006) 2.07
Dephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases. Genes Dev (1999) 1.43
Choline availability modulates human neuroblastoma cell proliferation and alters the methylation of the promoter region of the cyclin-dependent kinase inhibitor 3 gene. J Neurochem (2004) 1.40
Kin28 is found within TFIIH and a Kin28-Ccl1-Tfb3 trimer complex with differential sensitivities to T-loop phosphorylation. Mol Cell Biol (2002) 1.37
Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expression. Mol Cell Biol (2000) 1.19
Human HTm4 is a hematopoietic cell cycle regulator. J Clin Invest (2002) 1.15
Transforming growth factor beta targeted inactivation of cyclin E:cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity. Proc Natl Acad Sci U S A (1999) 1.09
Identification of novel mitosis regulators through data mining with human centromere/kinetochore proteins as group queries. BMC Cell Biol (2012) 1.04
The tumor suppressor CDKN3 controls mitosis. J Cell Biol (2013) 1.01
Mitogen-activated protein kinase phosphatase-1 in rat arterial smooth muscle cell proliferation. J Clin Invest (1996) 0.96
Protein tyrosine phosphatases in glioma biology. Acta Neuropathol (2009) 0.92
Association of protein tyrosine phosphatases (PTPs)-1B with c-Met receptor and modulation of corneal epithelial wound healing. Invest Ophthalmol Vis Sci (2008) 0.91
Regulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection. Sci Rep (2014) 0.88
p90 ribosomal S6 kinase 2 is associated with and dephosphorylated by protein phosphatase 2Cdelta. Biochem J (2004) 0.87
Overexpression of major CDKN3 transcripts is associated with poor survival in lung adenocarcinoma. Br J Cancer (2015) 0.85
Protein tyrosine and serine-threonine phosphatases in the sea urchin, Strongylocentrotus purpuratus: identification and potential functions. Dev Biol (2006) 0.84
A critical role of CDKN3 in Bcr-Abl-mediated tumorigenesis. PLoS One (2014) 0.84
Perinatal choline deficiency produces abnormal sensory inhibition in Sprague-Dawley rats. Brain Res (2008) 0.84
Identifying CDKN3 Gene Expression as a Prognostic Biomarker in Lung Adenocarcinoma via Meta-analysis. Cancer Inform (2015) 0.82
Genome-wide analysis of alternative splicing during dendritic cell response to a bacterial challenge. PLoS One (2013) 0.81
Quality assessment of whole genome mapping data in the refined familial spastic paraplegia interval on chromosome 14q. Genome Res (1998) 0.81
Perspectives in cell cycle regulation: lessons from an anoxic vertebrate. Curr Genomics (2009) 0.80
The cell cycle associated protein, HTm4, is expressed in differentiating cells of the hematopoietic and central nervous system in mice. J Mol Histol (2005) 0.79
Antitumor activity of (R,R')-4-methoxy-1-naphthylfenoterol in a rat C6 glioma xenograft model in the mouse. Pharmacol Res Perspect (2013) 0.78
Topological properties of co-occurrence networks in published gene expression signatures. Bioinform Biol Insights (2008) 0.78
Purification and crystallization of the CDK-associated protein phosphatase KAP expressed in Escherichia coli. Protein Sci (1998) 0.78
Machine learning methods for prediction of CDK-inhibitors. PLoS One (2010) 0.76
Cyclin-dependent kinase-associated protein phosphatase is overexpressed in alcohol-related hepatocellular carcinoma and influences xenograft tumor growth. Oncol Rep (2012) 0.76
Critical Roles of Dual-Specificity Phosphatases in Neuronal Proteostasis and Neurological Diseases. Int J Mol Sci (2017) 0.75
Expression and alternative splicing of the cyclin-dependent kinase inhibitor-3 gene in human cancer. Int J Biochem Cell Biol (2017) 0.75
A novel genetic system to detect protein-protein interactions. Nature (1989) 43.83
Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. Mol Cell Biol (1988) 13.78
Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme. J Biol Chem (1989) 11.06
Mammalian G1 cyclins. Cell (1993) 9.04
Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev (1993) 8.03
Cyclin A is required at two points in the human cell cycle. EMBO J (1992) 7.96
Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement. Cell (1988) 6.88
mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. Cell (1991) 6.25
Association of human cyclin E with a periodic G1-S phase protein kinase. Science (1992) 5.98
Cyclin A is required for the onset of DNA replication in mammalian fibroblasts. Cell (1991) 5.98
D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell (1992) 5.51
Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. Genes Dev (1993) 5.32
A family of human cdc2-related protein kinases. EMBO J (1992) 4.96
Cyclin-dependent regulation of G1 in mammalian fibroblasts. Science (1993) 4.81
Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase. Nature (1991) 4.36
Role of phosphorylation in p34cdc2 activation: identification of an activating kinase. Mol Biol Cell (1992) 4.17
A Tyr/Ser protein phosphatase encoded by vaccinia virus. Nature (1991) 3.35
Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. Cell (1991) 3.34
Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation. Trends Biochem Sci (1990) 3.20
Driving the cell cycle: M phase kinase, its partners, and substrates. Cell (1990) 3.06
The cdk2 kinase is required for the G1-to-S transition in mammalian cells. Oncogene (1993) 2.99
Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts. J Cell Biol (1993) 2.83
Protein tyrosine phosphatases. Annu Rev Biochem (1993) 2.37
1002 protein phosphatases? Annu Rev Cell Biol (1992) 2.27
The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts. Oncogene (1993) 2.23
cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein. Oncogene (1992) 2.17
Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15. Proc Natl Acad Sci U S A (1993) 2.12
Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe. Genes Dev (1990) 1.83
The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase. Proc Natl Acad Sci U S A (1993) 1.81
Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B. Proc Natl Acad Sci U S A (1990) 1.74
Expression cloning of a human dual-specificity phosphatase. Proc Natl Acad Sci U S A (1992) 1.59
Control of M-phase by maturation-promoting factor. Curr Opin Cell Biol (1990) 1.31
A yeast protein phosphatase related to the vaccinia virus VH1 phosphatase is induced by nitrogen starvation. Proc Natl Acad Sci U S A (1992) 1.27
A protein-tyrosine/serine phosphatase encoded by the genome of the cyanobacterium Nostoc commune UTEX 584. J Biol Chem (1993) 1.25
The baculovirus Autographa californica encodes a protein tyrosine phosphatase. J Biol Chem (1993) 1.21
Two potentially oncogenic cyclins, cyclin A and cyclin D1, share common properties of subunit configuration, tyrosine phosphorylation and physical association with the Rb protein. Oncogene (1993) 1.12
A protein phosphatase related to the vaccinia virus VH1 is encoded in the genomes of several orthopoxviruses and a baculovirus. Proc Natl Acad Sci U S A (1993) 1.03
The mammalian cdc2 protein kinase: mechanisms of regulation during the cell cycle. J Cell Sci Suppl (1989) 0.95
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell (1997) 29.13
An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature (2000) 23.17
p21 is a universal inhibitor of cyclin kinases. Nature (1993) 15.55
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature (1993) 13.68
Role of the INK4a locus in tumor suppression and cell mortality. Cell (1996) 11.41
p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature (1994) 10.95
RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell (1999) 8.55
Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature (1995) 8.53
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature (1994) 8.22
Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science (1995) 7.25
Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement. Cell (1988) 6.88
Cyclin G is a transcriptional target of the p53 tumor suppressor protein. EMBO J (1994) 6.83
The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis. Cell (1988) 6.45
mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. Cell (1991) 6.25
Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2. Nature (1993) 5.70
p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev (1995) 5.63
D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell (1992) 5.51
Human D-type cyclin. Cell (1991) 5.47
A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science (1995) 5.46
Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF. Cell (1989) 5.35
Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. Genes Dev (1993) 5.32
Construction of a Schizosaccharomyces pombe gene bank in a yeast bacterial shuttle vector and its use to isolate genes by complementation. Mol Gen Genet (1982) 5.17
Four mating-type genes control sexual differentiation in the fission yeast. EMBO J (1988) 5.00
Reversible tyrosine phosphorylation of cdc2: dephosphorylation accompanies activation during entry into mitosis. Cell (1989) 4.68
The product of the mei3+ gene, expressed under control of the mating-type locus, induces meiosis and sporulation in fission yeast. EMBO J (1987) 4.45
The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells. Cell (1989) 4.43
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc Natl Acad Sci U S A (1996) 4.33
Cdc25 cell-cycle phosphatase as a target of c-myc. Nature (1996) 4.23
cdc2 is a component of the M phase-specific histone H1 kinase: evidence for identity with MPF. Cell (1988) 4.12
p21-containing cyclin kinases exist in both active and inactive states. Genes Dev (1994) 4.08
p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. Cell (1995) 4.08
p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase. EMBO J (1987) 3.91
Functionally homologous cell cycle control genes in budding and fission yeast. Nature (1982) 3.78
Myc activates telomerase. Genes Dev (1998) 3.74
Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation. Genes Dev (1993) 3.70
Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev (1996) 3.61
Construction of an improved host strain for two hybrid screening. Nucleic Acids Res (1994) 3.43
Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase. Cell (1991) 3.37
Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. Cell (1991) 3.34
Involvement of cdc13+ in mitotic control in Schizosaccharomyces pombe: possible interaction of the gene product with microtubules. EMBO J (1988) 3.27
Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair. Nature (1994) 3.21
Identification of p34 and p13, human homologs of the cell cycle regulators of fission yeast encoded by cdc2+ and suc1+. Cell (1987) 3.12
A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells. Cell (1989) 3.08
Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate. Nature (1989) 3.07
CDC25 phosphatases as potential human oncogenes. Science (1995) 2.84
Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2. Proc Natl Acad Sci U S A (1990) 2.77
Cyclin is a component of the sea urchin egg M-phase specific histone H1 kinase. EMBO J (1989) 2.75
Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication. Nature (1989) 2.67
Repression of cyclin D1: a novel function of MYC. Mol Cell Biol (1994) 2.67
Site-specific mutagenesis of cdc2+, a cell cycle control gene of the fission yeast Schizosaccharomyces pombe. Mol Cell Biol (1986) 2.66
cdt1 is an essential target of the Cdc10/Sct1 transcription factor: requirement for DNA replication and inhibition of mitosis. EMBO J (1994) 2.64
Vectors for the construction of gene banks and the integration of cloned genes in Schizosaccharomyces pombe and Saccharomyces cerevisiae. Plasmid (1986) 2.58
Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes. Mol Biol Cell (1993) 2.57
The fission yeast cell cycle control gene cdc2: isolation of a sequence suc1 that suppresses cdc2 mutant function. Mol Gen Genet (1986) 2.46
Distinct nuclear and spindle pole body population of cyclin-cdc2 in fission yeast. Nature (1990) 2.46
Growth-regulated expression of D-type cyclin genes in human diploid fibroblasts. Proc Natl Acad Sci U S A (1992) 2.43
Inhibition of ras-induced proliferation and cellular transformation by p16INK4. Science (1995) 2.42
Involvement of ras in sexual differentiation but not in growth control in fission yeast. EMBO J (1986) 2.31
Deletion of the p16 and p15 genes in human bladder tumors. J Natl Cancer Inst (1995) 2.25
Isolation of chromosomal origins of replication in yeast. Nature (1980) 2.20
Sct1 functions in partnership with Cdc10 in a transcription complex that activates cell cycle START and inhibits differentiation. Cell (1993) 2.19
Involvement of a type 1 protein phosphatase encoded by bws1+ in fission yeast mitotic control. Cell (1989) 2.16
Sucl+ encodes a predicted 13-kilodalton protein that is essential for cell viability and is directly involved in the division cycle of Schizosaccharomyces pombe. Mol Cell Biol (1987) 2.13
Interaction between cdc13+ and cdc2+ in the control of mitosis in fission yeast; dissociation of the G1 and G2 roles of the cdc2+ protein kinase. EMBO J (1987) 2.10
Intermediate filament reorganization during mitosis is mediated by p34cdc2 phosphorylation of vimentin. Cell (1990) 2.08
Cloning and characterization of murine p16INK4a and p15INK4b genes. Oncogene (1995) 2.05
A specific inhibitor of the ran1+ protein kinase regulates entry into meiosis in Schizosaccharomyces pombe. Nature (1988) 1.87
Activation of M-phase-specific histone H1 kinase by modification of the phosphorylation of its p34cdc2 and cyclin components. Genes Dev (1990) 1.86
Activation of human CDC2 protein as a histone H1 kinase is associated with complex formation with the p62 subunit. Proc Natl Acad Sci U S A (1989) 1.80
Homology between the ran1+ gene of fission yeast and protein kinases. EMBO J (1986) 1.76
Interaction between ran1+ protein kinase and cAMP dependent protein kinase as negative regulators of fission yeast meiosis. EMBO J (1991) 1.72
Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins. Genomics (1992) 1.70
Mutations associated with familial melanoma impair p16INK4 function. Nat Genet (1995) 1.69
Phosphorylation of gamma-tubulin regulates microtubule organization in budding yeast. Dev Cell (2001) 1.60
Two new multi-purpose multicopy Schizosaccharomyces pombe shuttle vectors, pSP1 and pSP2. Curr Genet (1993) 1.58
MaRX: an approach to genetics in mammalian cells. Science (1999) 1.58
Identification of seven new cut genes involved in Schizosaccharomyces pombe mitosis. J Cell Sci (1993) 1.58
A connection between pre-mRNA splicing and the cell cycle in fission yeast: cdc28+ is allelic with prp8+ and encodes an RNA-dependent ATPase/helicase. Mol Biol Cell (1996) 1.55
Physical interaction of mammalian CDC37 with CDK4. J Biol Chem (1996) 1.53
Interaction between the Cig1 and Cig2 B-type cyclins in the fission yeast cell cycle. Mol Cell Biol (1994) 1.50
p53-independent role of MDM2 in TGF-beta1 resistance. Science (1998) 1.48
Population explosion in the cyclin family. Curr Biol (1991) 1.46
Oscillation of MPF is accompanied by periodic association between cdc25 and cdc2-cyclin B. Cell (1992) 1.44
14-3-3 proteins associate with cdc25 phosphatases. Proc Natl Acad Sci U S A (1995) 1.44
Prospective evaluation of three smoking interventions in 205 recovering alcoholics: one-year results of Project SCRAP-Tobacco. J Consult Clin Psychol (1997) 1.42
Fission yeast cdc25 is a cell-cycle regulated protein. Biochem Biophys Res Commun (1990) 1.41
Molecular rearrangement of mating-type genes in fission yeast. Nature (1982) 1.41
Subcellular distribution of p21 and PCNA in normal and repair-deficient cells following DNA damage. Curr Biol (1996) 1.41
Human p53 inhibits growth in Schizosaccharomyces pombe. Mol Cell Biol (1992) 1.38
Pub1 acts as an E6-AP-like protein ubiquitiin ligase in the degradation of cdc25. EMBO J (1996) 1.37
Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation. Genes Dev (1995) 1.33
cdc2 and the regulation of mitosis: six interacting mcs genes. Genetics (1989) 1.32
An alternative eukaryotic DNA excision repair pathway. Mol Cell Biol (1995) 1.31
Characterization of the fission yeast mcs2 cyclin and its associated protein kinase activity. EMBO J (1993) 1.31
A role for the p34cdc2 kinase and phosphatases in the regulation of phosphorylation and disassembly of lamin B2 during the cell cycle. EMBO J (1991) 1.30
A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2. Oncogene (1999) 1.29
Exposure measurement in cohort studies: the challenges of prospective data collection. Epidemiol Rev (1998) 1.28
A complex containing p34cdc2 and cyclin B phosphorylates the nuclear lamin and disassembles nuclei of clam oocytes in vitro. J Cell Biol (1991) 1.24