Published in J Neurosci on July 13, 2005
Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of α-synuclein in Parkinson's disease models. Hum Mol Genet (2013) 1.94
Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contexts. J Cell Sci (2009) 1.78
The role of tau in neurodegeneration. Mol Neurodegener (2009) 1.54
Tau phosphorylated at tyrosine 394 is found in Alzheimer's disease tangles and can be a product of the Abl-related kinase, Arg. J Alzheimers Dis (2010) 1.26
Early axonopathy preceding neurofibrillary tangles in mutant tau transgenic mice. Am J Pathol (2007) 1.26
Arg/Abl2 promotes invasion and attenuates proliferation of breast cancer in vivo. Oncogene (2012) 1.20
c-Abl in neurodegenerative disease. J Mol Neurosci (2011) 1.15
The role of tau kinases in Alzheimer's disease. Curr Opin Drug Discov Devel (2010) 1.15
Structure of core domain of fibril-forming PHF/Tau fragments. Biophys J (2005) 1.09
The importance of tau phosphorylation for neurodegenerative diseases. Front Neurol (2013) 1.05
Tau and tauopathies. Prog Mol Biol Transl Sci (2012) 1.04
Neuronal c-Abl overexpression leads to neuronal loss and neuroinflammation in the mouse forebrain. J Alzheimers Dis (2011) 1.04
Protein phosphatases and Alzheimer's disease. Prog Mol Biol Transl Sci (2012) 1.03
Tyrosine phosphorylation of tau accompanies disease progression in transgenic mouse models of tauopathy. Neuropathol Appl Neurobiol (2010) 1.02
A possible link between astrocyte activation and tau nitration in Alzheimer's disease. Neurobiol Dis (2008) 1.01
Altered subcellular distribution of c-Abl in Alzheimer's disease. J Alzheimers Dis (2009) 0.99
Neuroprotective efficacy of a new brain-penetrating C-Abl inhibitor in a murine Parkinson's disease model. PLoS One (2013) 0.97
Tau potentiates nerve growth factor-induced mitogen-activated protein kinase signaling and neurite initiation without a requirement for microtubule binding. J Biol Chem (2010) 0.96
Dysregulation of protein phosphorylation/dephosphorylation in Alzheimer's disease: a therapeutic target. J Biomed Biotechnol (2006) 0.96
Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance. EMBO Mol Med (2013) 0.96
EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers. PLoS One (2014) 0.91
Tau as a biomarker of neurodegenerative diseases. Biomark Med (2008) 0.91
Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearance. J Mol Med (Berl) (2013) 0.89
Connecting cell-cycle activation to neurodegeneration in Drosophila. Biochim Biophys Acta (2006) 0.87
The microtubule-associated protein tau is phosphorylated by Syk. Biochim Biophys Acta (2007) 0.86
Roles of cholesterol and lipids in the etiopathogenesis of Alzheimer's disease. J Biomed Biotechnol (2006) 0.86
Dual modification of Alzheimer's disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach. Acta Neuropathol (2011) 0.84
Increased tau phosphorylation and aggregation in the hippocampus of mice overexpressing corticotropin-releasing factor. J Alzheimers Dis (2015) 0.83
Tyrosine Kinase Inhibition Regulates Early Systemic Immune Changes and Modulates the Neuroimmune Response in α-Synucleinopathy. J Clin Cell Immunol (2014) 0.83
Novel therapeutic strategies for neurodegenerative disease. Psychogeriatrics (2009) 0.83
Neuronal c-Abl activation leads to induction of cell cycle and interferon signaling pathways. J Neuroinflammation (2012) 0.80
Selective tau tyrosine nitration in non-AD tauopathies. Acta Neuropathol (2011) 0.80
Oxidative Stress, DNA Damage, and c-Abl Signaling: At the Crossroad in Neurodegenerative Diseases? Int J Cell Biol (2012) 0.80
Tyrosine phosphorylation of tau by the SRC family kinases lck and fyn. Mol Neurodegener (2011) 0.80
Roles of tau protein in health and disease. Acta Neuropathol (2017) 0.80
Altered distribution of the EphA4 kinase in hippocampal brain tissue of patients with Alzheimer's disease correlates with pathology. Acta Neuropathol Commun (2014) 0.78
Functional mechanisms and roles of adaptor proteins in abl-regulated cytoskeletal actin dynamics. J Signal Transduct (2012) 0.77
Functional Impact of Corticotropin-Releasing Factor Exposure on Tau Phosphorylation and Axon Transport. PLoS One (2016) 0.77
Saitohin, which is nested within the tau gene, interacts with tau and Abl and its human-specific allele influences Abl phosphorylation. J Cell Biochem (2011) 0.76
Mass spectrometry-based proteomics and peptidomics for biomarker discovery in neurodegenerative diseases. Int J Clin Exp Pathol (2008) 0.76
Regulation of mitochondrial functions by protein phosphorylation and dephosphorylation. Cell Biosci (2016) 0.76
Electrochemical investigations into kinase-catalyzed transformations of tau protein. ACS Chem Neurosci (2013) 0.76
Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer's disease. Acta Neuropathol Commun (2016) 0.76
The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation. Sci Rep (2017) 0.75
Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat Med (2006) 9.07
Tyrosine kinases as targets for cancer therapy. N Engl J Med (2005) 6.24
In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs. Mayo Clin Proc (2015) 4.70
Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia. Nat Genet (2004) 3.96
Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature (2003) 3.77
Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J Clin Invest (2009) 3.55
Expression analysis of G Protein-Coupled Receptors in mouse macrophages. Immunome Res (2008) 3.54
Conformational control inhibition of the BCR-ABL1 tyrosine kinase, including the gatekeeper T315I mutant, by the switch-control inhibitor DCC-2036. Cancer Cell (2011) 3.49
Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition. Nat Rev Cancer (2007) 3.32
Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell (2013) 3.10
Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer. Cancer Discov (2013) 2.87
Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells. Nat Med (2006) 2.69
Differential regulation of myeloid leukemias by the bone marrow microenvironment. Nat Med (2013) 2.48
Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer. J Natl Cancer Inst (2011) 2.47
Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F. PLoS One (2006) 2.42
Critical role for Gab2 in transformation by BCR/ABL. Cancer Cell (2002) 2.42
Tau phosphorylation: the therapeutic challenge for neurodegenerative disease. Trends Mol Med (2009) 2.39
A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9. Proc Natl Acad Sci U S A (2002) 2.19
Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop. Proc Natl Acad Sci U S A (2002) 2.13
A role of matrix metalloproteinase-8 in atherosclerosis. Circ Res (2009) 1.72
Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits. Am J Pathol (2006) 1.68
Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis. J Biol Chem (2007) 1.68
Essential role for Stat5a/b in myeloproliferative neoplasms induced by BCR-ABL1 and JAK2(V617F) in mice. Blood (2012) 1.67
Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles. Blood (2008) 1.61
Expression of Gal4-dependent transgenes in cells of the mononuclear phagocyte system labeled with enhanced cyan fluorescent protein using Csf1r-Gal4VP16/UAS-ECFP double-transgenic mice. J Leukoc Biol (2007) 1.57
Physiological release of endogenous tau is stimulated by neuronal activity. EMBO Rep (2013) 1.57
Functional and structural properties of mammalian acyl-coenzyme A thioesterases. Prog Lipid Res (2010) 1.54
Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations. Cancer Cell (2004) 1.52
Right on target: eradicating leukemic stem cells. Trends Mol Med (2007) 1.49
Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling. Proc Natl Acad Sci U S A (2010) 1.46
Rapid tyrosine phosphorylation of neuronal proteins including tau and focal adhesion kinase in response to amyloid-beta peptide exposure: involvement of Src family protein kinases. J Neurosci (2002) 1.46
Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation. EMBO J (2002) 1.45
The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation. Proc Natl Acad Sci U S A (2010) 1.45
Autoinhibition of Bcr-Abl through its SH3 domain. Mol Cell (2003) 1.43
Re-induction of hyponatremia after rapid overcorrection of hyponatremia reduces mortality in rats. Kidney Int (2009) 1.39
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection. Proc Natl Acad Sci U S A (2011) 1.38
Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases. J Biol Chem (2008) 1.38
Comparison of cellular ribonucleoprotein complexes associated with the APOBEC3F and APOBEC3G antiviral proteins. J Virol (2008) 1.37
Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo. J Neurosci (2003) 1.36
Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons. J Cell Sci (2004) 1.36
G-protein-coupled receptor expression, function, and signaling in macrophages. J Leukoc Biol (2007) 1.33
Genetic and expression analysis of MET, MACC1, and HGF in metastatic colorectal cancer: response to met inhibition in patient xenografts and pathologic correlations. Clin Cancer Res (2011) 1.32
PART is part of Alzheimer disease. Acta Neuropathol (2015) 1.31
Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice. Biochem Biophys Res Commun (2009) 1.28
Early axonopathy preceding neurofibrillary tangles in mutant tau transgenic mice. Am J Pathol (2007) 1.26
Detection, quantitation, purification, and identification of cardiac proteins S-thiolated during ischemia and reperfusion. J Biol Chem (2002) 1.25
Membrane-bound beta-amyloid oligomers are recruited into lipid rafts by a fyn-dependent mechanism. FASEB J (2007) 1.24
Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments. J Cell Biol (2003) 1.24
A role for tau at the synapse in Alzheimer's disease pathogenesis. Neuropharmacology (2013) 1.21
Molecular motors implicated in the axonal transport of tau and alpha-synuclein. J Cell Sci (2005) 1.20
Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation. Proc Natl Acad Sci U S A (2007) 1.20
Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression. J Neurochem (2007) 1.20
Determination of protein stoichiometry within protein complexes using absolute quantification and multiple reaction monitoring. Anal Chem (2010) 1.20
CD74-NRG1 fusions in lung adenocarcinoma. Cancer Discov (2014) 1.19
Charcot-Marie-Tooth disease neurofilament mutations disrupt neurofilament assembly and axonal transport. Hum Mol Genet (2002) 1.16
Familial Danish dementia: a novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-beta. J Neuropathol Exp Neurol (2002) 1.16
The active form of glycogen synthase kinase-3beta is associated with granulovacuolar degeneration in neurons in Alzheimer's disease. Acta Neuropathol (2001) 1.15
Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain. J Neurochem (2010) 1.15
Characterisation of cytoskeletal abnormalities in mice transgenic for wild-type human tau and familial Alzheimer's disease mutants of APP and presenilin-1. Neurobiol Dis (2004) 1.14
Peroxiredoxin1 prevents excessive endothelial activation and early atherosclerosis. Circ Res (2008) 1.14
Dynamic association of tau with neuronal membranes is regulated by phosphorylation. Neurobiol Aging (2011) 1.13
The melanocortin 2 receptor accessory protein exists as a homodimer and is essential for the function of the melanocortin 2 receptor in the mouse y1 cell line. Endocrinology (2007) 1.12
Protein deiminases: new players in the developmentally regulated loss of neural regenerative ability. Dev Biol (2011) 1.12
Fourteen years of plant proteomics reflected in Proteomics: moving from model species and 2DE-based approaches to orphan species and gel-free platforms. Proteomics (2015) 1.11
An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: relationship to cystatins and the tumor suppressor TIG1. Structure (2005) 1.11
ApoC-I and ApoC-III as potential plasmatic markers to distinguish between ischemic and hemorrhagic stroke. Proteomics (2004) 1.11
Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin. FASEB J (2008) 1.11
Reprogramming of tau alternative splicing by spliceosome-mediated RNA trans-splicing: implications for tauopathies. Proc Natl Acad Sci U S A (2005) 1.10
Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease. FASEB J (2008) 1.08
Macrophage activation and differentiation signals regulate schlafen-4 gene expression: evidence for Schlafen-4 as a modulator of myelopoiesis. PLoS One (2011) 1.08