| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone.
|
CMAJ
|
2009
|
9.83
|
|
2
|
Unintended medication discrepancies at the time of hospital admission.
|
Arch Intern Med
|
2005
|
8.94
|
|
3
|
Outpatient gatifloxacin therapy and dysglycemia in older adults.
|
N Engl J Med
|
2006
|
7.01
|
|
4
|
Hyperbaric oxygen for carbon monoxide poisoning : a systematic review and critical analysis of the evidence.
|
Toxicol Rev
|
2005
|
5.75
|
|
5
|
Risk of incident diabetes among patients treated with statins: population based study.
|
BMJ
|
2013
|
5.40
|
|
6
|
Chlorthalidone versus hydrochlorothiazide for the treatment of hypertension in older adults: a population-based cohort study.
|
Ann Intern Med
|
2013
|
5.34
|
|
7
|
Bisphosphonate use and the risk of subtrochanteric or femoral shaft fractures in older women.
|
JAMA
|
2011
|
5.33
|
|
8
|
Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort study.
|
BMJ
|
2010
|
4.73
|
|
9
|
A substantial and confusing variation exists in handling of baseline covariates in randomized controlled trials: a review of trials published in leading medical journals.
|
J Clin Epidemiol
|
2009
|
4.48
|
|
10
|
Statin toxicity from macrolide antibiotic coprescription: a population-based cohort study.
|
Ann Intern Med
|
2013
|
4.35
|
|
11
|
Thiazolidinediones and cardiovascular outcomes in older patients with diabetes.
|
JAMA
|
2007
|
4.25
|
|
12
|
Clustering of opioid prescribing and opioid-related mortality among family physicians in Ontario.
|
Can Fam Physician
|
2011
|
4.13
|
|
13
|
Opioid dose and drug-related mortality in patients with nonmalignant pain.
|
Arch Intern Med
|
2011
|
4.11
|
|
14
|
Cyclo-oxygenase-2 inhibitors versus non-selective non-steroidal anti-inflammatory drugs and congestive heart failure outcomes in elderly patients: a population-based cohort study.
|
Lancet
|
2004
|
3.65
|
|
15
|
Long-term analgesic use after low-risk surgery: a retrospective cohort study.
|
Arch Intern Med
|
2012
|
3.52
|
|
16
|
Antipsychotic drugs and hyperglycemia in older patients with diabetes.
|
Arch Intern Med
|
2009
|
3.43
|
|
17
|
Drugs and the QT interval - caveat doctor.
|
N Engl J Med
|
2004
|
3.29
|
|
18
|
Observational study of upper gastrointestinal haemorrhage in elderly patients given selective cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs.
|
BMJ
|
2002
|
3.21
|
|
19
|
Risk-treatment mismatch in the pharmacotherapy of heart failure.
|
JAMA
|
2005
|
3.05
|
|
20
|
Statins and the risk of herpes zoster: a population-based cohort study.
|
Clin Infect Dis
|
2013
|
2.74
|
|
21
|
Trends in opioid use and dosing among socio-economically disadvantaged patients.
|
Open Med
|
2011
|
2.51
|
|
22
|
Facing up to the prescription opioid crisis.
|
BMJ
|
2011
|
2.43
|
|
23
|
The burden of premature opioid-related mortality.
|
Addiction
|
2014
|
2.42
|
|
24
|
Testing multiple statistical hypotheses resulted in spurious associations: a study of astrological signs and health.
|
J Clin Epidemiol
|
2006
|
2.35
|
|
25
|
Trimethoprim-sulfamethoxazole induced hyperkalaemia in elderly patients receiving spironolactone: nested case-control study.
|
BMJ
|
2011
|
2.20
|
|
26
|
Effect of selective cyclooxygenase 2 inhibitors and naproxen on short-term risk of acute myocardial infarction in the elderly.
|
Arch Intern Med
|
2003
|
2.18
|
|
27
|
Cholinesterase inhibitors and hospitalization for bradycardia: a population-based study.
|
PLoS Med
|
2009
|
1.94
|
|
28
|
New fibrate use and acute renal outcomes in elderly adults: a population-based study.
|
Ann Intern Med
|
2012
|
1.91
|
|
29
|
Sex-and age-based differences in the delivery and outcomes of critical care.
|
CMAJ
|
2007
|
1.91
|
|
30
|
Hemorrhage during warfarin therapy associated with cotrimoxazole and other urinary tract anti-infective agents: a population-based study.
|
Arch Intern Med
|
2010
|
1.87
|
|
31
|
Use of other opioids during methadone therapy: a population-based study.
|
Addiction
|
2012
|
1.72
|
|
32
|
Rates of hemorrhage during warfarin therapy for atrial fibrillation.
|
CMAJ
|
2012
|
1.68
|
|
33
|
The risk of postpartum hemorrhage with selective serotonin reuptake inhibitors and other antidepressants.
|
J Clin Psychopharmacol
|
2008
|
1.66
|
|
34
|
Persistence with therapy among patients treated with warfarin for atrial fibrillation.
|
Arch Intern Med
|
2012
|
1.65
|
|
35
|
Impaired renal function modifies the risk of severe hypoglycaemia among users of insulin but not glyburide: a population-based nested case-control study.
|
Nephrol Dial Transplant
|
2010
|
1.65
|
|
36
|
Oral bisphosphonate use in the elderly is not associated with acute kidney injury.
|
Kidney Int
|
2012
|
1.64
|
|
37
|
Statins and intracerebral hemorrhage: a retrospective cohort study.
|
Arch Neurol
|
2011
|
1.63
|
|
38
|
A risk quantification instrument for acute acetaminophen overdose patients treated with N-acetylcysteine.
|
Ann Emerg Med
|
2005
|
1.60
|
|
39
|
Isotretinoin use and the risk of inflammatory bowel disease: a population-based cohort study.
|
J Invest Dermatol
|
2012
|
1.59
|
|
40
|
Opioid dose and risk of road trauma in Canada: a population-based study.
|
JAMA Intern Med
|
2013
|
1.59
|
|
41
|
Risk of upper gastrointestinal hemorrhage in warfarin users treated with nonselective NSAIDs or COX-2 inhibitors.
|
Arch Intern Med
|
2005
|
1.56
|
|
42
|
Hyperbaric oxygen for carbon monoxide poisoning.
|
Cochrane Database Syst Rev
|
2011
|
1.56
|
|
43
|
Comparative adherence to oxybutynin or tolterodine among older patients.
|
Eur J Clin Pharmacol
|
2011
|
1.54
|
|
44
|
Proton pump inhibitors and hospitalization for Clostridium difficile-associated disease: a population-based study.
|
Clin Infect Dis
|
2006
|
1.48
|
|
45
|
Colchicine poisoning: the dark side of an ancient drug.
|
Clin Toxicol (Phila)
|
2010
|
1.43
|
|
46
|
Suboptimal use of statin therapy in elderly patients with atherosclerosis: a population-based study.
|
J Vasc Surg
|
2008
|
1.42
|
|
47
|
Safety of influenza vaccination in patients with myasthenia gravis: a population-based study.
|
Muscle Nerve
|
2009
|
1.41
|
|
48
|
The effect of publication on Internet-based solicitation of personal-injury litigants.
|
CMAJ
|
2007
|
1.41
|
|
49
|
Effect of a centralized prescription network on inappropriate prescriptions for opioid analgesics and benzodiazepines.
|
CMAJ
|
2012
|
1.40
|
|
50
|
Use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers and cardiovascular outcomes in chronic dialysis patients: a population-based cohort study.
|
Arch Intern Med
|
2012
|
1.40
|
|
51
|
Orlistat and acute kidney injury: an analysis of 953 patients.
|
Arch Intern Med
|
2011
|
1.40
|
|
52
|
No increase in adverse events during aliskiren use among ontario patients receiving angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers.
|
Can J Cardiol
|
2013
|
1.39
|
|
53
|
Gastrointestinal bleeding after the introduction of COX 2 inhibitors: ecological study.
|
BMJ
|
2004
|
1.36
|
|
54
|
Missed opportunities in the secondary prevention of myocardial infarction: an assessment of the effects of statin underprescribing on mortality.
|
Am Heart J
|
2006
|
1.36
|
|
55
|
Blood glucose test strips: options to reduce usage.
|
CMAJ
|
2009
|
1.34
|
|
56
|
Trimethoprim-sulfamethoxazole-induced hyperkalemia in patients receiving inhibitors of the renin-angiotensin system: a population-based study.
|
Arch Intern Med
|
2010
|
1.30
|
|
57
|
Are broad-spectrum fluoroquinolones more likely to cause Clostridium difficile-associated disease?
|
Antimicrob Agents Chemother
|
2006
|
1.27
|
|
58
|
Reformulation of controlled-release oxycodone and pharmacy dispensing patterns near the US-Canada border.
|
Open Med
|
2012
|
1.20
|
|
59
|
Considerations when prescribing trimethoprim-sulfamethoxazole.
|
CMAJ
|
2011
|
1.20
|
|
60
|
The risk of hypotension following co-prescription of macrolide antibiotics and calcium-channel blockers.
|
CMAJ
|
2011
|
1.19
|
|
61
|
Carbon monoxide treatment guidelines must acknowledge the limitations of the existing evidence.
|
Am J Respir Crit Care Med
|
2013
|
1.13
|
|
62
|
Antidepressants, warfarin, and the risk of hemorrhage.
|
J Clin Psychopharmacol
|
2005
|
1.07
|
|
63
|
Beta-blockers, trimethoprim-sulfamethoxazole, and the risk of hyperkalemia requiring hospitalization in the elderly: a nested case-control study.
|
Clin J Am Soc Nephrol
|
2010
|
1.04
|
|
64
|
The effect of antidepressant warnings on prescribing trends in Ontario, Canada.
|
Am J Public Health
|
2007
|
1.02
|
|
65
|
Polymorphism of the MDR1/ABCB1 C3435T drug-transporter and resistance to anticonvulsant drugs: a meta-analysis.
|
Epilepsia
|
2008
|
1.01
|
|
66
|
Proton pump inhibitors and clopidogrel: putting the interaction in perspective.
|
Circulation
|
2009
|
1.00
|
|
67
|
Clopidogrel with or without omeprazole in coronary disease.
|
N Engl J Med
|
2011
|
0.99
|
|
68
|
Fluoroquinolone therapy and idiosyncratic acute liver injury: a population-based study.
|
CMAJ
|
2012
|
0.96
|
|
69
|
Identifying individuals with a reduced GFR using ambulatory laboratory database surveillance.
|
J Am Soc Nephrol
|
2005
|
0.93
|
|
70
|
Hospital admissions for hyperkalemia with trimethoprim-sulfamethoxazole: a cohort study using health care database codes for 393,039 older women with urinary tract infections.
|
Am J Kidney Dis
|
2011
|
0.92
|
|
71
|
Ciprofloxacin-induced theophylline toxicity: a population-based study.
|
Eur J Clin Pharmacol
|
2011
|
0.91
|
|
72
|
Kappa statistic.
|
CMAJ
|
2005
|
0.91
|
|
73
|
Trimethoprim/sulfamethoxazole-induced phenytoin toxicity in the elderly: a population-based study.
|
Br J Clin Pharmacol
|
2011
|
0.89
|
|
74
|
Inequitable distribution of implantable cardioverter defibrillators in Ontario.
|
Int J Technol Assess Health Care
|
2007
|
0.87
|
|
75
|
Recurrent ibuprofen-induced aseptic meningitis.
|
Ann Pharmacother
|
2004
|
0.87
|
|
76
|
Multidose activated charcoal for yellow oleander poisoning.
|
Lancet
|
2003
|
0.87
|
|
77
|
Comparing two types of macrolide antibiotics for the purpose of assessing population-based drug interactions.
|
BMJ Open
|
2013
|
0.87
|
|
78
|
Comparative effectiveness of angiotensin-receptor blockers for preventing macrovascular disease in patients with diabetes: a population-based cohort study.
|
CMAJ
|
2013
|
0.85
|
|
79
|
Deliberate self-poisoning in Ontario following the terrorist attacks of September 11, 2001.
|
JAMA
|
2005
|
0.84
|
|
80
|
Synthetic cannabinoids.
|
CMAJ
|
2013
|
0.84
|
|
81
|
Evaluating the Effectiveness of First-Time Methadone Maintenance Therapy Across Northern, Rural, and Urban Regions of Ontario, Canada.
|
J Addict Med
|
2015
|
0.84
|
|
82
|
Clinical consequences of generic warfarin substitution: an ecological study.
|
JAMA
|
2006
|
0.83
|
|
83
|
Clinical and demographic characteristics of patients receiving different oral hypoglycemic agents.
|
Pharmacoepidemiol Drug Saf
|
2009
|
0.83
|
|
84
|
Adverse cardiac events in older patients receiving venlafaxine: a population-based study.
|
J Clin Psychiatry
|
2014
|
0.83
|
|
85
|
A case of recurrent meningitis.
|
CMAJ
|
2006
|
0.82
|
|
86
|
Beta-blockers and cardiovascular outcomes in dialysis patients: a cohort study in Ontario, Canada.
|
Nephrol Dial Transplant
|
2011
|
0.82
|
|
87
|
Five things to know about..."bath salts".
|
CMAJ
|
2012
|
0.82
|
|
88
|
Antipsychotic drugs and the risk of hyperglycemia in older adults without diabetes: a population-based observational study.
|
Am J Geriatr Psychiatry
|
2011
|
0.82
|
|
89
|
Risk of serious falls associated with oxybutynin and tolterodine: a population based study.
|
J Urol
|
2011
|
0.81
|
|
90
|
Selective serotonin reuptake inhibitors and pulmonary arterial hypertension: a case-control study.
|
Chest
|
2011
|
0.80
|
|
91
|
Tramadol.
|
CMAJ
|
2013
|
0.80
|
|
92
|
Psychotropic medications and motor vehicle collisions in patients with dementia.
|
J Am Geriatr Soc
|
2008
|
0.80
|
|
93
|
Extracorporeal treatment for thallium poisoning: recommendations from the EXTRIP Workgroup.
|
Clin J Am Soc Nephrol
|
2012
|
0.80
|
|
94
|
A new predictor of toxicity following acetaminophen overdose based on pretreatment exposure.
|
Clin Toxicol (Phila)
|
2005
|
0.79
|
|
95
|
Rosiglitazone and the case for safety over certainty.
|
JAMA
|
2010
|
0.79
|
|
96
|
Professional Pharmacy Services and Patient Complexity: An Observational Study.
|
J Pharm Pharm Sci
|
2015
|
0.79
|
|
97
|
Impact of the JUPITER trial on statin prescribing for primary prevention.
|
Pharmacotherapy
|
2013
|
0.78
|
|
98
|
Effects of funding policy changes and health warnings on the use of erythropoiesis-stimulating agents.
|
J Oncol Pract
|
2012
|
0.78
|
|
99
|
Sevelamer prescriptions after reporting of the Dialysis Clinical Outcomes Revisited (DCOR) trial findings: An analysis of 5,495 patients receiving maintenance dialysis in Ontario, Canada.
|
Am J Kidney Dis
|
2011
|
0.78
|
|
100
|
Drug-induced hepatotoxicity.
|
N Engl J Med
|
2003
|
0.78
|
|
101
|
Appropriateness of spironolactone prescribing in heart failure patients: a population-based study.
|
J Card Fail
|
2006
|
0.78
|
|
102
|
Risk of heart failure and edema associated with the use of pregabalin: a systematic review.
|
Syst Rev
|
2013
|
0.77
|
|
103
|
How many "Me-Too" drugs are enough? The case of physician preferences for specific statins.
|
Ann Pharmacother
|
2006
|
0.77
|
|
104
|
Dihydropyridine calcium channel blockers and cardiovascular outcomes in elderly patients: a population-based study.
|
Can J Cardiol
|
2008
|
0.77
|
|
105
|
Antenatal use of selective serotonin-reuptake inhibitors and QT interval prolongation in newborns.
|
Pediatrics
|
2008
|
0.77
|
|
106
|
Discoloration of skin and urine after treatment with hydroxocobalamin for cyanide poisoning.
|
CMAJ
|
2009
|
0.76
|
|
107
|
Hospitalization for hemorrhage among warfarin recipients prescribed amiodarone.
|
Am J Cardiol
|
2013
|
0.76
|
|
108
|
Enhanced elimination of dabigatran through extracorporeal methods.
|
J Med Toxicol
|
2015
|
0.76
|
|
109
|
Using fractional polynomials to model the effect of cumulative duration of exposure on outcomes: applications to cohort and nested case-control designs.
|
Pharmacoepidemiol Drug Saf
|
2014
|
0.75
|
|
110
|
Reply to Strandberg and Tienari.
|
Clin Infect Dis
|
2014
|
0.75
|
|
111
|
Opioids versus nonsteroidal anti-inflammatory drugs in noncancer pain.
|
Can Fam Physician
|
2012
|
0.75
|
|
112
|
Do statins decrease the risk of colorectal cancer?
|
CMAJ
|
2005
|
0.75
|
|
113
|
Drug safety in patients with heart failure.
|
Arch Intern Med
|
2005
|
0.75
|
|
114
|
Effect of a course-based intervention and effect of medical regulation on physicians' opioid prescribing.
|
Can Fam Physician
|
2013
|
0.75
|
|
115
|
Safety of valproic acid in patients with chronic obstructive pulmonary disease: a population-based cohort study.
|
Pharmacoepidemiol Drug Saf
|
2015
|
0.75
|
|
116
|
Chlorthalidone versus hydrochlorothiazide.
|
Ann Intern Med
|
2013
|
0.75
|
|
117
|
Prescription Stimulant Use and Hospitalization for Psychosis or Mania: A Population-Based Study.
|
J Clin Psychopharmacol
|
2015
|
0.75
|
|
118
|
Are selective COX 2 inhibitors superior to traditional NSAIDs? Little is known about COX 2 inhibitors.
|
BMJ
|
2002
|
0.75
|
|
119
|
Antidepressants, metoprolol and the risk of bradycardia.
|
Ther Adv Psychopharmacol
|
2012
|
0.75
|
|
120
|
Melatonin.
|
CMAJ
|
2012
|
0.75
|
|
121
|
Withholding 4-methylpyrazole pretreatment in suspected toxic alcohol ingestions.
|
Acad Emerg Med
|
2005
|
0.75
|
|
122
|
Does gastric acid suppression increase the risk of community-acquired pneumonia?
|
CMAJ
|
2005
|
0.75
|
|
123
|
Experts Consensus Recommendations for the Management of Calcium Channel Blocker Poisoning in Adults.
|
Crit Care Med
|
2016
|
0.75
|
|
124
|
Combining activated charcoal with whole-bowel irrigation.
|
Clin Pharmacol Ther
|
2002
|
0.75
|
|
125
|
The headache of teenage acne.
|
CMAJ
|
2004
|
0.75
|
|
126
|
Carbon monoxide poisoning.
|
CMAJ
|
2014
|
0.75
|
|
127
|
Is morphine exposure associated with acute chest syndrome in children with vaso-occlusive crisis of sickle cell disease? A 6-year case-crossover study.
|
Clin Ther
|
2007
|
0.75
|
|
128
|
The impact of policies to reduce blood glucose test strip utilization and costs in Canada.
|
Can J Public Health
|
2015
|
0.75
|
|
129
|
Pseudoephedrine-induced toxic epidermal necrolysis.
|
Arch Dermatol
|
2005
|
0.75
|
|
130
|
Painful decision-making at FDA.
|
Expert Opin Drug Saf
|
2014
|
0.75
|
|
131
|
Do Ontario patients with heart failure have equal access to life-saving technology?
|
Healthc Q
|
2008
|
0.75
|
|
132
|
The impact of federal warnings on publically funded desmopressin utilization among children in Ontario.
|
J Pediatr Urol
|
2011
|
0.75
|
|
133
|
N-acetylcysteine for the treatment of clove oil-induced fulminant hepatic failure.
|
J Toxicol Clin Toxicol
|
2004
|
0.75
|
|
134
|
Impact of a Graduated Approach on Opioid Initiation and Loss of Earnings Following Workplace Injury: A Time Series Analysis.
|
J Occup Environ Med
|
2017
|
0.75
|
|
135
|
Lipophilic β-Blockers and Suicide in the Elderly.
|
J Clin Psychopharmacol
|
2017
|
0.75
|