Published in J Biol Chem on April 13, 2011
12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity. Thromb Haemost (2013) 0.94
Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation. Mol Pharmacol (2011) 0.92
Platelets and atherogenesis: Platelet anti-aggregation activity and endothelial protection from tomatoes (Solanum lycopersicum L.). Exp Ther Med (2012) 0.87
Protein kinase C isoform ε negatively regulates ADP-induced calcium mobilization and thromboxane generation in platelets. Arterioscler Thromb Vasc Biol (2012) 0.83
The inhibitory mechanism of crude saponin fraction from Korean Red Ginseng in collagen-induced platelet aggregation. J Ginseng Res (2015) 0.82
Platelet signaling: a complex interplay between inhibitory and activatory networks. J Thromb Haemost (2016) 0.81
Protein kinase Cε and protein kinase Cθ double-deficient mice have a bleeding diathesis. J Thromb Haemost (2012) 0.77
Non-additive interactions between mitochondrial complex IV blockers and hypoxia in rat carotid body responses. Respir Physiol Neurobiol (2013) 0.75
A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem (1985) 90.20
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem (1991) 8.92
The extended protein kinase C superfamily. Biochem J (1998) 5.84
Prostaglandins and thromboxanes. Annu Rev Biochem (1978) 3.47
Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem J (1993) 2.64
Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation. Proc Natl Acad Sci U S A (1998) 2.42
Signaling events underlying thrombus formation. J Thromb Haemost (2003) 2.07
The sevenfold way of PKC regulation. Cell Signal (1998) 2.06
Impaired activation of platelets lacking protein kinase C-theta isoform. Blood (2009) 1.87
Factors responsible for ADP-induced release reaction of human platelets. Am J Physiol (1975) 1.70
Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection. J Exp Med (2001) 1.65
Induction of the fibrinogen receptor on human platelets by intracellular mediators. J Biol Chem (1987) 1.61
In vivo thrombus formation in murine models. Circ Res (2007) 1.54
Molecular mechanism of thromboxane A(2)-induced platelet aggregation. Essential role for p2t(ac) and alpha(2a) receptors. J Biol Chem (1999) 1.51
Nucleotide receptor signaling in platelets. J Thromb Haemost (2006) 1.42
Feedback regulation of phospholipase C-beta by protein kinase C. J Biol Chem (1990) 1.41
PKCalpha regulates platelet granule secretion and thrombus formation in mice. J Clin Invest (2009) 1.41
A prototypic platelet septin and its participation in secretion. Proc Natl Acad Sci U S A (2002) 1.36
The role of ADP receptors in platelet function. Front Biosci (2006) 1.34
Differential role of protein kinase C delta isoform in agonist-induced dense granule secretion in human platelets. J Biol Chem (2003) 1.33
Regulation of outside-in signaling in platelets by integrin-associated protein kinase C beta. J Biol Chem (2004) 1.32
Molecular basis of platelet granule secretion. Arterioscler Thromb Vasc Biol (2003) 1.29
Reciprocal cross-talk between P2Y1 and P2Y12 receptors at the level of calcium signaling in human platelets. Blood (2004) 1.25
Protein kinase Calpha: disease regulator and therapeutic target. Trends Pharmacol Sci (2009) 1.25
Synergy between Ca2+ and protein kinase C is the major factor in determining the level of secretion from human platelets. Biochem J (1993) 1.23
ADP receptors on platelets. Thromb Haemost (1996) 1.22
Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis. J Biol Chem (2003) 1.20
Protein kinase C- and calcium-regulated pathways independently synergize with Gi pathways in agonist-induced fibrinogen receptor activation. Biochem J (2002) 1.19
Inhibition of protein kinase C by staurosporine promotes elevated accumulations of inositol trisphosphates and tetrakisphosphate in human platelets exposed to thrombin. J Biol Chem (1989) 1.18
Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation. J Thromb Haemost (2009) 1.17
Direct evidence for a role for Ca2+ in amine storage granule secretion by human platelets. Thromb Res (1980) 1.17
Phosphorylation of SNAP-23 in activated human platelets. J Biol Chem (2003) 1.15
PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation. Blood (2006) 1.12
Functional divergence of platelet protein kinase C (PKC) isoforms in thrombus formation on collagen. J Biol Chem (2010) 1.12
Activation of ADP receptors and platelet function. Thromb Haemost (1997) 1.09
Isoform-specific functions of protein kinase C: the platelet paradigm. Biochem Soc Trans (2007) 1.07
Protein kinase C[delta] differentially regulates platelet functional responses. Arterioscler Thromb Vasc Biol (2009) 1.07
Protein kinase C activates the plasma membrane Ca2+ pump isoform 4b by phosphorylation of an inhibitory region downstream of the calmodulin-binding domain. J Biol Chem (1996) 1.07
Discovery of potent and selective PKC-theta inhibitors. Bioorg Med Chem Lett (2006) 1.05
Identification and functional characterization of protein kinase C isozymes in platelets and HEL cells. J Biol Chem (1992) 1.03
Differential roles of the PKC novel isoforms, PKCdelta and PKCepsilon, in mouse and human platelets. PLoS One (2008) 1.02
Signalling events underlying platelet aggregation induced by the glycoprotein VI agonist convulxin. Eur J Biochem (2001) 1.01
Dual role of platelet protein kinase C in thrombus formation: stimulation of pro-aggregatory and suppression of procoagulant activity in platelets. J Biol Chem (2007) 1.00
The therapeutic role of targeting protein kinase C in solid and hematologic malignancies. Expert Opin Investig Drugs (2007) 0.99
Protein kinase C phosphorylation of syntaxin 4 in thrombin-activated human platelets. J Biol Chem (2000) 0.99
A new protein kinase C, nPKC eta', and nPKC theta are expressed in human platelets: involvement of nPKC eta' and nPKC theta in signal transduction stimulated by PAF. Biochem Biophys Res Commun (1993) 0.97
Genetic analysis of the role of protein kinase Ctheta in platelet function and thrombus formation. PLoS One (2008) 0.93
Protein kinase Ctheta negatively regulates store-independent Ca2+ entry and phosphatidylserine exposure downstream of glycoprotein VI in platelets. J Biol Chem (2010) 0.92
Identification of protein kinase Calpha as an essential, but not sufficient, cytosolic factor for Ca2+-induced alpha- and dense-core granule secretion in platelets. J Biol Chem (2001) 0.91
Direct demonstration of involvement of protein kinase Calpha in the Ca2+-induced platelet aggregation. J Biol Chem (2003) 0.91
Mechanism of activation and functional role of protein kinase Ceta in human platelets. J Biol Chem (2009) 0.90
Effect of the concentration of Ca2+ in the suspending medium on the responses of human and rabbit platelets to aggregating agents. Thromb Haemost (1989) 0.89
Differential involvement of tyrosine and serine/threonine kinases in platelet integrin alphaIIbbeta3 exposure. Arterioscler Thromb Vasc Biol (1998) 0.88
Concomitant activation of Gi protein-coupled receptor and protein kinase C or phospholipase C is required for platelet aggregation. FEBS Lett (1999) 0.85
Plasma membrane Ca2+-ATPase isoform 4b is phosphorylated on tyrosine 1176 in activated human platelets. Thromb Haemost (2003) 0.84
PKCtheta in platelet activation. Blood (2009) 0.84
Go6976 abrogates GPVI-mediated platelet functional responses in human platelets through inhibition of Syk. J Thromb Haemost (2011) 0.83
Protein kinase C inhibitors enhance G-protein induced phospholipase A2 activation in intact human platelets. FEBS Lett (1996) 0.83
Adenosine diphosphate(ADP) does not induce thromboxane A2 generation in human platelets. Blood (2002) 0.82
Protein kinase C alpha enhances sodium-calcium exchange during store-operated calcium entry in mouse platelets. Cell Calcium (2010) 0.82
Evidence that cytosolic phospholipase A2 is down-regulated by protein kinase C in intact human platelets stimulated with fluoroaluminate. FEBS Lett (1999) 0.76
Platelet-collagen interaction: is GPVI the central receptor? Blood (2003) 3.81
The transmembrane protein meckelin (MKS3) is mutated in Meckel-Gruber syndrome and the wpk rat. Nat Genet (2006) 3.19
PLA2G6, encoding a phospholipase A2, is mutated in neurodegenerative disorders with high brain iron. Nat Genet (2006) 2.97
A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2. Blood (2005) 2.90
JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia. Blood (2010) 2.83
Clinical and molecular characterisation of hereditary dopamine transporter deficiency syndrome: an observational cohort and experimental study. Lancet Neurol (2010) 2.60
The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade. J Biol Chem (2007) 2.24
Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow. J Biol Chem (2005) 2.07
GPIb-dependent platelet activation is dependent on Src kinases but not MAP kinase or cGMP-dependent kinase. Blood (2003) 2.05
Recommendations for the validation of immunoassays used for detection of host antibodies against biotechnology products. J Pharm Biomed Anal (2008) 2.05
Dual role of collagen in factor XII-dependent thrombus formation. Blood (2009) 2.01
Mutations in VIPAR cause an arthrogryposis, renal dysfunction and cholestasis syndrome phenotype with defects in epithelial polarization. Nat Genet (2010) 2.00
Mutations of the catalytic subunit of RAB3GAP cause Warburg Micro syndrome. Nat Genet (2005) 1.98
Integrin alpha2beta1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCgamma2. J Cell Biol (2003) 1.84
A novel thromboxane A2 receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis. Blood (2009) 1.70
A germline mutation in BLOC1S3/reduced pigmentation causes a novel variant of Hermansky-Pudlak syndrome (HPS8). Am J Hum Genet (2005) 1.68
Combined in vivo depletion of glycoprotein VI and C-type lectin-like receptor 2 severely compromises hemostasis and abrogates arterial thrombosis in mice. Arterioscler Thromb Vasc Biol (2013) 1.68
Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane. Blood (2013) 1.65
Homozygous loss-of-function mutations in the gene encoding the dopamine transporter are associated with infantile parkinsonism-dystonia. J Clin Invest (2009) 1.60
Enrichment of FLI1 and RUNX1 mutations in families with excessive bleeding and platelet dense granule secretion defects. Blood (2013) 1.60
Requirement of VPS33B, a member of the Sec1/Munc18 protein family, in megakaryocyte and platelet alpha-granule biogenesis. Blood (2005) 1.52
Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function. Blood (2013) 1.49
CLEC-2 activates Syk through dimerization. Blood (2010) 1.49
Adhesion of human and mouse platelets to collagen under shear: a unifying model. FASEB J (2005) 1.46
A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function. J Exp Med (2010) 1.45
PKCalpha regulates platelet granule secretion and thrombus formation in mice. J Clin Invest (2009) 1.41
Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen. J Biol Chem (2004) 1.40
Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling. J Biol Chem (2002) 1.39
Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins. Blood (2003) 1.39
A critical role for phospholipase Cgamma2 in alphaIIbbeta3-mediated platelet spreading. J Biol Chem (2003) 1.36
Loss-of-function mutations in RAB18 cause Warburg micro syndrome. Am J Hum Genet (2011) 1.36
Renal cells activate the platelet receptor CLEC-2 through podoplanin. Biochem J (2008) 1.35
Regulation of proplatelet formation and platelet release by integrin alpha IIb beta3. Blood (2006) 1.35
DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets. J Virol (2006) 1.31
The monoamine neurotransmitter disorders: an expanding range of neurological syndromes. Lancet Neurol (2011) 1.30
CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development. Blood (2011) 1.30
A review of inherited platelet disorders with guidelines for their management on behalf of the UKHCDO. Br J Haematol (2006) 1.30
Evaluation of participants with suspected heritable platelet function disorders including recommendation and validation of a streamlined agonist panel. Blood (2012) 1.29
Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signaling. J Biol Chem (2010) 1.29
Murine GPVI stimulates weak integrin activation in PLCgamma2-/- platelets: involvement of PLCgamma1 and PI3-kinase. Blood (2003) 1.26
Immunogenicity of biologically-derived therapeutics: assessment and interpretation of nonclinical safety studies. Regul Toxicol Pharmacol (2009) 1.24
GPVI levels in platelets: relationship to platelet function at high shear. Blood (2003) 1.23
Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear. PLoS One (2010) 1.22
Segregation of platelet aggregatory and procoagulant microdomains in thrombus formation: regulation by transient integrin activation. Arterioscler Thromb Vasc Biol (2007) 1.22
Towards complete analysis of the platelet proteome. Proteomics (2002) 1.21
Mutations in TTC37 cause trichohepatoenteric syndrome (phenotypic diarrhea of infancy). Gastroenterology (2010) 1.20
Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI. Blood (2005) 1.19
JAK2V617F leads to intrinsic changes in platelet formation and reactivity in a knock-in mouse model of essential thrombocythemia. Blood (2013) 1.18
Phospholipase C beta 1 deficiency is associated with early-onset epileptic encephalopathy. Brain (2010) 1.18
Reference curves for aggregation and ATP secretion to aid diagnose of platelet-based bleeding disorders: effect of inhibition of ADP and thromboxane A(2) pathways. Platelets (2007) 1.17
Critical role for ERK1/2 in bone marrow and fetal liver-derived primary megakaryocyte differentiation, motility, and proplatelet formation. Exp Hematol (2009) 1.16
Critical role of Src-Syk-PLC{gamma}2 signaling in megakaryocyte migration and thrombopoiesis. Blood (2010) 1.15
A novel role for PECAM-1 in megakaryocytokinesis and recovery of platelet counts in thrombocytopenic mice. Blood (2007) 1.15
Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C. Blood (2002) 1.15
Tec regulates platelet activation by GPVI in the absence of Btk. Blood (2003) 1.14
The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis. Blood (2009) 1.13
Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in platelets. Biochem J (2002) 1.12
Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization, secondary mediators, and Rac. Blood (2010) 1.11
A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3. Hum Mol Genet (2011) 1.10
Involvement of Src kinases and PLCgamma2 in clot retraction. Thromb Res (2006) 1.09
The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression. J Biol Chem (2012) 1.08
A global proteomics approach identifies novel phosphorylated signaling proteins in GPVI-activated platelets: involvement of G6f, a novel platelet Grb2-binding membrane adapter. Proteomics (2006) 1.08
Extensive analysis of the human platelet proteome by two-dimensional gel electrophoresis and mass spectrometry. Proteomics (2004) 1.07
Zebrafish vps33b, an ortholog of the gene responsible for human arthrogryposis-renal dysfunction-cholestasis syndrome, regulates biliary development downstream of the onecut transcription factor hnf6. Development (2005) 1.07
G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2. J Biol Chem (2008) 1.06
Bile acid-CoA ligase deficiency--a new inborn error of bile acid metabolism. J Inherit Metab Dis (2011) 1.06
Critical role of FcR gamma-chain, LAT, PLCgamma2 and thrombin in arteriolar thrombus formation upon mild, laser-induced endothelial injury in vivo. Microcirculation (2008) 1.05
Dasatinib enhances megakaryocyte differentiation but inhibits platelet formation. Blood (2011) 1.04
Recessive germline SDHA and SDHB mutations causing leukodystrophy and isolated mitochondrial complex II deficiency. J Med Genet (2012) 1.04
Developmental decisions in Dictyostelium discoideum. Dev Biol (2005) 1.03
Epilepsy due to PNPO mutations: genotype, environment and treatment affect presentation and outcome. Brain (2014) 1.03
Differential roles of the PKC novel isoforms, PKCdelta and PKCepsilon, in mouse and human platelets. PLoS One (2008) 1.02
PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks. J Cell Biol (2011) 1.02
Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny. PLoS One (2012) 1.01
Improved ethanol yield and reduced Minimum Ethanol Selling Price (MESP) by modifying low severity dilute acid pretreatment with deacetylation and mechanical refining: 1) Experimental. Biotechnol Biofuels (2012) 1.01
Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains. Biochem J (2009) 1.00
Associations among genotype, clinical phenotype, and intracellular localization of trafficking proteins in ARC syndrome. Hum Mutat (2012) 1.00
Mutations in SLC29A3, encoding an equilibrative nucleoside transporter ENT3, cause a familial histiocytosis syndrome (Faisalabad histiocytosis) and familial Rosai-Dorfman disease. PLoS Genet (2010) 0.99
Evidence for genetic heterogeneity in D-2-hydroxyglutaric aciduria. Hum Mutat (2010) 0.98
Design and validation of a metabolic disorder resequencing microarray (BRUM1). Hum Mutat (2010) 0.98
Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis. Hum Mol Genet (2012) 0.98
Distinct but critical roles for integrin alphaIIbbeta3 in platelet lamellipodia formation on fibrinogen, collagen-related peptide and thrombin. FEBS J (2006) 0.97
Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels. Circ Res (2011) 0.97
Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites. Biochem J (2004) 0.96
Differential effects of reduced glycoprotein VI levels on activation of murine platelets by glycoprotein VI ligands. Biochem J (2002) 0.96
Sphingosine kinase 2 (Sphk2) regulates platelet biogenesis by providing intracellular sphingosine 1-phosphate (S1P). Blood (2013) 0.95
Vav family proteins are required for optimal regulation of PLCgamma2 by integrin alphaIIbbeta3. Biochem J (2007) 0.95
Distinct roles of GPVI and integrin alpha(2)beta(1) in platelet shape change and aggregation induced by different collagens. Br J Pharmacol (2002) 0.95
The synovial fluid adiponectin-leptin ratio predicts pain with knee osteoarthritis. Clin Rheumatol (2010) 0.95
SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase. J Biol Chem (2004) 0.94
CD31 is required on CD4+ T cells to promote T cell survival during Salmonella infection. J Immunol (2011) 0.93
Delineation of the region in the glycoprotein VI tail required for association with the Fc receptor gamma-chain. J Biol Chem (2003) 0.93
SCL-mediated regulation of the cell-cycle regulator p21 is critical for murine megakaryopoiesis. Blood (2011) 0.92
Glycoprotein IIb-IIIa-dependent aggregation by glycoprotein Ibalpha is reinforced by a Src family kinase inhibitor (PP1)-sensitive signalling pathway. Biochem J (2002) 0.92
The physiological and pathophysiological roles of platelet CLEC-2. Thromb Haemost (2013) 0.92
Constitutive dimerization of glycoprotein VI (GPVI) in resting platelets is essential for binding to collagen and activation in flowing blood. J Biol Chem (2012) 0.92
Solid phase synthesis and SAR of small molecule agonists for the GPR40 receptor. Bioorg Med Chem Lett (2007) 0.92
Applying proteomics technology to platelet research. Mass Spectrom Rev (2005) 0.90
DNA-PKcs-dependent signaling of DNA damage in Dictyostelium discoideum. Curr Biol (2005) 0.90