Published in Immunol Today on November 01, 1990
A novel mechanism of action of tetracyclines: effects on nitric oxide synthases. Proc Natl Acad Sci U S A (1996) 1.90
Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglycerides. Mol Cell Biol (1994) 1.27
Removal of a 3' non-coding sequence is an initial step in degradation of gro alpha mRNA and is regulated by interleukin-1. Nucleic Acids Res (1992) 1.21
Cyclic AMP-independent activation of transcription factor NF-kappa B in HL60 cells by tumor necrosis factors alpha and beta. Mol Cell Biol (1991) 1.04
Neuron-specific effects of interleukin-1β are mediated by a novel isoform of the IL-1 receptor accessory protein. J Neurosci (2011) 1.00
Phosphorylation of the small heat-shock protein is regulated by interleukin 1, tumour necrosis factor, growth factors, bradykinin and ATP. Biochem J (1991) 0.94
Cytokine receptors: structure and signal transduction. Clin Exp Immunol (1992) 0.89
Histamine enhances interleukin (IL)-1-induced IL-1 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells. Comparison with IL-1 receptor antagonist. J Clin Invest (1993) 0.87
Lysosomal cysteine endopeptidases mediate interleukin 1-stimulated cartilage proteoglycan degradation. Biochem J (1992) 0.87
Early events of human T lymphocyte activation are associated with type I protein kinase A activity. J Clin Invest (1993) 0.84
Cellular signalling mechanisms in B lymphocytes. Biochem J (1993) 0.84
Evidence that responses of articular chondrocytes to interleukin-1 and basic fibroblast growth factor are not mediated by protein kinase C. Biochem J (1991) 0.78
Staurosporine, but not Ro 31-8220, induces interleukin 2 production and synergizes with interleukin 1alpha in EL4 thymoma cells. Biochem J (1997) 0.78
Demonstration of the presence of an interleukin-1 receptor on the surface of murine astrocytes and its regulation by cytokines and Theiler's virus. Immunology (1994) 0.78
Investigation of guanine-nucleotide-binding protein involvement and regulation of cyclic AMP metabolism in interleukin 1 signal transduction. Biochem J (1992) 0.78
Regulation of electrolyte transport with IL-1beta in rabbit distal colon. Mediators Inflamm (1995) 0.77
IL-1 signal transduction. Immunol Today (1991) 0.77
How does interleukin 1 activate cells? Cyclic AMP and interleukin 1 signal transduction. Immunol Today (1990) 2.48
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature (2001) 5.95
Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell (1994) 4.50
Tumour necrosis factor alpha stimulates resorption and inhibits synthesis of proteoglycan in cartilage. Nature (1986) 4.24
A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling. Proc Natl Acad Sci U S A (2000) 3.69
Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability. Mol Cell Biol (2001) 3.12
Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries. Biochem Pharmacol (2000) 2.70
Interleukin 1 signaling occurs exclusively via the type I receptor. Proc Natl Acad Sci U S A (1993) 2.67
Pig catabolin is a form of interleukin 1. Cartilage and bone resorb, fibroblasts make prostaglandin and collagenase, and thymocyte proliferation is augmented in response to one protein. Biochem J (1984) 2.47
Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade. Mol Cell Biol (2000) 2.45
p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes. J Biol Chem (1999) 2.38
A cartilage catabolic factor from synovium. Biochem J (1979) 2.11
The 3' untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR. Mol Cell Biol (2001) 2.09
Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling. J Biol Chem (1998) 1.99
The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products. J Leukoc Biol (2000) 1.94
Prevalence of radiographic osteoarthritis--it all depends on your point of view. Rheumatology (Oxford) (2006) 1.94
Interleukin-1 beta (IL-1 beta) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro. Neurosci Lett (1996) 1.70
Pig interleukin 1. Purification of two immunologically different leukocyte proteins that cause cartilage resorption, lymphocyte activation, and fever. J Exp Med (1985) 1.70
Do patients with rheumatoid arthritis established on methotrexate and folic acid 5 mg daily need to continue folic acid supplements long term? Rheumatology (Oxford) (2000) 1.67
Regulation of tumour necrosis factor alpha mRNA stability by the mitogen-activated protein kinase p38 signalling cascade. FEBS Lett (2000) 1.66
Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels. J Immunol (1997) 1.64
Annotating genes with potential roles in the immune system: six new members of the IL-1 family. Trends Immunol (2001) 1.59
Interleukin 1 induces NF-kappa B through its type I but not its type II receptor in lymphocytes. J Biol Chem (1992) 1.57
Dexamethasone destabilizes cyclooxygenase 2 mRNA by inhibiting mitogen-activated protein kinase p38. Mol Cell Biol (2001) 1.55
Purification to homogeneity of pig leucocyte catabolin, a protein that causes cartilage resorption in vitro. Biochem J (1983) 1.54
A p38 MAP kinase inhibitor regulates stability of interleukin-1-induced cyclooxygenase-2 mRNA. FEBS Lett (1998) 1.52
Osteoblasts mediate interleukin 1 stimulation of bone resorption by rat osteoclasts. J Exp Med (1986) 1.50
Characterization of catabolin, the major product of pig synovial tissue that induces resorption of cartilage proteoglycan in vitro. Biochem J (1981) 1.46
Identification of catabolin, a protein fro synovium which induces degradation of cartilage in organ culture. Biochem Biophys Res Commun (1980) 1.45
Identification of a common class of high affinity receptors for both types of porcine interleukin-1 on connective tissue cells. Nature (1987) 1.45
Interleukin-1. Int J Biochem Cell Biol (1998) 1.44
Patterns of radiological progression in early rheumatoid arthritis: results of an 8 year prospective study. J Rheumatol (1998) 1.40
FGF-2 is bound to perlecan in the pericellular matrix of articular cartilage, where it acts as a chondrocyte mechanotransducer. Osteoarthritis Cartilage (2007) 1.40
IL-1 and TNF transmodulate epidermal growth factor receptors by a protein kinase C-independent mechanism. J Immunol (1989) 1.33
Effects of oxidants and antioxidants on nuclear factor kappa B activation in three different cell lines: evidence against a universal hypothesis involving oxygen radicals. Biochim Biophys Acta (1995) 1.33
Oncostatin M and leukemia inhibitory factor trigger overlapping and different signals through partially shared receptor complexes. J Biol Chem (1994) 1.31
Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases. Evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation. Arthritis Rheum (1993) 1.30
The evolution of the MAP kinase pathways: coduplication of interacting proteins leads to new signaling cascades. J Mol Evol (1999) 1.27
p38 MAPK is required for CD40-induced gene expression and proliferation in B lymphocytes. J Immunol (1998) 1.26
Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase. J Immunol (2000) 1.26
T cell proliferation in response to interleukins 2 and 7 requires p38MAP kinase activation. J Biol Chem (1997) 1.24
Identification of proteinases in rheumatoid synovium. Detection of leukocyte elastase cathepsin G and another serine proteinase. Biochim Biophys Acta (1980) 1.21
Distinct regions of the human granulocyte-colony-stimulating factor receptor cytoplasmic domain are required for proliferation and gene induction. Mol Cell Biol (1993) 1.20
Involvement of stress-activated protein kinase and p38 mitogen-activated protein kinase in mIgM-induced apoptosis of human B lymphocytes. Proc Natl Acad Sci U S A (1996) 1.19
Inhibition of nuclear factor kappaB by direct modification in whole cells--mechanism of action of nordihydroguaiaritic acid, curcumin and thiol modifiers. Biochem Pharmacol (1998) 1.19
Radiographic patterns and response to corticosteroid hip injection. Ann Rheum Dis (1997) 1.18
Down-modulation of epidermal growth factor receptor affinity in fibroblasts treated with interleukin 1 or tumor necrosis factor is associated with phosphorylation at a site other than threonine 654. J Biol Chem (1990) 1.18
The chemotactic factor N-formylmethionyl-leucyl-phenylalanine activates microtubule-associated protein 2 (MAP) kinase and a MAP kinase kinase in polymorphonuclear leucocytes. Biochem J (1993) 1.17
Binding of interleukin-18 to the interleukin-1 receptor homologous receptor IL-1Rrp1 leads to activation of signaling pathways similar to those used by interleukin-1. J Interferon Cytokine Res (1998) 1.15
Interleukin-1 beta and interleukin-1 alpha stimulate the plasminogen activator activity and prostaglandin E2 levels of human synovial cells. Arthritis Rheum (1987) 1.14
Ras, protein kinase C zeta, and I kappa B kinases 1 and 2 are downstream effectors of CD44 during the activation of NF-kappa B by hyaluronic acid fragments in T-24 carcinoma cells. J Immunol (2000) 1.14
Pig interleukin 1 (catabolin) is a potent stimulator of bone resorption in vitro. Calcif Tissue Int (1985) 1.13
Studies into the effect of the tyrosine kinase inhibitor herbimycin A on NF-kappa B activation in T lymphocytes. Evidence for covalent modification of the p50 subunit. J Biol Chem (1995) 1.13
Characterization of proteins from human synovium and mononuclear leucocytes that induce resorption of cartilage proteoglycan in vitro. Biochem J (1983) 1.12
Lymphocytes induce resorption of cartilage by producing catabolin. Biochem J (1982) 1.11
Rac1 regulates interleukin 1-induced nuclear factor kappaB activation in an inhibitory protein kappaBalpha-independent manner by enhancing the ability of the p65 subunit to transactivate gene expression. J Biol Chem (2000) 1.11
Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses. J Immunol (1994) 1.10
Interleukin 1 and tumour necrosis factor increase phosphorylation of fibroblast proteins. FEBS Lett (1988) 1.09
Stress-activated protein kinase/Jun N-terminal kinase is required for interleukin (IL)-1-induced IL-6 and IL-8 gene expression in the human epidermal carcinoma cell line KB. J Biol Chem (1998) 1.08
Interleukin 1 and tumor necrosis factor stimulate two novel protein kinases that phosphorylate the heat shock protein hsp27 and beta-casein. J Biol Chem (1993) 1.08
Daunorubicin activates NFkappaB and induces kappaB-dependent gene expression in HL-60 promyelocytic and Jurkat T lymphoma cells. J Biol Chem (1997) 1.08
Selective activation of JNK/SAPK by interleukin-1 in rabbit liver is mediated by MKK7. FEBS Lett (1997) 1.07
Activation of NF-kappa B and induction of vascular cell adhesion molecule-1 and intracellular adhesion molecule-1 expression in human glial cells by IL-1. Modulation by antioxidants. J Immunol (1994) 1.07
Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta. Oncogene (1993) 1.06
Interleukin 1 and tumour necrosis factor increase phosphorylation of the small heat shock protein. Effects in fibroblasts, Hep G2 and U937 cells. FEBS Lett (1989) 1.06
Evidence of two mechanisms for the activation of the glucose transporter GLUT1 by anisomycin: p38(MAP kinase) activation and protein synthesis inhibition in mammalian cells. J Physiol (1997) 1.05
Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1. Mol Cell Biol (2001) 1.05
The P38 mitogen-activated protein kinase inhibitor SB203580 antagonizes the inhibitory effects of interleukin-1beta on long-term potentiation in the rat dentate gyrus in vitro. Neuroscience (1999) 1.03
The role of the interleukin-1/Toll-like receptor superfamily in inflammation and host defence. Microbes Infect (2000) 1.03
Murine interleukin-1 receptor: differences in binding properties between fibroblastic and thymoma cells and evidence for a two-chain receptor model. FEBS Lett (1987) 1.01
Interleukin-1 activates transcription factor NF kappa B in glial cells. Biochem J (1993) 1.00
Induction of cyclo-oxygenase by interleukin-1 in rheumatoid synovial cells. FEBS Lett (1987) 1.00
Murine interleukin 1 receptor. Direct identification by ligand blotting and purification to homogeneity of an interleukin 1-binding glycoprotein. J Biol Chem (1988) 0.99
Measurement and prediction of radiological progression in early rheumatoid arthritis. J Rheumatol (1994) 0.99
Inhibition of interleukin 1-stimulated cartilage proteoglycan degradation by a lipophilic inactivator of cysteine endopeptidases. Biochem J (1992) 0.99
Interleukin 1 stimulates hexose transport in fibroblasts by increasing the expression of glucose transporters. J Biol Chem (1990) 0.99
Internalin B activates nuclear factor-kappa B via Ras, phosphoinositide 3-kinase, and Akt. J Biol Chem (2001) 0.97
Interleukin 1 alpha activates two forms of p54 alpha mitogen-activated protein kinase in rabbit liver. J Exp Med (1994) 0.96
The anti-inflammatory cytokine, interleukin (IL)-10, blocks the inhibitory effect of IL-1 beta on long term potentiation. A role for JNK. J Biol Chem (2001) 0.96
Cellular proliferation and activation of NF kappa B are induced by autocrine production of tumor necrosis factor alpha in the human T lymphoma line HuT 78. J Biol Chem (1995) 0.96
Lysyl oxidase: evidence that pyridoxal phosphate is a cofactor. Biochem Biophys Res Commun (1982) 0.96
Characterization of CD44 induction by IL-1: a critical role for Egr-1. J Immunol (1999) 0.95
Ceramide activates NFkappaB by inducing the processing of p105. J Biol Chem (1998) 0.94
Interleukin-1 activates a novel protein kinase that phosphorylates the epidermal-growth-factor receptor peptide T669. Biochem J (1994) 0.92
Topoisomerase II is required for mitoxantrone to signal nuclear factor kappa B activation in HL60 cells. J Biol Chem (2000) 0.92
The cartilage-resorbing protein catabolin is made by synovial fibroblasts and its production is increased by phorbol myristate acetate. Biochem J (1983) 0.91
A method to predict residues conferring functional differences between related proteins: application to MAP kinase pathways. Protein Sci (2000) 0.90
The inhibition of lysyl oxidase in vivo by isoniazid and its reversal by pyridoxal. Effect on collagen cross-linking in the chick embryo. Biochem J (1984) 0.90
Interleukin-1 inhibits the synthesis of collagen by fibroblasts. Biochem Int (1986) 0.89
Interleukin-1 alpha modulates collagen gene expression in cultured synovial cells. Biochem J (1988) 0.89
Development of a novel 2D proteomics approach for the identification of proteins secreted by primary chondrocytes after stimulation by IL-1 and oncostatin M. Rheumatology (Oxford) (2006) 0.88
Extracts of feverfew inhibit mitogen-induced human peripheral blood mononuclear cell proliferation and cytokine mediated responses: a cytotoxic effect. Br J Clin Pharmacol (1987) 0.88
Phosphorylated HSP27 associates with the activation-dependent cytoskeleton in human platelets. Blood (1994) 0.88
Divergent roles for Ras and Rap in the activation of p38 mitogen-activated protein kinase by interleukin-1. J Biol Chem (2000) 0.87