Published in Biochem J on January 15, 1982
Pig catabolin is a form of interleukin 1. Cartilage and bone resorb, fibroblasts make prostaglandin and collagenase, and thymocyte proliferation is augmented in response to one protein. Biochem J (1984) 2.47
Chondrocyte-mediated depletion of articular cartilage proteoglycans in vitro. Biochem J (1985) 1.63
Microscopical studies of necrotising scleritis. I. Cellular aspects. Br J Ophthalmol (1984) 1.09
The cartilage-resorbing protein catabolin is made by synovial fibroblasts and its production is increased by phorbol myristate acetate. Biochem J (1983) 0.91
An arthritogenic lymphokine in the rat. J Exp Med (1985) 0.88
Light and electron microscopy of corneal melting syndrome (Mooren's ulcer). Br J Ophthalmol (1982) 0.88
Differential responses of human articular cartilage to retinol. Ann Rheum Dis (1984) 0.79
Porcine catabolin stimulates prostaglandin E2 secretion but does not affect intracellular cyclic AMP production in pig synovial fibroblasts. Ann Rheum Dis (1985) 0.78
Cytokine modulation of chondrocyte metabolism--in vivo and in vitro effects of piroxicam. Inflammation (1984) 0.75
Production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells. Proc Natl Acad Sci U S A (1976) 5.40
Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor (interleukin 1). Proc Natl Acad Sci U S A (1981) 4.89
Participation of monocyte-macrophages and lymphocytes in the production of a factor that stimulates collagenase and prostaglandin release by rheumatoid synovial cells. J Clin Invest (1979) 3.34
Purification to apparent homogeneity of murine interleukin 1. J Immunol (1981) 3.33
A cartilage catabolic factor from synovium. Biochem J (1979) 2.11
Synthesis of collagenase and neutral proteases by articular chondrocytes: stimulation by a macrophage-derived factor. Biochem Biophys Res Commun (1978) 1.66
Human mononuclear cell factors mediate cartilage matrix degradation through chondrocyte activation. J Clin Invest (1981) 1.64
Characterization of catabolin, the major product of pig synovial tissue that induces resorption of cartilage proteoglycan in vitro. Biochem J (1981) 1.46
Human synovium releases a factor which stimulates chondrocyte production of PGE and plasminogen activator. Nature (1980) 1.45
Identification of catabolin, a protein fro synovium which induces degradation of cartilage in organ culture. Biochem Biophys Res Commun (1980) 1.45
Revised nomenclature for antigen-nonspecific T-cell proliferation and helper factors. Cell Immunol (1979) 1.44
Stimulation of human synovial fibroblast plasminogen activator production by mononuclear cell supernatants. J Immunol (1981) 1.21
Macrophage factor that induces neutral protease secretion by normal rabbit chondrocytes. Studies of some properties and effects on metabolism of chondrocytes. Eur J Biochem (1980) 1.19
Purification and properties of human B cell-activating factor. J Immunol (1979) 1.17
Induction of the synthesis of latent collagenase and latent neutral protease in chondrocytes by a factor synthesized by activated macrophages. Arthritis Rheum (1980) 1.07
Mechanism of stimulation of prostaglandin synthesis by a factor from rheumatoid synovial tissue. Proc Natl Acad Sci U S A (1981) 0.86
Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell (1994) 4.50
Tumour necrosis factor alpha stimulates resorption and inhibits synthesis of proteoglycan in cartilage. Nature (1986) 4.24
Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability. Mol Cell Biol (2001) 3.12
Pig catabolin is a form of interleukin 1. Cartilage and bone resorb, fibroblasts make prostaglandin and collagenase, and thymocyte proliferation is augmented in response to one protein. Biochem J (1984) 2.47
Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade. Mol Cell Biol (2000) 2.45
p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes. J Biol Chem (1999) 2.38
A cartilage catabolic factor from synovium. Biochem J (1979) 2.11
The 3' untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR. Mol Cell Biol (2001) 2.09
Prevalence of radiographic osteoarthritis--it all depends on your point of view. Rheumatology (Oxford) (2006) 1.94
Pig interleukin 1. Purification of two immunologically different leukocyte proteins that cause cartilage resorption, lymphocyte activation, and fever. J Exp Med (1985) 1.70
Do patients with rheumatoid arthritis established on methotrexate and folic acid 5 mg daily need to continue folic acid supplements long term? Rheumatology (Oxford) (2000) 1.67
Regulation of tumour necrosis factor alpha mRNA stability by the mitogen-activated protein kinase p38 signalling cascade. FEBS Lett (2000) 1.66
Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels. J Immunol (1997) 1.64
Interleukin 1 induces NF-kappa B through its type I but not its type II receptor in lymphocytes. J Biol Chem (1992) 1.57
Dexamethasone destabilizes cyclooxygenase 2 mRNA by inhibiting mitogen-activated protein kinase p38. Mol Cell Biol (2001) 1.55
Purification to homogeneity of pig leucocyte catabolin, a protein that causes cartilage resorption in vitro. Biochem J (1983) 1.54
A p38 MAP kinase inhibitor regulates stability of interleukin-1-induced cyclooxygenase-2 mRNA. FEBS Lett (1998) 1.52
Osteoblasts mediate interleukin 1 stimulation of bone resorption by rat osteoclasts. J Exp Med (1986) 1.50
Characterization of catabolin, the major product of pig synovial tissue that induces resorption of cartilage proteoglycan in vitro. Biochem J (1981) 1.46
Identification of catabolin, a protein fro synovium which induces degradation of cartilage in organ culture. Biochem Biophys Res Commun (1980) 1.45
Identification of a common class of high affinity receptors for both types of porcine interleukin-1 on connective tissue cells. Nature (1987) 1.45
Interleukin-1. Int J Biochem Cell Biol (1998) 1.44
Patterns of radiological progression in early rheumatoid arthritis: results of an 8 year prospective study. J Rheumatol (1998) 1.40
FGF-2 is bound to perlecan in the pericellular matrix of articular cartilage, where it acts as a chondrocyte mechanotransducer. Osteoarthritis Cartilage (2007) 1.40
How does interleukin 1 activate cells? Interleukin 1 signal transduction. Immunol Today (1990) 1.37
IL-1 and TNF transmodulate epidermal growth factor receptors by a protein kinase C-independent mechanism. J Immunol (1989) 1.33
Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases. Evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation. Arthritis Rheum (1993) 1.30
p38 MAPK is required for CD40-induced gene expression and proliferation in B lymphocytes. J Immunol (1998) 1.26
T cell proliferation in response to interleukins 2 and 7 requires p38MAP kinase activation. J Biol Chem (1997) 1.24
Identification of proteinases in rheumatoid synovium. Detection of leukocyte elastase cathepsin G and another serine proteinase. Biochim Biophys Acta (1980) 1.21
Involvement of stress-activated protein kinase and p38 mitogen-activated protein kinase in mIgM-induced apoptosis of human B lymphocytes. Proc Natl Acad Sci U S A (1996) 1.19
Radiographic patterns and response to corticosteroid hip injection. Ann Rheum Dis (1997) 1.18
Down-modulation of epidermal growth factor receptor affinity in fibroblasts treated with interleukin 1 or tumor necrosis factor is associated with phosphorylation at a site other than threonine 654. J Biol Chem (1990) 1.18
The chemotactic factor N-formylmethionyl-leucyl-phenylalanine activates microtubule-associated protein 2 (MAP) kinase and a MAP kinase kinase in polymorphonuclear leucocytes. Biochem J (1993) 1.17
Interleukin-1 beta and interleukin-1 alpha stimulate the plasminogen activator activity and prostaglandin E2 levels of human synovial cells. Arthritis Rheum (1987) 1.14
Pig interleukin 1 (catabolin) is a potent stimulator of bone resorption in vitro. Calcif Tissue Int (1985) 1.13
Characterization of proteins from human synovium and mononuclear leucocytes that induce resorption of cartilage proteoglycan in vitro. Biochem J (1983) 1.12
Interleukin 1 and tumour necrosis factor increase phosphorylation of fibroblast proteins. FEBS Lett (1988) 1.09
Stress-activated protein kinase/Jun N-terminal kinase is required for interleukin (IL)-1-induced IL-6 and IL-8 gene expression in the human epidermal carcinoma cell line KB. J Biol Chem (1998) 1.08
Interleukin 1 and tumor necrosis factor stimulate two novel protein kinases that phosphorylate the heat shock protein hsp27 and beta-casein. J Biol Chem (1993) 1.08
Selective activation of JNK/SAPK by interleukin-1 in rabbit liver is mediated by MKK7. FEBS Lett (1997) 1.07
Interleukin 1 and tumour necrosis factor increase phosphorylation of the small heat shock protein. Effects in fibroblasts, Hep G2 and U937 cells. FEBS Lett (1989) 1.06
Evidence of two mechanisms for the activation of the glucose transporter GLUT1 by anisomycin: p38(MAP kinase) activation and protein synthesis inhibition in mammalian cells. J Physiol (1997) 1.05
Murine interleukin-1 receptor: differences in binding properties between fibroblastic and thymoma cells and evidence for a two-chain receptor model. FEBS Lett (1987) 1.01
Murine interleukin 1 receptor. Direct identification by ligand blotting and purification to homogeneity of an interleukin 1-binding glycoprotein. J Biol Chem (1988) 0.99
Measurement and prediction of radiological progression in early rheumatoid arthritis. J Rheumatol (1994) 0.99
Inhibition of interleukin 1-stimulated cartilage proteoglycan degradation by a lipophilic inactivator of cysteine endopeptidases. Biochem J (1992) 0.99
Interleukin 1 stimulates hexose transport in fibroblasts by increasing the expression of glucose transporters. J Biol Chem (1990) 0.99
Interleukin 1 alpha activates two forms of p54 alpha mitogen-activated protein kinase in rabbit liver. J Exp Med (1994) 0.96
Interleukin-1 activates a novel protein kinase that phosphorylates the epidermal-growth-factor receptor peptide T669. Biochem J (1994) 0.92
The cartilage-resorbing protein catabolin is made by synovial fibroblasts and its production is increased by phorbol myristate acetate. Biochem J (1983) 0.91
Interleukin-1 inhibits the synthesis of collagen by fibroblasts. Biochem Int (1986) 0.89
Interleukin-1 alpha modulates collagen gene expression in cultured synovial cells. Biochem J (1988) 0.89
Development of a novel 2D proteomics approach for the identification of proteins secreted by primary chondrocytes after stimulation by IL-1 and oncostatin M. Rheumatology (Oxford) (2006) 0.88
Phosphorylated HSP27 associates with the activation-dependent cytoskeleton in human platelets. Blood (1994) 0.88
Neutral protease from the polymorphonuclear leucocytes of human rheumatoid synovial fluid. Clin Sci Mol Med (1974) 0.87
Lysosomal cysteine endopeptidases mediate interleukin 1-stimulated cartilage proteoglycan degradation. Biochem J (1992) 0.87
Interleukin-1 signal transduction. Increased GTP binding and hydrolysis in membranes of a murine thymoma line (EL4). J Biol Chem (1990) 0.87
Multiple joint avascular necrosis: beware of tuberculosis and human immunodeficiency virus--a rare but important cause. Br J Rheumatol (1995) 0.86
Synergistic activation of JNK/SAPK by interleukin-1 and platelet-derived growth factor is independent of Rac and Cdc42. Biochem J (1999) 0.85
D-2-hydroxyglutaric aciduria in association with spondyloenchondromatosis. Skeletal Radiol (2000) 0.85
Studies on the fate of receptor-bound 125I-interleukin 1 beta in porcine synovial fibroblasts. J Immunol (1987) 0.84
Isolation and characterization of human plasma alpha 1-proteinase inhibitor and a conformational study of its interaction with proteinases. Biochem J (1976) 0.83
Interleukin 1 activates jun N-terminal kinases JNK1 and JNK2 but not extracellular regulated MAP kinase (ERK) in human glomerular mesangial cells. FEBS Lett (1996) 0.82
Interleukin 1: purification and biochemical aspects of its action on cartilage. J Rheumatol (1987) 0.82
The mechanical joint score: a new clinical index of joint damage in rheumatoid arthritis. Rheumatology (Oxford) (2002) 0.82
Prediction of radiographic damage in hands and feet in rheumatoid arthritis by clinical evaluation. Clin Rheumatol (1994) 0.81
Reduction of post-traumatic osteoporosis after external fixation of tibial fractures. Injury (1995) 0.80
The binding subunit of pertussis toxin inhibits IL-1 induction of IL-2 and prostaglandin production. J Immunol (1992) 0.80
A common class of receptors for the two types of porcine interleukin-1 on articular chondrocytes. Lymphokine Res (1986) 0.80
High-density lipoproteins differentially modulate cytokine-induced expression of E-selectin and cyclooxygenase-2. Arterioscler Thromb Vasc Biol (1999) 0.80
Small joint synovitis in rheumatoid arthritis: should it be assessed separately? Br J Rheumatol (1995) 0.80
Basic fibroblast growth factor: an extracellular mechanotransducer in articular cartilage? Biochem Soc Trans (2006) 0.80
Porcine collagenase from synovial fibroblasts: cDNA sequence and modulation of expression of RNA in vitro by various cytokines. Matrix (1991) 0.78
Dual specificity of the interleukin 1- and tumor necrosis factor-activated beta casein kinase. J Biol Chem (1997) 0.78
Serological characterization of acidic (pI 5.5) and neutral (pI 7.1) forms of 17kD and 35kD interleukin-1. Lymphokine Res (1986) 0.78
The proinflammatory and chondral activities of leukemia inhibitory factor in goat joints are partially a function of interleukin-1. J Interferon Cytokine Res (1999) 0.77
Identification of a cytoplasmic protein kinase regulated by IL-1 that phosphorylates the small heat shock protein, hsp27. J Immunol (1991) 0.77
Molecular cloning and sequence of porcine interleukin 6 cDNA and expression of mRNA in synovial fibroblasts in vitro. Cytokine (1991) 0.77
Specific activation of beta-casein kinase by the inflammatory cytokines interleukin 1 and tumour necrosis factor. Biochem J (1994) 0.77
Regulation of GLUT1 in response to cellular stress. Biochem Soc Trans (1997) 0.76
The inhibition of interleukin 1-stimulated cartilage proteoglycan degradation by cysteine endopeptidase inactivators. Agents Actions Suppl (1993) 0.76
Interleukin 1 increases the production of collagenase but does not influence the phagocytosis of collagen fibrils. Matrix (1990) 0.76
Isolation and characterization of tryase, a serine proteinase from rat liver. Biochem J (1981) 0.75
Hydrolysis of the elastase substrate succinyltrialanine nitroanilide by a metal-dependent enzyme in rheumatoid synovial fluid. J Clin Invest (1977) 0.75
Specific detection of an interleukin 1- and tumour necrosis factor-activated beta-casein kinase in HeLa and KB cells. Cytokine (1997) 0.75
Studies on the murine interleukin-1 receptor. Dev Biol Stand (1988) 0.75