Published in J Lipid Res on April 20, 2011
Assessing cholesterol storage in live cells and C. elegans by stimulated Raman scattering imaging of phenyl-Diyne cholesterol. Sci Rep (2015) 0.96
RNAi-based functional profiling of loci from blood lipid genome-wide association studies identifies genes with cholesterol-regulatory function. PLoS Genet (2013) 0.94
Analysis of cholesterol trafficking with fluorescent probes. Methods Cell Biol (2012) 0.91
A comparative study on fluorescent cholesterol analogs as versatile cellular reporters. J Lipid Res (2015) 0.90
Echovirus 1 entry into polarized Caco-2 cells depends on dynamin, cholesterol, and cellular factors associated with macropinocytosis. J Virol (2013) 0.89
Systemic AAV9 gene transfer in adult GM1 gangliosidosis mice reduces lysosomal storage in CNS and extends lifespan. Hum Mol Genet (2015) 0.82
Not on the menu: autophagy-independent clearance of prions. Prion (2013) 0.78
Bis(monoacylglycero)phosphate: a secondary storage lipid in the gangliosidoses. J Lipid Res (2015) 0.78
Simvastatin induced neurite outgrowth unveils role of cell surface cholesterol and acetyl CoA carboxylase in SH-SY5Y cells. PLoS One (2013) 0.76
Fluorescent Sterols and Cholesteryl Esters as Probes for Intracellular Cholesterol Transport. Lipid Insights (2016) 0.75
Interleaflet Coupling, Pinning, and Leaflet Asymmetry-Major Players in Plasma Membrane Nanodomain Formation. Front Cell Dev Biol (2017) 0.75
A Molecular Probe for the Detection of Polar Lipids in Live Cells. PLoS One (2016) 0.75
Filipin-dependent inhibition of cholera toxin: evidence for toxin internalization and activation through caveolae-like domains. J Cell Biol (1998) 4.94
Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progression. PLoS One (2009) 2.90
Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro. Mol Cell Biol (2004) 2.65
Alterations in the permeability of Neurospora crassa due to polyene antibiotics. J Bacteriol (1961) 2.62
Studies on the biological properties of polyene antibiotics. Evidence for the direct interaction of filipin with cholesterol. J Biol Chem (1972) 2.47
Order of lipid phases in model and plasma membranes. Proc Natl Acad Sci U S A (2009) 2.47
Cholesterol modulates membrane traffic along the endocytic pathway in sphingolipid-storage diseases. Nat Cell Biol (1999) 2.16
Cyclodextrin overcomes the transport defect in nearly every organ of NPC1 mice leading to excretion of sequestered cholesterol as bile acid. J Lipid Res (2009) 1.87
Jamming the endosomal system: lipid rafts and lysosomal storage diseases. Trends Cell Biol (2000) 1.85
Differential subcellular localization of cholesterol, gangliosides, and glycosaminoglycans in murine models of mucopolysaccharide storage disorders. J Comp Neurol (2004) 1.74
Analysis of brain lipids by high performance thin-layer chromatography and densitometry. J Lipid Res (1983) 1.71
Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells. Proc Natl Acad Sci U S A (2009) 1.69
GM1-ganglioside accumulation at the mitochondria-associated ER membranes links ER stress to Ca(2+)-dependent mitochondrial apoptosis. Mol Cell (2009) 1.66
Storage solutions: treating lysosomal disorders of the brain. Nat Rev Neurosci (2005) 1.65
GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis. Mol Cell (2004) 1.64
Secondary accumulation of gangliosides in lysosomal storage disorders. Semin Cell Dev Biol (2004) 1.34
GM1 gangliosidosis: review of clinical, molecular, and therapeutic aspects. Mol Genet Metab (2008) 1.33
Cholesterol accumulation in NPC1-deficient neurons is ganglioside dependent. Curr Biol (2003) 1.33
Lipidomic analysis and electron transport chain activities in C57BL/6J mouse brain mitochondria. J Neurochem (2008) 1.29
Accumulation of cholera toxin and GM1 ganglioside in the early endosome of Niemann-Pick C1-deficient cells. Proc Natl Acad Sci U S A (2001) 1.28
Generalized CNS disease and massive GM1-ganglioside accumulation in mice defective in lysosomal acid beta-galactosidase. Hum Mol Genet (1997) 1.24
Sphingolipid storage induces accumulation of intracellular cholesterol by stimulating SREBP-1 cleavage. J Biol Chem (2003) 1.23
Multi-system disorders of glycosphingolipid and ganglioside metabolism. J Lipid Res (2010) 1.22
Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport. J Biol Chem (2004) 1.22
Cholesterol reporter molecules. Biosci Rep (2007) 1.20
Paper chromatography of antifungal antibiotics. Appl Microbiol (1955) 1.14
Glycosphingolipid accumulation inhibits cholesterol efflux via the ABCA1/apolipoprotein A-I pathway: 1-phenyl-2-decanoylamino-3-morpholino-1-propanol is a novel cholesterol efflux accelerator. J Biol Chem (2005) 1.07
An electrophoretic variant of beta-galactosidase with altered catalytic properties in a patient with GM1 gangliosidosis. Proc Natl Acad Sci U S A (1975) 1.06
Rapid preparation of nuclei-depleted detergent-resistant membrane fractions suitable for proteomics analysis. BMC Cell Biol (2008) 1.03
The filipin complex. Biochemistry (1968) 1.02
Substrate reduction reduces gangliosides in postnatal cerebrum-brainstem and cerebellum in GM1 gangliosidosis mice. J Lipid Res (2005) 1.02
Complete correction of enzymatic deficiency and neurochemistry in the GM1-gangliosidosis mouse brain by neonatal adeno-associated virus-mediated gene delivery. Mol Ther (2007) 1.01
Gangliosides as apoptotic signals in ER stress response. Cell Death Differ (2006) 1.01
Filipin as a cholesterol probe. I. Morphology of filipin-cholesterol interaction in lipid model systems. Eur J Cell Biol (1984) 0.96
N-butyldeoxygalactonojirimycin reduces neonatal brain ganglioside content in a mouse model of GM1 gangliosidosis. J Neurochem (2004) 0.94
Inheritance of lysosomal acid beta-galactosidase activity and gangliosides in crosses of DBA/2J and knockout mice. Biochem Genet (2004) 0.92
Increased levels of GM2 ganglioside in fibroblasts from a patient with juvenile Niemann-Pick disease type C. Brain Dev (1998) 0.89
Fluorometric evidence for the binding of cholesterol to the filipin complex. J Antibiot (Tokyo) (1971) 0.86
Oxidation products of cholesteryl linoleate are resistant to hydrolysis in macrophages, form complexes with proteins, and are present in human atherosclerotic lesions. J Lipid Res (1997) 0.85
Detergent-resistant membrane subfractions containing proteins of plasma membrane, mitochondrial, and internal membrane origins. J Biochem Biophys Methods (2007) 0.82
Filipin as a fluorescent probe of lipoprotein-derived sterols on thin-layer chromatograms. Anal Biochem (1996) 0.81
Abnormalities of cerebral lipids in GM1-gangliosidoses, infantile, juvenile, and chronic type. Jpn J Exp Med (1986) 0.81
A comparative study of cytoplasmic granules imaged by the real-time microscope, Nile Red and Filipin in fibroblasts from patients with lipid storage diseases. J Inherit Metab Dis (2005) 0.80
Lipid composition of whole brain and cerebellum in Hurler syndrome (MPS IH) mice. Neurochem Res (2011) 0.79
Distinct alterations in phospholipid metabolism in brains of apolipoprotein E-deficient mice. J Neurosci Res (1999) 0.78
Quantified increases of cholesterol, total lipid and globotriaosylceramide in filipin-positive Niemann-Pick type C fibroblasts. Clin Chim Acta (2001) 0.78
Cholesterol and Abeta aggregation. Pharmacopsychiatry (2003) 0.78
Early diagnosis and prevention of genetic disease. Ann Clin Biochem (1979) 0.78
Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease. Nat Med (2007) 2.57
The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer. Nutr Metab (Lond) (2007) 1.75
Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report. Nutr Metab (Lond) (2010) 1.46
Cardiolipin and electron transport chain abnormalities in mouse brain tumor mitochondria: lipidomic evidence supporting the Warburg theory of cancer. J Lipid Res (2008) 1.44
Antiangiogenic and proapoptotic effects of dietary restriction on experimental mouse and human brain tumors. Clin Cancer Res (2004) 1.37
Perspectives on the metabolic management of epilepsy through dietary reduction of glucose and elevation of ketone bodies. J Neurochem (2003) 1.36
Pericyte deficiencies lead to aberrant tumor vascularizaton in the brain of the NG2 null mouse. Dev Biol (2010) 1.34
Lipidomic analysis and electron transport chain activities in C57BL/6J mouse brain mitochondria. J Neurochem (2008) 1.29
Management of multifactorial idiopathic epilepsy in EL mice with caloric restriction and the ketogenic diet: role of glucose and ketone bodies. Nutr Metab (Lond) (2004) 1.22
Up-regulation of NG2 proteoglycan and interferon-induced transmembrane proteins 1 and 3 in mouse astrocytoma: a membrane proteomics approach. Cancer Lett (2008) 1.22
A single intravenous rAAV injection as late as P20 achieves efficacious and sustained CNS Gene therapy in Canavan mice. Mol Ther (2013) 1.19
Metastatic cancer cells with macrophage properties: evidence from a new murine tumor model. Int J Cancer (2008) 1.13
Caloric restriction in C57BL/6J mice mimics therapeutic fasting in humans. Lipids Health Dis (2006) 1.12
Differentiating N-linked glycan structural isomers in metastatic and nonmetastatic tumor cells using sequential mass spectrometry. Glycobiology (2008) 1.11
Drug/diet synergy for managing malignant astrocytoma in mice: 2-deoxy-D-glucose and the restricted ketogenic diet. Nutr Metab (Lond) (2008) 1.07
Itaconic acid is a mammalian metabolite induced during macrophage activation. J Am Chem Soc (2011) 1.06
Dynamic simulation of cardiolipin remodeling: greasing the wheels for an interpretative approach to lipidomics. J Lipid Res (2010) 1.05
Differential effects of energy stress on AMPK phosphorylation and apoptosis in experimental brain tumor and normal brain. Mol Cancer (2008) 1.04
Akt-dependent proapoptotic effects of dietary restriction on late-stage management of a phosphatase and tensin homologue/tuberous sclerosis complex 2-deficient mouse astrocytoma. Clin Cancer Res (2008) 1.04
A novel pre-clinical in vivo mouse model for malignant brain tumor growth and invasion. J Neurooncol (2010) 1.03
The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer. PLoS One (2013) 1.02
Hypothesis: are neoplastic macrophages/microglia present in glioblastoma multiforme? ASN Neuro (2011) 1.00
Therapeutic response in feline sandhoff disease despite immunity to intracranial gene therapy. Mol Ther (2013) 0.97
AAV-mediated gene delivery in adult GM1-gangliosidosis mice corrects lysosomal storage in CNS and improves survival. PLoS One (2010) 0.96
Glutamine targeting inhibits systemic metastasis in the VM-M3 murine tumor model. Int J Cancer (2010) 0.95
Glucose-dependent de novo lipogenesis in B lymphocytes: a requirement for atp-citrate lyase in lipopolysaccharide-induced differentiation. J Biol Chem (2014) 0.95
N-butyldeoxygalactonojirimycin reduces neonatal brain ganglioside content in a mouse model of GM1 gangliosidosis. J Neurochem (2004) 0.94
Neurochemical, morphological, and neurophysiological abnormalities in retinas of Sandhoff and GM1 gangliosidosis mice. J Neurochem (2007) 0.94
Sexual dysfunction and sudden death in epileptic male EL mice: inheritance and prevention with the ketogenic diet. Epilepsia (2003) 0.93
Glycolipid and ganglioside metabolism imbalances in Huntington's disease. Neurobiol Dis (2007) 0.93
Influence of caloric restriction on motor behavior, longevity, and brain lipid composition in Sandhoff disease mice. J Neurosci Res (2006) 0.93
N-butyldeoxygalactonojirimycin reduces brain ganglioside and GM2 content in neonatal Sandhoff disease mice. Neurochem Int (2007) 0.92
Thematic review series: sphingolipids. Ganglioside GM3 suppresses the proangiogenic effects of vascular endothelial growth factor and ganglioside GD1a. J Lipid Res (2008) 0.92
Inheritance of lysosomal acid beta-galactosidase activity and gangliosides in crosses of DBA/2J and knockout mice. Biochem Genet (2004) 0.92
Oxygenation prevents sudden death in seizure-prone mice. Epilepsia (2004) 0.91
Influence of caloric restriction on constitutive expression of NF-κB in an experimental mouse astrocytoma. PLoS One (2011) 0.91
Calorie restriction as an anti-invasive therapy for malignant brain cancer in the VM mouse. ASN Neuro (2010) 0.90
Hippocampal neurons and glia in epileptic EL mice. J Neurocytol (2003) 0.90
Influence of methotrexate and cisplatin on tumor progression and survival in the VM mouse model of systemic metastatic cancer. Int J Cancer (2010) 0.89
Comparative analysis of brain lipids in mice, cats, and humans with Sandhoff disease. Lipids (2008) 0.88
Examination of the brain mitochondrial lipidome using shotgun lipidomics. Methods Mol Biol (2009) 0.87
Improvement in motor and exploratory behavior in Rett syndrome mice with restricted ketogenic and standard diets. Epilepsy Behav (2009) 0.86
Perspectives on the mesenchymal origin of metastatic cancer. Cancer Metastasis Rev (2010) 0.86
Brain mitochondrial lipid abnormalities in mice susceptible to spontaneous gliomas. Lipids (2008) 0.86
In vitro growth environment produces lipidomic and electron transport chain abnormalities in mitochondria from non-tumorigenic astrocytes and brain tumours. ASN Neuro (2009) 0.86
Gene-linked shift in ganglioside distribution influences growth and vascularity in a mouse astrocytoma. J Neurochem (2006) 0.85
Absence of pathogenic mitochondrial DNA mutations in mouse brain tumors. BMC Cancer (2005) 0.85
Does the existing standard of care increase glioblastoma energy metabolism? Lancet Oncol (2010) 0.84
Cerebellar lipid differences between R6/1 transgenic mice and humans with Huntington's disease. J Neurochem (2010) 0.82
A mathematical model for the determination of steady-state cardiolipin remodeling mechanisms using lipidomic data. PLoS One (2011) 0.82
Dietary restriction promotes vessel maturation in a mouse astrocytoma. J Oncol (2011) 0.80
The EL mouse: a natural model of autism and epilepsy. Epilepsia (2011) 0.80
Ethylenedioxy-PIP2 oxalate reduces ganglioside storage in juvenile Sandhoff disease mice. Neurochem Res (2013) 0.80
Lipid composition of whole brain and cerebellum in Hurler syndrome (MPS IH) mice. Neurochem Res (2011) 0.79
Peripheral nervous system manifestations in a Sandhoff disease mouse model: nerve conduction, myelin structure, lipid analysis. J Negat Results Biomed (2007) 0.79
Autosomal dominant inheritance of brain cardiolipin fatty acid abnormality in VM/DK mice: association with hypoxic-induced cognitive insensitivity. Lipids (2013) 0.78
Restricted ketogenic diet enhances the therapeutic action of N-butyldeoxynojirimycin towards brain GM2 accumulation in adult Sandhoff disease mice. J Neurochem (2010) 0.77
Brain lipid analysis in mice with Rett syndrome. Neurochem Res (2008) 0.77
Bis(monoacylglycero)phosphate as a Macrophage Enriched Phospholipid. Lipids (2015) 0.76
Behavioral seizure correlates in animal models of epilepsy: a road map for assay selection, data interpretation, and the search for causal mechanisms. Epilepsy Behav (2006) 0.75
Ganglioside storage diseases: on the road to management. Adv Neurobiol (2014) 0.75