Study of Mental Activity and Regular Training (SMART) in at risk individuals: a randomised double blind, sham controlled, longitudinal trial.

PubWeight™: 0.80‹?›

🔗 View Article (PMC 3110111)

Published in BMC Geriatr on April 21, 2011

Authors

Nicola J Gates1, Michael Valenzuela, Perminder S Sachdev, Nalin A Singh, Bernhard T Baune, Henry Brodaty, Chao Suo, Nidhi Jain, Guy C Wilson, Yi Wang, Michael K Baker, Dominique Williamson, Nasim Foroughi, Maria A Fiatarone Singh

Author Affiliations

1: School of Psychiatry, University of New South Wales, and Neuropsychiatric Institute, Prince of Wales Hospital, Randwick NSW 2031, Australia. nicola.gates@student.unsw.edu.au

Associated clinical trials:

Cognitive-motor Rehabilitation Program Using Virtual Reality for Middle-aged Individuals at High Dementia Risk | NCT02832921

Articles cited by this

"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res (1975) 301.74

The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care (1992) 144.02

Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res (1983) 41.26

A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol (1994) 30.72

A new clinical scale for the staging of dementia. Br J Psychiatry (1982) 21.77

The mini-mental state examination: a comprehensive review. J Am Geriatr Soc (1992) 15.32

Progress in development of the index of ADL. Gerontologist (1970) 15.21

A new rating scale for Alzheimer's disease. Am J Psychiatry (1984) 15.16

Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychol Sci (2003) 11.59

The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. Behav Res Ther (1995) 11.36

Effects of cognitive training interventions with older adults: a randomized controlled trial. JAMA (2002) 9.87

The structure of psychological well-being revisited. J Pers Soc Psychol (1995) 9.68

Leisure activities and the risk of dementia in the elderly. N Engl J Med (2003) 8.77

The 6-minute walk: a new measure of exercise capacity in patients with chronic heart failure. Can Med Assoc J (1985) 8.06

Long-term effects of cognitive training on everyday functional outcomes in older adults. JAMA (2006) 7.60

Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older. Ann Intern Med (2006) 7.14

Aerobic exercise training increases brain volume in aging humans. J Gerontol A Biol Sci Med Sci (2006) 6.89

Participation in cognitively stimulating activities and risk of incident Alzheimer disease. JAMA (2002) 6.18

Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci (2007) 5.20

Education and the prevalence of dementia and Alzheimer's disease. Neurology (1993) 4.68

Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. Eur J Neurosci (2004) 4.64

Enriched environments, experience-dependent plasticity and disorders of the nervous system. Nat Rev Neurosci (2006) 4.08

Cholinesterase inhibitors for patients with Alzheimer's disease: systematic review of randomised clinical trials. BMJ (2005) 3.83

Methods and processes of the CONSORT Group: example of an extension for trials assessing nonpharmacologic treatments. Ann Intern Med (2008) 3.63

A cognitive training program based on principles of brain plasticity: results from the Improvement in Memory with Plasticity-based Adaptive Cognitive Training (IMPACT) study. J Am Geriatr Soc (2009) 3.58

Utility of TICS-M for the assessment of cognitive function in older adults. Int J Geriatr Psychiatry (2003) 3.56

Memory enhancement in healthy older adults using a brain plasticity-based training program: a randomized, controlled study. Proc Natl Acad Sci U S A (2006) 3.35

Estimation of skeletal muscle mass by bioelectrical impedance analysis. J Appl Physiol (1985) (2000) 3.31

Brain reserve and dementia: a systematic review. Psychol Med (2005) 3.24

Perceived exertion: a note on "history" and methods. Med Sci Sports (1973) 2.81

Validation of tetrapolar bioelectrical impedance method to assess human body composition. J Appl Physiol (1985) (1986) 2.77

Exercise comes of age: rationale and recommendations for a geriatric exercise prescription. J Gerontol A Biol Sci Med Sci (2002) 2.57

Administration and interpretation of the Trail Making Test. Nat Protoc (2006) 2.18

The impact of resistance exercise on the cognitive function of the elderly. Med Sci Sports Exerc (2007) 1.94

Abbreviating the Duke Social Support Index for use in chronically ill elderly individuals. Psychosomatics (1993) 1.94

The Quality of Life Scale (QOLS): reliability, validity, and utilization. Health Qual Life Outcomes (2003) 1.88

Brain reserve and cognitive decline: a non-parametric systematic review. Psychol Med (2006) 1.82

A cross-sectional validation study of the FICSIT common data base static balance measures. Frailty and Injuries: Cooperative Studies of Intervention Techniques. J Gerontol A Biol Sci Med Sci (1995) 1.71

Improvement of cognitive function by mental and/or individualized aerobic training in healthy elderly subjects. Int J Sports Med (2002) 1.70

The GPCOG: a new screening test for dementia designed for general practice. J Am Geriatr Soc (2002) 1.57

The Bayer Activities of Daily Living Scale (B-ADL). Dement Geriatr Cogn Disord (1998) 1.53

Clinical trials in mild cognitive impairment: lessons for the future. J Neurol Neurosurg Psychiatry (2005) 1.47

Subjective Memory Impairment. A review of its definitions indicates the need for a comprehensive set of standardised and validated criteria. Eur Psychiatry (2008) 1.31

Endurance and strength training outcomes on cognitively impaired and cognitively intact older adults: a meta-analysis. J Nutr Health Aging (2008) 1.24

Memory training alters hippocampal neurochemistry in healthy elderly. Neuroreport (2003) 1.24

Long-term improvements in cognitive performance through computer-assisted cognitive training: a pilot study in a residential home for older people. Aging Ment Health (2003) 1.18

Assessment of complex mental activity across the lifespan: development of the Lifetime of Experiences Questionnaire (LEQ). Psychol Med (2006) 1.14

Methodological issues in primary prevention trials for neurodegenerative dementia. J Alzheimers Dis (2009) 1.04

BDNF, metabolic risk factors, and resistance training in middle-aged individuals. Med Sci Sports Exerc (2008) 1.03

The Bayer-Activities of Daily Living Scale (B-ADL): results from a validation study in three European countries. Dement Geriatr Cogn Disord (2001) 1.02

The Alzheimer's Disease Assessment Scale-Cognitive subscale: normative data for older adult controls. Alzheimer Dis Assoc Disord (2004) 0.94

Cognitive health benefits of strengthening exercise for community-dwelling older adults. J Clin Exp Neuropsychol (2010) 0.92

The characteristics of patients with uncertain/mild cognitive impairment on the Alzheimer disease assessment scale-cognitive subscale. Alzheimer Dis Assoc Disord (2006) 0.80

The Bayer: Activities of Daily Living Scale (B-ADL) in the differentiation between mild to moderate dementia and normal aging. Rev Bras Psiquiatr (2008) 0.77

Articles by these authors

A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39

Global prevalence of dementia: a Delphi consensus study. Lancet (2005) 23.30

Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27

Mild cognitive impairment. Lancet (2006) 10.21

American College of Sports Medicine position stand. Exercise and physical activity for older adults. Med Sci Sports Exerc (2009) 8.89

Signaling networks assembled by oncogenic EGFR and c-Met. Proc Natl Acad Sci U S A (2008) 5.08

The connectome of a decision-making neural network. Science (2012) 3.70

Structural mechanism of plant aquaporin gating. Nature (2005) 3.64

A protein kinase, interacting with two calcineurin B-like proteins, regulates K+ transporter AKT1 in Arabidopsis. Cell (2006) 3.58

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev (2002) 3.49

Quantitative susceptibility map reconstruction from MR phase data using bayesian regularization: validation and application to brain imaging. Magn Reson Med (2010) 3.43

Benign prostatic hyperplasia: prostatic arterial embolization versus transurethral resection of the prostate--a prospective, randomized, and controlled clinical trial. Radiology (2013) 3.32

Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinoma. PLoS One (2011) 3.10

Calculation of susceptibility through multiple orientation sampling (COSMOS): a method for conditioning the inverse problem from measured magnetic field map to susceptibility source image in MRI. Magn Reson Med (2009) 3.03

Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast. Mol Cell (2008) 3.01

Analysis of the human endogenous coregulator complexome. Cell (2011) 2.97

Genomic dissection of population substructure of Han Chinese and its implication in association studies. Am J Hum Genet (2009) 2.93

Optimizing de novo transcriptome assembly from short-read RNA-Seq data: a comparative study. BMC Bioinformatics (2011) 2.88

Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases. Sci Signal (2010) 2.64

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine. Nature (2013) 2.52

Nonpharmacological therapies in Alzheimer's disease: a systematic review of efficacy. Dement Geriatr Cogn Disord (2010) 2.49

The updated biology of hypoxia-inducible factor. EMBO J (2012) 2.49

Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis. Autophagy (2011) 2.47

High-velocity resistance training increases skeletal muscle peak power in older women. J Am Geriatr Soc (2002) 2.44

Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. Gastroenterology (2006) 2.43

Exploration of gene-gene interaction effects using entropy-based methods. Eur J Hum Genet (2007) 2.42

Caring for Aged Dementia Care Resident Study (CADRES) of person-centred care, dementia-care mapping, and usual care in dementia: a cluster-randomised trial. Lancet Neurol (2009) 2.38

Intracranial calcifications and hemorrhages: characterization with quantitative susceptibility mapping. Radiology (2013) 2.29

Integration of balance and strength training into daily life activity to reduce rate of falls in older people (the LiFE study): randomised parallel trial. BMJ (2012) 2.29

Childhood obesity in Australia remains a widespread health concern that warrants population-wide prevention programs. Med J Aust (2009) 2.24

[Malaria situation in the People's Republic of China in 2010]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi (2011) 2.13

Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. Nat Genet (2011) 2.13

Mutations in SLC20A2 are a major cause of familial idiopathic basal ganglia calcification. Neurogenetics (2013) 2.11

A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints. J Biol Chem (2007) 2.09

Quantitative MR susceptibility mapping using piece-wise constant regularized inversion of the magnetic field. Magn Reson Med (2008) 2.09

Robust isothermal electric control of exchange bias at room temperature. Nat Mater (2010) 2.09

High-intensity progressive resistance training improves flat-ground walking in older adults with symptomatic peripheral arterial disease. J Am Geriatr Soc (2013) 2.08

Meta-analysis of effectiveness of first-generation drug-eluting stents versus coronary artery bypass grafting for unprotected left main coronary disease. Am J Cardiol (2012) 2.07

ZNF804A and schizophrenia susceptibility in Asian populations. Am J Med Genet B Neuropsychiatr Genet (2012) 2.06

Morphology enabled dipole inversion (MEDI) from a single-angle acquisition: comparison with COSMOS in human brain imaging. Magn Reson Med (2011) 2.05

Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents. Bioorg Med Chem (2008) 2.03

Nonlinear regularization for per voxel estimation of magnetic susceptibility distributions from MRI field maps. IEEE Trans Med Imaging (2009) 2.02

Determinants of disparities between perceived and physiological risk of falling among elderly people: cohort study. BMJ (2010) 2.02

Morphology enabled dipole inversion for quantitative susceptibility mapping using structural consistency between the magnitude image and the susceptibility map. Neuroimage (2011) 2.02

Increased risk of cognitive impairment in patients with diabetes is associated with metformin. Diabetes Care (2013) 1.99

A multifactorial approach to understanding fall risk in older people. J Am Geriatr Soc (2010) 1.97

The effects of multidimensional home-based exercise on functional performance in elderly people. J Gerontol A Biol Sci Med Sci (2004) 1.97

Association of Vimentin overexpression and hepatocellular carcinoma metastasis. Oncogene (2004) 1.94

Loss of Insl3: a potential predisposing factor for testicular torsion. J Urol (2010) 1.93

Anthropometric assessment of 10-y changes in body composition in the elderly. Am J Clin Nutr (2004) 1.92

Diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease: a review. Curr Opin Neurol (2008) 1.92

cAMP-dependent protein kinase A selects the excited state of the membrane substrate phospholamban. J Mol Biol (2011) 1.90

The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging Behav (2014) 1.90

A novel background field removal method for MRI using projection onto dipole fields (PDF). NMR Biomed (2011) 1.88

A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. Stem Cells Dev (2009) 1.87

EZH2 protein: a promising immunomarker for the detection of hepatocellular carcinomas in liver needle biopsies. Gut (2011) 1.87

GWAS identifies novel susceptibility loci on 6p21.32 and 21q21.3 for hepatocellular carcinoma in chronic hepatitis B virus carriers. PLoS Genet (2012) 1.86

Management of agitation and aggression associated with Alzheimer disease. Nat Rev Neurol (2009) 1.86

A three-country randomized controlled trial of a psychosocial intervention for caregivers combined with pharmacological treatment for patients with Alzheimer disease: effects on caregiver depression. Am J Geriatr Psychiatry (2008) 1.81

An international consensus study of neuroleptic malignant syndrome diagnostic criteria using the Delphi method. J Clin Psychiatry (2011) 1.80

Multiple biological pathways link cognitive lifestyle to protection from dementia. Biol Psychiatry (2011) 1.79

A spatially organized representation of colour in macaque cortical area V2. Nature (2003) 1.75

A randomized controlled trial of high versus low intensity weight training versus general practitioner care for clinical depression in older adults. J Gerontol A Biol Sci Med Sci (2005) 1.74

A new XRCC1-containing complex and its role in cellular survival of methyl methanesulfonate treatment. Mol Cell Biol (2004) 1.73

Synthesis of mono-carbonyl analogues of curcumin and their effects on inhibition of cytokine release in LPS-stimulated RAW 264.7 macrophages. Bioorg Med Chem (2010) 1.73

Changing malaria transmission and implications in China towards National Malaria Elimination Programme between 2010 and 2012. PLoS One (2013) 1.72

Streamlined analysis schema for high-throughput identification of endogenous protein complexes. Proc Natl Acad Sci U S A (2010) 1.72

Validity of parent-reported vaccination status for adolescents aged 13-17 years: National Immunization Survey-Teen, 2008. Public Health Rep (2011) 1.71

A 4-gigabase physical map unlocks the structure and evolution of the complex genome of Aegilops tauschii, the wheat D-genome progenitor. Proc Natl Acad Sci U S A (2013) 1.70

Oxidative modification of von Willebrand factor by neutrophil oxidants inhibits its cleavage by ADAMTS13. Blood (2009) 1.70

Ultrasound-guided establishment of hip arthroscopy portals. Arthroscopy (2009) 1.67

Cervical cancer screening and management practices among providers in the National Breast and Cervical Cancer Early Detection Program (NBCCEDP). Cancer (2007) 1.66

Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia. Blood (2006) 1.65

Prevalence, incidence, and risk factors of lacunar infarcts in a community sample. Neurology (2009) 1.64

Fast photoacoustic imaging system based on 320-element linear transducer array. Phys Med Biol (2004) 1.63

Molecular dynamics simulations of proteins in lipid bilayers. Curr Opin Struct Biol (2005) 1.62

Nonlinear formulation of the magnetic field to source relationship for robust quantitative susceptibility mapping. Magn Reson Med (2012) 1.62

Discrete neuroanatomical networks are associated with specific cognitive abilities in old age. J Neurosci (2011) 1.61

Power training improves balance in healthy older adults. J Gerontol A Biol Sci Med Sci (2006) 1.59

Lifespan mental activity predicts diminished rate of hippocampal atrophy. PLoS One (2008) 1.59

Fine mapping and identification of a candidate gene SSH1 in disseminated superficial actinic porokeratosis. Hum Mutat (2004) 1.59

Mitral apparatus assessment by delayed enhancement CMR: relative impact of infarct distribution on mitral regurgitation. JACC Cardiovasc Imaging (2013) 1.58

DNA methylation downregulated mir-10b acts as a tumor suppressor in gastric cancer. Gastric Cancer (2014) 1.56

Neuroimmunological effects of physical exercise in depression. Brain Behav Immun (2011) 1.54

BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/beta-catenin signalling. J Cell Mol Med (2008) 1.54

Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation defects. Lab Invest (2008) 1.54

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics (2013) 1.53

Conserved recurrent gene mutations correlate with pathway deregulation and clinical outcomes of lung adenocarcinoma in never-smokers. BMC Med Genomics (2014) 1.53

Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress. Proc Natl Acad Sci U S A (2011) 1.52

Radiolabeling of MAG3-morpholino oligomers with 188Re at high labeling efficiency and specific radioactivity for tumor pretargeting. Appl Radiat Isot (2006) 1.52

Abnormalities of the fornix in mild cognitive impairment are related to episodic memory loss. J Alzheimers Dis (2012) 1.52

Neuropsychiatric symptoms in Alzheimer's disease: past progress and anticipation of the future. Alzheimers Dement (2013) 1.51

Chinese water-pipe smoking and the risk of COPD. Chest (2014) 1.51

[Malaria situation in the People's Republic Of China in 2007]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi (2008) 1.50

[Malaria situation in the People's Republic of China in 2006]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi (2007) 1.50

Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells. J Biol Chem (2008) 1.48

Efficient synthesis of imidazoles from aldehydes and 1,2-diketones using microwave irradiation. Org Lett (2004) 1.48

Contrast-enhanced anatomic imaging as compared to contrast-enhanced tissue characterization for detection of left ventricular thrombus. JACC Cardiovasc Imaging (2009) 1.48

The Falls Efficacy Scale International (FES-I). A comprehensive longitudinal validation study. Age Ageing (2010) 1.48