Published in Brain on April 22, 2011
Mathematical modeling of PDGF-driven glioblastoma reveals optimized radiation dosing schedules. Cell (2014) 1.79
The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance. EMBO Mol Med (2013) 1.59
Current strategies for identification of glioma stem cells: adequate or unsatisfactory? J Oncol (2012) 1.40
Chondroitin sulfate proteoglycans potently inhibit invasion and serve as a central organizer of the brain tumor microenvironment. J Neurosci (2013) 1.20
Size Does Matter: Why Polyploid Tumor Cells are Critical Drug Targets in the War on Cancer. Front Oncol (2014) 1.00
Glioblastoma multiforme therapy and mechanisms of resistance. Pharmaceuticals (Basel) (2013) 1.00
Isolation and expansion of human glioblastoma multiforme tumor cells using the neurosphere assay. J Vis Exp (2011) 0.98
Constitutive activation of myosin-dependent contractility sensitizes glioma tumor-initiating cells to mechanical inputs and reduces tissue invasion. Cancer Res (2015) 0.98
Twisted tango: brain tumor neurovascular interactions. Nat Neurosci (2011) 0.95
Marker-independent method for isolating slow-dividing cancer stem cells in human glioblastoma. Neoplasia (2013) 0.95
AAV ancestral reconstruction library enables selection of broadly infectious viral variants. Gene Ther (2015) 0.91
Perivascular stem cell niche in head and neck cancer. Cancer Lett (2012) 0.90
CDC20 maintains tumor initiating cells. Oncotarget (2015) 0.90
Glioblastoma stem cells: Molecular characteristics and therapeutic implications. World J Stem Cells (2014) 0.86
Strategies for isolating and enriching cancer stem cells: well begun is half done. Stem Cells Dev (2013) 0.84
Multiplex mapping of chromatin accessibility and DNA methylation within targeted single molecules identifies epigenetic heterogeneity in neural stem cells and glioblastoma. Genome Res (2013) 0.83
Stem-like cells and therapy resistance in squamous cell carcinomas. Adv Pharmacol (2012) 0.83
Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate. Nat Biotechnol (2016) 0.82
Decoding the cancer stem cell hypothesis in glioblastoma. CNS Oncol (2013) 0.82
Expression and functional heterogeneity of chemokine receptors CXCR4 and CXCR7 in primary patient-derived glioblastoma cells. PLoS One (2013) 0.82
p53 upregulated modulator of apoptosis sensitizes drug-resistant U251 glioblastoma stem cells to temozolomide through enhanced apoptosis. Mol Med Rep (2015) 0.80
A microRNA Link to Glioblastoma Heterogeneity. Cancers (Basel) (2012) 0.80
A comprehensive profile of recurrent glioblastoma. Oncogene (2016) 0.79
Detection of primary cilia in human glioblastoma. J Neurooncol (2014) 0.79
An inhibitor of K+ channels modulates human endometrial tumor-initiating cells. Cancer Cell Int (2011) 0.79
Transforming growth factor β1-induced astrocyte migration is mediated in part by activating 5-lipoxygenase and cysteinyl leukotriene receptor 1. J Neuroinflammation (2012) 0.79
Histological Characterization of the Tumorigenic "Peri-Necrotic Niche" Harboring Quiescent Stem-Like Tumor Cells in Glioblastoma. PLoS One (2016) 0.79
Cancer Stem Cell Quiescence and Plasticity as Major Challenges in Cancer Therapy. Stem Cells Int (2016) 0.78
Docetaxel-induced polyploidization may underlie chemoresistance and disease relapse. Cancer Lett (2015) 0.78
Targeting MCM2 function as a novel strategy for the treatment of highly malignant breast tumors. Oncotarget (2015) 0.78
Glial progenitors as targets for transformation in glioma. Adv Cancer Res (2014) 0.78
Identification and isolation of slow-dividing cells in human glioblastoma using carboxy fluorescein succinimidyl ester (CFSE). J Vis Exp (2012) 0.77
New treatment strategies to eradicate cancer stem cells and niches in glioblastoma. Neurol Med Chir (Tokyo) (2013) 0.77
Targeting a Plk1-Controlled Polarity Checkpoint in Therapy-Resistant Glioblastoma-Propagating Cells. Cancer Res (2015) 0.77
Precursor States of Brain Tumor Initiating Cell Lines Are Predictive of Survival in Xenografts and Associated with Glioblastoma Subtypes. Stem Cell Reports (2015) 0.77
ASYMMETRIC CELL DIVISION: IMPLICATIONS FOR GLIOMA DEVELOPMENT AND TREATMENT. Transl Neurosci (2013) 0.77
Repair of liver mediated by adult mouse liver neuro-glia antigen 2-positive progenitor cell transplantation in a mouse model of cirrhosis. Sci Rep (2016) 0.77
An overview of therapeutic approaches to brain tumor stem cells. Med J Islam Repub Iran (2012) 0.76
Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis. Oncotarget (2016) 0.76
Potentiation of temozolomide antitumor effect by purine receptor ligands able to restrain the in vitro growth of human glioblastoma stem cells. Purinergic Signal (2015) 0.76
Scalable Production of Glioblastoma Tumor-initiating Cells in 3 Dimension Thermoreversible Hydrogels. Sci Rep (2016) 0.75
Measuring Cell Viscoelastic Properties Using a Microfluidic Extensional Flow Device. Biophys J (2016) 0.75
Radiotherapy followed by aurora kinase inhibition targets tumor-propagating cells in human glioblastoma. Mol Cancer Ther (2014) 0.75
Tumor-initiating cell frequency is relevant for glioblastoma aggressiveness. Oncotarget (2016) 0.75
PCM1 Depletion Inhibits Glioblastoma Cell Ciliogenesis and Increases Cell Death and Sensitivity to Temozolomide. Transl Oncol (2016) 0.75
New Horizons in Enhancing the Proliferation and Differentiation of Neural Stem Cells Using Stimulatory Effects of the Short Time Exposure to Radiofrequency Radiation. J Biomed Phys Eng (2015) 0.75
Label-retaining assay enriches tumor-initiating cells in glioblastoma spheres cultivated in serum-free medium. Oncol Lett (2016) 0.75
Human Cytomegalovirus-Infected Glioblastoma Cells Display Stem Cell-Like Phenotypes. mSphere (2017) 0.75
Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A (2003) 59.17
Stem cells, cancer, and cancer stem cells. Nature (2001) 50.27
The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol (2007) 49.11
Identification of human brain tumour initiating cells. Nature (2004) 38.87
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature (2006) 27.91
Identification and expansion of human colon-cancer-initiating cells. Nature (2006) 24.44
Identification of a cancer stem cell in human brain tumors. Cancer Res (2003) 24.02
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature (1994) 21.59
Identification of pancreatic cancer stem cells. Cancer Res (2007) 18.36
Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell (2006) 15.16
Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res (2004) 14.73
Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res (2005) 13.89
Macrophage diversity enhances tumor progression and metastasis. Cell (2010) 13.41
ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays. J Immunol Methods (2009) 9.00
Identification and expansion of the tumorigenic lung cancer stem cell population. Cell Death Differ (2007) 8.08
Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature (2006) 7.69
Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell (2009) 7.09
Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood (2002) 6.64
A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. Cell (2010) 6.47
CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles. Cancer Res (2007) 6.21
Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic. Cancer Res (2005) 5.87
Brain tumour stem cells. Nat Rev Cancer (2006) 5.84
Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro. Glia (2002) 5.81
Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. Cell (2010) 5.57
Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line. Proc Natl Acad Sci U S A (2004) 5.32
PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. Cell Stem Cell (2009) 4.94
SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma. Cell Stem Cell (2009) 3.89
Analysing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution. J Immunol Methods (2000) 3.89
Stem and progenitor-like cells contribute to the aggressive behavior of human epithelial ovarian cancer. Cancer Res (2005) 3.79
Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma. Stem Cells (2007) 3.47
CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. Int J Cancer (2008) 3.46
Characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells. Biochem Biophys Res Commun (2006) 3.35
A hierarchy of self-renewing tumor-initiating cell types in glioblastoma. Cancer Cell (2010) 3.34
Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia. Blood (1999) 3.33
Replication licensing--defining the proliferative state? Trends Cell Biol (2002) 2.91
Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas. Lab Invest (2008) 2.79
Identification of A2B5+CD133- tumor-initiating cells in adult human gliomas. Neurosurgery (2008) 2.33
Identification of cancer stem cells in Ewing's sarcoma. Cancer Res (2009) 2.15
Neurosphere formation is an independent predictor of clinical outcome in malignant glioma. Stem Cells (2009) 2.10
The utility and limitations of glycosylated human CD133 epitopes in defining cancer stem cells. J Mol Med (Berl) (2008) 2.04
Proliferation of human glioblastoma stem cells occurs independently of exogenous mitogens. Stem Cells (2009) 1.96
Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinoma. Clin Exp Metastasis (2009) 1.71
CD133 is a marker of bioenergetic stress in human glioma. PLoS One (2008) 1.63
Comparative analysis of the frequency and distribution of stem and progenitor cells in the adult mouse brain. Stem Cells (2008) 1.47
Primitive, quiescent and difficult to kill: the role of non-proliferating stem cells in chronic myeloid leukemia. Cell Cycle (2006) 1.43
The MCM complex: its role in DNA replication and implications for cancer therapy. Curr Cancer Drug Targets (2005) 1.29
A2B5 cells from human glioblastoma have cancer stem cell properties. Brain Pathol (2009) 1.28
Isolation, expansion, and differentiation of adult Mammalian neural stem and progenitor cells using the neurosphere assay. Methods Mol Biol (2009) 1.23
Targeting DNA checkpoint kinases in cancer therapy. Cancer Biol Ther (2003) 1.17
Aldehyde dehydrogenase 1 positive glioblastoma cells show brain tumor stem cell capacity. Neuro Oncol (2010) 1.15
How powerful is CD133 as a cancer stem cell marker in brain tumors? Cancer Treat Rev (2009) 1.10
Tumour angiogenesis: its mechanism and therapeutic implications in malignant gliomas. J Clin Neurosci (2009) 1.06
Glioblastoma formation from cell population depleted of Prominin1-expressing cells. PLoS One (2009) 1.05
Deoxycholate promotes survival of breast cancer cells by reducing the level of pro-apoptotic ceramide. Breast Cancer Res (2008) 1.03
Tight junctions: a barrier to the initiation and progression of breast cancer? J Biomed Biotechnol (2009) 1.01
ORC-associated replication factors as biomarkers for cancer. Biotechnol Adv (2004) 0.92
Suppressing glioblastoma stem cell function by aldehyde dehydrogenase inhibition with chloramphenicol or disulfiram as a new treatment adjunct: an hypothesis. Curr Stem Cell Res Ther (2009) 0.89
Inhibitors of the G2 DNA damage checkpoint and their potential for cancer therapy. Prog Cell Cycle Res (2003) 0.84
Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res (2004) 14.73
Brain tumour stem cells. Nat Rev Cancer (2006) 5.84
Plasma membrane nanoswitches generate high-fidelity Ras signal transduction. Nat Cell Biol (2007) 3.90
Quantitation of microRNAs using a modified Invader assay. RNA (2004) 3.12
Mash1 specifies neurons and oligodendrocytes in the postnatal brain. EMBO J (2004) 2.55
Enumeration of neural stem and progenitor cells in the neural colony-forming cell assay. Stem Cells (2008) 2.33
The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition. Genome Biol (2008) 2.29
Patient engagement programs for recognition and initial treatment of depression in primary care: a randomized trial. JAMA (2013) 2.12
Neural stem cell isolation and characterization. Methods Enzymol (2006) 2.03
Health disparities and stroke: the influence of insurance status on the prevalence of patient safety indicators and hospital-acquired conditions. J Neurosurg (2015) 2.03
Isolation and expansion of the adult mouse neural stem cells using the neurosphere assay. J Vis Exp (2010) 1.64
The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance. EMBO Mol Med (2013) 1.59
Skeletal overexpression of gremlin impairs bone formation and causes osteopenia. Endocrinology (2004) 1.58
Midterm clinical and angiographic follow-up for the first Food and Drug Administration-approved prospective, Single-Arm Trial of Primary Stenting for Stroke: SARIS (Stent-Assisted Recanalization for Acute Ischemic Stroke). Neurosurgery (2011) 1.55
The EphA2 receptor drives self-renewal and tumorigenicity in stem-like tumor-propagating cells from human glioblastomas. Cancer Cell (2012) 1.50
Notch signaling in astrocytes and neuroblasts of the adult subventricular zone in health and after cortical injury. Dev Neurosci (2006) 1.48
A histone deacetylase inhibitor, azelaic bishydroxamic acid, shows cytotoxicity on Epstein-Barr virus transformed B-cell lines: a potential therapy for posttransplant lymphoproliferative disease. Transplantation (2002) 1.48
Comparative analysis of the frequency and distribution of stem and progenitor cells in the adult mouse brain. Stem Cells (2008) 1.47
EphA3 maintains tumorigenicity and is a therapeutic target in glioblastoma multiforme. Cancer Cell (2013) 1.44
Tumor cell-selective cytotoxicity by targeting cell cycle checkpoints. FASEB J (2003) 1.43
Nur77 regulates lipolysis in skeletal muscle cells. Evidence for cross-talk between the beta-adrenergic and an orphan nuclear hormone receptor pathway. J Biol Chem (2005) 1.41
Human neural stem cells ameliorate autoimmune encephalomyelitis in non-human primates. Ann Neurol (2009) 1.30
Establishing embryonic mouse neural stem cell culture using the neurosphere assay. J Vis Exp (2011) 1.29
Human T cells armed with Her2/neu bispecific antibodies divide, are cytotoxic, and secrete cytokines with repeated stimulation. Clin Cancer Res (2006) 1.26
Breast cancer stem cells: implications for therapy of breast cancer. Breast Cancer Res (2008) 1.26
Activation of the MAPK module from different spatial locations generates distinct system outputs. Mol Biol Cell (2008) 1.25
Histone-deacetylase inhibitors for the treatment of cancer. Cell Cycle (2004) 1.24
Isolation, expansion, and differentiation of adult Mammalian neural stem and progenitor cells using the neurosphere assay. Methods Mol Biol (2009) 1.23
Chondroitin sulfate proteoglycans potently inhibit invasion and serve as a central organizer of the brain tumor microenvironment. J Neurosci (2013) 1.20
Electrospun micro- and nanofiber tubes for functional nervous regeneration in sciatic nerve transections. BMC Biotechnol (2008) 1.18
CtBPs promote cell survival through the maintenance of mitotic fidelity. Mol Cell Biol (2009) 1.12
Determination of somatic and cancer stem cell self-renewing symmetric division rate using sphere assays. PLoS One (2011) 1.11
Purification of immature neuronal cells from neural stem cell progeny. PLoS One (2011) 1.11
KSR1 modulates the sensitivity of mitogen-activated protein kinase pathway activation in T cells without altering fundamental system outputs. Mol Cell Biol (2009) 1.10
Sonic hedgehog and notch signaling can cooperate to regulate neurogenic divisions of neocortical progenitors. PLoS One (2011) 1.10
Inhibition of S/G2 phase CDK4 reduces mitotic fidelity. J Biol Chem (2006) 1.10
Histone deacetylase inhibitors specifically kill nonproliferating tumour cells. Oncogene (2004) 1.10
The origins of cancer robustness and evolvability. Integr Biol (Camb) (2010) 1.07
Low proliferation and differentiation capacities of adult hippocampal stem cells correlate with memory dysfunction in humans. Brain (2010) 1.07
Isolation and characterization of adult neural stem cells. Methods Mol Biol (2011) 1.06
Abnormal patterns of the renal veins. Anat Cell Biol (2012) 1.06
MicroRNA-182-5p targets a network of genes involved in DNA repair. RNA (2012) 1.06
The cancer stem cell hypothesis: failures and pitfalls. Neurosurgery (2011) 1.04
Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice. Cancer Res (2006) 1.03
What is the biology and optimal treatment for papillary microcarcinoma of the thyroid? J Surg Res (2006) 1.02
Using the neurosphere assay to quantify neural stem cells in vivo. Curr Pharm Biotechnol (2007) 1.02
Analytical performance of the Investigational Use Only Cervista HPV HR test as determined by a multi-center study. J Clin Virol (2009) 1.01
Cyclin A/cdk2 regulates adenomatous polyposis coli-dependent mitotic spindle anchoring. J Biol Chem (2009) 1.00
YB-1 bridges neural stem cells and brain tumor-initiating cells via its roles in differentiation and cell growth. Cancer Res (2011) 1.00
Chemokine receptor CXCR3 promotes growth of glioma. Carcinogenesis (2010) 0.99
The EBNA-3 gene family proteins disrupt the G2/M checkpoint. Oncogene (2004) 0.98
Isolation and expansion of human glioblastoma multiforme tumor cells using the neurosphere assay. J Vis Exp (2011) 0.98
Intravenous neural stem cells abolish nociceptive hypersensitivity and trigger nerve regeneration in experimental neuropathy. Pain (2012) 0.98
NFIX regulates neural progenitor cell differentiation during hippocampal morphogenesis. Cereb Cortex (2012) 0.97
Bromodeoxyuridine induces senescence in neural stem and progenitor cells. Stem Cells (2008) 0.96
Resilience to transformation and inherent genetic and functional stability of adult neural stem cells ex vivo. Cancer Res (2007) 0.96
The mitogen-activated protein kinase scaffold KSR1 is required for recruitment of extracellular signal-regulated kinase to the immunological synapse. Mol Cell Biol (2009) 0.96
Transplantation of nanostructured composite scaffolds results in the regeneration of chronically injured spinal cords. ACS Nano (2010) 0.95
A high-throughput platform for lentiviral overexpression screening of the human ORFeome. PLoS One (2011) 0.94
14-3-3 acts as an intramolecular bridge to regulate cdc25B localization and activity. J Biol Chem (2003) 0.94
Neural-colony forming cell assay: an assay to discriminate bona fide neural stem cells from neural progenitor cells. J Vis Exp (2011) 0.94
Ethynyldeoxyuridine (EdU) suppresses in vitro population expansion and in vivo tumor progression of human glioblastoma cells. J Neurooncol (2011) 0.93
Embryonic stem-derived versus somatic neural stem cells: a comparative analysis of their developmental potential and molecular phenotype. Stem Cells (2005) 0.92
Generation and differentiation of neurospheres from murine embryonic day 14 central nervous system tissue. Methods Mol Biol (2005) 0.92
The neuroblast assay: an assay for the generation and enrichment of neuronal progenitor cells from differentiating neural stem cell progeny using flow cytometry. J Vis Exp (2012) 0.92
In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity. PLoS One (2013) 0.92
MAPK pathway activation delays G2/M progression by destabilizing Cdc25B. J Biol Chem (2009) 0.92
Targeted versus tailored multimedia patient engagement to enhance depression recognition and treatment in primary care: randomized controlled trial protocol for the AMEP2 study. BMC Health Serv Res (2013) 0.92
A role for homologous recombination and abnormal cell-cycle progression in radioresistance of glioma-initiating cells. Mol Cancer Ther (2012) 0.91
Cyclin A/Cdk2 regulates Cdh1 and claspin during late S/G2 phase of the cell cycle. Cell Cycle (2014) 0.91
Stem cell transplantation for ischemic stroke. Cochrane Database Syst Rev (2010) 0.91
Podocalyxin-like protein is expressed in glioblastoma multiforme stem-like cells and is associated with poor outcome. PLoS One (2013) 0.91
Intraluminal middle cerebral artery occlusion (MCAO) model for ischemic stroke with laser doppler flowmetry guidance in mice. J Vis Exp (2011) 0.90
Methods to culture, differentiate, and characterize neural stem cells from the adult and embryonic mouse central nervous system. Methods Mol Biol (2013) 0.90
Coexistence of multiple anomalies in the hepatobiliary system. Anat Cell Biol (2012) 0.90
Prevalence of patient safety indicators and hospital-acquired conditions in those treated for unruptured cerebral aneurysms: establishing standard performance measures using the Nationwide Inpatient Sample database. J Neurosurg (2013) 0.90
Caffeine promotes apoptosis in mitotic spindle checkpoint-arrested cells. J Biol Chem (2006) 0.90
Radiation-induced primary cerebral atypical teratoid/rhabdoid tumour in an adult. J Clin Neurosci (2013) 0.89
Response of estrogen receptor-positive breast cancer tumorspheres to antiestrogen treatments. PLoS One (2011) 0.89
Brain cancer stem cells: Think twice before going flat. Cell Stem Cell (2009) 0.89
Inhibition of histone deacetylase 3 produces mitotic defects independent of alterations in histone H3 lysine 9 acetylation and methylation. Mol Pharmacol (2010) 0.88
Neurogenic potential of progenitor cells isolated from postmortem human Parkinsonian brains. Brain Res (2012) 0.87
BMHP1-derived self-assembling peptides: hierarchically assembled structures with self-healing propensity and potential for tissue engineering applications. ACS Nano (2011) 0.87
Identity, fate and potential of cells grown as neurospheres: species matters. Stem Cell Rev (2011) 0.87
ELK4 neutralization sensitizes glioblastoma to apoptosis through downregulation of the anti-apoptotic protein Mcl-1. Neuro Oncol (2011) 0.87
Fighting fire with fire: the revival of thermotherapy for gliomas. Anticancer Res (2014) 0.87