Published in Glia on September 01, 2002
Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci U S A (2007) 11.94
Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci U S A (2003) 10.56
Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell (2005) 5.51
HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr Biol (2006) 5.17
Cancer stem cells: an evolving concept. Nat Rev Cancer (2012) 4.57
Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res (2008) 3.99
Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis. J Clin Oncol (2008) 3.84
Integrin alpha 6 regulates glioblastoma stem cells. Cell Stem Cell (2010) 3.82
Eyes wide open: a critical review of sphere-formation as an assay for stem cells. Cell Stem Cell (2011) 3.55
PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo. Genes Dev (2008) 3.50
Emerging insights into the molecular and cellular basis of glioblastoma. Genes Dev (2012) 3.44
NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts. Stem Cells (2010) 3.42
Drug-selected human lung cancer stem cells: cytokine network, tumorigenic and metastatic properties. PLoS One (2008) 3.36
The Gli code: an information nexus regulating cell fate, stemness and cancer. Trends Cell Biol (2007) 3.14
Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase. Head Neck (2010) 2.76
Stem-like cells in bone sarcomas: implications for tumorigenesis. Neoplasia (2005) 2.62
Relationship of glioblastoma multiforme to neural stem cell regions predicts invasive and multifocal tumor phenotype. Neuro Oncol (2007) 2.56
STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells. Stem Cells (2009) 2.46
Neurosphere formation is an independent predictor of clinical outcome in malignant glioma. Stem Cells (2009) 2.10
mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma. Neoplasia (2005) 2.04
Angiogenesis-independent tumor growth mediated by stem-like cancer cells. Proc Natl Acad Sci U S A (2006) 1.96
Cancer stem cells in glioblastoma. Genes Dev (2015) 1.91
Mathematical modeling of PDGF-driven glioblastoma reveals optimized radiation dosing schedules. Cell (2014) 1.79
Notch signaling enhances nestin expression in gliomas. Neoplasia (2006) 1.73
Adult neural stem cells in the mammalian central nervous system. Cell Res (2009) 1.64
Isolation and expansion of the adult mouse neural stem cells using the neurosphere assay. J Vis Exp (2010) 1.64
Cancer stem cells in gliomas: identifying and understanding the apex cell in cancer's hierarchy. Glia (2011) 1.63
Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisions. Cell Death Dis (2011) 1.59
The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance. EMBO Mol Med (2013) 1.59
The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance. Clin Cancer Res (2010) 1.58
Cell migration in the normal and pathological postnatal mammalian brain. Prog Neurobiol (2009) 1.56
Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma. Proc Natl Acad Sci U S A (2007) 1.54
Hes3 regulates cell number in cultures from glioblastoma multiforme with stem cell characteristics. Sci Rep (2013) 1.51
The Notch signaling pathway as a mediator of tumor survival. Carcinogenesis (2013) 1.50
Knock down of HIF-1alpha in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres. Mol Cancer (2010) 1.50
Evidence for label-retaining tumour-initiating cells in human glioblastoma. Brain (2011) 1.48
Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma. Cancer Res (2009) 1.46
The nuclear receptor tailless induces long-term neural stem cell expansion and brain tumor initiation. Genes Dev (2010) 1.45
Non-small cell lung cancer cells survived ionizing radiation treatment display cancer stem cell and epithelial-mesenchymal transition phenotypes. Mol Cancer (2013) 1.41
The p75 neurotrophin receptor is a central regulator of glioma invasion. PLoS Biol (2007) 1.40
The functional role of Notch signaling in human gliomas. Neuro Oncol (2009) 1.39
Phase I trial of MK-0752 in children with refractory CNS malignancies: a pediatric brain tumor consortium study. J Clin Oncol (2011) 1.39
The interface between glial progenitors and gliomas. Acta Neuropathol (2008) 1.33
Notch: from neural development to neurological disorders. J Neurochem (2008) 1.31
ClC3 is a critical regulator of the cell cycle in normal and malignant glial cells. J Neurosci (2008) 1.30
Gliosarcoma stem cells undergo glial and mesenchymal differentiation in vivo. Stem Cells (2010) 1.29
Molecular mechanisms of chemoresistance in osteosarcoma (Review). Oncol Lett (2014) 1.29
Elimination of human lung cancer stem cells through targeting of the stem cell factor-c-kit autocrine signaling loop. Cancer Res (2009) 1.28
Chloride accumulation drives volume dynamics underlying cell proliferation and migration. J Neurophysiol (2008) 1.28
CD133, CD15/SSEA-1, CD34 or side populations do not resume tumor-initiating properties of long-term cultured cancer stem cells from human malignant glio-neuronal tumors. BMC Cancer (2010) 1.26
Fluorescence-guided surgical sampling of glioblastoma identifies phenotypically distinct tumour-initiating cell populations in the tumour mass and margin. Br J Cancer (2012) 1.25
Identification of cell surface glycoprotein markers for glioblastoma-derived stem-like cells using a lectin microarray and LC-MS/MS approach. J Proteome Res (2010) 1.23
Activation of multiple ERBB family receptors mediates glioblastoma cancer stem-like cell resistance to EGFR-targeted inhibition. Neoplasia (2012) 1.22
Glioblastoma Multiforme Oncogenomics and Signaling Pathways. Clin Med Oncol (2009) 1.21
In vivo models of primary brain tumors: pitfalls and perspectives. Neuro Oncol (2012) 1.21
DNER, an epigenetically modulated gene, regulates glioblastoma-derived neurosphere cell differentiation and tumor propagation. Stem Cells (2009) 1.20
Notch, neural stem cells, and brain tumors. Cold Spring Harb Symp Quant Biol (2008) 1.19
Using the molecular classification of glioblastoma to inform personalized treatment. J Pathol (2014) 1.17
Pathological and molecular progression of astrocytomas in a GFAP:12 V-Ha-Ras mouse astrocytoma model. Am J Pathol (2005) 1.15
Dual blocking of mTor and PI3K elicits a prodifferentiation effect on glioblastoma stem-like cells. Neuro Oncol (2010) 1.15
Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity. Genes Dev (2012) 1.15
Laminin alpha 2 enables glioblastoma stem cell growth. Ann Neurol (2012) 1.13
Biological significance of prolactin in gynecologic cancers. Cancer Res (2009) 1.13
The characteristics of astrocytomas and oligodendrogliomas are caused by two distinct and interchangeable signaling formats. Neoplasia (2005) 1.12
Therapeutic targeting of constitutive PARP activation compromises stem cell phenotype and survival of glioblastoma-initiating cells. Cell Death Differ (2013) 1.12
Glioma stem cells are more aggressive in recurrent tumors with malignant progression than in the primary tumor, and both can be maintained long-term in vitro. BMC Cancer (2008) 1.11
Neurosphere culture and human organotypic model to evaluate brain tumor stem cells. Methods Mol Biol (2009) 1.11
Determination of somatic and cancer stem cell self-renewing symmetric division rate using sphere assays. PLoS One (2011) 1.11
Reinduction of ErbB2 in astrocytes promotes radial glial progenitor identity in adult cerebral cortex. Genes Dev (2007) 1.11
The cancer stem cell paradigm: a new understanding of tumor development and treatment. Expert Opin Ther Targets (2010) 1.09
GFAP-Cre-mediated activation of oncogenic K-ras results in expansion of the subventricular zone and infiltrating glioma. Mol Cancer Res (2009) 1.09
EphA2 promotes infiltrative invasion of glioma stem cells in vivo through cross-talk with Akt and regulates stem cell properties. Oncogene (2014) 1.08
Wnt activation promotes neuronal differentiation of glioblastoma. Cell Death Dis (2013) 1.08
Therapeutic vaccination against autologous cancer stem cells with mRNA-transfected dendritic cells in patients with glioblastoma. Cancer Immunol Immunother (2013) 1.08
Cisplatin restores TRAIL apoptotic pathway in glioblastoma-derived stem cells through up-regulation of DR5 and down-regulation of c-FLIP. Cancer Invest (2011) 1.08
Brain tumor stem cells maintain overall phenotype and tumorigenicity after in vitro culturing in serum-free conditions. Neuro Oncol (2010) 1.07
Notch signaling contributes to the maintenance of both normal neural stem cells and patient-derived glioma stem cells. BMC Cancer (2011) 1.07
Brain Tumor Stem-Like Cells Identified by Neural Stem Cell Marker CD15. Transl Oncol (2009) 1.06
The zinc finger transcription factor ZFX is required for maintaining the tumorigenic potential of glioblastoma stem cells. Stem Cells (2014) 1.05
Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol (2013) 1.05
Targeting glioma stem cells: a novel framework for brain tumors. Cancer Sci (2011) 1.03
Gamma-secretase represents a therapeutic target for the treatment of invasive glioma mediated by the p75 neurotrophin receptor. PLoS Biol (2008) 1.03
Arrested neural and advanced mesenchymal differentiation of glioblastoma cells-comparative study with neural progenitors. BMC Cancer (2009) 1.03
Differential expression of 2',3'-cyclic-nucleotide 3'-phosphodiesterase and neural lineage markers correlate with glioblastoma xenograft infiltration and patient survival. Clin Cancer Res (2012) 1.03
Cancer stem cells in brain tumor biology. Cold Spring Harb Symp Quant Biol (2009) 1.02
Clinical relevance of tumor cells with stem-like properties in pediatric brain tumors. PLoS One (2011) 1.02
Radioresistance of glioma stem cells: intrinsic characteristic or property of the 'microenvironment-stem cell unit'? Mol Oncol (2011) 1.01
Neuron-to-astrocyte transition: phenotypic fluidity and the formation of hybrid asterons in differentiating neurospheres. J Comp Neurol (2005) 1.01
Common astrocytic programs during brain development, injury and cancer. Trends Neurosci (2009) 1.01
Tumor initiating cells in malignant gliomas: biology and implications for therapy. J Mol Med (Berl) (2009) 1.01
Novel anti-apoptotic microRNAs 582-5p and 363 promote human glioblastoma stem cell survival via direct inhibition of caspase 3, caspase 9, and Bim. PLoS One (2014) 1.01
Sphere culture of murine lung cancer cell lines are enriched with cancer initiating cells. PLoS One (2012) 1.00
High-throughput flow cytometry screening reveals a role for junctional adhesion molecule a as a cancer stem cell maintenance factor. Cell Rep (2013) 0.99
Quiescent adult neural stem cells are exceptionally sensitive to cosmic radiation. Exp Neurol (2007) 0.99
β-Catenin Signalling in Glioblastoma Multiforme and Glioma-Initiating Cells. Chemother Res Pract (2012) 0.99
Chemokine CXCL12 in neurodegenerative diseases: an SOS signal for stem cell-based repair. Trends Neurosci (2012) 0.99
Inhibition of notch signaling induces neural differentiation in Ewing sarcoma. Am J Pathol (2007) 0.98
Organotypic slice cultures of human glioblastoma reveal different susceptibilities to treatments. Neuro Oncol (2013) 0.98
Role of microRNAs in maintaining cancer stem cells. Adv Drug Deliv Rev (2014) 0.97
The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes. EBioMedicine (2015) 0.97
Stem-like cells in bone sarcomas: implications for tumorigenesis. Neoplasia (2005) 2.62
Aldehyde dehydrogenase-expressing colon stem cells contribute to tumorigenesis in the transition from colitis to cancer. Cancer Res (2009) 2.40
Phenotypic and functional characterization of adult brain neuropoiesis. Proc Natl Acad Sci U S A (2005) 2.08
Neural stem cell heterogeneity demonstrated by molecular phenotyping of clonal neurospheres. Proc Natl Acad Sci U S A (2002) 2.04
Microglia instruct subventricular zone neurogenesis. Glia (2006) 2.02
A novel classification system for spinal instability in neoplastic disease: an evidence-based approach and expert consensus from the Spine Oncology Study Group. Spine (Phila Pa 1976) (2010) 1.91
Central nervous system cancers. J Natl Compr Canc Netw (2013) 1.82
Mesenchymal stem cells spontaneously express neural proteins in culture and are neurogenic after transplantation. Stem Cells (2005) 1.73
Spinal instability neoplastic score: an analysis of reliability and validity from the spine oncology study group. J Clin Oncol (2011) 1.69
GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis. Mol Cell (2004) 1.64
The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance. EMBO Mol Med (2013) 1.59
Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma. Cancer Res (2009) 1.46
Effect of apolipoprotein E genotype on the outcome after anterior cervical decompression and fusion in patients with cervical spondylotic myelopathy. J Neurosurg Spine (2009) 1.42
Bone marrow transdifferentiation in brain after transplantation: a retrospective study. Lancet (2004) 1.38
Expression of pluripotent stem cell reprogramming factors by prostate tumor initiating cells. J Urol (2010) 1.34
Regulated expression of ATF5 is required for the progression of neural progenitor cells to neurons. J Neurosci (2003) 1.31
Mini-open lateral retroperitoneal lumbar spine approach using psoas muscle retraction technique. Technical report and initial results on six patients. Eur Spine J (2013) 1.22
Chondroitin sulfate proteoglycans potently inhibit invasion and serve as a central organizer of the brain tumor microenvironment. J Neurosci (2013) 1.20
Temporally restricted substrate interactions direct fate and specification of neural precursors derived from embryonic stem cells. Proc Natl Acad Sci U S A (2006) 1.20
Instability and impending instability of the thoracolumbar spine in patients with spinal metastases: a systematic review. Int J Oncol (2011) 1.19
PCR inhibition by reverse transcriptase leads to an overestimation of amplification efficiency. Nucleic Acids Res (2005) 1.18
Comparing effects of kyphoplasty, vertebroplasty, and non-surgical management in a systematic review of randomized and non-randomized controlled studies. Eur Spine J (2012) 1.17
Downregulation of activating transcription factor 5 is required for differentiation of neural progenitor cells into astrocytes. J Neurosci (2005) 1.15
Central nervous system cancers. J Natl Compr Canc Netw (2011) 1.13
Residual tumor cells are unique cellular targets in glioblastoma. Ann Neurol (2010) 1.13
Purification of immature neuronal cells from neural stem cell progeny. PLoS One (2011) 1.11
ATF5 regulates the proliferation and differentiation of oligodendrocytes. Mol Cell Neurosci (2005) 1.10
Low proliferation and differentiation capacities of adult hippocampal stem cells correlate with memory dysfunction in humans. Brain (2010) 1.07
Reliability analysis of the epidural spinal cord compression scale. J Neurosurg Spine (2010) 1.06
Decision making in the surgical treatment of cervical spine metastases. Spine (Phila Pa 1976) (2009) 1.04
Derivation and large-scale expansion of multipotent astroglial neural progenitors from adult human brain. Development (2006) 1.04
An assessment of the reliability of the Enneking and Weinstein-Boriani-Biagini classifications for staging of primary spinal tumors by the Spine Oncology Study Group. Spine (Phila Pa 1976) (2009) 1.03
Anticancer effects of niclosamide in human glioblastoma. Clin Cancer Res (2013) 1.03
Treatment of metastatic spinal lesions with a navigational bipolar radiofrequency ablation device: a multicenter retrospective study. Pain Physician (2014) 1.02
Astrocytes as stem cells: nomenclature, phenotype, and translation. Glia (2003) 1.02
Using the neurosphere assay to quantify neural stem cells in vivo. Curr Pharm Biotechnol (2007) 1.02
Neuron-to-astrocyte transition: phenotypic fluidity and the formation of hybrid asterons in differentiating neurospheres. J Comp Neurol (2005) 1.01
Production of neurospheres from CNS tissue. Methods Mol Biol (2008) 1.01
Common astrocytic programs during brain development, injury and cancer. Trends Neurosci (2009) 1.01
Quiescent adult neural stem cells are exceptionally sensitive to cosmic radiation. Exp Neurol (2007) 0.99
Bromodeoxyuridine induces senescence in neural stem and progenitor cells. Stem Cells (2008) 0.96
Production and analysis of neurospheres from acutely dissociated and postmortem CNS specimens. Methods Mol Biol (2002) 0.95
Contralateral femoral nerve compression: An unrecognized complication after extreme lateral interbody fusion (XLIF). J Clin Neurosci (2010) 0.94
Primary spine tumors: diagnosis and treatment. Cancer Control (2014) 0.93
Ethynyldeoxyuridine (EdU) suppresses in vitro population expansion and in vivo tumor progression of human glioblastoma cells. J Neurooncol (2011) 0.93
Transplantation of multipotent astrocytic stem cells into a rat model of neonatal hypoxic-ischemic encephalopathy. Brain Res (2006) 0.93
Management of spinal meningiomas: surgical results and a review of the literature. Neurosurg Focus (2007) 0.93
Diffusion tensor imaging tractography in patients with intramedullary tumors: comparison with intraoperative findings and value for prediction of tumor resectability. J Neurosurg Spine (2010) 0.92
Gliotypic neural stem cells transiently adopt tumorigenic properties during normal differentiation. Stem Cells (2009) 0.90
Fusion of neural stem cells in culture. Exp Neurol (2006) 0.89
Comparison of polymethylmethacrylate versus expandable cage in anterior vertebral column reconstruction after posterior extracavitary corpectomy in lumbar and thoraco-lumbar metastatic spine tumors. Eur Spine J (2011) 0.88
In vivo intermittent hypoxia elicits enhanced expansion and neuronal differentiation in cultured neural progenitors. Exp Neurol (2012) 0.88
Management of metastatic spine disease. Curr Opin Support Palliat Care (2010) 0.88
Posterior transpedicular corpectomy for malignant cervical spine tumors. Eur Spine J (2009) 0.87
Subventricular zone microglia possess a unique capacity for massive in vitro expansion. Glia (2008) 0.87
Neurogenic potential of progenitor cells isolated from postmortem human Parkinsonian brains. Brain Res (2012) 0.87
Neural trans-differentiation potential of hepatic oval cells in the neonatal mouse brain. Exp Neurol (2003) 0.86
Bromodeoxyuridine inhibits cancer cell proliferation in vitro and in vivo. Neoplasia (2008) 0.86
Biomechanical analysis of an interspinous fusion device as a stand-alone and as supplemental fixation to posterior expandable interbody cages in the lumbar spine. J Neurosurg Spine (2013) 0.86
Spinal radiosurgery for metastatic disease of the spine. Cancer Control (2007) 0.85
Central nervous system cancers: Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw (2005) 0.85
MR microscopy of rat hippocampal slice cultures: a novel model for studying cellular processes and chronic perturbations to tissue microstructure. Neuroimage (2005) 0.85
Cellular fusion for gene delivery to SCA1 affected Purkinje neurons. Mol Cell Neurosci (2011) 0.85
Neural stem cells, scaffolds, and chaperones. Nat Biotechnol (2002) 0.84
A preclinical assessment of neural stem cells as delivery vehicles for anti-amyloid therapeutics. PLoS One (2012) 0.84
Biomechanical comparison of anterior cervical spine instrumentation techniques with and without supplemental posterior fusion after different corpectomy and discectomy combinations: Laboratory investigation. J Neurosurg Spine (2012) 0.84
Ionizing radiation enhances the engraftment of transplanted in vitro-derived multipotent astrocytic stem cells. Stem Cells (2005) 0.83
Lysophosphatidic acid induces clonal generation of mouse neurospheres via proliferation of Sca-1- and AC133-positive neural progenitors. Stem Cells Dev (2004) 0.83
Balloon kyphoplasty in the treatment of metastatic tumors of the upper thoracic spine. J Neurosurg Spine (2011) 0.83
Metastatic spinal cord compression. J Natl Compr Canc Netw (2005) 0.82
In vitro-derived "neural stem cells" function as neural progenitors without the capacity for self-renewal. Stem Cells (2005) 0.82
Isolation of neural progenitor cells from the human adult subventricular zone based on expression of the cell surface marker CD271. Stem Cells Transl Med (2014) 0.82
Transplantation of an indigenous neural stem cell population leading to hyperplasia and atypical integration. Cloning Stem Cells (2002) 0.81
Gelatinized copper-capillary alginate gel functions as an injectable tissue scaffolding system for stem cell transplants. J Biomater Sci Polym Ed (2010) 0.81
A method for a more complete in vitro Parkinson's model: slice culture bioassay for modeling maintenance and repair of the nigrostriatal circuit. J Neurosci Methods (2006) 0.81
A degradable, bioactive, gelatinized alginate hydrogel to improve stem cell/growth factor delivery and facilitate healing after myocardial infarction. Med Hypotheses (2012) 0.80
Astrocytic stem cells in the adult brain. Neurosurg Clin N Am (2007) 0.80
Stem cells as a potential therapy for epilepsy. Exp Neurol (2012) 0.80
Surgical management of primary and metastatic spinal tumors. Cancer Control (2014) 0.79
Detection of primary cilia in human glioblastoma. J Neurooncol (2014) 0.79
Atlantoaxial stabilization utilizing atlas translaminar fixation. J Clin Neurosci (2010) 0.78
Transplantation of embryonic and adult neural stem cells in the granuloprival cerebellum of the weaver mutant mouse. Stem Cells (2009) 0.78
Management of nerve sheath tumors arising in the sympathetic chain. Cancer Control (2008) 0.77