Published in Immunology on March 29, 2011
Memory CD4+ T cells protect against influenza through multiple synergizing mechanisms. J Clin Invest (2012) 1.95
The utility and limitations of current Web-available algorithms to predict peptides recognized by CD4 T cells in response to pathogen infection. J Immunol (2012) 1.13
CD4 T cell help is limiting and selective during the primary B cell response to influenza virus infection. J Virol (2013) 1.02
Trivalent inactivated influenza vaccines induce broad immunological reactivity to both internal virion components and influenza surface proteins. Vaccine (2012) 0.93
A human CD4+ T cell epitope in the influenza hemagglutinin is cross-reactive to influenza A virus subtypes and to influenza B virus. J Virol (2012) 0.92
Characterization of influenza vaccine immunogenicity using influenza antigen microarrays. PLoS One (2013) 0.86
Tissue Distribution of Memory T and B Cells in Rhesus Monkeys following Influenza A Infection. J Immunol (2015) 0.83
Memory CD4 T cell-mediated immunity against influenza A virus: more than a little helpful. Arch Immunol Ther Exp (Warsz) (2013) 0.83
The Role of CD4 T Cell Memory in Generating Protective Immunity to Novel and Potentially Pandemic Strains of Influenza. Front Immunol (2016) 0.79
The peptide specificity of the endogenous T follicular helper cell repertoire generated after protein immunization. PLoS One (2012) 0.78
Flow Cytometric and Cytokine ELISpot Approaches To Characterize the Cell-Mediated Immune Response in Ferrets following Influenza Virus Infection. J Virol (2016) 0.78
Global epidemiology of influenza: past and present. Annu Rev Med (2000) 7.80
Homeostasis of naive and memory T cells. Immunity (2008) 7.48
Memory CD8 T-cell differentiation during viral infection. J Virol (2004) 6.75
Cytotoxic T-cell memory without antigen. Nature (1994) 6.55
Persistence of memory CD8 T cells in MHC class I-deficient mice. Science (1999) 6.20
Cytokine control of memory T-cell development and survival. Nat Rev Immunol (2003) 5.99
Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat Immunol (2003) 3.82
T cell fitness determined by signal strength. Nat Immunol (2003) 3.65
Diversity in T cell memory: an embarrassment of riches. Immunity (2009) 3.31
From vaccines to memory and back. Immunity (2010) 3.30
Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation. J Exp Med (2005) 2.59
Rapid culling of the CD4+ T cell repertoire in the transition from effector to memory. Immunity (2008) 2.56
CD4+ T-cell memory: generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza. Immunol Rev (2006) 2.49
Impairment of immunological memory in the absence of MHC despite survival of memory T cells. Nat Immunol (2002) 2.42
Apoptosis regulators Bim and Fas function concurrently to control autoimmunity and CD8+ T cell contraction. Immunity (2008) 2.26
Antigen persistence and the control of local T cell memory by migrant respiratory dendritic cells after acute virus infection. J Exp Med (2010) 2.22
Generation and maintenance of immunological memory. Semin Immunol (2004) 2.06
Multiple choices: regulation of memory CD8 T cell generation and homeostasis by interleukin (IL)-7 and IL-15. J Exp Med (2002) 2.03
A critical role for B cells in the development of memory CD4 cells. J Immunol (2000) 1.97
Heterogeneity of CD4+ memory T cells: functional modules for tailored immunity. Eur J Immunol (2009) 1.92
The kinetic stability of MHC class II:peptide complexes is a key parameter that dictates immunodominance. Immunity (2005) 1.88
CD4(+) T cell effectors can become memory cells with high efficiency and without further division. Nat Immunol (2001) 1.88
CD4+ memory T cells: functional differentiation and homeostasis. Immunol Rev (2006) 1.84
CD95, BIM and T cell homeostasis. Nat Rev Immunol (2009) 1.73
Influenza vaccine--outmaneuvering antigenic shift and drift. N Engl J Med (2004) 1.72
Memory CD4 T cells direct protective responses to influenza virus in the lungs through helper-independent mechanisms. J Virol (2010) 1.72
Antigen decoding by T lymphocytes: from synapses to fate determination. Nat Immunol (2001) 1.72
Increased competition for antigen during priming negatively impacts the generation of memory CD4 T cells. Proc Natl Acad Sci U S A (2007) 1.71
Involvement of avidity for major histocompatibility complex in homeostasis of naive and memory T cells. J Exp Med (2003) 1.71
Vaccination and antigenic drift in influenza. Vaccine (2008) 1.56
IL-15 regulates both quantitative and qualitative features of the memory CD8 T cell pool. J Immunol (2009) 1.45
The potential of CD4 T-cell memory. Immunology (2010) 1.40
The relationship between immunodominance, DM editing, and the kinetic stability of MHC class II:peptide complexes. Immunol Rev (2005) 1.38
Vaccines for pandemic influenza. Emerg Infect Dis (2006) 1.37
T cell repertoires and competitive exclusion. J Theor Biol (1994) 1.32
Surviving the crash: transitioning from effector to memory CD8+ T cell. Semin Immunol (2009) 1.31
Uneven distribution of MHC class II epitopes within the influenza virus. Vaccine (2005) 1.31
IL-7 and IL-15: biology and roles in T-Cell immunity in health and disease. Crit Rev Immunol (2008) 1.22
Changing perspective on immunization against influenza. Vaccine (2007) 1.19
The impact of DM on MHC class II-restricted antigen presentation can be altered by manipulation of MHC-peptide kinetic stability. J Exp Med (2006) 1.18
Influenza vaccines. Vaccine (2009) 1.17
Memory T-lymphocyte survival does not require T-cell receptor expression. Proc Natl Acad Sci U S A (2008) 1.12
Cellular competition modulates survival and selection of CD8+ T cells. Eur J Immunol (1996) 1.11
Immunodominance in CD4 T-cell responses: implications for immune responses to influenza virus and for vaccine design. Expert Rev Vaccines (2007) 1.10
CD4 memory T cells survive and proliferate but fail to differentiate in the absence of CD40. J Exp Med (2006) 1.07
Fas Bim boom! Immunity (2008) 1.05
Analyses of the specificity of CD4 T cells during the primary immune response to influenza virus reveals dramatic MHC-linked asymmetries in reactivity to individual viral proteins. Viral Immunol (2010) 1.02
Homeostasis of T cell diversity. Cell Mol Immunol (2005) 1.02
Generation, persistence and plasticity of CD4 T-cell memories. Immunology (2010) 1.01
CD4 T-cell memory. Semin Immunol (2004) 1.01
Homeostatic turnover of virus-specific memory CD8 T cells occurs stochastically and is independent of CD4 T cell help. J Immunol (2010) 0.99
The concept of space and competition in immune regulation. Immunology (2004) 0.95
Memory T-cell competition for bone marrow seeding. Immunology (2003) 0.95
Regulation of memory T cells by γc cytokines. Cytokine (2009) 0.93
Ablation of SLP-76 signaling after T cell priming generates memory CD4 T cells impaired in steady-state and cytokine-driven homeostasis. Proc Natl Acad Sci U S A (2009) 0.92
Influenza--the goal of control. N Engl J Med (2007) 0.91
Abortive activation of CD4 T cell responses during competitive priming in vivo. Proc Natl Acad Sci U S A (2009) 0.90
Reflections on CD8 T-cell activation and memory. Immunol Res (2004) 0.89
Immunodominance of CD4 T cells to foreign antigens is peptide intrinsic and independent of molecular context: implications for vaccine design. J Immunol (2008) 0.87
Role of IL-15 and IL-21 in viral immunity: applications for vaccines and therapies. Expert Rev Vaccines (2009) 0.83
Long-term stability of diverse immunological memory. J Theor Biol (2001) 0.82
Lymphocyte memory and affinity selection. J Theor Biol (1995) 0.76
The kinetic stability of MHC class II:peptide complexes is a key parameter that dictates immunodominance. Immunity (2005) 1.88
MR1 uses an endocytic pathway to activate mucosal-associated invariant T cells. J Exp Med (2008) 1.67
The relationship between immunodominance, DM editing, and the kinetic stability of MHC class II:peptide complexes. Immunol Rev (2005) 1.38
CD4+CD25+ regulatory T cell repertoire formation shaped by differential presentation of peptides from a self-antigen. J Immunol (2008) 1.27
The impact of DM on MHC class II-restricted antigen presentation can be altered by manipulation of MHC-peptide kinetic stability. J Exp Med (2006) 1.18
CD4+ T-cell expansion predicts neutralizing antibody responses to monovalent, inactivated 2009 pandemic influenza A(H1N1) virus subtype H1N1 vaccine. J Infect Dis (2012) 1.15
The utility and limitations of current Web-available algorithms to predict peptides recognized by CD4 T cells in response to pathogen infection. J Immunol (2012) 1.13
Immunodominance in CD4 T-cell responses: implications for immune responses to influenza virus and for vaccine design. Expert Rev Vaccines (2007) 1.10
Analyses of the specificity of CD4 T cells during the primary immune response to influenza virus reveals dramatic MHC-linked asymmetries in reactivity to individual viral proteins. Viral Immunol (2010) 1.02
CD4 T cell help is limiting and selective during the primary B cell response to influenza virus infection. J Virol (2013) 1.02
Long-term persistence of CD4(+) but rapid disappearance of CD8(+) T cells expressing an MHC class I-restricted TCR of nanomolar affinity. Mol Ther (2012) 0.99
Energetics and cooperativity of the hydrogen bonding and anchor interactions that bind peptides to MHC class II protein. J Mol Biol (2005) 0.98
Understanding the focused CD4 T cell response to antigen and pathogenic organisms. Immunol Res (2009) 0.94
Trivalent inactivated influenza vaccines induce broad immunological reactivity to both internal virion components and influenza surface proteins. Vaccine (2012) 0.93
Abortive activation of CD4 T cell responses during competitive priming in vivo. Proc Natl Acad Sci U S A (2009) 0.90
Immunodominance of CD4 T cells to foreign antigens is peptide intrinsic and independent of molecular context: implications for vaccine design. J Immunol (2008) 0.87
The control of the specificity of CD4 T cell responses: thresholds, breakpoints, and ceilings. Front Immunol (2013) 0.87
Generation of MHC class II-peptide ligands for CD4 T-cell allorecognition of MHC class II molecules. Curr Opin Organ Transplant (2010) 0.82
Host differences in influenza-specific CD4 T cell and B cell responses are modulated by viral strain and route of immunization. PLoS One (2012) 0.82
Peptide-binding motifs for the I-Ad MHC class II molecule: alternate pH-dependent binding behavior. Biochemistry (2006) 0.82
An MHC class II restriction bias in CD4 T cell responses toward I-A is altered to I-E in DM-deficient mice. J Immunol (2008) 0.82
The relative energetic contributions of dominant P1 pocket versus hydrogen bonding interactions to peptide:class II stability: implications for the mechanism of DM function. Mol Immunol (2007) 0.80
Cutting edge: Heterosubtypic influenza infection antagonizes elicitation of immunological reactivity to hemagglutinin. J Immunol (2013) 0.80
Conformation of MHC class II I-A(g7) is sensitive to the P9 anchor amino acid in bound peptide. Int Immunol (2007) 0.80
Orchestration of CD4 T cell epitope preferences after multipeptide immunization. J Immunol (2013) 0.78
The use of nanolipoprotein particles to enhance the immunostimulatory properties of innate immune agonists against lethal influenza challenge. Biomaterials (2013) 0.78
Replacement of the membrane proximal region of I-A(d) MHC class II molecule with I-E-derived sequences promotes production of an active and stable soluble heterodimer without altering peptide-binding specificity. J Immunol Methods (2005) 0.78
The peptide specificity of the endogenous T follicular helper cell repertoire generated after protein immunization. PLoS One (2012) 0.78
Measurement of peptide dissociation from MHC class II molecules. Curr Protoc Immunol (2007) 0.77
Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells. Virology (2010) 0.77
Loss in CD4 T-cell responses to multiple epitopes in influenza due to expression of one additional MHC class II molecule in the host. Immunology (2012) 0.76
T cell immunology for the clinician. Pediatr Infect Dis J (2011) 0.75