Published in Immunity on December 19, 2008
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. Science (2011) 15.45
mTOR regulates memory CD8 T-cell differentiation. Nature (2009) 10.07
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Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. Immunity (2011) 5.43
Transcriptional control of effector and memory CD8+ T cell differentiation. Nat Rev Immunol (2012) 4.44
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Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells. Immunity (2011) 3.58
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Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells. Nat Immunol (2009) 3.19
The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function. Nat Immunol (2011) 3.03
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How the TCR balances sensitivity and specificity for the recognition of self and pathogens. Nat Immunol (2012) 1.80
DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice. J Exp Med (2011) 1.79
An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells. Nat Immunol (2009) 1.78
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Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Krüppel-like factors KLF4 and KLF2. Nat Immunol (2009) 1.73
IL-7 promotes T(H)1 development and serum IL-7 predicts clinical response to interferon-β in multiple sclerosis. Sci Transl Med (2011) 1.73
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Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome. Blood (2010) 1.66
Homeostatic proliferation fails to efficiently reactivate HIV-1 latently infected central memory CD4+ T cells. PLoS Pathog (2011) 1.64
Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin. Nat Immunol (2017) 1.64
Identification, isolation and in vitro expansion of human and nonhuman primate T stem cell memory cells. Nat Protoc (2012) 1.63
Depletion of CD4⁺ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques. J Clin Invest (2011) 1.62
The liver kinase B1 is a central regulator of T cell development, activation, and metabolism. J Immunol (2011) 1.62
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Alternative memory in the CD8 T cell lineage. Trends Immunol (2011) 1.60
Anti-IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function. Proc Natl Acad Sci U S A (2012) 1.60
Plasticity in programming of effector and memory CD8 T-cell formation. Immunol Rev (2010) 1.59
A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity. Immunity (2011) 1.58
Extracellular adenosine regulates naive T cell development and peripheral maintenance. J Exp Med (2013) 1.57
IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infection. Proc Natl Acad Sci U S A (2010) 1.54
IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells. Proc Natl Acad Sci U S A (2012) 1.54
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Optimized peptide vaccines eliciting extensive CD8 T-cell responses with therapeutic antitumor effects. Cancer Res (2009) 1.49
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Derivation and maintenance of virtual memory CD8 T cells. J Immunol (2012) 1.40
The Influences of Cell Type and ZnO Nanoparticle Size on Immune Cell Cytotoxicity and Cytokine Induction. Nanoscale Res Lett (2009) 1.40
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T-cell growth, cell surface organization, and the galectin-glycoprotein lattice. Immunol Rev (2009) 1.30
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The transcription factor Foxo1 controls central-memory CD8+ T cell responses to infection. Immunity (2013) 1.23
DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritis. EMBO Mol Med (2010) 1.23
Telomeres and immunological diseases of aging. Gerontology (2009) 1.22
IL-7-producing stromal cells are critical for lymph node remodeling. Blood (2012) 1.22
Cutting edge: resident memory CD8 T cells occupy frontline niches in secondary lymphoid organs. J Immunol (2014) 1.22
Post-thymic maturation: young T cells assert their individuality. Nat Rev Immunol (2011) 1.22
The Role of Inflammatory Cytokines, the RANKL/OPG Axis, and the Immunoskeletal Interface in Physiological Bone Turnover and Osteoporosis. Scientifica (Cairo) (2013) 1.20
T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice. J Clin Invest (2011) 1.20
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Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCID. Blood (2011) 1.19
Homeostatic expansion and phenotypic conversion of human T cells depend on peripheral interactions with APCs. J Immunol (2010) 1.18
ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation. Immunity (2015) 1.17
Non-hematopoietic cells in lymph nodes drive memory CD8 T cell inflation during murine cytomegalovirus infection. PLoS Pathog (2011) 1.17
Interleukin-7 promotes the survival of human CD4+ effector/memory T cells by up-regulating Bcl-2 proteins and activating the JAK/STAT signalling pathway. Immunology (2010) 1.15
Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8(+) T cells. Immunol Cell Biol (2011) 1.14
A potent vaccination strategy that circumvents lymphodepletion for effective antitumor adoptive T-cell therapy. Cancer Res (2012) 1.14
IL-7 induces expression and activation of integrin α4β7 promoting naive T-cell homing to the intestinal mucosa. Blood (2012) 1.14
Th1-driven immune reconstitution disease in Mycobacterium avium-infected mice. Blood (2010) 1.13
TCR-dependent transformation of mature memory phenotype T cells in mice. J Clin Invest (2011) 1.13
Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice. J Immunol (2010) 1.13
Critical roles for Rac GTPases in T-cell migration to and within lymph nodes. Blood (2010) 1.11
IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo. Proc Natl Acad Sci U S A (2011) 1.10
Decreased diacylglycerol metabolism enhances ERK activation and augments CD8+ T cell functional responses. J Biol Chem (2010) 1.09
Autoreactive memory CD4+ T lymphocytes that mediate chronic uveitis reside in the bone marrow through STAT3-dependent mechanisms. J Immunol (2011) 1.09
Lineage-specific T-cell reconstitution following in vivo CD4+ and CD8+ lymphocyte depletion in nonhuman primates. Blood (2010) 1.08
Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells. J Exp Med (2002) 7.11
Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection. J Exp Med (2005) 6.59
A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity (2008) 6.41
Selective stimulation of T cell subsets with antibody-cytokine immune complexes. Science (2006) 6.38
The role of interleukin-2 during homeostasis and activation of the immune system. Nat Rev Immunol (2012) 3.97
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Homeostasis of memory T cells. Immunol Rev (2006) 3.69
Interleukin 15 controls both proliferation and survival of a subset of memory-phenotype CD8(+) T cells. J Exp Med (2002) 3.20
Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells. J Exp Med (2002) 3.06
Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}. Proc Natl Acad Sci U S A (2006) 3.04
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Antiviral CD4+ memory T cells are IL-15 dependent. J Exp Med (2007) 2.29
ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes. Nat Immunol (2011) 2.21
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T cell receptor-dependent regulation of lipid rafts controls naive CD8+ T cell homeostasis. Immunity (2010) 2.17
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Simultaneous deletion of MyD88 and Trif delays major histocompatibility and minor antigen mismatch allograft rejection. Eur J Immunol (2006) 1.69
Potential use of IL-2/anti-IL-2 antibody immune complexes for the treatment of cancer and autoimmune disease. Expert Opin Biol Ther (2006) 1.61
An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2. J Exp Med (2007) 1.59
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IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25. Proc Natl Acad Sci U S A (2010) 1.50
Regulation of naive T cell function by the NF-kappaB2 pathway. Nat Immunol (2006) 1.49
Direct stimulation of naive T cells by membrane vesicles from antigen-presenting cells: distinct roles for CD54 and B7 molecules. Proc Natl Acad Sci U S A (2003) 1.38
IL-7/anti-IL-7 mAb complexes restore T cell development and induce homeostatic T Cell expansion without lymphopenia. J Immunol (2008) 1.38
Regulation of naïve and memory T-cell homeostasis. Microbes Infect (2002) 1.25
Aging leads to disturbed homeostasis of memory phenotype CD8(+) cells. J Exp Med (2002) 1.24
A major histocompatibility complex class I-dependent subset of memory phenotype CD8+ cells. J Exp Med (2006) 1.15
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Interleukin-21 is critically required in autoimmune and allogeneic responses to islet tissue in murine models. Diabetes (2011) 1.11
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The lymphopenic environment of CD132 (common gamma-chain)-deficient hosts elicits rapid homeostatic proliferation of naive T cells via IL-15. J Immunol (2008) 0.99
Direct stimulation of T cells by membrane vesicles from antigen-presenting cells. Proc Natl Acad Sci U S A (2006) 0.96
IL-2/IL-2Ab complexes induce regulatory T cell expansion and protect against proteinuric CKD. J Am Soc Nephrol (2012) 0.96
Unique features of naive CD8+ T cell activation by IL-2. J Immunol (2013) 0.86
Ex vivo-expanded DCs induce donor-specific central and peripheral tolerance and prolong the acceptance of donor skin grafts. Blood (2011) 0.84
The role of interleukin-2 in memory CD8 cell differentiation. Adv Exp Med Biol (2010) 0.84
Measurement of T and B cell turnover with bromodeoxyuridine. Curr Protoc Immunol (2007) 0.84
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Knowing one's self: central tolerance revisited. Nat Immunol (2003) 0.83
Interleukin 7, maestro of the immune system. Semin Immunol (2012) 0.83
Is IL-7 from dendritic cells essential for the homeostasis of CD4+ T cells? Nat Immunol (2010) 0.81
IL-21 contributes to fatal inflammatory disease in the absence of Foxp3+ T regulatory cells. J Immunol (2014) 0.80
Dendritic cell internalization of α-galactosylceramide from CD8 T cells induces potent antitumor CD8 T-cell responses. Cancer Res (2011) 0.79
Systemic human T cell developmental processes in humanized mice cotransplanted with human fetal thymus/liver tissue and hematopoietic stem cells. Transplantation (2012) 0.78
TGF-β puts the brakes on homeostatic proliferation. Nat Immunol (2012) 0.78
On the TRAIL of homeostatic memory T cells. Nat Immunol (2006) 0.77
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