PubRank

Gilles Pagès

Author PubWeight™ 50.09‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory. Neuron 2002 2.93
2 Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. Immunity 2008 2.16
3 The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis. Diabetes 2005 1.96
4 Identification of two Sp1 phosphorylation sites for p42/p44 mitogen-activated protein kinases: their implication in vascular endothelial growth factor gene transcription. J Biol Chem 2002 1.94
5 MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo. Circulation 2004 1.69
6 A functional role for the p62-ERK1 axis in the control of energy homeostasis and adipogenesis. EMBO Rep 2010 1.40
7 Extracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradation. Mol Cell Biol 2005 1.34
8 p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1)-dependent signaling contributes to epithelial skin carcinogenesis. Cancer Res 2006 1.27
9 ERK2 but not ERK1 plays a key role in hepatocyte replication: an RNAi-mediated ERK2 knockdown approach in wild-type and ERK1 null hepatocytes. Hepatology 2007 1.26
10 Tristetraprolin inhibits Ras-dependent tumor vascularization by inducing vascular endothelial growth factor mRNA degradation. Mol Biol Cell 2007 1.25
11 TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation. J Biol Chem 2011 1.21
12 Molecular mechanisms of resistance to tumour anti-angiogenic strategies. J Oncol 2010 1.17
13 MAPK and JNK transduction pathways can phosphorylate Sp1 to activate the uPA minimal promoter element and endogenous gene transcription. Blood 2004 1.15
14 The MAPK ERK1 is a negative regulator of the adult steady-state splenic erythropoiesis. Blood 2010 1.11
15 Regulatory mechanisms of fear extinction and depression-like behavior. Neuropsychopharmacology 2007 1.11
16 Endothelial cells genetically selected from differentiating mouse embryonic stem cells incorporate at sites of neovascularization in vivo. J Cell Sci 2002 1.09
17 Mechanisms of resistance to anti-angiogenesis therapies. Biochimie 2013 1.05
18 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae. J Immunol 2007 1.04
19 Poly(A)-binding protein-interacting protein 2, a strong regulator of vascular endothelial growth factor mRNA. J Biol Chem 2004 1.03
20 Six1 regulates stem cell repair potential and self-renewal during skeletal muscle regeneration. J Cell Biol 2012 1.03
21 A synonymous polymorphism of the Tristetraprolin (TTP) gene, an AU-rich mRNA-binding protein, affects translation efficiency and response to Herceptin treatment in breast cancer patients. Hum Mol Genet 2011 1.02
22 Post-transcriptional regulation of the DUSP6/MKP-3 phosphatase by MEK/ERK signaling and hypoxia. J Cell Physiol 2011 1.02
23 Imatinib mesylate (STI571) decreases the vascular endothelial growth factor plasma concentration in patients with chronic myeloid leukemia. Blood 2004 1.02
24 Deletion of ERK1 and ERK2 in the CNS causes cortical abnormalities and neonatal lethality: Erk1 deficiency enhances the impairment of neurogenesis in Erk2-deficient mice. J Neurosci 2011 1.02
25 The CXCL7/CXCR1/2 axis is a key driver in the growth of clear cell renal cell carcinoma. Cancer Res 2013 1.01
26 Cutting edge: Extracellular signal-related kinase is not required for negative selection of developing T cells. J Immunol 2009 0.97
27 Constitutive ERK activity induces downregulation of tristetraprolin, a major protein controlling interleukin8/CXCL8 mRNA stability in melanoma cells. Am J Physiol Cell Physiol 2011 0.97
28 The extracellular regulated kinase-1 (ERK1) controls regulated alpha-secretase-mediated processing, promoter transactivation, and mRNA levels of the cellular prion protein. J Biol Chem 2011 0.93
29 12-Lipoxygenase and the regulation of hypoxia-inducible factor in prostate cancer cells. Exp Cell Res 2010 0.93
30 ERK1 plays a critical protective role against N-methyl-D-aspartate-induced retinal injury. J Neurosci Res 2008 0.92
31 Influence of the VEGF-A 936C>T germinal polymorphism on tumoral VEGF expression in head and neck cancer. Pharmacogenomics 2009 0.92
32 Multiple division cycles and long-term survival of hepatocytes are distinctly regulated by extracellular signal-regulated kinases ERK1 and ERK2. Hepatology 2009 0.92
33 Bevacizumab/docetaxel association is more efficient than docetaxel alone in reducing breast and prostate cancer cell growth: a new paradigm for understanding the therapeutic effect of combined treatment. Eur J Cancer 2010 0.91
34 Control of pro-angiogenic cytokine mRNA half-life in cancer: the role of AU-rich elements and associated proteins. J Interferon Cytokine Res 2014 0.89
35 Mechanical allodynia but not thermal hyperalgesia is impaired in mice deficient for ERK2 in the central nervous system. Pain 2012 0.89
36 Dual role of Sp3 transcription factor as an inducer of apoptosis and a marker of tumour aggressiveness. PLoS One 2009 0.88
37 Inducible expression of a MAP kinase phosphatase-3-GFP chimera specifically blunts fibroblast growth and ras-dependent tumor formation in nude mice. J Cell Physiol 2004 0.88
38 Implication of the ERK pathway on the post-transcriptional regulation of VEGF mRNA stability. Methods Mol Biol 2010 0.86
39 ERK1 and ERK2 are required for radial glial maintenance and cortical lamination. Genes Cells 2010 0.86
40 VEGF spliced variants: possible role of anti-angiogenesis therapy. J Nucleic Acids 2011 0.86
41 Differentiation of mouse embryonic stem cells into endothelial cells: genetic selection and potential use in vivo. Methods Mol Biol 2006 0.83
42 ERK1 regulates the hematopoietic stem cell niches. PLoS One 2012 0.82
43 Up-regulation of intestinal vascular endothelial growth factor by Afa/Dr diffusely adhering Escherichia coli. PLoS One 2007 0.79
44 Insulin-like growth factor-I activates extracellularly regulated kinase to regulate the p450 side-chain cleavage insulin-like response element in granulosa cells. Endocrinology 2010 0.78
45 MAP kinase phosphatase-1: a link between cell signaling and histone phosphorylation. Focus on "Histone H3 as a novel substrate for MAP kinase phosphatase-1". Am J Physiol Cell Physiol 2008 0.77
46 VEGF Splicing and the Role of VEGF Splice Variants: From Physiological-Pathological Conditions to Specific Pre-mRNA Splicing. Methods Mol Biol 2015 0.75
47 [The vascular endothelial growth factor (VEGF): a model of gene regulation and a marker of tumour aggressiveness. An obvious therapeutic target?]. J Soc Biol 2009 0.75
48 Contrasted effects of the multitarget TKi vandetanib on docetaxel-sensitive and docetaxel-resistant prostate cancer cell lines. Urol Oncol 2012 0.75