Published in J Immunol on February 01, 2007
Regulation of airway MUC5AC expression by IL-1beta and IL-17A; the NF-kappaB paradigm. J Immunol (2009) 1.47
Tumor suppressor cylindromatosis acts as a negative regulator for Streptococcus pneumoniae-induced NFAT signaling. J Biol Chem (2008) 1.12
Nonencapsulated Streptococcus pneumoniae: Emergence and Pathogenesis. MBio (2016) 1.01
Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway. J Biol Chem (2012) 0.98
Dysregulated inflammation as a risk factor for pneumonia in the elderly. Aging Dis (2011) 0.93
Streptococcus pneumoniae synergizes with nontypeable Haemophilus influenzae to induce inflammation via upregulating TLR2. BMC Immunol (2008) 0.93
Mouse models for human otitis media. Brain Res (2009) 0.92
MKP1 regulates the induction of MUC5AC mucin by Streptococcus pneumoniae pneumolysin by inhibiting the PAK4-JNK signaling pathway. J Biol Chem (2008) 0.90
Two atypical enteropathogenic Escherichia coli strains induce the production of secreted and membrane-bound mucins to benefit their own growth at the apical surface of human mucin-secreting intestinal HT29-MTX cells. Infect Immun (2010) 0.89
Opposing roles of PAK2 and PAK4 in synergistic induction of MUC5AC mucin by bacterium NTHi and EGF. Biochem Biophys Res Commun (2007) 0.87
2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced MUC5AC expression: aryl hydrocarbon receptor-independent/EGFR/ERK/p38-dependent SP1-based transcription. Am J Respir Cell Mol Biol (2010) 0.86
JNK activation is responsible for mucus overproduction in smoke inhalation injury. Respir Res (2010) 0.85
Differential regulation of Streptococcus pneumoniae-induced human MUC5AC mucin expression through distinct MAPK pathways. Am J Transl Res (2009) 0.83
Vinpocetine inhibits Streptococcus pneumoniae-induced upregulation of mucin MUC5AC expression via induction of MKP-1 phosphatase in the pathogenesis of otitis media. J Immunol (2015) 0.79
Nucleoside diphosphate kinase and flagellin from Pseudomonas aeruginosa induce interleukin 1 expression via the Akt/NF-κB signaling pathways. Infect Immun (2014) 0.78
Up-regulation of bradykinin B2 receptor by Pseudomonas aeruginosa via the NF-κB pathway. Curr Microbiol (2011) 0.78
Nontypeable Haemophilus influenzae-Induced MyD88 Short Expression Is Regulated by Positive IKKβ and CREB Pathways and Negative ERK1/2 Pathway. PLoS One (2015) 0.77
Pseudomonas aeruginosa GroEL stimulates production of PTX3 by activating the NF-κB pathway and simultaneously down-regulating microRNA-9. Infect Immun (2016) 0.75
PKCθ synergizes with TLR-dependent TRAF6 signaling pathway to upregulate MUC5AC mucin via CARMA1. PLoS One (2012) 0.75
T cells suppress memory-dependent rapid mucous cell metaplasia in mouse airways. Respir Res (2016) 0.75
Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med (2011) 13.18
Serotype replacement in disease after pneumococcal vaccination. Lancet (2011) 7.14
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J (2003) 6.44
Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol Cell Biol (2009) 4.95
Interleukin-17A mediates acquired immunity to pneumococcal colonization. PLoS Pathog (2008) 4.05
JunD reduces tumor angiogenesis by protecting cells from oxidative stress. Cell (2004) 3.30
CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonization. Proc Natl Acad Sci U S A (2005) 3.30
ERK implication in cell cycle regulation. Biochim Biophys Acta (2006) 2.96
The role of erk1 and erk2 in multiple stages of T cell development. Immunity (2005) 2.96
Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory. Neuron (2002) 2.93
Clinical prediction rule for identifying children with cerebrospinal fluid pleocytosis at very low risk of bacterial meningitis. JAMA (2007) 2.91
Hypoxia and cancer. J Mol Med (Berl) (2007) 2.89
Pneumococcal capsular polysaccharide structure predicts serotype prevalence. PLoS Pathog (2009) 2.69
Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. Cancer Res (2009) 2.62
PHD2 mutation and congenital erythrocytosis with paraganglioma. N Engl J Med (2008) 2.56
Transcriptional regulation of the Vascular Endothelial Growth Factor gene--a concert of activating factors. Cardiovasc Res (2005) 2.52
Hypoxia signalling controls metabolic demand. Curr Opin Cell Biol (2007) 2.49
Hypoxia-induced autophagy: cell death or cell survival? Curr Opin Cell Biol (2009) 2.45
T(H)17-based vaccine design for prevention of Streptococcus pneumoniae colonization. Cell Host Microbe (2011) 2.30
Interference between Streptococcus pneumoniae and Staphylococcus aureus: In vitro hydrogen peroxide-mediated killing by Streptococcus pneumoniae. J Bacteriol (2006) 2.22
Antibody-independent, interleukin-17A-mediated, cross-serotype immunity to pneumococci in mice immunized intranasally with the cell wall polysaccharide. Infect Immun (2006) 2.20
Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. Immunity (2008) 2.16
Proximal femoral nails compared with reverse distal femoral locking plates in intertrochanteric fractures with a compromised lateral wall; a randomised controlled trial. Int Orthop (2014) 2.15
Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer. J Cell Mol Med (2009) 2.13
Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections. Immunity (2007) 2.07
CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors. Proc Natl Acad Sci U S A (2011) 2.06
Extracellular signal-regulated kinase 5 SUMOylation antagonizes shear stress-induced antiinflammatory response and endothelial nitric oxide synthase expression in endothelial cells. Circ Res (2008) 2.01
NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathway. J Biol Chem (2004) 1.97
Are anticapsular antibodies the primary mechanism of protection against invasive pneumococcal disease? PLoS Med (2005) 1.97
The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis. Diabetes (2005) 1.96
Identification of two Sp1 phosphorylation sites for p42/p44 mitogen-activated protein kinases: their implication in vascular endothelial growth factor gene transcription. J Biol Chem (2002) 1.94
Disrupting proton dynamics and energy metabolism for cancer therapy. Nat Rev Cancer (2013) 1.93
Induction of hypoxia-inducible factor-1alpha by transcriptional and translational mechanisms. J Biol Chem (2002) 1.90
Identification of promiscuous KIF20A long peptides bearing both CD4+ and CD8+ T-cell epitopes: KIF20A-specific CD4+ T-cell immunity in patients with malignant tumor. Clin Cancer Res (2013) 1.87
The apoptotic response to pneumolysin is Toll-like receptor 4 dependent and protects against pneumococcal disease. Infect Immun (2005) 1.86
HIF-1alpha and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome. Int J Cancer (2007) 1.86
Development and validation of a multivariable predictive model to distinguish bacterial from aseptic meningitis in children in the post-Haemophilus influenzae era. Pediatrics (2002) 1.85
Effect of antibiotic pretreatment on cerebrospinal fluid profiles of children with bacterial meningitis. Pediatrics (2008) 1.78
Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility. J Cell Biol (2006) 1.76
Factors associated with adverse outcomes in children with diabetic ketoacidosis-related cerebral edema. J Pediatr (2002) 1.75
PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis. Proc Natl Acad Sci U S A (2008) 1.72
Epidemiologic evidence for serotype-specific acquired immunity to pneumococcal carriage. J Infect Dis (2008) 1.72
MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo. Circulation (2004) 1.69
The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 AND TRAF7. J Biol Chem (2005) 1.68
Glucocorticoids synergistically enhance nontypeable Haemophilus influenzae-induced Toll-like receptor 2 expression via a negative cross-talk with p38 MAP kinase. J Biol Chem (2002) 1.67
Oxygen, a source of life and stress. FEBS Lett (2007) 1.67
Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways. J Immunol (2002) 1.63
Antimicrobial activity of innate immune molecules against Streptococcus pneumoniae, Moraxella catarrhalis and nontypeable Haemophilus influenzae. BMC Infect Dis (2004) 1.63
Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels. Mol Cell Biol (2007) 1.62
Hypoxia and energetic tumour metabolism. Curr Opin Genet Dev (2010) 1.61
Vitamin D receptor negatively regulates bacterial-stimulated NF-kappaB activity in intestine. Am J Pathol (2010) 1.57
HIF at a glance. J Cell Sci (2009) 1.55
Association of the pneumococcal pilus with certain capsular serotypes but not with increased virulence. J Clin Microbiol (2007) 1.51
TGF-beta induces p65 acetylation to enhance bacteria-induced NF-kappaB activation. EMBO J (2007) 1.49
SpxB is a suicide gene of Streptococcus pneumoniae and confers a selective advantage in an in vivo competitive colonization model. J Bacteriol (2007) 1.48
Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy. Circ Res (2009) 1.47
Retracted Molecular characterization of Legionella pneumophila-induced interleukin-8 expression in T cells. BMC Microbiol (2010) 1.46
Antibody-independent, CD4+ T-cell-dependent protection against pneumococcal colonization elicited by intranasal immunization with purified pneumococcal proteins. Infect Immun (2007) 1.45
Inhibition of p38 MAPK by glucocorticoids via induction of MAPK phosphatase-1 enhances nontypeable Haemophilus influenzae-induced expression of toll-like receptor 2. J Biol Chem (2002) 1.44
The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling. EMBO Rep (2006) 1.43
Nontypeable Haemophilus influenzae lipoprotein P6 induces MUC5AC mucin transcription via TLR2-TAK1-dependent p38 MAPK-AP1 and IKKbeta-IkappaBalpha-NF-kappaB signaling pathways. Biochem Biophys Res Commun (2004) 1.42
Leprosy and the adaptation of human toll-like receptor 1. PLoS Pathog (2010) 1.41
A functional role for the p62-ERK1 axis in the control of energy homeostasis and adipogenesis. EMBO Rep (2010) 1.40
Pulseless right groin… bounding distal pulses. J Invasive Cardiol (2011) 1.39
Protection against nasopharyngeal colonization by Streptococcus pneumoniae is mediated by antigen-specific CD4+ T cells. Infect Immun (2008) 1.39
Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF. J Biol Chem (2005) 1.38
Impaired innate and adaptive immunity to Streptococcus pneumoniae and its effect on colonization in an infant mouse model. Infect Immun (2009) 1.35
Signalling via the hypoxia-inducible factor-1alpha requires multiple posttranslational modifications. Cell Signal (2005) 1.35
Antibodies to conserved pneumococcal antigens correlate with, but are not required for, protection against pneumococcal colonization induced by prior exposure in a mouse model. Infect Immun (2005) 1.35
Extracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradation. Mol Cell Biol (2005) 1.34
Next generation pneumococcal vaccines. Curr Opin Immunol (2011) 1.34
ERK nuclear translocation is dimerization-independent but controlled by the rate of phosphorylation. J Biol Chem (2009) 1.31
Harnessing the hypoxia-inducible factor in cancer and ischemic disease. Biochem Pharmacol (2006) 1.31
Transforming growth factor-beta -Smad signaling pathway cooperates with NF-kappa B to mediate nontypeable Haemophilus influenzae-induced MUC2 mucin transcription. J Biol Chem (2002) 1.30
p53 regulates Toll-like receptor 3 expression and function in human epithelial cell lines. Mol Cell Biol (2008) 1.29
Inhibition of prolyl hydroxylase domain proteins promotes therapeutic revascularization. Circulation (2009) 1.29
p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1)-dependent signaling contributes to epithelial skin carcinogenesis. Cancer Res (2006) 1.27