Published in Curr Opin Chem Biol on May 23, 2011
An expanded eukaryotic genetic code. Science (2003) 4.66
Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Chem Biol (2006) 3.15
Reassessing the role of the secreted protease CPAF in Chlamydia trachomatis infection through genetic approaches. Pathog Dis (2014) 2.50
trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. Biochemistry (2007) 1.97
Adding amino acids with novel reactivity to the genetic code of Saccharomyces cerevisiae. J Am Chem Soc (2003) 1.93
Progress toward an expanded eukaryotic genetic code. Chem Biol (2003) 1.66
A genetically encoded photocaged amino acid. J Am Chem Soc (2004) 1.65
Crystal structure of Streptococcus pyogenes sortase A: implications for sortase mechanism. J Biol Chem (2009) 1.52
Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infect Immun (2009) 1.49
Site-specific PEGylation of proteins containing unnatural amino acids. Bioorg Med Chem Lett (2004) 1.43
Analysis of the substrate specificity of the Staphylococcus aureus sortase transpeptidase SrtA. Biochemistry (2004) 1.34
Biochemical evidence for an editing role of thioesterase II in the biosynthesis of the polyketide pikromycin. J Biol Chem (2002) 1.31
Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition. Biopolymers (2010) 1.26
The Chlamydia protease CPAF regulates host and bacterial proteins to maintain pathogen vacuole integrity and promote virulence. Cell Host Microbe (2011) 1.21
Facile synthesis of site-specifically acetylated and methylated histone proteins: reagents for evaluation of the histone code hypothesis. Proc Natl Acad Sci U S A (2003) 1.20
Staphylococcus aureus sortase transpeptidase SrtA: insight into the kinetic mechanism and evidence for a reverse protonation catalytic mechanism. Biochemistry (2005) 1.19
Development of a high-performance liquid chromatography assay and revision of kinetic parameters for the Staphylococcus aureus sortase transpeptidase SrtA. Anal Biochem (2004) 1.17
Nonenzymatic assembly of natural polyubiquitin chains of any linkage composition and isotopic labeling scheme. J Am Chem Soc (2011) 1.17
Mutagenesis studies of substrate recognition and catalysis in the sortase A transpeptidase from Staphylococcus aureus. J Biol Chem (2008) 1.07
Mutational analysis of active site residues in the Staphylococcus aureus transpeptidase SrtA. Biochemistry (2007) 1.07
Phosphorus-based SAHA analogues as histone deacetylase inhibitors. Org Lett (2003) 1.04
Engineering the substrate specificity of Staphylococcus aureus Sortase A. The beta6/beta7 loop from SrtB confers NPQTN recognition to SrtA. J Biol Chem (2007) 1.03
Vinyl sulfones: inhibitors of SrtA, a transpeptidase required for cell wall protein anchoring and virulence in Staphylococcus aureus. J Am Chem Soc (2004) 1.00
Use of pH and kinetic isotope effects to establish chemistry as rate-limiting in oxidation of a peptide substrate by LSD1. Biochemistry (2009) 0.99
Complexation of peptidoglycan intermediates by the lipoglycodepsipeptide antibiotic ramoplanin: minimal structural requirements for intermolecular complexation and fibril formation. Proc Natl Acad Sci U S A (2002) 0.98
Controlled enzymatic synthesis of natural-linkage, defined-length polyubiquitin chains using lysines with removable protecting groups. Chem Commun (Camb) (2011) 0.98
Autocatalytic intramolecular isopeptide bond formation in gram-positive bacterial pili: a QM/MM simulation. J Am Chem Soc (2010) 0.97
Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B. Bioorg Med Chem Lett (2008) 0.96
A general method for scanning unnatural amino acid mutagenesis. ACS Chem Biol (2009) 0.95
Light-induced helix formation. J Am Chem Soc (2002) 0.93
Condensed E. coli cultures for highly efficient production of proteins containing unnatural amino acids. Bioorg Med Chem Lett (2010) 0.91
Site-specific incorporation of fluorotyrosines into proteins in Escherichia coli by photochemical disguise. Biochemistry (2010) 0.89
Inhibition of the Staphylococcus aureus sortase transpeptidase SrtA by phosphinic peptidomimetics. Bioorg Med Chem (2004) 0.89
Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and -independent manners. ACS Chem Biol (2012) 0.89
A method for multi-codon scanning mutagenesis of proteins based on asymmetric transposons. Protein Eng Des Sel (2011) 0.88
Techniques used to study transcription on chromatin templates. Methods Enzymol (2004) 0.87
Functional analysis of the lipoglycodepsipeptide antibiotic ramoplanin. Chem Biol (2002) 0.87
An unexpected interaction between the modular polyketide synthases, erythromycin DEBS1 and pikromycin PikAIV, leads to efficient triketide lactone synthesis. Biochemistry (2002) 0.86
Thermodynamic characterization of the binding interaction between the histone demethylase LSD1/KDM1 and CoREST. Biochemistry (2010) 0.86
A crystal structure of a dimer of the antibiotic ramoplanin illustrates membrane positioning and a potential Lipid II docking interface. Proc Natl Acad Sci U S A (2009) 0.85
Chlamydia protease-like activity factor (CPAF): characterization of proteolysis activity in vitro and development of a nanomolar affinity CPAF zymogen-derived inhibitor. Biochemistry (2011) 0.84
Peptide mass fingerprinting using isotopically encoded photo-crosslinking amino acids. Mol Biosyst (2008) 0.83
Structure and function of the macrolide biosensor protein, MphR(A), with and without erythromycin. J Mol Biol (2009) 0.83
Generation of ramoplanin-resistant Staphylococcus aureus. FEMS Microbiol Lett (2010) 0.82
Probing of the cis-5-phenyl proline scaffold as a platform for the synthesis of mechanism-based inhibitors of the Staphylococcus aureus sortase SrtA isoform. Bioorg Med Chem (2009) 0.81
Studies on the biosynthesis of the lipodepsipeptide antibiotic Ramoplanin A2. Bioorg Med Chem (2011) 0.80
An economical and preparative orthogonal solid phase synthesis of fluorescein and rhodamine derivatized peptides: FRET substrates for the Staphylococcus aureus sortase SrtA transpeptidase reaction. Chem Commun (Camb) (2002) 0.78
Staphylococcus aureus sortase A contributes to the Trojan horse mechanism of immune defense evasion with its intrinsic resistance to Cys184 oxidation. Biochemistry (2011) 0.78
Monitoring β-secretase activity in living cells with a membrane-anchored FRET probe. Angew Chem Int Ed Engl (2012) 0.78
Photochemical control of bacterial signal processing using a light-activated erythromycin. Mol Biosyst (2011) 0.78
Sortase-catalyzed initiator attachment enables high yield growth of a stealth polymer from the C terminus of a protein. Macromol Rapid Commun (2013) 0.77
Experimental methods for scanning unnatural amino acid mutagenesis. Methods Mol Biol (2012) 0.77
Rational protein sequence diversification by multi-codon scanning mutagenesis. Methods Mol Biol (2013) 0.77
Solvent dependence of intramolecular electron transfer in a helical oligoproline assembly. J Am Chem Soc (2004) 0.76
Genetic encoding of the post-translational modification 2-hydroxyisobutyryl-lysine. Org Biomol Chem (2015) 0.75
Profiling natural product biosynthesis. Chem Biol (2004) 0.75
Synthesis of [n]- and [n.n]cyclophanes by using Suzuki-Miyaura coupling. J Org Chem (2002) 0.75
Photochemical control of FlAsH labeling of proteins. Bioorg Med Chem Lett (2009) 0.75