Published in Mol Cell Endocrinol on May 17, 2011
α-MSH Stimulates Glucose Uptake in Mouse Muscle and Phosphorylates Rab-GTPase-Activating Protein TBC1D1 Independently of AMPK. PLoS One (2016) 1.37
Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. Mol Metab (2013) 1.14
The melanocortin receptors and their accessory proteins. Front Endocrinol (Lausanne) (2013) 0.87
Melanocortin agonists stimulate lipolysis in human adipose tissue explants but not in adipocytes. BMC Res Notes (2015) 0.77
Activation of Melanocortin Receptors MC 1 and MC 5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy. Mediators Inflamm (2016) 0.76
Melanocortin receptor accessory proteins in adrenal disease and obesity. Front Neurosci (2015) 0.76
α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors. Mol Metab (2016) 0.75
Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5. PLoS One (2015) 0.75
α-MSH and Foxc2 promote fatty acid oxidation through C/EBPβ negative transcription in mice adipose tissue. Sci Rep (2016) 0.75
Blubber transcriptome response to acute stress axis activation involves transient changes in adipogenesis and lipolysis in a fasting-adapted marine mammal. Sci Rep (2017) 0.75
Molecular mechanism of 7TM receptor activation--a global toggle switch model. Annu Rev Pharmacol Toxicol (2006) 3.33
Ligand binding and micro-switches in 7TM receptor structures. Trends Pharmacol Sci (2009) 2.33
Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptor α in mouse liver reveals extensive sharing of binding sites. Mol Cell Biol (2011) 1.77
The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss. J Clin Invest (2014) 1.61
Metal ion site engineering indicates a global toggle switch model for seven-transmembrane receptor activation. J Biol Chem (2006) 1.35
A gut feeling for obesity: 7TM sensors on enteroendocrine cells. Cell Metab (2008) 1.35
Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act? Trends Pharmacol Sci (2007) 1.33
In vivo characterization of high Basal signaling from the ghrelin receptor. Endocrinology (2009) 1.08
NK1 receptor fused to beta-arrestin displays a single-component, high-affinity molecular phenotype. Mol Pharmacol (2002) 1.08
Importance of constitutive activity and arrestin-independent mechanisms for intracellular trafficking of the ghrelin receptor. Mol Endocrinol (2007) 1.07
Laboratory animals as surrogate models of human obesity. Acta Pharmacol Sin (2012) 1.01
Dietary fat decreases intestinal levels of the anorectic lipids through a fat sensor. FASEB J (2010) 0.99
Chronic administration of the glucagon-like peptide-1 analog, liraglutide, delays the onset of diabetes and lowers triglycerides in UCD-T2DM rats. Diabetes (2010) 0.96
Ago-allosteric modulation and other types of allostery in dimeric 7TM receptors. J Recept Signal Transduct Res (2006) 0.95
Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines. Cell Metab (2012) 0.95
Long-acting lipidated analogue of human pancreatic polypeptide is slowly released into circulation. J Med Chem (2011) 0.94
Fibroblast growth factor 21 (FGF21) and glucagon-like peptide 1 contribute to diabetes resistance in glucagon receptor-deficient mice. Diabetes (2013) 0.93
Identification and in vivo and in vitro characterization of long acting and melanocortin 4 receptor (MC4-R) selective α-melanocyte-stimulating hormone (α-MSH) analogues. J Med Chem (2012) 0.93
L-Arginine improves multiple physiological parameters in mice exposed to diet-induced metabolic disturbances. Amino Acids (2011) 0.91
Design, synthesis, structural and functional characterization of novel melanocortin agonists based on the cyclotide kalata B1. J Biol Chem (2012) 0.91
Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39. FEBS Lett (2008) 0.90
Melanocortin 4 receptor mutations in obese Czech children: studies of prevalence, phenotype development, weight reduction response, and functional analysis. J Clin Endocrinol Metab (2007) 0.89
GPR39 splice variants versus antisense gene LYPD1: expression and regulation in gastrointestinal tract, endocrine pancreas, liver, and white adipose tissue. Mol Endocrinol (2007) 0.89
The young Göttingen minipig as a model of childhood and adolescent obesity: influence of diet and gender. Obesity (Silver Spring) (2013) 0.89
Gender-associated differences in metabolic syndrome-related parameters in Göttingen minipigs. Comp Med (2007) 0.88
Acylation type determines ghrelin's effects on energy homeostasis in rodents. Endocrinology (2012) 0.88
Increased susceptibility to diet-induced obesity in GPRC6A receptor knockout mice. J Endocrinol (2013) 0.87
Distinct in vitro interaction pattern of dopamine receptor subtypes with adaptor proteins involved in post-endocytotic receptor targeting. FEBS Lett (2004) 0.87
MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans. Diabetes (2010) 0.86
Ultrasound can predict regenerate stiffness in distraction osteogenesis. Clin Orthop Relat Res (2002) 0.86
Influence of castration-induced testosterone and estradiol deficiency on obesity and glucose metabolism in male Göttingen minipigs. Steroids (2010) 0.86
PheVI:09 (Phe6.44) as a sliding microswitch in seven-transmembrane (7TM) G protein-coupled receptor activation. J Biol Chem (2012) 0.85
Fmoc solid-phase synthesis of C-terminal peptide thioesters by formation of a backbone pyroglutamyl imide moiety. Angew Chem Int Ed Engl (2009) 0.85
Evaluation of different methods for assessment of insulin sensitivity in Gottingen minipigs: introduction of a new, simpler method. Am J Physiol Regul Integr Comp Physiol (2009) 0.85
β-Cell Specific Overexpression of GPR39 Protects against Streptozotocin-Induced Hyperglycemia. Int J Endocrinol (2011) 0.84
A second disulfide bridge from the N-terminal domain to extracellular loop 2 dampens receptor activity in GPR39. Biochemistry (2008) 0.84
Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop. J Biol Chem (2012) 0.83
Agonism and antagonism at the insulin receptor. PLoS One (2012) 0.81
Risperidone treatment increases CB1 receptor binding in rat brain. Neuroendocrinology (2009) 0.81
An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor. J Med Chem (2012) 0.81
Unique interaction pattern for a functionally biased ghrelin receptor agonist. J Biol Chem (2011) 0.81
An enteroendocrine full package solution. Cell Metab (2010) 0.80
Functional importance of GLP-1 receptor species and expression levels in cell lines. Regul Pept (2012) 0.80
Effects of a maternal diet supplemented with chocolate and fructose beverage during gestation and lactation on rat dams and their offspring. Clin Exp Pharmacol Physiol (2011) 0.80
Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine in mice. Biochim Biophys Acta (2011) 0.80
Peptide hormone isoforms: N-terminally branched PYY3-36 isoforms give improved lipid and fat-cell metabolism in diet-induced obese mice. J Pept Sci (2010) 0.79
Deficiency of the GPR39 receptor is associated with obesity and altered adipocyte metabolism. FASEB J (2011) 0.79
Modulation of the constitutive activity of the ghrelin receptor by use of pharmacological tools and mutagenesis. Methods Enzymol (2010) 0.79
Early onset inflammation in pre-insulin-resistant diet-induced obese rats does not affect the vasoreactivity of isolated small mesenteric arteries. Pharmacology (2012) 0.79
Modifying the conserved C-terminal tyrosine of the peptide hormone PYY3-36 to improve Y2 receptor selectivity. J Pept Sci (2009) 0.79
Physiology of meiosis-activating sterol: endogenous formation and mode of action. Hum Reprod (2003) 0.79
Synthesis and evaluation of novel lipidated neuromedin U analogs with increased stability and effects on food intake. J Pept Sci (2014) 0.78
Adipose weight gain during chronic insulin treatment of mice results from changes in lipid storage without affecting de novo synthesis of palmitate. PLoS One (2013) 0.78
Fluctuating hyperglycaemia increases oxidative stress response in lean rats compared to sustained hyperglycaemia despite lower glycaemic exposure. Diab Vasc Dis Res (2011) 0.78
Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity. PLoS One (2010) 0.77
Handling a tricycle: orthogonal versus random oxidation of the tricyclic inhibitor cystine knotted peptide gurmarin. Peptides (2012) 0.77
Serendipitous discovery of a new class of agonists for the melanocortin 1 and 4 receptors and a new class of cyclophanes. Bioorg Med Chem Lett (2011) 0.77
Novel α-MSH analog causes weight loss in obese rats and minipigs and improves insulin sensitivity. J Endocrinol (2014) 0.77
Laparoscopic Roux-en-Y gastric bypass in super obese Göttingen minipigs. Am J Transl Res (2013) 0.76
Improving membrane binding as a design strategy for amphipathic peptide hormones: 2-helix variants of PYY3-36. J Pept Sci (2012) 0.75
Does Glucagon-like Peptide-1 Ameliorate Oxidative Stress in Diabetes? Evidence Based on Experimental and Clinical Studies. Curr Diabetes Rev (2016) 0.75
The influence of conformational restriction in the C-terminus of growth hormone secretagogues on their potency. Eur J Med Chem (2002) 0.75
Stability, liposome interaction, and in vivo pharmacology of ghrelin in liposomal suspensions. Int J Pharm (2009) 0.75
Model-based Discovery of Synthetic Agonists for the Zn<sup<2+</sup>-sensing G Protein Coupled Receptor 39 (GPR39) Reveals Novel Biological Functions. J Med Chem (2017) 0.75