Published in J Biol Chem on March 27, 2006
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor. Nature (2010) 3.19
G protein coupled receptor structure and activation. Biochim Biophys Acta (2006) 2.48
Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation. Nat Struct Mol Biol (2009) 2.32
Stabilization of the human beta2-adrenergic receptor TM4-TM3-TM5 helix interface by mutagenesis of Glu122(3.41), a critical residue in GPCR structure. J Mol Biol (2007) 1.63
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A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors. J Biol Chem (2009) 1.25
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Conserved water-mediated hydrogen bond network between TM-I, -II, -VI, and -VII in 7TM receptor activation. J Biol Chem (2010) 0.99
Neoceptors: reengineering GPCRs to recognize tailored ligands. Trends Pharmacol Sci (2007) 0.94
Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonist. J Biol Chem (2011) 0.92
Pirenzepine promotes the dimerization of muscarinic M1 receptors through a three-step binding process. J Biol Chem (2009) 0.92
Structure, function and physiological consequences of virally encoded chemokine seven transmembrane receptors. Br J Pharmacol (2008) 0.91
Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183). J Biol Chem (2012) 0.88
Probing the binding site of the A1 adenosine receptor reengineered for orthogonal recognition by tailored nucleosides. Biochemistry (2007) 0.88
Congenital hypogonadotropic hypogonadism due to GnRH receptor mutations in three brothers reveal sites affecting conformation and coupling. PLoS One (2012) 0.85
Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop. J Biol Chem (2012) 0.83
Activation induces structural changes in the liganded angiotensin II type 1 receptor. J Biol Chem (2009) 0.82
G-protein coupled receptor 83 (GPR83) signaling determined by constitutive and zinc(II)-induced activity. PLoS One (2013) 0.81
Interactions of the melanocortin-4 receptor with the peptide agonist NDP-MSH. J Mol Biol (2010) 0.80
Understanding functional residues of the cannabinoid CB1. Curr Top Med Chem (2010) 0.78
Extracellular pH regulates zinc signaling via an Asp residue of the zinc-sensing receptor (ZnR/GPR39). J Biol Chem (2012) 0.78
Ligand-mimicking receptor variant discloses binding and activation mode of prolactin-releasing peptide. J Biol Chem (2012) 0.77
Free backbone carbonyls mediate rhodopsin activation. Nat Struct Mol Biol (2016) 0.77
Retinal Conformation Changes Rhodopsin's Dynamic Ensemble. Biophys J (2015) 0.76
Uncovering the triggers for GPCR activation using solid-state NMR spectroscopy. J Magn Reson (2015) 0.76
Structural basis for constitutive activity and agonist-induced activation of the enteroendocrine fat sensor GPR119. Br J Pharmacol (2014) 0.75
The essential role for aromatic cluster in the β3 adrenergic receptor. Acta Pharmacol Sin (2012) 0.75
Molecular Mechanism of Action for Allosteric Modulators and Agonists in CC-chemokine Receptor 5 (CCR5). J Biol Chem (2016) 0.75
Investigation of allosteric coupling in human β2-adrenergic receptor in the presence of intracellular loop 3. BMC Struct Biol (2016) 0.75
Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants. Nat Genet (2010) 5.44
Molecular mechanism of 7TM receptor activation--a global toggle switch model. Annu Rev Pharmacol Toxicol (2006) 3.33
Ligand binding and micro-switches in 7TM receptor structures. Trends Pharmacol Sci (2009) 2.33
High constitutive signaling of the ghrelin receptor--identification of a potent inverse agonist. Mol Endocrinol (2003) 1.97
GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes. Endocrinology (2013) 1.89
High constitutive activity of a virus-encoded seven transmembrane receptor in the absence of the conserved DRY motif (Asp-Arg-Tyr) in transmembrane helix 3. Mol Pharmacol (2005) 1.86
The chemokine system -- a major regulator of angiogenesis in health and disease. APMIS (2004) 1.72
Localization of HCMV UL33 and US27 in endocytic compartments and viral membranes. Traffic (2002) 1.65
GPR39 signaling is stimulated by zinc ions but not by obestatin. Endocrinology (2006) 1.60
Murine cytomegalovirus (CMV) M33 and human CMV US28 receptors exhibit similar constitutive signaling activities. J Virol (2002) 1.56
Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor. J Biol Chem (2003) 1.50
Common structural basis for constitutive activity of the ghrelin receptor family. J Biol Chem (2004) 1.49
Metal ion enhanced binding of AMD3100 to Asp262 in the CXCR4 receptor. Biochemistry (2003) 1.40
The human herpes virus 8-encoded chemokine receptor is required for angioproliferation in a murine model of Kaposi's sarcoma. J Immunol (2005) 1.35
The minor binding pocket: a major player in 7TM receptor activation. Trends Pharmacol Sci (2010) 1.35
A gut feeling for obesity: 7TM sensors on enteroendocrine cells. Cell Metab (2008) 1.35
Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act? Trends Pharmacol Sci (2007) 1.33
Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity. J Biol Chem (2006) 1.32
A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin. Endocrinology (2012) 1.31
A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors. J Biol Chem (2009) 1.25
Oxyntomodulin differentially affects glucagon-like peptide-1 receptor beta-arrestin recruitment and signaling through Galpha(s). J Pharmacol Exp Ther (2007) 1.22
Structural biology: A moving story of receptors. Nature (2008) 1.22
The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis. J Biol Chem (2003) 1.20
GPR119 as a fat sensor. Trends Pharmacol Sci (2012) 1.20
Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation. Trends Pharmacol Sci (2004) 1.15
Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. Mol Metab (2013) 1.14
Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor. J Biol Chem (2007) 1.13
AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor. Biochem Pharmacol (2005) 1.11
In vivo characterization of high Basal signaling from the ghrelin receptor. Endocrinology (2009) 1.08
NK1 receptor fused to beta-arrestin displays a single-component, high-affinity molecular phenotype. Mol Pharmacol (2002) 1.08
Importance of constitutive activity and arrestin-independent mechanisms for intracellular trafficking of the ghrelin receptor. Mol Endocrinol (2007) 1.07
Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling. Mol Endocrinol (2005) 1.07
A physicogenetic method to assign ligand-binding relationships between 7TM receptors. Bioorg Med Chem Lett (2005) 1.06
Similar activation of signal transduction pathways by the herpesvirus-encoded chemokine receptors US28 and ORF74. Virology (2004) 1.06
Phosphorylation of the beta2-adrenergic receptor in plasma membranes by intrinsic GRK5. Biochemistry (2007) 1.05
CC and CX3C chemokines differentially interact with the N terminus of the human cytomegalovirus-encoded US28 receptor. J Biol Chem (2004) 1.01
Enteroendocrine cell types revisited. Curr Opin Pharmacol (2013) 1.00
Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding. J Biol Chem (2008) 0.99
Dimerization of ADAR2 is mediated by the double-stranded RNA binding domain. RNA (2006) 0.99
Dietary fat decreases intestinal levels of the anorectic lipids through a fat sensor. FASEB J (2010) 0.99
Preparation and evaluation of sulfur-containing metal chelators. Org Biomol Chem (2003) 0.99
Conserved water-mediated hydrogen bond network between TM-I, -II, -VI, and -VII in 7TM receptor activation. J Biol Chem (2010) 0.99
Allosteric and orthosteric sites in CC chemokine receptor (CCR5), a chimeric receptor approach. J Biol Chem (2011) 0.98
Characterization of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotype. Mol Endocrinol (2004) 0.97
Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism. J Biol Chem (2007) 0.96
G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction. Endocrinology (2009) 0.96
A highly conserved glycine within linker I and the extreme C terminus of G protein alpha subunits interact cooperatively in switching G protein-coupled receptor-to-effector specificity. J Pharmacol Exp Ther (2004) 0.95
Ago-allosteric modulation and other types of allostery in dimeric 7TM receptors. J Recept Signal Transduct Res (2006) 0.95
Ghrelin receptor mutations--too little height and too much hunger. J Clin Invest (2006) 0.95
Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines. Cell Metab (2012) 0.95
Biased and constitutive signaling in the CC-chemokine receptor CCR5 by manipulating the interface between transmembrane helices 6 and 7. J Biol Chem (2013) 0.95
Long-acting lipidated analogue of human pancreatic polypeptide is slowly released into circulation. J Med Chem (2011) 0.94
Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors. J Biol Chem (2002) 0.94
Identification of a novel site within G protein alpha subunits important for specificity of receptor-G protein interaction. Mol Pharmacol (2004) 0.93
Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor. Mol Pharmacol (2008) 0.93
Molecular mechanism of agonism and inverse agonism in the melanocortin receptors: Zn(2+) as a structural and functional probe. Ann N Y Acad Sci (2003) 0.93
Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonist. J Biol Chem (2011) 0.92
L-Arginine improves multiple physiological parameters in mice exposed to diet-induced metabolic disturbances. Amino Acids (2011) 0.91
GluVII:06--a highly conserved and selective anchor point for non-peptide ligands in chemokine receptors. Curr Top Med Chem (2006) 0.91
Development of a BRET2 screening assay using beta-arrestin 2 mutants. J Biomol Screen (2004) 0.90
Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39. FEBS Lett (2008) 0.90
Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry. FEBS Lett (2003) 0.90
Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists. Bioorg Med Chem Lett (2012) 0.90
Melanocortin 4 receptor mutations in obese Czech children: studies of prevalence, phenotype development, weight reduction response, and functional analysis. J Clin Endocrinol Metab (2007) 0.89
GPR39 splice variants versus antisense gene LYPD1: expression and regulation in gastrointestinal tract, endocrine pancreas, liver, and white adipose tissue. Mol Endocrinol (2007) 0.89
Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3. J Biol Chem (2007) 0.89
Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8. Mol Pharmacol (2007) 0.88
Activation of the CXCR3 chemokine receptor through anchoring of a small molecule chelator ligand between TM-III, -IV, and -VI. Mol Pharmacol (2006) 0.88
Acylation type determines ghrelin's effects on energy homeostasis in rodents. Endocrinology (2012) 0.88
Bioorthogonal fluorescent labeling of functional G-protein-coupled receptors. Chembiochem (2014) 0.87
The virus-encoded chemokine vMIP-II inhibits virus-induced Tc1-driven inflammation. J Virol (2003) 0.87
Increased susceptibility to diet-induced obesity in GPRC6A receptor knockout mice. J Endocrinol (2013) 0.87
Characterization of G-protein coupled receptor kinase interaction with the neurokinin-1 receptor using bioluminescence resonance energy transfer. Mol Pharmacol (2007) 0.87
Distinct in vitro interaction pattern of dopamine receptor subtypes with adaptor proteins involved in post-endocytotic receptor targeting. FEBS Lett (2004) 0.87
Characterization of murine melanocortin receptors mediating adipocyte lipolysis and examination of signalling pathways involved. Mol Cell Endocrinol (2011) 0.86
MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans. Diabetes (2010) 0.86