Published in PLoS One on May 26, 2011
Identification and characterization of microRNAs in Phaseolus vulgaris by high-throughput sequencing. BMC Genomics (2012) 1.16
Age-associated miRNA alterations in skeletal muscle from rhesus monkeys reversed by caloric restriction. Aging (Albany NY) (2013) 1.00
Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing. BMC Genomics (2012) 0.99
Dependence of intracellular and exosomal microRNAs on viral E6/E7 oncogene expression in HPV-positive tumor cells. PLoS Pathog (2015) 0.97
Different miRNA expression profiles between human breast cancer tumors and serum. Front Genet (2014) 0.94
MicroRNA-152 and -181a participate in human dermal fibroblasts senescence acting on cell adhesion and remodeling of the extra-cellular matrix. Aging (Albany NY) (2012) 0.92
Deep sequencing identifies circulating mouse miRNAs that are functionally implicated in manifestations of aging and responsive to calorie restriction. Aging (Albany NY) (2013) 0.90
Identification of potential microRNA-target pairs associated with osteopetrosis by deep sequencing, iTRAQ proteomics and bioinformatics. Eur J Hum Genet (2013) 0.87
microRNA profiling in the zoonotic parasite Echinococcus canadensis using a high-throughput approach. Parasit Vectors (2015) 0.85
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From cellular senescence to age-associated diseases: the miRNA connection. Longev Healthspan (2012) 0.85
Bioinformatic Resources of microRNA Sequences, Gene Targets, and Genetic Variation. Front Genet (2012) 0.84
Modulation of cancer traits by tumor suppressor microRNAs. Int J Mol Sci (2013) 0.82
Expression of senescence-associated microRNAs and target genes in cellular aging and modulation by tocotrienol-rich fraction. Oxid Med Cell Longev (2014) 0.81
Genome wide expression profiling of p53 regulated miRNAs in neuroblastoma. Sci Rep (2015) 0.81
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A simple high-throughput technology enables gain-of-function screening of human microRNAs. Biotechniques (2013) 0.80
Identification and characterization of microRNAs by high through-put sequencing in mesenchymal stem cells and bone tissue from mice of age-related osteoporosis. PLoS One (2013) 0.80
Deep sequencing identification of novel glucocorticoid-responsive miRNAs in apoptotic primary lymphocytes. PLoS One (2013) 0.79
The Intricate Interplay between Mechanisms Underlying Aging and Cancer. Aging Dis (2014) 0.79
microRNA expression profile of peripheral blood mononuclear cells of Klinefelter syndrome. Exp Ther Med (2012) 0.79
Analysis of MicroRNA Expression Profiles in Weaned Pig Skeletal Muscle after Lipopolysaccharide Challenge. Int J Mol Sci (2015) 0.78
The evolutionary young miR-1290 favors mitotic exit and differentiation of human neural progenitors through altering the cell cycle proteins. Cell Death Dis (2014) 0.78
Identification of novel microRNAs in primates by using the synteny information and small RNA deep sequencing data. Int J Mol Sci (2013) 0.77
Identification of General and Heart-Specific miRNAs in Sheep (Ovis aries). PLoS One (2015) 0.77
Inference of Target Gene Regulation via miRNAs during Cell Senescence by Using the MiRaGE Server. Aging Dis (2012) 0.77
E2F7 regulates transcription and maturation of multiple microRNAs to restrain cell proliferation. Nucleic Acids Res (2016) 0.77
Characterization of Senescence of Culture-expanded Human Adipose-derived Mesenchymal Stem Cells. Int J Stem Cells (2016) 0.77
Conserved Senescence Associated Genes and Pathways in Primary Human Fibroblasts Detected by RNA-Seq. PLoS One (2016) 0.76
Identification of miRNAs during mouse postnatal ovarian development and superovulation. J Ovarian Res (2015) 0.76
Potential roles of DNA methylation in the initiation and establishment of replicative senescence revealed by array-based methylome and transcriptome analyses. PLoS One (2017) 0.75
Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence. Biol Res (2016) 0.75
MicroRNA profile comparison of the corneal endothelia of young and old mice: implications for senescence of the corneal endothelium. Mol Vis (2013) 0.75
Integrated profiling of microRNA expression in membranous nephropathy using high-throughput sequencing technology. Int J Mol Med (2013) 0.75
mirPRo-a novel standalone program for differential expression and variation analysis of miRNAs. Sci Rep (2015) 0.75
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc (2009) 137.99
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A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics (2003) 82.89
Differential expression analysis for sequence count data. Genome Biol (2010) 64.56
A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A (1995) 32.89
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A microRNA component of the p53 tumour suppressor network. Nature (2007) 19.25
Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol (2007) 16.55
Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem (2010) 12.06
microRNAs as oncogenes and tumor suppressors. Dev Biol (2006) 10.68
Discovering microRNAs from deep sequencing data using miRDeep. Nat Biotechnol (2008) 10.17
A comparison of background correction methods for two-colour microarrays. Bioinformatics (2007) 8.59
miRiad roles for the miR-17-92 cluster in development and disease. Cell (2008) 8.02
miR2Disease: a manually curated database for microRNA deregulation in human disease. Nucleic Acids Res (2008) 6.30
Next-generation DNA sequencing techniques. N Biotechnol (2009) 6.02
miRNAs in human cancer. J Pathol (2010) 6.02
The role of let-7 in cell differentiation and cancer. Endocr Relat Cancer (2010) 3.95
Desperately seeking microRNA targets. Nat Struct Mol Biol (2010) 3.85
Accumulation of senescent cells in mitotic tissue of aging primates. Mech Ageing Dev (2006) 3.14
Expression profiling of microRNAs by deep sequencing. Brief Bioinform (2009) 2.71
MicroRNAs as regulators of differentiation and cell fate decisions. Cell Stem Cell (2010) 2.57
The biology of replicative senescence. Eur J Cancer (1997) 2.42
Cellular senescence in usual type uterine leiomyoma. Fertil Steril (2009) 2.34
Uncovering the complexity of transcriptomes with RNA-Seq. J Biomed Biotechnol (2010) 2.32
Senescent cells as a source of inflammatory factors for tumor progression. Cancer Metastasis Rev (2010) 2.32
miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging. Aging Cell (2010) 2.31
MicroRNAs 1, 133, and 206: critical factors of skeletal and cardiac muscle development, function, and disease. Int J Biochem Cell Biol (2009) 2.30
Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukaemia. PLoS One (2008) 2.27
MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1. Circulation (2009) 2.05
p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation. Mol Syst Biol (2008) 2.04
MicroRNAs as effectors of brain function with roles in ischemia and injury, neuroprotection, and neurodegeneration. J Cereb Blood Flow Metab (2010) 1.92
microRNA expression patterns reveal differential expression of target genes with age. PLoS One (2010) 1.92
Advantages of next-generation sequencing versus the microarray in epigenetic research. Brief Funct Genomic Proteomic (2009) 1.91
miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A. Genes Dev (2009) 1.91
Critical pathways in cellular senescence and immortalization revealed by gene expression profiling. Oncogene (2008) 1.81
miR-29 and miR-30 regulate B-Myb expression during cellular senescence. Proc Natl Acad Sci U S A (2010) 1.81
Ultra-high throughput sequencing-based small RNA discovery and discrete statistical biomarker analysis in a collection of cervical tumours and matched controls. BMC Biol (2010) 1.80
The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence. Cancer Res (2010) 1.60
Cellular senescence: molecular mechanisms, in vivo significance, and redox considerations. Antioxid Redox Signal (2009) 1.60
MicroRNA-34a regulation of endothelial senescence. Biochem Biophys Res Commun (2010) 1.58
Stepwise up-regulation of microRNA expression levels from replicating to reversible and irreversible growth arrest states in WI-38 human fibroblasts. J Cell Physiol (2009) 1.54
MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence. Aging (Albany NY) (2010) 1.53
Aging and microRNA expression in human skeletal muscle: a microarray and bioinformatics analysis. Physiol Genomics (2010) 1.43
WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway. Cancer Res (2009) 1.39
Pathway analysis of senescence-associated miRNA targets reveals common processes to different senescence induction mechanisms. Biochim Biophys Acta (2009) 1.36
Molecular biology: the expanding world of small RNAs. Nature (2008) 1.35
MicroRNA transcriptome profiles during swine skeletal muscle development. BMC Genomics (2009) 1.35
MicroRNAs and lung cancer: new oncogenes and tumor suppressors, new prognostic factors and potential therapeutic targets. Curr Med Chem (2009) 1.34
miR-17-92 cluster: ups and downs in cancer and aging. Biogerontology (2010) 1.32
Exprtarget: an integrative approach to predicting human microRNA targets. PLoS One (2010) 1.31
Discovery of microRNAs and other small RNAs in solid tumors. Nucleic Acids Res (2010) 1.28
Novel modulators of senescence, aging, and longevity: Small non-coding RNAs enter the stage. Exp Gerontol (2010) 1.28
MiRNA profile associated with replicative senescence, extended cell culture, and ectopic telomerase expression in human foreskin fibroblasts. PLoS One (2010) 1.19
N-t-butyl hydroxylamine, a hydrolysis product of alpha-phenyl-N-t-butyl nitrone, is more potent in delaying senescence in human lung fibroblasts. J Biol Chem (2000) 1.14
MicroRNA regulation of ionizing radiation-induced premature senescence. Int J Radiat Oncol Biol Phys (2010) 1.08
Differential miRNA expression and their target genes between NGX6-positive and negative colon cancer cells. Mol Cell Biochem (2010) 1.04
Bioinformatic identification and characterization of human endothelial cell-restricted genes. BMC Genomics (2010) 0.95
miR-20a and miR-290, multi-faceted players with a role in tumourigenesis and senescence. J Cell Mol Med (2010) 0.93
MicroRNA regulation in cardiovascular disease. Curr Drug Targets (2010) 0.89
Targeting major vault protein in senescence-associated apoptosis resistance. Expert Opin Ther Targets (2009) 0.88
MicroRNAs, epigenetics and disease. Essays Biochem (2010) 0.88
Roles of GSK3 in metabolic shift toward abnormal anabolism in cell senescence. Ann N Y Acad Sci (2010) 0.88
Senescent vs. non-senescent cells in the human annulus in vivo: cell harvest with laser capture microdissection and gene expression studies with microarray analysis. BMC Biotechnol (2010) 0.83
New surprises from the deep--the family of small regulatory RNAs increases. ScientificWorldJournal (2010) 0.80
MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function. Proc Natl Acad Sci U S A (2005) 5.35
Symbiosis insights through metagenomic analysis of a microbial consortium. Nature (2006) 5.04
Inheritance of a cancer-associated MLH1 germ-line epimutation. N Engl J Med (2007) 4.87
Germline epimutation of MLH1 in individuals with multiple cancers. Nat Genet (2004) 4.74
Temporal linkage between the phenotypic and genomic responses to caloric restriction. Proc Natl Acad Sci U S A (2004) 3.00
Identification and correction of systematic error in high-throughput sequence data. BMC Bioinformatics (2011) 2.98
Metformin improves healthspan and lifespan in mice. Nat Commun (2013) 2.68
Germ-line epigenetic modification of the murine A vy allele by nutritional supplementation. Proc Natl Acad Sci U S A (2006) 2.63
Transcriptional interference by independently regulated genes occurs in any relative arrangement of the genes and is influenced by chromosomal integration position. Mol Cell Biol (2002) 1.78
Delayed and accelerated aging share common longevity assurance mechanisms. PLoS Genet (2008) 1.76
Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell (2013) 1.71
microRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells. PLoS One (2009) 1.67
c-kit is required for cardiomyocyte terminal differentiation. Circ Res (2008) 1.58
Additive regulation of hepatic gene expression by dwarfism and caloric restriction. Physiol Genomics (2004) 1.50
Identification of potential caloric restriction mimetics by microarray profiling. Physiol Genomics (2005) 1.46
Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites. Ann N Y Acad Sci (2002) 1.36
5' tRNA halves are present as abundant complexes in serum, concentrated in blood cells, and modulated by aging and calorie restriction. BMC Genomics (2013) 1.30
Gene expression and physiologic responses of the heart to the initiation and withdrawal of caloric restriction. J Gerontol A Biol Sci Med Sci (2006) 1.25
eShadow: a tool for comparing closely related sequences. Genome Res (2004) 1.18
A sustained dietary change increases epigenetic variation in isogenic mice. PLoS Genet (2011) 1.16
Genome methylation in D. melanogaster is found at specific short motifs and is independent of DNMT2 activity. Genome Res (2014) 1.12
Detection of weakly conserved ancestral mammalian regulatory sequences by primate comparisons. Genome Biol (2007) 1.08
Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging. Mol Aspects Med (2005) 1.06
Centromere remodeling in Hoolock leuconedys (Hylobatidae) by a new transposable element unique to the gibbons. Genome Biol Evol (2012) 1.02
5'-YRNA fragments derived by processing of transcripts from specific YRNA genes and pseudogenes are abundant in human serum and plasma. Physiol Genomics (2013) 1.02
Paramutation: the tip of an epigenetic iceberg? Trends Genet (2009) 0.97
PCR-based expression analysis and identification of microRNAs. J RNAi Gene Silencing (2005) 0.96
Primate-specific evolution of an LDLR enhancer. Genome Biol (2006) 0.94
Maternal obesity and diabetes induces latent metabolic defects and widespread epigenetic changes in isogenic mice. Epigenetics (2013) 0.94
Methyl donors change the germline epigenetic state of the A(vy) allele. FASEB J (2007) 0.92
CpG methylation of a silent controlling element in the murine Avy allele is incomplete and unresponsive to methyl donor supplementation. PLoS One (2010) 0.92
Phyloepigenomic comparison of great apes reveals a correlation between somatic and germline methylation states. Genome Res (2011) 0.91
Activation-induced cytidine deaminase (AID) is necessary for the epithelial-mesenchymal transition in mammary epithelial cells. Proc Natl Acad Sci U S A (2013) 0.90
Deep sequencing identifies circulating mouse miRNAs that are functionally implicated in manifestations of aging and responsive to calorie restriction. Aging (Albany NY) (2013) 0.90
Iron accumulation during cellular senescence in human fibroblasts in vitro. Antioxid Redox Signal (2003) 0.89
Gender and age-dependent differences in the mitochondrial apoptogenic pathway in Alzheimer's disease. Free Radic Biol Med (2008) 0.89
MetMap enables genome-scale Methyltyping for determining methylation states in populations. PLoS Comput Biol (2010) 0.89
CpG hypomethylation in a large domain encompassing the embryonic beta-like globin genes in primitive erythrocytes. Mol Cell Biol (2007) 0.88
Inherited epimutation or a haplotypic basis for the propensity to silence? Nat Genet (2007) 0.87
Chromatin insulation by a transcriptional activator. Proc Natl Acad Sci U S A (2003) 0.87
Iron accumulation during cellular senescence. Ann N Y Acad Sci (2004) 0.86
Postprandial induction of chaperone gene expression is rapid in mice. J Nutr (2002) 0.85
The penetrance of an epigenetic trait in mice is progressively yet reversibly increased by selection and environment. Proc Biol Sci (2012) 0.85
VISTA Region Viewer (RViewer)--a computational system for prioritizing genomic intervals for biomedical studies. Bioinformatics (2011) 0.85
LPA and PLG sequence variation and kringle IV-2 copy number in two populations. Hum Hered (2008) 0.85
Statin-induced changes in gene expression in EBV-transformed and native B-cells. Hum Mol Genet (2013) 0.83
N-tert-butyl hydroxylamine, a mitochondrial antioxidant, protects human retinal pigment epithelial cells from iron overload: relevance to macular degeneration. FASEB J (2007) 0.83
Now you see it: genome methylation makes a comeback in Drosophila. Bioessays (2014) 0.82
Hepatic gene expression profiling of streptozotocin-induced diabetes. Diabetes Technol Ther (2003) 0.81
Obesity in BSB mice is correlated with expression of genes for iron homeostasis and leptin. Obes Res (2004) 0.80
Therapeutic approaches to delay the onset of Alzheimer's disease. J Aging Res (2011) 0.79
Germline epimutation in humans. Pharmacogenomics (2008) 0.78
mRNA-Seq reveals complex patterns of gene regulation and expression in the mouse skeletal muscle transcriptome associated with calorie restriction. Physiol Genomics (2012) 0.77
Controlling elements are wild cards in the epigenomic deck. Proc Natl Acad Sci U S A (2007) 0.77
Development of a bioassay to screen for chemicals mimicking the anti-aging effects of calorie restriction. Biochem Biophys Res Commun (2010) 0.77
Epigenetic inheritance: a contributor to species differentiation? DNA Cell Biol (2012) 0.76
A role for epigenetic inheritance in modern evolutionary theory? A comment in response to Dickins and Rahman. Proc Biol Sci (2013) 0.75
Activators antagonize heterochromatic silencing: reply to Eissenberg. Bioessays (2002) 0.75