Regulation of mRNA translation and stability by microRNAs.

The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet (2010) 15.87

A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? Cell (2011) 10.50

The functional role of long non-coding RNA in human carcinomas. Mol Cancer (2011) 6.37

Ribosome profiling shows that miR-430 reduces translation before causing mRNA decay in zebrafish. Science (2012) 4.61

MicroRNA functions in stress responses. Mol Cell (2010) 4.46

Mapping the human miRNA interactome by CLASH reveals frequent noncanonical binding. Cell (2013) 4.28

Small RNA sorting: matchmaking for Argonautes. Nat Rev Genet (2010) 4.27

Mechanisms and consequences of alternative polyadenylation. Mol Cell (2011) 3.96

MicroRNA regulation by RNA-binding proteins and its implications for cancer. Nat Rev Cancer (2011) 3.91

A parsimonious model for gene regulation by miRNAs. Science (2011) 3.79

The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC. Nat Struct Mol Biol (2012) 3.42

Long intergenic noncoding RNAs: new links in cancer progression. Cancer Res (2011) 3.38

MicroRNAs and other non-coding RNAs as targets for anticancer drug development. Nat Rev Drug Discov (2013) 3.33

miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors. Mol Cell (2010) 3.27

The rise of regulatory RNA. Nat Rev Genet (2014) 3.02

MicroRNA sequence and expression analysis in breast tumors by deep sequencing. Cancer Res (2011) 3.02

IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab (2012) 2.80

MicroRNAs in the p53 network: micromanagement of tumour suppression. Nat Rev Cancer (2012) 2.78

Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants. Mol Cell (2011) 2.73

miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs. Nat Struct Mol Biol (2011) 2.70

Biogenesis, turnover, and mode of action of plant microRNAs. Plant Cell (2013) 2.65

miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT. Nat Struct Mol Biol (2011) 2.61

YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29. Nat Cell Biol (2012) 2.59

Extracellular microRNA: a new source of biomarkers. Mutat Res (2011) 2.55

The Host Shapes the Gut Microbiota via Fecal MicroRNA. Cell Host Microbe (2016) 2.48

The emerging field of RNA nanotechnology. Nat Nanotechnol (2010) 2.45

The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease. Cell Death Differ (2013) 2.41

Stabilization of hepatitis C virus RNA by an Ago2-miR-122 complex. Proc Natl Acad Sci U S A (2012) 2.39

Alternative cleavage and polyadenylation: extent, regulation and function. Nat Rev Genet (2013) 2.37

Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm. Mol Cell (2011) 2.33

Flow-Dependent Regulation of Kruppel-Like Factor 2 Is Mediated by MicroRNA-92a. Circulation (2011) 2.29

MicroRNAs inhibit the translation of target mRNAs on the endoplasmic reticulum in Arabidopsis. Cell (2013) 2.28

MicroRNAs: Processing, Maturation, Target Recognition and Regulatory Functions. Mol Cell Pharmacol (2011) 2.25

Vive la différence: biogenesis and evolution of microRNAs in plants and animals. Genome Biol (2011) 2.21

Concern Misregulation of AUXIN RESPONSE FACTOR 8 underlies the developmental abnormalities caused by three distinct viral silencing suppressors in Arabidopsis. PLoS Pathog (2011) 2.12

Regulation of eukaryotic gene expression by the untranslated gene regions and other non-coding elements. Cell Mol Life Sci (2012) 1.96

MicroRNA-128 governs neuronal excitability and motor behavior in mice. Science (2013) 1.95

MicroRNA in TLR signaling and endotoxin tolerance. Cell Mol Immunol (2011) 1.86

Vigilance and validation: Keys to success in RNAi screening. ACS Chem Biol (2010) 1.85

Autoregulation of microRNA biogenesis by let-7 and Argonaute. Nature (2012) 1.85

Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation. Blood (2011) 1.80

Argonaute proteins couple chromatin silencing to alternative splicing. Nat Struct Mol Biol (2012) 1.80

Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities. Blood (2010) 1.79

Comprehensive profiling of circulating microRNA via small RNA sequencing of cDNA libraries reveals biomarker potential and limitations. Proc Natl Acad Sci U S A (2013) 1.79

MicroRNA-mediated regulation of T helper cell differentiation and plasticity. Nat Rev Immunol (2013) 1.75

Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7). RNA (2012) 1.74

Aberrant regulation and function of microRNAs in cancer. Curr Biol (2014) 1.72

Breast cancer - one term, many entities? J Clin Invest (2011) 1.72

Functional interplay between RNA-binding protein HuR and microRNAs. Curr Protein Pept Sci (2012) 1.71

MicroRNA-21 orchestrates high glucose-induced signals to TOR complex 1, resulting in renal cell pathology in diabetes. J Biol Chem (2011) 1.70

miR-122 activates hepatitis C virus translation by a specialized mechanism requiring particular RNA components. Nucleic Acids Res (2011) 1.67

microRNAs associated with the different human Argonaute proteins. Nucleic Acids Res (2012) 1.66

Genome-wide characterization of miR-34a induced changes in protein and mRNA expression by a combined pulsed SILAC and microarray analysis. Mol Cell Proteomics (2011) 1.59

Analysis of microRNA knockouts in mice. Hum Mol Genet (2010) 1.59

HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA. Nucleic Acids Res (2012) 1.58

MicroRNAs in β-cell biology, insulin resistance, diabetes and its complications. Diabetes (2011) 1.56

The mRNA stability factor HuR inhibits microRNA-16 targeting of COX-2. Mol Cancer Res (2011) 1.56

In Vivo Inhibition of miR-155 Promotes Recovery after Experimental Mouse Stroke. J Neurosci (2015) 1.55

Functional interactions among microRNAs and long noncoding RNAs. Semin Cell Dev Biol (2014) 1.55

Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation. Int J Genomics (2014) 1.54

Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cells. EMBO Rep (2012) 1.52

Unambiguous identification of miRNA:target site interactions by different types of ligation reactions. Mol Cell (2014) 1.51

Nuclear outsourcing of RNA interference components to human mitochondria. PLoS One (2011) 1.49

A conserved PUF-Ago-eEF1A complex attenuates translation elongation. Nat Struct Mol Biol (2012) 1.47

miR-449 inhibits cell proliferation and is down-regulated in gastric cancer. Mol Cancer (2011) 1.46

Human cytomegalovirus microRNA miR-US4-1 inhibits CD8(+) T cell responses by targeting the aminopeptidase ERAP1. Nat Immunol (2011) 1.46

Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis. Proc Natl Acad Sci U S A (2015) 1.46

The regulation of mRNA stability in mammalian cells: 2.0. Gene (2012) 1.46

Human RNA methyltransferase BCDIN3D regulates microRNA processing. Cell (2012) 1.46

Structural basis for the recruitment of the human CCR4-NOT deadenylase complex by tristetraprolin. Nat Struct Mol Biol (2013) 1.45

Liver-specific microRNA-122: Biogenesis and function. RNA Biol (2012) 1.45

MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11. Nat Commun (2013) 1.43

MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1 (RASA1). J Biol Chem (2013) 1.43

Long-lasting alterations to DNA methylation and ncRNAs could underlie the effects of fetal alcohol exposure in mice. Dis Model Mech (2013) 1.42

NF-kB and c-Jun induce the expression of the oncogenic miR-221 and miR-222 in prostate carcinoma and glioblastoma cells. Nucleic Acids Res (2011) 1.42

MicroRegulators come of age in senescence. Trends Genet (2011) 1.42

Airway epithelial miRNA expression is altered in asthma. Am J Respir Crit Care Med (2012) 1.42

Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis. Nat Protoc (2014) 1.41

Concern microRNA-218 Inhibits Oxygen-induced Retinal Neovascularization via Reducing the Expression of Roundabout 1. Chin Med J (Engl) (2016) 1.38

CFIm25 links alternative polyadenylation to glioblastoma tumour suppression. Nature (2014) 1.38

ISMARA: automated modeling of genomic signals as a democracy of regulatory motifs. Genome Res (2014) 1.37

Coupled 5' nucleotide recognition and processivity in Xrn1-mediated mRNA decay. Mol Cell (2011) 1.36

PRIDB: a Protein-RNA interface database. Nucleic Acids Res (2010) 1.33

Small RNAs in early mammalian development: from gametes to gastrulation. Development (2011) 1.33

MIR@NT@N: a framework integrating transcription factors, microRNAs and their targets to identify sub-network motifs in a meta-regulation network model. BMC Bioinformatics (2011) 1.33

Regulation of cyclin T1 and HIV-1 Replication by microRNAs in resting CD4+ T lymphocytes. J Virol (2011) 1.32

Limiting Ago protein restricts RNAi and microRNA biogenesis during early development in Xenopus laevis. Genes Dev (2011) 1.30

The role of microRNAs in cholesterol efflux and hepatic lipid metabolism. Annu Rev Nutr (2011) 1.30

MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor. Circ Res (2013) 1.30

Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis. J Clin Invest (2013) 1.30

Endogenous origins of HIV-1 G-to-A hypermutation and restriction in the nonpermissive T cell line CEM2n. PLoS Pathog (2012) 1.29

Quantitative studies of Epstein-Barr virus-encoded microRNAs provide novel insights into their regulation. J Virol (2010) 1.27

MicroRNA profiles in allograft tissues and paired urines associate with chronic allograft dysfunction with IF/TA. Am J Transplant (2011) 1.27

Regulation of complement factor H (CFH) by multiple miRNAs in Alzheimer's disease (AD) brain. Mol Neurobiol (2012) 1.26

NF-кB-regulated micro RNAs (miRNAs) in primary human brain cells. Exp Neurol (2011) 1.26

Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases. Trends Mol Med (2011) 1.25

Base pairing between hepatitis C virus RNA and microRNA 122 3' of its seed sequence is essential for genome stabilization and production of infectious virus. J Virol (2012) 1.25

miR-139-5p is a regulator of metastatic pathways in breast cancer. RNA (2013) 1.25

Fabrication of 14 different RNA nanoparticles for specific tumor targeting without accumulation in normal organs. RNA (2013) 1.24

A survey of the sorghum transcriptome using single-molecule long reads. Nat Commun (2016) 1.24

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet (2008) 32.08

Upstream and downstream of mTOR. Genes Dev (2004) 21.61

The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet (2010) 15.87

Inhibition of translational initiation by Let-7 MicroRNA in human cells. Science (2005) 13.84

Relief of microRNA-mediated translational repression in human cells subjected to stress. Cell (2006) 12.73

Repression of protein synthesis by miRNAs: how many mechanisms? Trends Cell Biol (2007) 9.65

Translational control in stress and apoptosis. Nat Rev Mol Cell Biol (2005) 8.91

Interferon signaling and treatment outcome in chronic hepatitis C. Proc Natl Acad Sci U S A (2008) 8.56

Single processing center models for human Dicer and bacterial RNase III. Cell (2004) 8.19

Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res (2006) 6.99

XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity (2004) 6.72

Regulation of cap-dependent translation by eIF4E inhibitory proteins. Nature (2005) 6.69

Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP. EMBO J (2002) 6.65

TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing. EMBO Rep (2005) 5.82

Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Res (2007) 5.45

mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. Science (2010) 4.81

Translational control of long-lasting synaptic plasticity and memory. Neuron (2009) 4.77

The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs. Nature (2009) 4.61

Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. Mol Cell (2009) 4.57

Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells. Curr Opin Cell Biol (2009) 4.56

Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis. RNA (2004) 4.50

RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. J Biol Chem (2007) 4.45

MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F. Science (2007) 4.33

A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus. Proc Natl Acad Sci U S A (2001) 4.16

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha. Mol Cell Biol (2002) 4.11

Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell (2010) 4.01

MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells. Nat Struct Mol Biol (2008) 3.98

Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms. Genes Dev (2005) 3.92

The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. Mol Cell Biol (2003) 3.90

eIF4E--from translation to transformation. Oncogene (2004) 3.78

Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2. Nature (2010) 3.77

Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. J Biol Chem (2005) 3.74

Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy. Nat Med (2009) 3.72

Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAs. Cell (2010) 3.57

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. EMBO J (2006) 3.57

eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. Cell (2007) 3.46

The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC. Nat Struct Mol Biol (2012) 3.42

Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases. EMBO J (2004) 3.29

Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature (2012) 3.13

eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression. Proc Natl Acad Sci U S A (2010) 3.13

The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. Cell (2008) 3.10

Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer. EMBO Rep (2004) 3.07

Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Mol Cell Biol (2004) 3.00

14-3-3sigma controls mitotic translation to facilitate cytokinesis. Nature (2007) 2.98

Effects of Dicer and Argonaute down-regulation on mRNA levels in human HEK293 cells. Nucleic Acids Res (2006) 2.96

Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells. Cancer Cell (2004) 2.91

Dissecting the role of mTOR: lessons from mTOR inhibitors. Biochim Biophys Acta (2009) 2.89

Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2. J Clin Invest (2007) 2.86

A new paradigm for translational control: inhibition via 5'-3' mRNA tethering by Bicoid and the eIF4E cognate 4EHP. Cell (2005) 2.80

Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control. Nat Cell Biol (2005) 2.80

The chromatoid body of male germ cells: similarity with processing bodies and presence of Dicer and microRNA pathway components. Proc Natl Acad Sci U S A (2006) 2.75

miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs. Nat Struct Mol Biol (2011) 2.70

Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2. Nature (2005) 2.67

miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT. Nat Struct Mol Biol (2011) 2.61

Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation. Cell (2009) 2.60

Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins. J Mol Biol (2002) 2.53

A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay. J Cell Biol (2005) 2.51

A novel role of the mammalian GSPT/eRF3 associating with poly(A)-binding protein in Cap/Poly(A)-dependent translation. J Biol Chem (2002) 2.43

mRNA helicases: the tacticians of translational control. Nat Rev Mol Cell Biol (2011) 2.41

Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control. EMBO J (2006) 2.41

A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A. Mol Cell Biol (2004) 2.38

eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay. Nat Struct Mol Biol (2004) 2.38

Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation. PLoS One (2007) 2.35

The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus. J Neurosci (2005) 2.33

Translational control of the innate immune response through IRF-7. Nature (2008) 2.30

Tumstatin, an endothelial cell-specific inhibitor of protein synthesis. Science (2002) 2.28

Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53. EMBO J (2007) 2.27

The dynamics of mammalian P body transport, assembly, and disassembly in vivo. Mol Biol Cell (2008) 2.25

The effects of adiponectin and metformin on prostate and colon neoplasia involve activation of AMP-activated protein kinase. Cancer Prev Res (Phila) (2008) 2.23

Translational homeostasis via the mRNA cap-binding protein, eIF4E. Mol Cell (2012) 2.19

Role of Dicer in posttranscriptional RNA silencing. Curr Top Microbiol Immunol (2008) 2.19

Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression. RNA (2009) 2.15

The Akt of translational control. Oncogene (2005) 2.15

Cap and cap-binding proteins in the control of gene expression. Wiley Interdiscip Rev RNA (2010) 2.11

Reconstitution reveals the functional core of mammalian eIF3. EMBO J (2007) 2.06

Regulation of eukaryotic initiation factor 4E by converging signaling pathways during metabotropic glutamate receptor-dependent long-term depression. J Neurosci (2006) 2.04

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest (2010) 2.04

Activation of GCN2 in UV-irradiated cells inhibits translation. Curr Biol (2002) 2.02

Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infection. Cell Host Microbe (2011) 2.01

Translation initiator EIF4G1 mutations in familial Parkinson disease. Am J Hum Genet (2011) 2.00

Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation. Proc Natl Acad Sci U S A (2005) 2.00

Two structurally atypical HEAT domains in the C-terminal portion of human eIF4G support binding to eIF4A and Mnk1. Structure (2006) 1.99

Eukaryotic translation initiation factor 4E availability controls the switch between cap-dependent and internal ribosomal entry site-mediated translation. Mol Cell Biol (2005) 1.99

A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay. Proc Natl Acad Sci U S A (2004) 1.97

A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. Mol Cell Proteomics (2005) 1.95

Akt-mediated YB-1 phosphorylation activates translation of silent mRNA species. Mol Cell Biol (2006) 1.93

Phosphorylation of eukaryotic translation initiation factor 4E is critical for growth. Mol Cell Biol (2002) 1.92

mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. Cell Metab (2013) 1.91

La autoantigen is necessary for optimal function of the poliovirus and hepatitis C virus internal ribosome entry site in vivo and in vitro. Mol Cell Biol (2004) 1.87

Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife (2013) 1.85

Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP. Genes Dev (2005) 1.84

Multiple independent domains of dGW182 function in miRNA-mediated repression in Drosophila. RNA (2009) 1.80

Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses. EMBO J (2006) 1.79

S6K1 plays a critical role in early adipocyte differentiation. Dev Cell (2010) 1.74

The leader of human immunodeficiency virus type 1 genomic RNA harbors an internal ribosome entry segment that is active during the G2/M phase of the cell cycle. J Virol (2003) 1.71

Signaling control of mRNA translation in cancer pathogenesis. Oncogene (2004) 1.71

Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs. RNA (2008) 1.69

A novel microarray approach reveals new tissue-specific signatures of known and predicted mammalian microRNAs. Nucleic Acids Res (2007) 1.68