Published in Infect Immun on June 06, 2011
Cyclic di-GMP: the first 25 years of a universal bacterial second messenger. Microbiol Mol Biol Rev (2013) 4.69
Pseudomonas biofilm matrix composition and niche biology. FEMS Microbiol Rev (2012) 2.00
Tangled bank of experimentally evolved Burkholderia biofilms reflects selection during chronic infections. Proc Natl Acad Sci U S A (2012) 1.23
Identification of broadly protective human antibodies to Pseudomonas aeruginosa exopolysaccharide Psl by phenotypic screening. J Exp Med (2012) 1.15
From in vitro to in vivo Models of Bacterial Biofilm-Related Infections. Pathogens (2013) 1.15
ChIP-Seq and RNA-Seq reveal an AmrZ-mediated mechanism for cyclic di-GMP synthesis and biofilm development by Pseudomonas aeruginosa. PLoS Pathog (2014) 1.07
Catheter-associated urinary tract infection by Pseudomonas aeruginosa is mediated by exopolysaccharide-independent biofilms. Infect Immun (2014) 0.92
AmrZ modulates Pseudomonas aeruginosa biofilm architecture by directly repressing transcription of the psl operon. J Bacteriol (2013) 0.90
Cyclic di-GMP-dependent signaling pathways in the pathogenic Firmicute Listeria monocytogenes. PLoS Pathog (2014) 0.87
Proteases, cystic fibrosis and the epithelial sodium channel (ENaC). Cell Tissue Res (2012) 0.85
Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms. Sci Adv (2016) 0.84
The Haemophilus influenzae Sap transporter mediates bacterium-epithelial cell homeostasis. Infect Immun (2012) 0.82
Which bacterial biofilm exopolysaccharide is preferred, Psl or alginate? J Bacteriol (2013) 0.81
Role of small colony variants in persistence of Pseudomonas aeruginosa infections in cystic fibrosis lungs. Infect Drug Resist (2015) 0.81
Subinhibitory concentration of kanamycin induces the Pseudomonas aeruginosa type VI secretion system. PLoS One (2013) 0.79
Molecular Microbiological Profile of Chronic Suppurative Otitis Media. J Clin Microbiol (2016) 0.77
Reconstruction of the metabolic network of Pseudomonas aeruginosa to interrogate virulence factor synthesis. Nat Commun (2017) 0.75
Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development. Mol Microbiol (1998) 17.18
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature (2001) 14.24
Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms. Nature (2000) 10.32
Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients. Proc Natl Acad Sci U S A (2006) 8.85
Extracellular DNA required for bacterial biofilm formation. Science (2002) 8.25
Bacterial biofilms: an emerging link to disease pathogenesis. Annu Rev Microbiol (2003) 7.29
Pseudomonas aeruginosa displays multiple phenotypes during development as a biofilm. J Bacteriol (2002) 6.98
GGDEF and EAL domains inversely regulate cyclic di-GMP levels and transition from sessility to motility. Mol Microbiol (2004) 6.13
Synthesis of multiple exoproducts in Pseudomonas aeruginosa is under the control of RhlR-RhlI, another set of regulators in strain PAO1 with homology to the autoinducer-responsive LuxR-LuxI family. J Bacteriol (1995) 5.99
Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A (1999) 5.58
A chemosensory system that regulates biofilm formation through modulation of cyclic diguanylate levels. Proc Natl Acad Sci U S A (2005) 5.03
Direct detection of bacterial biofilms on the middle-ear mucosa of children with chronic otitis media. JAMA (2006) 4.53
A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms. Mol Microbiol (2006) 4.49
Signals, regulatory networks, and materials that build and break bacterial biofilms. Microbiol Mol Biol Rev (2009) 4.11
P. aeruginosa quorum-sensing systems and virulence. Curr Opin Microbiol (2003) 4.08
Two genetic loci produce distinct carbohydrate-rich structural components of the Pseudomonas aeruginosa biofilm matrix. J Bacteriol (2004) 3.92
Evolving concepts in biofilm infections. Cell Microbiol (2009) 3.90
Role of flagella in pathogenesis of Pseudomonas aeruginosa pulmonary infection. Infect Immun (1998) 3.43
Identification of psl, a locus encoding a potential exopolysaccharide that is essential for Pseudomonas aeruginosa PAO1 biofilm formation. J Bacteriol (2004) 3.39
Putative exopolysaccharide synthesis genes influence Pseudomonas aeruginosa biofilm development. J Bacteriol (2004) 3.21
Mucosal biofilm formation on middle-ear mucosa in the chinchilla model of otitis media. JAMA (2002) 2.96
Flagella, motility and invasive virulence of Pseudomonas aeruginosa. J Gen Microbiol (1988) 2.94
The impact of quorum sensing and swarming motility on Pseudomonas aeruginosa biofilm formation is nutritionally conditional. Mol Microbiol (2006) 2.94
Assembly and development of the Pseudomonas aeruginosa biofilm matrix. PLoS Pathog (2009) 2.85
Pseudomonas aeruginosa biofilms in the respiratory tract of cystic fibrosis patients. Pediatr Pulmonol (2009) 2.53
Analysis of Pseudomonas aeruginosa conditional psl variants reveals roles for the psl polysaccharide in adhesion and maintaining biofilm structure postattachment. J Bacteriol (2006) 2.53
Loss of virulence associated with absence of flagellum in an isogenic mutant of Pseudomonas aeruginosa in the burned-mouse model. Infect Immun (1982) 2.48
Characterization of colony morphology variants isolated from Pseudomonas aeruginosa biofilms. Appl Environ Microbiol (2005) 2.41
Pseudomonas aeruginosa uses a cyclic-di-GMP-regulated adhesin to reinforce the biofilm extracellular matrix. Mol Microbiol (2010) 2.24
Pseudomonas aeruginosa rugose small-colony variants have adaptations that likely promote persistence in the cystic fibrosis lung. J Bacteriol (2009) 2.22
Streptococcus pneumoniae forms surface-attached communities in the middle ear of experimentally infected chinchillas. J Infect Dis (2009) 2.10
Distribution, organization, and ecology of bacteria in chronic wounds. J Clin Microbiol (2008) 2.05
Genetic and biochemical analyses of the Pseudomonas aeruginosa Psl exopolysaccharide reveal overlapping roles for polysaccharide synthesis enzymes in Psl and LPS production. Mol Microbiol (2009) 1.91
Phosphorylcholine decreases early inflammation and promotes the establishment of stable biofilm communities of nontypeable Haemophilus influenzae strain 86-028NP in a chinchilla model of otitis media. Infect Immun (2006) 1.71
Quorum sensing and motility mediate interactions between Pseudomonas aeruginosa and Agrobacterium tumefaciens in biofilm cocultures. Proc Natl Acad Sci U S A (2006) 1.68
Role of sialic acid and complex carbohydrate biosynthesis in biofilm formation by nontypeable Haemophilus influenzae in the chinchilla middle ear. Infect Immun (2005) 1.65
Quorum-sensing regulation of the biofilm matrix genes (pel) of Pseudomonas aeruginosa. J Bacteriol (2007) 1.60
Global position analysis of the Pseudomonas aeruginosa quorum-sensing transcription factor LasR. Mol Microbiol (2009) 1.55
Nutrient availability as a mechanism for selection of antibiotic tolerant Pseudomonas aeruginosa within the CF airway. PLoS Pathog (2010) 1.50
In situ growth rates and biofilm development of Pseudomonas aeruginosa populations in chronic lung infections. J Bacteriol (2007) 1.46
Pathogens causing recurrent and difficult-to-treat acute otitis media, 2003-2006. Clin Pediatr (Phila) (2008) 1.40
Pseudomonas aeruginosa forms biofilms in acute infection independent of cell-to-cell signaling. Infect Immun (2007) 1.39
Does Pseudomonas aeruginosa use intercellular signalling to build biofilm communities? Cell Microbiol (2006) 1.36
The role of flagellin versus motility in acute lung disease caused by Pseudomonas aeruginosa. J Infect Dis (2007) 1.26
Haemophilus influenzae luxS mutants form a biofilm and have increased virulence. Microb Pathog (2005) 1.19
Mucosal biofilm formation on middle-ear mucosa in a nonhuman primate model of chronic suppurative otitis media. Laryngoscope (2005) 1.15
Influence of the hydrodynamic environment on quorum sensing in Pseudomonas aeruginosa biofilms. J Bacteriol (2007) 1.11
Impact of Pseudomonas aeruginosa quorum sensing on biofilm persistence in an in vivo intraperitoneal foreign-body infection model. Microbiology (2007) 1.09
LuxS promotes biofilm maturation and persistence of nontypeable haemophilus influenzae in vivo via modulation of lipooligosaccharides on the bacterial surface. Infect Immun (2009) 1.08
The Pseudomonas aeruginosa exopolysaccharide Psl facilitates surface adherence and NF-kappaB activation in A549 cells. MBio (2010) 0.98
Quorum sensing is necessary for the virulence of Pseudomonas aeruginosa during urinary tract infection. Kidney Int (2009) 0.91
Inhibition of proteases in Pseudomonas otitis media in chinchillas. Otolaryngol Head Neck Surg (1996) 0.85
Pseudomonas aeruginosa las and rhl quorum-sensing systems are important for infection and inflammation in a rat prostatitis model. Microbiology (2009) 0.84
Bacterial competition: surviving and thriving in the microbial jungle. Nat Rev Microbiol (2010) 5.63
Pseudomonas aeruginosa anaerobic respiration in biofilms: relationships to cystic fibrosis pathogenesis. Dev Cell (2002) 4.94
A component of innate immunity prevents bacterial biofilm development. Nature (2002) 4.73
The cidA murein hydrolase regulator contributes to DNA release and biofilm development in Staphylococcus aureus. Proc Natl Acad Sci U S A (2007) 4.07
Identification of psl, a locus encoding a potential exopolysaccharide that is essential for Pseudomonas aeruginosa PAO1 biofilm formation. J Bacteriol (2004) 3.39
The EPS matrix: the "house of biofilm cells". J Bacteriol (2007) 3.38
Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound. Microbiology (2002) 3.37
Alginate is not a significant component of the extracellular polysaccharide matrix of PA14 and PAO1 Pseudomonas aeruginosa biofilms. Proc Natl Acad Sci U S A (2003) 3.02
The impact of quorum sensing and swarming motility on Pseudomonas aeruginosa biofilm formation is nutritionally conditional. Mol Microbiol (2006) 2.94
Assembly and development of the Pseudomonas aeruginosa biofilm matrix. PLoS Pathog (2009) 2.85
Role of polysaccharides in Pseudomonas aeruginosa biofilm development. Curr Opin Microbiol (2007) 2.74
Analysis of Pseudomonas aeruginosa conditional psl variants reveals roles for the psl polysaccharide in adhesion and maintaining biofilm structure postattachment. J Bacteriol (2006) 2.53
Understanding the control of Pseudomonas aeruginosa alginate synthesis and the prospects for management of chronic infections in cystic fibrosis. Mol Microbiol (2005) 2.49
Characterization of colony morphology variants isolated from Pseudomonas aeruginosa biofilms. Appl Environ Microbiol (2005) 2.41
The exopolysaccharide alginate protects Pseudomonas aeruginosa biofilm bacteria from IFN-gamma-mediated macrophage killing. J Immunol (2005) 2.30
Anaerobic metabolism and quorum sensing by Pseudomonas aeruginosa biofilms in chronically infected cystic fibrosis airways: rethinking antibiotic treatment strategies and drug targets. Adv Drug Deliv Rev (2002) 2.27
Pseudomonas aeruginosa uses a cyclic-di-GMP-regulated adhesin to reinforce the biofilm extracellular matrix. Mol Microbiol (2010) 2.24
Pseudomonas aeruginosa rugose small-colony variants have adaptations that likely promote persistence in the cystic fibrosis lung. J Bacteriol (2009) 2.22
Statistical analysis of Pseudomonas aeruginosa biofilm development: impact of mutations in genes involved in twitching motility, cell-to-cell signaling, and stationary-phase sigma factor expression. Appl Environ Microbiol (2002) 2.19
Streptococcus pneumoniae forms surface-attached communities in the middle ear of experimentally infected chinchillas. J Infect Dis (2009) 2.10
Heavy metal resistance of biofilm and planktonic Pseudomonas aeruginosa. Appl Environ Microbiol (2003) 2.06
The pel polysaccharide can serve a structural and protective role in the biofilm matrix of Pseudomonas aeruginosa. PLoS Pathog (2011) 2.04
Pseudomonas biofilm matrix composition and niche biology. FEMS Microbiol Rev (2012) 2.00
Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator. Blood (2008) 1.97
Genetic and biochemical analyses of the Pseudomonas aeruginosa Psl exopolysaccharide reveal overlapping roles for polysaccharide synthesis enzymes in Psl and LPS production. Mol Microbiol (2009) 1.91
The Haemophilus influenzae HMW1 adhesin is glycosylated in a process that requires HMW1C and phosphoglucomutase, an enzyme involved in lipooligosaccharide biosynthesis. Mol Microbiol (2003) 1.84
Survival and growth in the presence of elevated copper: transcriptional profiling of copper-stressed Pseudomonas aeruginosa. J Bacteriol (2006) 1.75
Phosphorylcholine decreases early inflammation and promotes the establishment of stable biofilm communities of nontypeable Haemophilus influenzae strain 86-028NP in a chinchilla model of otitis media. Infect Immun (2006) 1.71
The Pel and Psl polysaccharides provide Pseudomonas aeruginosa structural redundancy within the biofilm matrix. Environ Microbiol (2011) 1.69
Quorum sensing and motility mediate interactions between Pseudomonas aeruginosa and Agrobacterium tumefaciens in biofilm cocultures. Proc Natl Acad Sci U S A (2006) 1.68
Phosphorus limitation enhances biofilm formation of the plant pathogen Agrobacterium tumefaciens through the PhoR-PhoB regulatory system. J Bacteriol (2004) 1.67
Pseudomonas aeruginosa biofilm matrix polysaccharide Psl is regulated transcriptionally by RpoS and post-transcriptionally by RsmA. Mol Microbiol (2010) 1.66
The Pseudomonas aeruginosa ribbon-helix-helix DNA-binding protein AlgZ (AmrZ) controls twitching motility and biogenesis of type IV pili. J Bacteriol (2006) 1.63
Indirect pathogenicity of Haemophilus influenzae and Moraxella catarrhalis in polymicrobial otitis media occurs via interspecies quorum signaling. MBio (2010) 1.59
Mouse organic solute transporter alpha deficiency alters FGF15 expression and bile acid metabolism. J Hepatol (2012) 1.51
The effect of the chemical, biological, and physical environment on quorum sensing in structured microbial communities. Anal Bioanal Chem (2006) 1.49
The extracellular matrix protects Pseudomonas aeruginosa biofilms by limiting the penetration of tobramycin. Environ Microbiol (2013) 1.47
Paraoxonase-2 deficiency enhances Pseudomonas aeruginosa quorum sensing in murine tracheal epithelia. Am J Physiol Lung Cell Mol Physiol (2006) 1.45
Beta toxin catalyzes formation of nucleoprotein matrix in staphylococcal biofilms. Proc Natl Acad Sci U S A (2010) 1.44
Long-term survival following a single treatment of kidney tumors with multiwalled carbon nanotubes and near-infrared radiation. Proc Natl Acad Sci U S A (2009) 1.41
Susceptibility of nontypeable Haemophilus influenzae to human beta-defensins is influenced by lipooligosaccharide acylation. Infect Immun (2002) 1.40
Probing prokaryotic social behaviors with bacterial "lobster traps". MBio (2010) 1.39
Survival of bacterial biofilms within neutrophil extracellular traps promotes nontypeable Haemophilus influenzae persistence in the chinchilla model for otitis media. J Innate Immun (2009) 1.37
The promise and peril of transcriptional profiling in biofilm communities. Curr Opin Microbiol (2007) 1.37
Pseudomonas aeruginosa Psl is a galactose- and mannose-rich exopolysaccharide. J Bacteriol (2007) 1.37
Phosphorylation of the Pseudomonas aeruginosa response regulator AlgR is essential for type IV fimbria-mediated twitching motility. J Bacteriol (2002) 1.37
Does Pseudomonas aeruginosa use intercellular signalling to build biofilm communities? Cell Microbiol (2006) 1.36
Self-produced exopolysaccharide is a signal that stimulates biofilm formation in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A (2012) 1.36
Nontypeable Haemophilus influenzae initiates formation of neutrophil extracellular traps. Infect Immun (2010) 1.35
Quorum-sensing control of antibiotic synthesis in Burkholderia thailandensis. J Bacteriol (2009) 1.33
The FleQ protein from Pseudomonas aeruginosa functions as both a repressor and an activator to control gene expression from the pel operon promoter in response to c-di-GMP. Nucleic Acids Res (2012) 1.32
The Staphylococcus aureus LytSR two-component regulatory system affects biofilm formation. J Bacteriol (2009) 1.31
Phosphorylcholine expression by nontypeable Haemophilus influenzae correlates with maturation of biofilm communities in vitro and in vivo. J Bacteriol (2007) 1.27
The alternative sigma factor AlgT represses Pseudomonas aeruginosa flagellum biosynthesis by inhibiting expression of fleQ. J Bacteriol (2005) 1.26
Pseudomonas aeruginosa Psl polysaccharide reduces neutrophil phagocytosis and the oxidative response by limiting complement-mediated opsonization. Cell Microbiol (2011) 1.25
Coinfection with Haemophilus influenzae promotes pneumococcal biofilm formation during experimental otitis media and impedes the progression of pneumococcal disease. J Infect Dis (2010) 1.25
Fluorescence-based reporter for gauging cyclic di-GMP levels in Pseudomonas aeruginosa. Appl Environ Microbiol (2012) 1.24
Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library. Cancer Res (2007) 1.23
Drosophila are protected from Pseudomonas aeruginosa lethality by transgenic expression of paraoxonase-1. J Clin Invest (2008) 1.22
Lipooligosaccharides containing phosphorylcholine delay pulmonary clearance of nontypeable Haemophilus influenzae. Infect Immun (2008) 1.20
Going local: technologies for exploring bacterial microenvironments. Nat Rev Microbiol (2013) 1.19
Conditional expression of the mutant Ki-rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model. Carcinogenesis (2005) 1.19
Mucin-Pseudomonas aeruginosa interactions promote biofilm formation and antibiotic resistance. Mol Microbiol (2006) 1.19
The AlgT-dependent transcriptional regulator AmrZ (AlgZ) inhibits flagellum biosynthesis in mucoid, nonmotile Pseudomonas aeruginosa cystic fibrosis isolates. J Bacteriol (2006) 1.18
The contribution of cell-cell signaling and motility to bacterial biofilm formation. MRS Bull (2011) 1.16
Pseudomonas aeruginosa flagellin and alginate elicit very distinct gene expression patterns in airway epithelial cells: implications for cystic fibrosis disease. J Immunol (2004) 1.16
Moraxella catarrhalis bacterium without endotoxin, a potential vaccine candidate. Infect Immun (2005) 1.15
Treatment of breast cancer through the application of irreversible electroporation using a novel minimally invasive single needle electrode. Breast Cancer Res Treat (2010) 1.14