Published in Cell Death Differ on June 10, 2011
Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells. J Exp Med (2013) 1.96
The crosstalk between autophagy and apoptosis: where does this lead? Protein Cell (2012) 1.60
Inhibition of hepatocyte autophagy increases tumor necrosis factor-dependent liver injury by promoting caspase-8 activation. Cell Death Differ (2013) 1.36
Strange attractors: DAMPs and autophagy link tumor cell death and immunity. Cell Death Dis (2013) 1.25
The role of the selective adaptor p62 and ubiquitin-like proteins in autophagy. Biomed Res Int (2014) 1.21
Macroautophagy is deregulated in murine and human lupus T lymphocytes. Autophagy (2012) 1.18
Canonical autophagy dependent on the class III phosphoinositide-3 kinase Vps34 is required for naive T-cell homeostasis. Proc Natl Acad Sci U S A (2012) 1.11
Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology. Trends Cell Biol (2015) 1.00
Influence of Atg5 mutation in SLE depends on functional IL-10 genotype. PLoS One (2013) 0.97
Crosstalk between apoptosis and autophagy: molecular mechanisms and therapeutic strategies in cancer. J Cell Death (2013) 0.96
Autophagy protein p62/SQSTM1 is involved in HAMLET-induced cell death by modulating apotosis in U87MG cells. Cell Death Dis (2013) 0.95
The contribution of autophagy to lymphocyte survival and homeostasis. Immunol Rev (2012) 0.95
Pharmacological regulators of autophagy and their link with modulators of lupus disease. Br J Pharmacol (2014) 0.93
Macroautophagy in T lymphocyte development and function. Front Immunol (2012) 0.93
Invariant NKT cells require autophagy to coordinate proliferation and survival signals during differentiation. J Immunol (2015) 0.88
Autophagy and the regulation of the immune response. Pharmacol Res (2012) 0.86
Disruption of autophagy by the histone deacetylase inhibitor MGCD0103 and its therapeutic implication in B-cell chronic lymphocytic leukemia. Leukemia (2014) 0.84
Modification of T cell responses by stem cell mobilization requires direct signaling of the T cell by G-CSF and IL-10. J Immunol (2014) 0.84
The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation. Elife (2016) 0.84
Nanomaterials and autophagy: new insights in cancer treatment. Cancers (Basel) (2013) 0.83
Metabolic profiling of human CD4+ cells following treatment with methotrexate and anti-TNF-α infliximab. Cell Cycle (2013) 0.83
Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis. Nat Rev Immunol (2016) 0.82
Metabolic regulation of organelle homeostasis in lupus T cells. Clin Immunol (2012) 0.81
Autophagy in autoimmune disease. J Mol Med (Berl) (2015) 0.81
Autophagy, a novel pathway to regulate calcium mobilization in T lymphocytes. Front Immunol (2013) 0.80
Autophagy is dispensable for B-cell development but essential for humoral autoimmune responses. Cell Death Differ (2015) 0.79
Autophagy protects from liver injury. Cell Death Differ (2013) 0.79
The Mucosal Immune System and Its Regulation by Autophagy. Front Immunol (2016) 0.78
Autophagy and autoimmunity. Clin Immunol (2017) 0.78
Autophagy, viruses, and intestinal immunity. Curr Opin Gastroenterol (2014) 0.77
Autophagy-independent functions of UVRAG are essential for peripheral naive T-cell homeostasis. Proc Natl Acad Sci U S A (2015) 0.77
The role of autophagy in microbial infection and immunity. Immunotargets Ther (2015) 0.76
Key roles of autophagy in regulating T-cell function. Eur J Immunol (2016) 0.76
Differential cytokine withdrawal-induced death sensitivity of effector T cells derived from distinct human CD8(+) memory subsets. Cell Death Discov (2017) 0.76
Vorinostat and hydroxychloroquine improve immunity and inhibit autophagy in metastatic colorectal cancer. Oncotarget (2016) 0.75
Autophagy and Autophagy-Related Proteins in CNS Autoimmunity. Front Immunol (2017) 0.75
Defective autophagy is associated with neuronal injury in a mouse model of multiple sclerosis. Bosn J Basic Med Sci (2017) 0.75
High-Dose Nicotinamide Suppresses ROS Generation and Augments Population Expansion during CD8(+) T Cell Activation. Mol Cells (2015) 0.75
Hepatitis B virus-triggered autophagy targets TNFRSF10B/death receptor 5 for degradation to limit TNFSF10/TRAIL response. Autophagy (2016) 0.75
Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging. Int J Mol Sci (2017) 0.75
Autophagy Improves the Immunosuppression of CD4+ T Cells by Mesenchymal Stem Cells Through Transforming Growth Factor-β1. Stem Cells Transl Med (2016) 0.75
Selective Impairment of TH17-Differentiation and Protection against Autoimmune Arthritis after Overexpression of BCL2A1 in T Lymphocytes. PLoS One (2016) 0.75
Common γ-chain cytokine signaling is required for macroautophagy induction during CD4(+) T-cell activation. Autophagy (2015) 0.75
Impaired Autophagy and Defective T Cell Homeostasis in Mice with T Cell-Specific Deletion of Receptor for Activated C Kinase 1. Front Immunol (2017) 0.75
Therapeutic Implications of Autophagy Inducers in Immunological Disorders, Infection, and Cancer. Int J Mol Sci (2017) 0.75
Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells. Nat Commun (2017) 0.75
Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature (1999) 23.62
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem (2007) 21.73
Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell (2004) 21.68
Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell (2005) 17.81
Autophagy in health and disease: a double-edged sword. Science (2004) 13.69
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol (2005) 11.63
A role for ubiquitin in selective autophagy. Mol Cell (2009) 8.43
Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J Cell Biol (2001) 7.68
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J (1995) 7.60
Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol (1998) 7.41
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat Cell Biol (2009) 7.35
Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat Cell Biol (2009) 6.69
The molecular machinery of autophagy: unanswered questions. J Cell Sci (2005) 6.67
A unified model for apical caspase activation. Mol Cell (2003) 6.12
A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med (2006) 6.01
p62 at the crossroads of autophagy, apoptosis, and cancer. Cell (2009) 5.97
Protein turnover via autophagy: implications for metabolism. Annu Rev Nutr (2007) 5.75
Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. Cell (2009) 5.55
Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim. Immunity (2002) 4.61
Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae. FEBS Lett (2007) 3.65
Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4. J Clin Invest (2006) 3.34
Autophagy: many paths to the same end. Mol Cell Biochem (2004) 2.79
Autophagy is induced in CD4+ T cells and important for the growth factor-withdrawal cell death. J Immunol (2006) 2.68
Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity. Immunity (2008) 2.62
Autophagy is essential for mitochondrial clearance in mature T lymphocytes. J Immunol (2009) 2.61
Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis. J Exp Med (1997) 2.59
FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells. Proc Natl Acad Sci U S A (2008) 2.52
Combined deficiency of proapoptotic regulators Bim and Fas results in the early onset of systemic autoimmunity. Immunity (2008) 2.48
Apoptosis regulators Bim and Fas function concurrently to control autoimmunity and CD8+ T cell contraction. Immunity (2008) 2.26
Caspase-independent cell death in T lymphocytes. Nat Immunol (2003) 1.99
Caspase-independent cell death: leaving the set without the final cut. Oncogene (2008) 1.74
The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death. Nat Immunol (2008) 1.73
Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes. Autophagy (2009) 1.67
Temporal regulation of intracellular organelle homeostasis in T lymphocytes by autophagy. J Immunol (2011) 1.61
The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing. J Biol Chem (2009) 1.44
Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism. J Neurochem (2009) 1.26
A role for autophagic protein beclin 1 early in lymphocyte development. J Immunol (2011) 1.18
Fas Bim boom! Immunity (2008) 1.05
Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group. N Engl J Med (2000) 41.18
Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc Natl Acad Sci U S A (2001) 24.34
A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell (2000) 17.61
Analyzing high-density oligonucleotide gene expression array data. J Cell Biochem (2000) 16.73
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature (1995) 13.80
Control of sexually transmitted diseases for AIDS prevention in Uganda: a randomised community trial. Rakai Project Study Group. Lancet (1999) 10.28
Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nat Genet (2000) 8.58
Feature extraction and normalization algorithms for high-density oligonucleotide gene expression array data. J Cell Biochem Suppl (2001) 8.50
Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation. Nat Genet (1999) 8.17
HIV-1 infection associated with abnormal vaginal flora morphology and bacterial vaginosis. Lancet (1997) 7.52
Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse. Cell (1994) 7.43
In vivo localization of DNA sequences and visualization of large-scale chromatin organization using lac operator/repressor recognition. J Cell Biol (1996) 6.78
Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc Natl Acad Sci U S A (2001) 6.68
Prevalence of specific language impairment in kindergarten children. J Speech Lang Hear Res (1997) 6.37
Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab (2001) 5.76
Carrying passengers as a risk factor for crashes fatal to 16- and 17-year-old drivers. JAMA (2000) 5.67
Accounting for unmeasured population substructure in case-control studies of genetic association using a novel latent-class model. Am J Hum Genet (2001) 5.66
CENP-E is a putative kinetochore motor that accumulates just before mitosis. Nature (1992) 5.54
Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature (2001) 5.51
Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3. Nat Genet (2000) 5.50
Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology (1992) 5.45
Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol Cell (1999) 5.28
Histone-like TAFs within the PCAF histone acetylase complex. Cell (1998) 5.26
Male circumcision and HIV acquisition and transmission: cohort studies in Rakai, Uganda. Rakai Project Team. AIDS (2000) 5.14
A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type. Genes Dev (1998) 5.14
Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase. Genes Dev (2001) 4.91
Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts. Science (1999) 4.69
Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3. Science (2000) 4.57
Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes. Cell (1994) 4.53
Metabolic regulation of brain Abeta by neprilysin. Science (2001) 4.47
The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature (1998) 4.47
Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus. Nature (1996) 4.41
The wheat and barley vernalization gene VRN3 is an orthologue of FT. Proc Natl Acad Sci U S A (2006) 4.38
Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc Natl Acad Sci U S A (2001) 4.30
Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Neuron (1990) 4.15
Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses. Blood (1998) 4.07
Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation. Lancet (1995) 4.07
Long-term restoration of immunity against Epstein-Barr virus infection by adoptive transfer of gene-modified virus-specific T lymphocytes. Nat Med (1996) 4.07
Crystal structure of four-stranded Oxytricha telomeric DNA. Nature (1992) 3.96
5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol (2000) 3.94
Aromatic hydrogen bond in sequence-specific protein DNA recognition. Nat Struct Biol (1996) 3.91
Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4. Cell (1996) 3.91
Molecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor. Proc Natl Acad Sci U S A (1992) 3.91
Requirement of the chemokine receptor CXCR3 for acute allograft rejection. J Exp Med (2000) 3.84
A regulatory role for ARF6 in receptor-mediated endocytosis. Science (1995) 3.82
Optical imaging of Cerenkov light generation from positron-emitting radiotracers. Phys Med Biol (2009) 3.81
The C5a chemoattractant receptor mediates mucosal defence to infection. Nature (1996) 3.73
Effectiveness of community health workers in the care of persons with diabetes. Diabet Med (2006) 3.66
Modulation of Dengue virus infection in human cells by alpha, beta, and gamma interferons. J Virol (2000) 3.61
PKD1 interacts with PKD2 through a probable coiled-coil domain. Nat Genet (1997) 3.58
A presynaptic inositol-5-phosphatase. Nature (1996) 3.54
A randomized, community trial of intensive sexually transmitted disease control for AIDS prevention, Rakai, Uganda. AIDS (1998) 3.54
Obesity and inequities in health in the developing world. Int J Obes Relat Metab Disord (2004) 3.49
Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. Mol Cell (1999) 3.47
A diverse new primate fauna from middle Eocene fissure-fillings in southeastern China. Nature (1994) 3.46
Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity. Mol Cell (2000) 3.44
Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins. J Neurosci (2000) 3.44
State estimates of Medicaid expenditures attributable to cigarette smoking, fiscal year 1993. Public Health Rep (1998) 3.41
Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A. Cell (1998) 3.40
Prevalence and genetic diversity of coronaviruses in bats from China. J Virol (2006) 3.37
Development and evaluation of functional gene arrays for detection of selected genes in the environment. Appl Environ Microbiol (2001) 3.36
Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1. Neuron (1999) 3.33
Several log increase in therapeutic transgene delivery by distinct adeno-associated viral serotype vectors. Mol Ther (2000) 3.32
Human monoclonal antibodies that inhibit binding of hepatitis C virus E2 protein to CD81 and recognize conserved conformational epitopes. J Virol (2000) 3.26
Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Proc Natl Acad Sci U S A (2001) 3.23
Targeted disruption of migration inhibitory factor gene reveals its critical role in sepsis. J Exp Med (1999) 3.23
Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway. Oncogene (1999) 3.23
TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. J Cell Biol (2001) 3.22
Sickle hemoglobin (HbS) allele and sickle cell disease: a HuGE review. Am J Epidemiol (2000) 3.17
Risk factors for seizure-related motor vehicle crashes in patients with epilepsy. Neurology (1999) 3.10
A herpesvirus of rhesus monkeys related to the human Kaposi's sarcoma-associated herpesvirus. J Virol (1997) 3.10
Real time detection of DNA.RNA hybridization in living cells. Proc Natl Acad Sci U S A (1998) 3.10
Mutations in the laminin alpha 2-chain gene (LAMA2) cause merosin-deficient congenital muscular dystrophy. Nat Genet (1995) 3.05
Complexins: cytosolic proteins that regulate SNAP receptor function. Cell (1995) 3.04
Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat. Neurotoxicology (1993) 3.00
Histone chaperone Asf1 is required for histone H3 lysine 56 acetylation, a modification associated with S phase in mitosis and meiosis. Proc Natl Acad Sci U S A (2006) 2.98
Human magnetic resonance imaging at 8 T. NMR Biomed (1998) 2.96
Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma. Nat Genet (1996) 2.96
ORegAnno: an open access database and curation system for literature-derived promoters, transcription factor binding sites and regulatory variation. Bioinformatics (2006) 2.93
Mortality associated with congenital heart defects in the United States: trends and racial disparities, 1979-1997. Circulation (2001) 2.92
Identification of a translation initiation factor 3 (eIF3) core complex, conserved in yeast and mammals, that interacts with eIF5. Mol Cell Biol (1998) 2.91
Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Development (1998) 2.90
Therapeutic benefit of intracerebral transplantation of bone marrow stromal cells after cerebral ischemia in rats. J Neurol Sci (2001) 2.84
Structural and magnetic phase diagram of CeFeAsO(1- x)F(x) and its relation to high-temperature superconductivity. Nat Mater (2008) 2.83
Basal cell carcinomas in mice overexpressing Gli2 in skin. Nat Genet (2000) 2.82
Genome-wide analysis of single-nucleotide polymorphisms in human expressed sequences. Nat Genet (2000) 2.82
Development of an extremely wear-resistant ultra high molecular weight polyethylene for total hip replacements. J Orthop Res (1999) 2.81
Mortality in neurofibromatosis 1: an analysis using U.S. death certificates. Am J Hum Genet (2001) 2.78
Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus. Nature (1995) 2.75
cisRED: a database system for genome-scale computational discovery of regulatory elements. Nucleic Acids Res (2006) 2.75
Superconductivity at 41 K and its competition with spin-density-wave instability in layered CeO1-xFxFeAs. Phys Rev Lett (2008) 2.72
Prediction of stroke outcome with echoplanar perfusion- and diffusion-weighted MRI. Neurology (1998) 2.72
A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. Mol Cell (1999) 2.71
An agent cleaving glucose-derived protein crosslinks in vitro and in vivo. Nature (1996) 2.71
New variants of a method of MRI scale standardization. IEEE Trans Med Imaging (2000) 2.69
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. Nat Cell Biol (2001) 2.69
Sex ratio associated with timing of insemination and length of the follicular phase in planned and unplanned pregnancies during use of natural family planning. Hum Reprod (1998) 2.67
Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature (1998) 2.65