Published in Nat Chem Biol on May 29, 2005
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell (2009) 11.26
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ (2008) 10.45
Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ (2011) 9.44
Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol (2008) 9.24
Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol (2010) 9.06
Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell (2008) 7.61
The science of stroke: mechanisms in search of treatments. Neuron (2010) 6.14
Identification of aneuploidy-selective antiproliferation compounds. Cell (2011) 4.45
Regulated necrosis: the expanding network of non-apoptotic cell death pathways. Nat Rev Mol Cell Biol (2014) 4.28
Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature (2011) 3.86
Virus inhibition of RIP3-dependent necrosis. Cell Host Microbe (2010) 3.70
Necroptosis as an alternative form of programmed cell death. Curr Opin Cell Biol (2010) 3.51
Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis. Proc Natl Acad Sci U S A (2012) 3.24
Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy. Am J Pathol (2006) 3.18
Necroptosis and its role in inflammation. Nature (2015) 3.01
Regulation of ferroptotic cancer cell death by GPX4. Cell (2014) 2.78
Cellular stress responses: cell survival and cell death. Int J Cell Biol (2010) 2.74
Necroptosis. N Engl J Med (2014) 2.71
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ (2014) 2.66
Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway. Proc Natl Acad Sci U S A (2011) 2.64
Many stimuli pull the necrotic trigger, an overview. Cell Death Differ (2011) 2.55
FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells. Proc Natl Acad Sci U S A (2008) 2.52
Mechanisms of necroptosis in T cells. J Exp Med (2011) 2.51
Programmed cell death in the plant immune system. Cell Death Differ (2011) 2.42
Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death. Cell Res (2013) 2.38
Caspase 8 inhibits programmed necrosis by processing CYLD. Nat Cell Biol (2011) 2.37
The diverse role of RIP kinases in necroptosis and inflammation. Nat Immunol (2015) 2.36
Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis. Cell Res (2013) 2.26
cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production. Cell Death Differ (2010) 2.26
Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium. Nat Immunol (2012) 2.25
Cell biology of ischemia/reperfusion injury. Int Rev Cell Mol Biol (2012) 2.24
Antigen-mediated T cell expansion regulated by parallel pathways of death. Proc Natl Acad Sci U S A (2008) 2.20
Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis. Proc Natl Acad Sci U S A (2010) 2.20
Alternative cell death mechanisms in development and beyond. Genes Dev (2010) 2.14
Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2013) 2.10
Programmed necrosis: backup to and competitor with apoptosis in the immune system. Nat Immunol (2011) 2.09
RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3. Cell (2014) 2.06
Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice. J Cereb Blood Flow Metab (2008) 2.06
Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment. J Cell Biol (2009) 2.02
Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance. J Clin Invest (2010) 1.97
RIP3: a molecular switch for necrosis and inflammation. Genes Dev (2013) 1.94
Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models. Cell Death Dis (2012) 1.94
Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death. Nat Rev Mol Cell Biol (2013) 1.89
The invasive chytrid fungus of amphibians paralyzes lymphocyte responses. Science (2013) 1.88
The Jekyll and Hyde functions of caspases. Dev Cell (2009) 1.87
RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell (2014) 1.77
Caspase-independent cell death: leaving the set without the final cut. Oncogene (2008) 1.74
Noncanonical autophagy promotes the visual cycle. Cell (2013) 1.74
TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation. Cell Death Differ (2012) 1.72
Chemotherapeutic approaches for targeting cell death pathways. Oncologist (2006) 1.70
Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: role for reactive oxygen species-enhanced MEK/ERK activation. J Allergy Clin Immunol (2013) 1.69
Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis. Proc Natl Acad Sci U S A (2010) 1.67
HMGB1 in health and disease. Mol Aspects Med (2014) 1.67
A novel role for RIP1 kinase in mediating TNFα production. Cell Death Dis (2012) 1.67
The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities. Antioxid Redox Signal (2012) 1.64
Synchronized renal tubular cell death involves ferroptosis. Proc Natl Acad Sci U S A (2014) 1.62
The molecular regulation of programmed necrotic cell injury. Trends Biochem Sci (2010) 1.55
TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members. Cell Death Dis (2011) 1.53
Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase. Cell Death Differ (2012) 1.53
Red blood cells induce necroptosis of lung endothelial cells and increase susceptibility to lung inflammation. Am J Respir Crit Care Med (2014) 1.52
Regulated cell death in AKI. J Am Soc Nephrol (2014) 1.50
MiR-21 in Extracellular Vesicles Leads to Neurotoxicity via TLR7 Signaling in SIV Neurological Disease. PLoS Pathog (2015) 1.50
Mathematical modelling of cell-fate decision in response to death receptor engagement. PLoS Comput Biol (2010) 1.49
Perispinal etanercept for post-stroke neurological and cognitive dysfunction: scientific rationale and current evidence. CNS Drugs (2014) 1.49
Diverse sequence determinants control human and mouse receptor interacting protein 3 (RIP3) and mixed lineage kinase domain-like (MLKL) interaction in necroptotic signaling. J Biol Chem (2013) 1.48
Neuronal cell death in neonatal hypoxia-ischemia. Ann Neurol (2011) 1.47
TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1. Cell Death Dis (2013) 1.46
Modulatory profiling identifies mechanisms of small molecule-induced cell death. Proc Natl Acad Sci U S A (2011) 1.45
Necrostatin decreases oxidative damage, inflammation, and injury after neonatal HI. J Cereb Blood Flow Metab (2010) 1.44
Live to die another way: modes of programmed cell death and the signals emanating from dying cells. Nat Rev Mol Cell Biol (2015) 1.44
Retracted The NAD-dependent deacetylase SIRT2 is required for programmed necrosis. Nature (2012) 1.44
Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death. J Cell Biol (2015) 1.43
Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery. Cell Death Differ (2011) 1.42
Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes. Cell Death Differ (2013) 1.42
Apoptosis, autophagy, necroptosis, and cancer metastasis. Mol Cancer (2015) 1.39
Neuroprotective strategies targeting apoptotic and necrotic cell death for stroke. Apoptosis (2009) 1.39
Neural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration. J Biol Chem (2009) 1.38
Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense. Proc Natl Acad Sci U S A (2014) 1.38
Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration. Proc Natl Acad Sci U S A (2012) 1.37
Autophagy in neurite injury and neurodegeneration: in vitro and in vivo models. Methods Enzymol (2009) 1.36
Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development. J Cell Mol Med (2013) 1.36
Active ras triggers death in glioblastoma cells through hyperstimulation of macropinocytosis. Mol Cancer Res (2008) 1.35
Going up in flames: necrotic cell injury and inflammatory diseases. Cell Mol Life Sci (2010) 1.35
The complex interplay between autophagy, apoptosis, and necrotic signals promotes T-cell homeostasis. Immunol Rev (2010) 1.35
Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis. Cell Death Dis (2014) 1.33
RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation. PLoS One (2011) 1.33
The cardioprotective effect of necrostatin requires the cyclophilin-D component of the mitochondrial permeability transition pore. Cardiovasc Drugs Ther (2007) 1.32
Dichotomy between RIP1- and RIP3-mediated necroptosis in tumor necrosis factor-α-induced shock. Mol Med (2012) 1.31
Killing a cancer: what are the alternatives? Nat Rev Cancer (2012) 1.30
Nitration of the mitochondrial complex I subunit NDUFB8 elicits RIP1- and RIP3-mediated necrosis. Free Radic Biol Med (2009) 1.30
Interactions between bacterial pathogens and mitochondrial cell death pathways. Nat Rev Microbiol (2010) 1.30
Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity. Proc Natl Acad Sci U S A (2011) 1.30
cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation. Cell Death Differ (2012) 1.29
Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice. Elife (2013) 1.28
Acute plasmalemma permeability and protracted clearance of injured cells after controlled cortical impact in mice. J Cereb Blood Flow Metab (2007) 1.27
The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage. Proc Natl Acad Sci U S A (2009) 1.27
Die another way--non-apoptotic mechanisms of cell death. J Cell Sci (2014) 1.27
Cell death in health and disease. J Cell Mol Med (2007) 1.27
Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase. ChemMedChem (2013) 1.25
Requirement of FADD, NEMO, and BAX/BAK for aberrant mitochondrial function in tumor necrosis factor alpha-induced necrosis. Mol Cell Biol (2011) 1.24
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature (2006) 24.39
The role of autophagy during the early neonatal starvation period. Nature (2004) 22.40
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell (2005) 21.01
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol (2005) 18.60
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest (2003) 16.67
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell (2007) 14.63
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J (2008) 12.89
Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor. Science (2003) 12.41
Autophagy in immunity and inflammation. Nature (2011) 11.16
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature (2008) 10.84
Autophagy in cell death: an innocent convict? J Clin Invest (2005) 10.70
A chemical method for fast and sensitive detection of DNA synthesis in vivo. Proc Natl Acad Sci U S A (2008) 10.09
Autophagy defends cells against invading group A Streptococcus. Science (2004) 9.53
Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol (2008) 9.24
LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci (2004) 9.20
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell (2009) 9.14
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol (2004) 8.85
The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med (2007) 8.82
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science (2005) 7.98
Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science (2007) 7.65
Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell (2008) 7.61
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell (2008) 7.32
FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J Cell Biol (2008) 7.16
Escape of intracellular Shigella from autophagy. Science (2004) 6.64
Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci (2003) 6.53
A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med (2006) 6.01
A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature (2009) 5.55
Multidimensional drug profiling by automated microscopy. Science (2004) 5.45
Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat Med (2002) 4.86
De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood. Nat Genet (2013) 4.71
Autophagy-deficient mice develop multiple liver tumors. Genes Dev (2011) 4.64
Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia. Proc Natl Acad Sci U S A (2005) 4.63
Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. J Biol Chem (2005) 4.56
Myocardial infarction accelerates atherosclerosis. Nature (2012) 4.48
Self- and actin-templated assembly of Mammalian septins. Dev Cell (2002) 4.48
A standardized kinesin nomenclature. J Cell Biol (2004) 4.43
The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. Cell (2012) 4.40
Reassembly of contractile actin cortex in cell blebs. J Cell Biol (2006) 4.31
Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. J Biol Chem (2002) 4.27
Single-molecule speckle analysis of actin filament turnover in lamellipodia. Science (2002) 4.27
Animal cytokinesis: from parts list to mechanisms. Annu Rev Biochem (2006) 4.23
Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Biol Chem (2007) 4.22
BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med (2008) 4.20
Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens. Cell Host Microbe (2008) 4.16
The dynamics of autophagy visualized in live cells: from autophagosome formation to fusion with endo/lysosomes. Autophagy (2005) 4.08
Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins. Autophagy (2010) 3.99
LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localization. Autophagy (2007) 3.91
Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem (2006) 3.77
The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol Biol Cell (2008) 3.72
Expansion and evolution of cell death programmes. Nat Rev Mol Cell Biol (2008) 3.59
Autophagy is essential for preimplantation development of mouse embryos. Science (2008) 3.55
A decade of caspases. Oncogene (2003) 3.55
Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. J Cell Biol (2003) 3.52
Necroptosis as an alternative form of programmed cell death. Curr Opin Cell Biol (2010) 3.51
Vertebrate shugoshin links sister centromere cohesion and kinetochore microtubule stability in mitosis. Cell (2004) 3.51
Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size. FEBS Lett (2006) 3.49
Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly. Cancer Cell (2009) 3.44
Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest (2010) 3.44
Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol (2004) 3.39
Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc Natl Acad Sci U S A (2007) 3.37
The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell (2003) 3.36
Induction of autophagy in axonal dystrophy and degeneration. J Neurosci (2006) 3.28
Branching microtubule nucleation in Xenopus egg extracts mediated by augmin and TPX2. Cell (2013) 3.26
Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell (2007) 3.21
In vivo requirement for Atg5 in antigen presentation by dendritic cells. Immunity (2010) 3.19
Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy. Am J Pathol (2006) 3.18
Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase. Nat Med (2002) 3.17
Integrating high-content screening and ligand-target prediction to identify mechanism of action. Nat Chem Biol (2007) 3.17
Poly(ADP-ribose) is required for spindle assembly and structure. Nature (2004) 3.11
Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance. Nature (2008) 3.09
Life and times of a cellular bleb. Biophys J (2007) 3.05
Two ubiquitin-like conjugation systems essential for autophagy. Semin Cell Dev Biol (2004) 3.04
Direct observation of microtubule dynamics at kinetochores in Xenopus extract spindles: implications for spindle mechanics. J Cell Biol (2003) 3.01
Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane. J Biol Chem (2011) 2.99
Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival. Cell (2011) 2.98
Coronavirus replication complex formation utilizes components of cellular autophagy. J Biol Chem (2003) 2.96
Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis. J Exp Med (2012) 2.92
EB1-microtubule interactions in Xenopus egg extracts: role of EB1 in microtubule stabilization and mechanisms of targeting to microtubules. Mol Biol Cell (2002) 2.92
A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery. Chem Biol (2011) 2.81
Determining the position of the cell division plane. Nature (2003) 2.80
Atg101, a novel mammalian autophagy protein interacting with Atg13. Autophagy (2009) 2.78
Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. EMBO J (2009) 2.72
Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation. Opt Lett (2003) 2.70
Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function. Nat Cell Biol (2005) 2.70
Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders. Nature (2003) 2.60
Intracellular inclusions containing mutant alpha1-antitrypsin Z are propagated in the absence of autophagic activity. J Biol Chem (2005) 2.60
Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex. J Cereb Blood Flow Metab (2004) 2.59
Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell (2011) 2.58
Negative regulation of Vps34 by Cdk mediated phosphorylation. Mol Cell (2010) 2.57
Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease). Am J Pathol (2005) 2.56
Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation. Mol Biol Cell (2004) 2.51
Cell death assays for drug discovery. Nat Rev Drug Discov (2011) 2.51