Published in Hum Mol Genet on June 30, 2011
Triplet repeat RNA structure and its role as pathogenic agent and therapeutic target. Nucleic Acids Res (2011) 1.29
A pathogenic mechanism in Huntington's disease involves small CAG-repeated RNAs with neurotoxic activity. PLoS Genet (2012) 1.20
RNA-mediated toxicity in neurodegenerative disease. Mol Cell Neurosci (2012) 1.07
Nucleotide excision repair, mismatch repair, and R-loops modulate convergent transcription-induced cell death and repeat instability. PLoS One (2012) 0.97
RNA toxicity in polyglutamine disorders: concepts, models, and progress of research. J Mol Med (Berl) (2013) 0.94
Mechanisms of RNA-induced toxicity in CAG repeat disorders. Cell Death Dis (2013) 0.91
The RNA-centred view of the synapse: non-coding RNAs and synaptic plasticity. Philos Trans R Soc Lond B Biol Sci (2014) 0.89
Polyglutamine (polyQ) disorders: the chromatin connection. Nucleus (2012) 0.88
The role of the immune system in triplet repeat expansion diseases. Mediators Inflamm (2015) 0.85
Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels. J Clin Invest (2016) 0.85
A screen for selective killing of cells with chromosomal instability induced by a spindle checkpoint defect. PLoS One (2012) 0.83
RNA-mediated pathogenic mechanisms in polyglutamine diseases and amyotrophic lateral sclerosis. Front Cell Neurosci (2014) 0.82
RNA pathogenesis via Toll-like receptor-activated inflammation in expanded repeat neurodegenerative diseases. Front Mol Neurosci (2013) 0.81
Polyglutamine repeats are associated to specific sequence biases that are conserved among eukaryotes. PLoS One (2012) 0.81
Small non-coding RNAs add complexity to the RNA pathogenic mechanisms in trinucleotide repeat expansion diseases. Front Mol Neurosci (2013) 0.81
Ubiquitous expression of CUG or CAG trinucleotide repeat RNA causes common morphological defects in a Drosophila model of RNA-mediated pathology. PLoS One (2012) 0.78
Distinct roles for Toll and autophagy pathways in double-stranded RNA toxicity in a Drosophila model of expanded repeat neurodegenerative diseases. Hum Mol Genet (2013) 0.78
Structural studies of CNG repeats. Nucleic Acids Res (2014) 0.78
Diced triplets expose neurons to RISC. PLoS Genet (2012) 0.78
The Enemy within: Innate Surveillance-Mediated Cell Death, the Common Mechanism of Neurodegenerative Disease. Front Neurosci (2016) 0.77
Drosophila melanogaster As a Model Organism to Study RNA Toxicity of Repeat Expansion-Associated Neurodegenerative and Neuromuscular Diseases. Front Cell Neurosci (2017) 0.75
Inheritance of a cancer-associated MLH1 germ-line epimutation. N Engl J Med (2007) 4.87
DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proc Natl Acad Sci U S A (2007) 3.24
Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA. Nucleic Acids Res (2012) 2.67
Germ-line epigenetic modification of the murine A vy allele by nutritional supplementation. Proc Natl Acad Sci U S A (2006) 2.63
Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription. Nucleic Acids Res (2009) 1.55
Molecular genetics of pseudoxanthoma elasticum: type and frequency of mutations in ABCC6. Hum Mutat (2005) 1.47
Erythroid Krüppel-like factor directly activates the basic Krüppel-like factor gene in erythroid cells. Mol Cell Biol (2007) 1.45
Contribution of mGluR and Fmr1 functional pathways to neurite morphogenesis, craniofacial development and fragile X syndrome. Hum Mol Genet (2006) 1.36
Common chromosomal fragile sites and cancer: focus on FRA16D. Cancer Lett (2005) 1.36
Huntingtin-deficient zebrafish exhibit defects in iron utilization and development. Hum Mol Genet (2007) 1.29
Glioma microvesicles carry selectively packaged coding and non-coding RNAs which alter gene expression in recipient cells. RNA Biol (2013) 1.26
Epigenetic inactivation of a cluster of genes flanking MLH1 in microsatellite-unstable colorectal cancer. Cancer Res (2007) 1.23
Periconceptional undernutrition in normal and overweight ewes leads to increased adrenal growth and epigenetic changes in adrenal IGF2/H19 gene in offspring. FASEB J (2010) 1.20
A sustained dietary change increases epigenetic variation in isogenic mice. PLoS Genet (2011) 1.16
Complexity of murine cardiomyocyte miRNA biogenesis, sequence variant expression and function. PLoS One (2012) 1.15
The pathogenic agent in Drosophila models of 'polyglutamine' diseases. Hum Mol Genet (2005) 1.06
Dietary restriction enhances germline stem cell maintenance. Aging Cell (2010) 1.05
Paternal high-fat diet consumption induces common changes in the transcriptomes of retroperitoneal adipose and pancreatic islet tissues in female rat offspring. FASEB J (2014) 1.03
Common chromosomal fragile site FRA16D mutation in cancer cells. Hum Mol Genet (2005) 1.00
Oligoastrocytomas: throwing the baby out with the bathwater? Acta Neuropathol (2014) 0.99
Sulfur amino acid metabolism in pregnancy: the impact of methionine in the maternal diet. J Nutr (2006) 0.99
Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species. Hum Mol Genet (2010) 0.98
Common chromosomal fragile site FRA16D tumor suppressor WWOX gene expression and metabolic reprograming in cells. Genes Chromosomes Cancer (2013) 0.97
High-resolution analysis of cytosine methylation in ancient DNA. PLoS One (2012) 0.96
Early priming minimizes the age-related immune compromise of CD8⁺ T cell diversity and function. PLoS Pathog (2012) 0.95
Maternal obesity and diabetes induces latent metabolic defects and widespread epigenetic changes in isogenic mice. Epigenetics (2013) 0.94
Epigenetic programming by maternal nutrition: shaping future generations. Epigenomics (2010) 0.93
Fetal growth restriction and the programming of heart growth and cardiac insulin-like growth factor 2 expression in the lamb. J Physiol (2011) 0.93
The Roles of PPARs in the Fetal Origins of Metabolic Health and Disease. PPAR Res (2008) 0.93
CpG methylation of a silent controlling element in the murine Avy allele is incomplete and unresponsive to methyl donor supplementation. PLoS One (2010) 0.92
Methyl donors change the germline epigenetic state of the A(vy) allele. FASEB J (2007) 0.92
Perturbation of the Akt/Gsk3-β signalling pathway is common to Drosophila expressing expanded untranslated CAG, CUG and AUUCU repeat RNAs. Hum Mol Genet (2011) 0.90
Disruption of lipid metabolism in the liver of the pregnant rat fed folate-deficient and methyl donor-deficient diets. Br J Nutr (2007) 0.89
Germline epimutation: A basis for epigenetic disease in humans. Ann N Y Acad Sci (2005) 0.89
Regulation of adult stem cell behavior by nutrient signaling. Cell Cycle (2011) 0.89
Inherited epimutation or a haplotypic basis for the propensity to silence? Nat Genet (2007) 0.87
Selective neuronal requirement for huntingtin in the developing zebrafish. Hum Mol Genet (2009) 0.87
miRspring: a compact standalone research tool for analyzing miRNA-seq data. Nucleic Acids Res (2013) 0.87
Epigenetics in disease: leader or follower? Epigenetics (2011) 0.86
Environmental influence on epigenetic inheritance at the Avy allele. Nutr Rev (2008) 0.86
The penetrance of an epigenetic trait in mice is progressively yet reversibly increased by selection and environment. Proc Biol Sci (2012) 0.85
Comparative toxicity of polyglutamine, polyalanine and polyleucine tracts in Drosophila models of expanded repeat disease. Hum Mol Genet (2011) 0.84
Periconceptional undernutrition programs changes in insulin-signaling molecules and microRNAs in skeletal muscle in singleton and twin fetal sheep. Biol Reprod (2014) 0.84
FRA16D common chromosomal fragile site oxido-reductase (FOR/WWOX) protects against the effects of ionizing radiation in Drosophila. Oncogene (2005) 0.82
Parental programming: how can we improve study design to discern the molecular mechanisms? Bioessays (2013) 0.82
RNA pathogenesis via Toll-like receptor-activated inflammation in expanded repeat neurodegenerative diseases. Front Mol Neurosci (2013) 0.81
Impact of embryo number and maternal undernutrition around the time of conception on insulin signaling and gluconeogenic factors and microRNAs in the liver of fetal sheep. Am J Physiol Endocrinol Metab (2014) 0.81
Know thy fly. Trends Genet (2007) 0.80
Maternal protein restriction increases hepatic glycogen storage in young rats. Pediatr Res (2003) 0.79
Dynamic mutations on the move in Banff. Nat Genet (2004) 0.79
The GM-CSF receptor utilizes β-catenin and Tcf4 to specify macrophage lineage differentiation. Differentiation (2011) 0.79
Elevated insulin sensitivity in low-protein offspring rats is prevented by a high-fat diet and is associated with visceral fat. Obesity (Silver Spring) (2009) 0.79
Germline epimutation in humans. Pharmacogenomics (2008) 0.78
Distinct roles for Toll and autophagy pathways in double-stranded RNA toxicity in a Drosophila model of expanded repeat neurodegenerative diseases. Hum Mol Genet (2013) 0.78
Ubiquitous expression of CUG or CAG trinucleotide repeat RNA causes common morphological defects in a Drosophila model of RNA-mediated pathology. PLoS One (2012) 0.78
Dynamic mutations: where are they now? Adv Exp Med Biol (2012) 0.77
Postnatal nutrition alters body composition in adult offspring exposed to maternal protein restriction. Br J Nutr (2008) 0.76
Early origins of heart disease: low birth weight and the role of the insulin-like growth factor system in cardiac hypertrophy. Clin Exp Pharmacol Physiol (2012) 0.76
Computational analysis, biochemical purification, and detection of tRNA-derived small RNA fragments. Methods Mol Biol (2014) 0.76
Promoter Methylation Analysis of IDH Genes in Human Gliomas. Front Oncol (2012) 0.75