Published in Hum Mol Genet on November 12, 2010
Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks. J Biol Chem (2014) 1.19
Feedback from rhodopsin controls rhodopsin exclusion in Drosophila photoreceptors. Nature (2011) 1.10
Tumor suppressor WWOX regulates glucose metabolism via HIF1α modulation. Cell Death Differ (2014) 1.00
Zfra is a small wizard in the mitochondrial apoptosis. Aging (Albany NY) (2010) 0.97
WW domain-containing oxidoreductase in neuronal injury and neurological diseases. Oncotarget (2014) 0.96
A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity. Nat Cell Biol (2015) 0.90
Tumor Suppressor WWOX and p53 Alterations and Drug Resistance in Glioblastomas. Front Oncol (2013) 0.86
Chromosomal instability causes sensitivity to metabolic stress. Oncogene (2014) 0.86
The tumor suppressor WW domain-containing oxidoreductase modulates cell metabolism. Exp Biol Med (Maywood) (2014) 0.85
Pleiotropic Functions of Tumor Suppressor WWOX in Normal and Cancer Cells. J Biol Chem (2015) 0.82
Introduction to a thematic issue for WWOX. Exp Biol Med (Maywood) (2015) 0.81
WWOX, the chromosomal fragile site FRA16D spanning gene: its role in metabolism and contribution to cancer. Exp Biol Med (Maywood) (2015) 0.79
Tumor Suppressor WWOX Contributes to the Elimination of Tumorigenic Cells in Drosophila melanogaster. PLoS One (2015) 0.78
WWOX modulates the gene expression profile in the T98G glioblastoma cell line rendering its phenotype less malignant. Oncol Rep (2014) 0.75
Genome-wide identification of hypoxia-induced enhancer regions. PeerJ (2015) 0.75
Role of WW domain proteins WWOX in development, prognosis, and treatment response of glioma. Exp Biol Med (Maywood) (2014) 0.75
Human SOD1 ALS Mutations in a Drosophila Knock-In Model Cause Severe Phenotypes and Reveal Dosage-Sensitive Gain and Loss of Function Components. Genetics (2016) 0.75
The role of WWOX polymorphisms on COPD susceptibility and pulmonary function traits in Chinese: a case-control study and family-based analysis. Sci Rep (2016) 0.75
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development (1993) 58.26
Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med (2009) 33.09
IDH1 and IDH2 mutations in gliomas. N Engl J Med (2009) 32.41
A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila. Nature (2007) 18.38
Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer (2008) 18.08
FlyBase: enhancing Drosophila Gene Ontology annotations. Nucleic Acids Res (2008) 12.15
Signatures of mutation and selection in the cancer genome. Nature (2010) 9.75
The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. Genetics (2004) 8.40
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. Proc Natl Acad Sci U S A (2010) 8.12
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature (2004) 7.21
Chromosome fragile sites. Annu Rev Genet (2007) 4.95
WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer. Cancer Res (2000) 4.07
Nox proteins in signal transduction. Free Radic Biol Med (2009) 3.47
Constitutive fragile sites and cancer. Science (1984) 3.30
The role of the kinases RIP1 and RIP3 in TNF-induced necrosis. Sci Signal (2010) 3.20
Epidemiology of mutations in superoxide dismutase in amyotrophic lateral sclerosis. Ann Neurol (1997) 2.84
D-2-hydroxyglutaric acid induces oxidative stress in cerebral cortex of young rats. Eur J Neurosci (2003) 2.62
Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells. Hum Mol Genet (2000) 2.56
NMDA receptor activation and respiratory chain complex V inhibition contribute to neurodegeneration in d-2-hydroxyglutaric aciduria. Eur J Neurosci (2002) 2.54
Targeted deletion of Wwox reveals a tumor suppressor function. Proc Natl Acad Sci U S A (2007) 2.37
Replacement of Fhit in cancer cells suppresses tumorigenicity. Proc Natl Acad Sci U S A (1997) 2.36
Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity. J Biol Chem (2000) 2.20
Reactive oxygen intermediates in TNF signaling. Mol Immunol (2002) 2.20
Fragile and unstable chromosomes in cancer: causes and consequences. Trends Genet (2001) 2.20
WWOX, the FRA16D gene, behaves as a suppressor of tumor growth. Cancer Res (2001) 2.12
Using Drosophila melanogaster to map human cancer pathways. Nat Rev Cancer (2005) 2.03
Mechanisms of common fragile site instability. Hum Mol Genet (2005) 1.69
The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism. J Biol Chem (2008) 1.67
The tricarboxylic acid cycle, an ancient metabolic network with a novel twist. PLoS One (2007) 1.60
Drosophila models for cancer research. Curr Opin Genet Dev (2005) 1.58
The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma. Cancer (2004) 1.49
Large common fragile site genes and cancer. Semin Cancer Biol (2006) 1.44
Subunit-destabilizing mutations in Drosophila copper/zinc superoxide dismutase: neuropathology and a model of dimer dysequilibrium. Proc Natl Acad Sci U S A (1995) 1.37
Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies. Mol Cancer Res (2003) 1.32
Alternative transcripts of the candidate tumor suppressor gene, WWOX, are expressed at high levels in human breast tumors. Oncogene (2002) 1.31
An opposing view on WWOX protein function as a tumor suppressor. Cancer Res (2003) 1.27
Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells. J Biol Chem (2008) 1.22
Signaling from membrane receptors to tumor suppressor WW domain-containing oxidoreductase. Exp Biol Med (Maywood) (2010) 1.19
Targeted ablation of the WW domain-containing oxidoreductase tumor suppressor leads to impaired steroidogenesis. Endocrinology (2008) 1.19
17beta-Estradiol upregulates and activates WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: potential role in cancerous progression of breast and prostate to a premetastatic state in vivo. Oncogene (2005) 1.18
Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene. PLoS One (2009) 1.18
A spontaneous mutation of the Wwox gene and audiogenic seizures in rats with lethal dwarfism and epilepsy. Genes Brain Behav (2009) 1.17
The role of cellular oxidative stress in regulating glycolysis energy metabolism in hepatoma cells. Mol Cancer (2009) 1.15
WOX1 is essential for UVB irradiation-induced apoptosis and down-regulated via translational blockade in UVB-induced cutaneous squamous cell carcinoma in vivo. Clin Cancer Res (2005) 1.14
WWOX hypomorphic mice display a higher incidence of B-cell lymphomas and develop testicular atrophy. Genes Chromosomes Cancer (2007) 1.13
IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain. Biochem Biophys Res Commun (2010) 1.08
Fragile gene product, Fhit, in oxidative and replicative stress responses. Cancer Sci (2009) 1.03
Induction of hsp70, hsp60, hsp83 and hsp26 and oxidative stress markers in benzene, toluene and xylene exposed Drosophila melanogaster: role of ROS generation. Toxicol Appl Pharmacol (2008) 1.02
Common chromosomal fragile site FRA16D mutation in cancer cells. Hum Mol Genet (2005) 1.00
Direct correlation between FRA3B expression and cigarette smoking. Genes Chromosomes Cancer (2002) 0.99
Transgenic analysis of the cSOD-null phenotypic syndrome in Drosophila. Genome (1998) 0.93
Phenotypic characterization of spontaneously mutated rats showing lethal dwarfism and epilepsy. Comp Med (2007) 0.92
FRA16D common chromosomal fragile site oxido-reductase (FOR/WWOX) protects against the effects of ionizing radiation in Drosophila. Oncogene (2005) 0.82
Know thy fly. Trends Genet (2007) 0.80
Chips with everything: DNA microarrays in infectious diseases. Lancet Infect Dis (2004) 1.87
The gene associated with trichorhinophalangeal syndrome in humans is overexpressed in breast cancer. Proc Natl Acad Sci U S A (2005) 1.80
Comparison of human placenta- and bone marrow-derived multipotent mesenchymal stem cells. Stem Cells Dev (2008) 1.74
Use of matrix-assisted laser desorption ionization-time of flight mass spectrometry to identify vancomycin-resistant enterococci and investigate the epidemiology of an outbreak. J Clin Microbiol (2012) 1.48
Molecular genetics of pseudoxanthoma elasticum: type and frequency of mutations in ABCC6. Hum Mutat (2005) 1.47
Contribution of mGluR and Fmr1 functional pathways to neurite morphogenesis, craniofacial development and fragile X syndrome. Hum Mol Genet (2006) 1.36
Common chromosomal fragile sites and cancer: focus on FRA16D. Cancer Lett (2005) 1.36
Huntingtin-deficient zebrafish exhibit defects in iron utilization and development. Hum Mol Genet (2007) 1.29
Development and validation of a novel molecular biomarker diagnostic test for the early detection of sepsis. Crit Care (2011) 1.26
Enhanced cerebrovascular expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 via the MEK/ERK pathway during cerebral ischemia in the rat. BMC Neurosci (2009) 1.06
The pathogenic agent in Drosophila models of 'polyglutamine' diseases. Hum Mol Genet (2005) 1.06
The UPF3B gene, implicated in intellectual disability, autism, ADHD and childhood onset schizophrenia regulates neural progenitor cell behaviour and neuronal outgrowth. Hum Mol Genet (2013) 1.04
Blockade of the MEK/ERK pathway with a raf inhibitor prevents activation of pro-inflammatory mediators in cerebral arteries and reduction in cerebral blood flow after subarachnoid hemorrhage in a rat model. J Cereb Blood Flow Metab (2010) 1.03
Common chromosomal fragile site FRA16D mutation in cancer cells. Hum Mol Genet (2005) 1.00
Common chromosomal fragile site FRA16D tumor suppressor WWOX gene expression and metabolic reprograming in cells. Genes Chromosomes Cancer (2013) 0.97
Double-stranded RNA is pathogenic in Drosophila models of expanded repeat neurodegenerative diseases. Hum Mol Genet (2011) 0.94
Perturbation of the Akt/Gsk3-β signalling pathway is common to Drosophila expressing expanded untranslated CAG, CUG and AUUCU repeat RNAs. Hum Mol Genet (2011) 0.90
Abnormalities of the RB1 pathway in ovarian serous papillary carcinoma as determined by overexpression of the p16(INK4A) protein. Int J Gynecol Pathol (2005) 0.89
Complex CGH alterations on chromosome arm 8p at candidate tumor suppressor gene loci in breast cancer cell lines. Cancer Genet Cytogenet (2005) 0.88
Selective neuronal requirement for huntingtin in the developing zebrafish. Hum Mol Genet (2009) 0.87
Cigarette smoke extracts promote vascular smooth muscle cell proliferation and enhances contractile responses in the vasculature and airway. Basic Clin Pharmacol Toxicol (2010) 0.85
Comparative toxicity of polyglutamine, polyalanine and polyleucine tracts in Drosophila models of expanded repeat disease. Hum Mol Genet (2011) 0.84
Bacterial artificial chromosome mutagenesis using recombineering. J Biomed Biotechnol (2010) 0.83
Conservation and expression of PIWI-interacting RNA pathway genes in male and female adult gonad of amniotes. Biol Reprod (2013) 0.83
Vincristine pharmacodynamics and pharmacogenetics in children with cancer: a limited-sampling, population modelling approach. J Paediatr Child Health (2011) 0.82
FRA16D common chromosomal fragile site oxido-reductase (FOR/WWOX) protects against the effects of ionizing radiation in Drosophila. Oncogene (2005) 0.82
Increased expression of vascular endothelin type B and angiotensin type 1 receptors in patients with ischemic heart disease. BMC Cardiovasc Disord (2009) 0.81
Know thy fly. Trends Genet (2007) 0.80
Dynamic mutations on the move in Banff. Nat Genet (2004) 0.79
Ubiquitous expression of CUG or CAG trinucleotide repeat RNA causes common morphological defects in a Drosophila model of RNA-mediated pathology. PLoS One (2012) 0.78
Distinct roles for Toll and autophagy pathways in double-stranded RNA toxicity in a Drosophila model of expanded repeat neurodegenerative diseases. Hum Mol Genet (2013) 0.78
Dynamic mutations: where are they now? Adv Exp Med Biol (2012) 0.77
Phase unwrapping algorithms for use in a true real-time optical body sensor system for use during radiotherapy. Appl Opt (2011) 0.77
Dendritic cells in leukemia and lymphoma. Leuk Lymphoma (2006) 0.75
Like-minded fellow. Midwives (2011) 0.75
Tread carefully. Midwives (2011) 0.75
Differential diagnosis of serous papillary carcinoma of the gynaecological tract and basal breast carcinoma: an immunohistochemical approach. Pathology (2010) 0.75
Radio active. Midwives (2014) 0.75
A test of temperament. Midwives (2011) 0.75
GPs should take annual health checks for people with learning difficulties seriously. BMJ (2011) 0.75
Breast is best ... until when? Midwives (2011) 0.75
More input for a growing problem. Midwives (2010) 0.75
Reaching out. Midwives (2014) 0.75
No room for complacency. Midwives (2011) 0.75
Out on her own. Midwives (2010) 0.75
Africa afresh. Midwives (2011) 0.75