SLC6 neurotransmitter transporters: structure, function, and regulation.

X-ray structure of dopamine transporter elucidates antidepressant mechanism. Nature (2013) 3.00

The Concise Guide to PHARMACOLOGY 2013/14: transporters. Br J Pharmacol (2013) 2.07

De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder. Mol Psychiatry (2013) 1.93

Structural basis for action by diverse antidepressants on biogenic amine transporters. Nature (2013) 1.56

Homozygous SLC6A17 mutations cause autosomal-recessive intellectual disability with progressive tremor, speech impairment, and behavioral problems. Am J Hum Genet (2015) 1.42

Identification of a 3rd Na+ Binding Site of the Glycine Transporter, GlyT2. PLoS One (2016) 1.40

Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature (2015) 1.30

Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain. Nat Rev Drug Discov (2013) 1.27

A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters. Nat Struct Mol Biol (2014) 1.26

X-ray structures and mechanism of the human serotonin transporter. Nature (2016) 1.21

Conformational dynamics of ligand-dependent alternating access in LeuT. Nat Struct Mol Biol (2014) 1.19

Neurogenetics and Nutrigenomics of Neuro-Nutrient Therapy for Reward Deficiency Syndrome (RDS): Clinical Ramifications as a Function of Molecular Neurobiological Mechanisms. J Addict Res Ther (2012) 1.19

The mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transporters. J Biol Chem (2012) 1.19

SLC6 transporters: structure, function, regulation, disease association and therapeutics. Mol Aspects Med (2013) 1.18

Amphetamines, new psychoactive drugs and the monoamine transporter cycle. Trends Pharmacol Sci (2014) 1.15

Ca(2+)/calmodulin-dependent protein kinase IIα (αCaMKII) controls the activity of the dopamine transporter: implications for Angelman syndrome. J Biol Chem (2012) 1.14

Baths salts, spice, and related designer drugs: the science behind the headlines. J Neurosci (2014) 1.14

The solute carrier 6 family of transporters. Br J Pharmacol (2012) 1.14

Neurosteroid interactions with synaptic and extrasynaptic GABA(A) receptors: regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability. Psychopharmacology (Berl) (2013) 1.14

A quantitative model of amphetamine action on the 5-HT transporter. Br J Pharmacol (2014) 1.11

GABA and Glutamate Transporters in Brain. Front Endocrinol (Lausanne) (2013) 1.06

How LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transporters. J Physiol (2013) 1.06

Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue. EMBO Rep (2012) 1.05

X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine. Nat Struct Mol Biol (2015) 1.04

Dopamine transporter phosphorylation site threonine 53 regulates substrate reuptake and amphetamine-stimulated efflux. J Biol Chem (2012) 1.04

SLC transporters as therapeutic targets: emerging opportunities. Nat Rev Drug Discov (2015) 1.02

The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction. Pflugers Arch (2013) 1.02

Temporal pattern of cocaine intake determines tolerance vs sensitization of cocaine effects at the dopamine transporter. Neuropsychopharmacology (2013) 1.01

Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket. J Biol Chem (2012) 1.01

SLC6A3 coding variant Ala559Val found in two autism probands alters dopamine transporter function and trafficking. Transl Psychiatry (2014) 1.00

Thermostabilisation of the serotonin transporter in a cocaine-bound conformation. J Mol Biol (2013) 0.99

Amphetamine actions at the serotonin transporter rely on the availability of phosphatidylinositol-4,5-bisphosphate. Proc Natl Acad Sci U S A (2013) 0.99

Switching the clientele: a lysine residing in the C terminus of the serotonin transporter specifies its preference for the coat protein complex II component SEC24C. J Biol Chem (2013) 0.95

The role of protein N-glycosylation in neural transmission. Glycobiology (2014) 0.95

A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter. Nat Commun (2013) 0.94

Probing binding pocket of serotonin transporter by single molecular force spectroscopy on living cells. J Biol Chem (2011) 0.94

High selectivity of the γ-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach. J Biol Chem (2012) 0.94

'Second-generation' mephedrone analogs, 4-MEC and 4-MePPP, differentially affect monoamine transporter function. Neuropsychopharmacology (2014) 0.93

Axonal targeting of the serotonin transporter in cultured rat dorsal raphe neurons is specified by SEC24C-dependent export from the endoplasmic reticulum. J Neurosci (2014) 0.92

Missense dopamine transporter mutations associate with adult parkinsonism and ADHD. J Clin Invest (2014) 0.92

Spontaneous Inward Opening of the Dopamine Transporter Is Triggered by PIP2-Regulated Dynamics of the N-Terminus. ACS Chem Neurosci (2015) 0.91

Structure and regulatory interactions of the cytoplasmic terminal domains of serotonin transporter. Biochemistry (2014) 0.90

Dopamine transporter endocytic trafficking in striatal dopaminergic neurons: differential dependence on dynamin and the actin cytoskeleton. J Neurosci (2013) 0.89

The vasculome of the mouse brain. PLoS One (2012) 0.89

Dopamine-mediated autocrine inhibitory circuit regulating human insulin secretion in vitro. Mol Endocrinol (2012) 0.89

Rare autism-associated variants implicate syntaxin 1 (STX1 R26Q) phosphorylation and the dopamine transporter (hDAT R51W) in dopamine neurotransmission and behaviors. EBioMedicine (2015) 0.89

Monoamine transporter structure, function, dynamics, and drug discovery: a computational perspective. AAPS J (2012) 0.89

In vivo amphetamine action is contingent on αCaMKII. Neuropsychopharmacology (2014) 0.88

Transport of biogenic amine neurotransmitters at the mouse blood-retina and blood-brain barriers by uptake1 and uptake2. J Cereb Blood Flow Metab (2012) 0.88

Transgenic mouse models for ADHD. Cell Tissue Res (2013) 0.88

The two Na+ sites in the human serotonin transporter play distinct roles in the ion coupling and electrogenicity of transport. J Biol Chem (2013) 0.88

Regulation of the Dopamine and Vesicular Monoamine Transporters: Pharmacological Targets and Implications for Disease. Pharmacol Rev (2015) 0.88

Aminorex, a metabolite of the cocaine adulterant levamisole, exerts amphetamine like actions at monoamine transporters. Neurochem Int (2013) 0.87

Ligand induced conformational changes of the human serotonin transporter revealed by molecular dynamics simulations. PLoS One (2013) 0.87

Computational and biochemical docking of the irreversible cocaine analog RTI 82 directly demonstrates ligand positioning in the dopamine transporter central substrate-binding site. J Biol Chem (2014) 0.87

X-linked creatine transporter deficiency: clinical aspects and pathophysiology. J Inherit Metab Dis (2014) 0.86

Structure, function, and plasticity of GABA transporters. Front Cell Neurosci (2014) 0.86

Substrate-induced Unlocking of the Inner Gate Determines the Catalytic Efficiency of a Neurotransmitter:Sodium Symporter. J Biol Chem (2015) 0.86

Electrical coupling between the human serotonin transporter and voltage-gated Ca(2+) channels. Cell Calcium (2014) 0.85

Membrane-permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine release. J Biol Chem (2013) 0.85

Binding Mode Selection Determines the Action of Ecstasy Homologs at Monoamine Transporters. Mol Pharmacol (2015) 0.84

The second sodium site in the dopamine transporter controls cation permeation and is regulated by chloride. J Biol Chem (2014) 0.84

Neurotransmitter transporters: structure meets function. Structure (2013) 0.84

Design and synthesis of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) analogues as novel probes for the serotonin transporter S1 and S2 binding sites. J Med Chem (2013) 0.84

Brain Region-Specific Trafficking of the Dopamine Transporter. J Neurosci (2015) 0.84

N-glycosylation in regulation of the nervous system. Adv Neurobiol (2014) 0.83

Properties of an inward-facing state of LeuT: conformational stability and substrate release. Biophys J (2015) 0.83

A conserved leucine occupies the empty substrate site of LeuT in the Na(+)-free return state. Nat Commun (2016) 0.83

Radioligand binding to nanodisc-reconstituted membrane transporters assessed by the scintillation proximity assay. Biochemistry (2013) 0.83

Computational approaches to detect allosteric pathways in transmembrane molecular machines. Biochim Biophys Acta (2016) 0.83

Neurofunctional imaging of β-cell dynamics. Diabetes Obes Metab (2012) 0.82

Widespread microRNA dysregulation in multiple system atrophy - disease-related alteration in miR-96. Eur J Neurosci (2013) 0.82

Augmentation of Creatine in the Heart. Mini Rev Med Chem (2015) 0.81

mTORC2/rictor signaling disrupts dopamine-dependent behaviors via defects in striatal dopamine neurotransmission. J Neurosci (2015) 0.81

Thermostabilization of the Human Serotonin Transporter in an Antidepressant-Bound Conformation. PLoS One (2015) 0.81

Zn(2+) reverses functional deficits in a de novo dopamine transporter variant associated with autism spectrum disorder. Mol Autism (2015) 0.81

Arousal from sleep in response to intermittent hypoxia in rat pups is modulated by medullary raphe GABAergic mechanisms. Am J Physiol Regul Integr Comp Physiol (2011) 0.81

Gene expression analyses of the spatio-temporal relationships of human medulloblastoma subgroups during early human neurogenesis. PLoS One (2014) 0.81

The serotonin transporter undergoes constitutive internalization and is primarily sorted to late endosomes and lysosomal degradation. J Biol Chem (2014) 0.80

Biophysical Approaches to the Study of LeuT, a Prokaryotic Homolog of Neurotransmitter Sodium Symporters. Methods Enzymol (2015) 0.80

Transition metal ion FRET uncovers K(+) regulation of a neurotransmitter/sodium symporter. Nat Commun (2016) 0.80

A combined approach using transporter-flux assays and mass spectrometry to examine psychostimulant street drugs of unknown content. ACS Chem Neurosci (2012) 0.80

Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram. ACS Med Chem Lett (2014) 0.80

Insights to ligand binding to the monoamine transporters-from homology modeling to LeuBAT and dDAT. Front Pharmacol (2015) 0.80

SLC6 family transporter SNF-10 is required for protease-mediated activation of sperm motility in C. elegans. Dev Biol (2014) 0.80

Dual Action of Zn2+ on the Transport Cycle of the Dopamine Transporter. J Biol Chem (2015) 0.80

Membrane transporters in self resistance of Cercospora nicotianae to the photoactivated toxin cercosporin. Curr Genet (2015) 0.80

Reciprocal Phosphorylation and Palmitoylation Control Dopamine Transporter Kinetics. J Biol Chem (2015) 0.79

Serotonin-induced down-regulation of cell surface serotonin transporter. Neurochem Int (2014) 0.79

Monoamine transporters: insights from molecular dynamics simulations. Front Pharmacol (2015) 0.79

Amphetamine action at the cocaine- and antidepressant-sensitive serotonin transporter is modulated by αCaMKII. J Neurosci (2015) 0.79

Discovery of novel-scaffold monoamine transporter ligands via in silico screening with the S1 pocket of the serotonin transporter. ACS Chem Neurosci (2014) 0.79

Mechanism of Paroxetine (Paxil) Inhibition of the Serotonin Transporter. Sci Rep (2016) 0.78

Differential regulation of the serotonin transporter by vesicle-associated membrane protein 2 in cells of neuronal versus non-neuronal origin. PLoS One (2014) 0.78

Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter. Nat Commun (2016) 0.78

Evolutionary history of the GABA transporter (GAT) group revealed by marine invertebrate GAT-1. PLoS One (2013) 0.78

Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporter. Sci Rep (2015) 0.78

Regulation of prostaglandin EP1 and EP4 receptor signaling by carrier-mediated ligand reuptake. Pharmacol Res Perspect (2014) 0.78

Ack1 is a dopamine transporter endocytic brake that rescues a trafficking-dysregulated ADHD coding variant. Proc Natl Acad Sci U S A (2015) 0.78

Antagonist-induced conformational changes in dopamine transporter extracellular loop two involve residues in a potential salt bridge. Neurochem Int (2013) 0.78

Correlation between genetic and geographic structure in Europe. Curr Biol (2008) 5.02

Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins. Nat Methods (2010) 2.77

The binding sites for cocaine and dopamine in the dopamine transporter overlap. Nat Neurosci (2008) 2.72

Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors. Mol Pharmacol (2007) 2.64

How curved membranes recruit amphipathic helices and protein anchoring motifs. Nat Chem Biol (2009) 2.38

Amphipathic motifs in BAR domains are essential for membrane curvature sensing. EMBO J (2009) 2.20

An intracellular interaction network regulates conformational transitions in the dopamine transporter. J Biol Chem (2008) 2.07

Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport. Neuron (2006) 2.00

Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype. Proc Natl Acad Sci U S A (2006) 1.69

Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle. Proc Natl Acad Sci U S A (2002) 1.68

The N terminus of monoamine transporters is a lever required for the action of amphetamines. J Biol Chem (2010) 1.58

Gr-1(high) CD11b+ cells suppress B cell differentiation and lupus-like disease in lupus-prone male mice. Arthritis Rheum (2013) 1.47

Location of the antidepressant binding site in the serotonin transporter: importance of Ser-438 in recognition of citalopram and tricyclic antidepressants. J Biol Chem (2009) 1.46

Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding. J Biol Chem (2003) 1.45

PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance. PLoS Biol (2013) 1.41

Severe bleeding after sinus floor elevation using the transcrestal technique: a case report. Eur J Oral Implantol (2012) 1.40

A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage. Proc Natl Acad Sci U S A (2012) 1.40

Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux. Mol Pharmacol (2008) 1.38

N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization. J Biol Chem (2002) 1.37

Membrane mobility and microdomain association of the dopamine transporter studied with fluorescence correlation spectroscopy and fluorescence recovery after photobleaching. Biochemistry (2007) 1.37

Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter. J Biol Chem (2009) 1.33

Molecular determinants for the complex binding specificity of the PDZ domain in PICK1. J Biol Chem (2005) 1.28

Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogs. J Neurosci (2009) 1.26

Membrane localization is critical for activation of the PICK1 BAR domain. Traffic (2008) 1.25

Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD. Proc Natl Acad Sci U S A (2009) 1.23

Regulation of dopamine transporter trafficking by intracellular amphetamine. Mol Pharmacol (2006) 1.22

Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters. Chem Commun (Camb) (2009) 1.21

Postendocytic sorting of constitutively internalized dopamine transporter in cell lines and dopaminergic neurons. J Biol Chem (2010) 1.17

Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ domain interactions. J Neurosci (2004) 1.17

AMPA receptor pHluorin-GluA2 reports NMDA receptor-induced intracellular acidification in hippocampal neurons. Proc Natl Acad Sci U S A (2013) 1.17

Identification of intra- and intermolecular disulfide bridges in the multidrug resistance transporter ABCG2. J Biol Chem (2005) 1.16

Recruitment of beta-arrestin2 to the dopamine D2 receptor: insights into anti-psychotic and anti-parkinsonian drug receptor signaling. Neuropharmacology (2008) 1.15

The solute carrier 6 family of transporters. Br J Pharmacol (2012) 1.14

Zinc potentiates an uncoupled anion conductance associated with the dopamine transporter. J Biol Chem (2004) 1.13

The role of zinc ions in reverse transport mediated by monoamine transporters. J Biol Chem (2002) 1.11

The binding sites for benztropines and dopamine in the dopamine transporter overlap. Neuropharmacology (2010) 1.11

Does bereavement-related first episode depression differ from other kinds of first depressions? Soc Psychiatry Psychiatr Epidemiol (2009) 1.10

Regulation of dopamine transporter function by protein-protein interactions: new discoveries and methodological challenges. J Neurochem (2010) 1.10

Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter. J Biol Chem (2012) 1.09

Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter. J Med Chem (2005) 1.07

Glycine transporter dimers: evidence for occurrence in the plasma membrane. J Biol Chem (2008) 1.07

Validity of the diagnosis of a single depressive episode in a case register. Clin Pract Epidemiol Ment Health (2009) 1.06

Interaction between genetic polymorphisms and stressful life events in first episode depression. J Affect Disord (2009) 1.06

Differences between early and late onset adult depression. Clin Pract Epidemiol Ment Health (2011) 1.05

Tandem facial amphiphiles for membrane protein stabilization. J Am Chem Soc (2010) 1.05

Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters. Proc Natl Acad Sci U S A (2011) 1.04

Phosphorylation of the norepinephrine transporter at threonine 258 and serine 259 is linked to protein kinase C-mediated transporter internalization. J Biol Chem (2006) 1.04

Both exogenous and endogenous interleukin-10 affects the maturation of bone-marrow-derived dendritic cells in vitro and strongly influences T-cell priming in vivo. Immunology (2002) 1.04

A sequential binding mechanism in a PDZ domain. Biochemistry (2009) 1.03

Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket. J Biol Chem (2012) 1.01

From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: synthesis and structure-activity relationship studies. J Med Chem (2008) 1.00

Interleukin-6 induces expression of Ifi202, an interferon-inducible candidate gene for lupus susceptibility. J Biol Chem (2004) 1.00

Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1. Eur J Neurosci (2008) 1.00

Increased expression of Ifi202, an IFN-activatable gene, in B6.Nba2 lupus susceptible mice inhibits p53-mediated apoptosis. J Immunol (2006) 1.00

Intracellular and circulating neuronal antinuclear antibodies in human epilepsy. Neurobiol Dis (2013) 0.98

Allosteric effects of R- and S-citalopram on the human 5-HT transporter: evidence for distinct high- and low-affinity binding sites. Eur J Pharmacol (2007) 0.97

Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDA receptor interaction. Angew Chem Int Ed Engl (2009) 0.97

A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins. Chemistry (2012) 0.96

Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. J Med Chem (2008) 0.96

Effect of Walker A mutation (K86M) on oligomerization and surface targeting of the multidrug resistance transporter ABCG2. J Cell Sci (2005) 0.96

Terpene trilactones from Ginkgo biloba are antagonists of cortical glycine and GABA(A) receptors. J Biol Chem (2003) 0.95

A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter. Nat Commun (2013) 0.94

Conformational basis for the Li(+)-induced leak current in the rat gamma-aminobutyric acid (GABA) transporter-1. J Physiol (2002) 0.94

Effects of MHC and gender on lupus-like autoimmunity in Nba2 congenic mice. J Immunol (2005) 0.93

Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study. Chem Commun (Camb) (2013) 0.93

Missense dopamine transporter mutations associate with adult parkinsonism and ADHD. J Clin Invest (2014) 0.92

Passive water and urea permeability of a human Na(+)-glutamate cotransporter expressed in Xenopus oocytes. J Physiol (2002) 0.92

Protein interacting with C kinase 1 (PICK1) reduces reinsertion rates of interaction partners sorted to Rab11-dependent slow recycling pathway. J Biol Chem (2012) 0.91

Use of fluorescence spectroscopy to study conformational changes in the beta 2-adrenoceptor. Methods Enzymol (2002) 0.90

Brain-derived neurotrophic factor (BDNF) enhances GABA transport by modulating the trafficking of GABA transporter-1 (GAT-1) from the plasma membrane of rat cortical astrocytes. J Biol Chem (2011) 0.89

Molecular basis for selective serotonin reuptake inhibition by the antidepressant agent fluoxetine (Prozac). Mol Pharmacol (2014) 0.89

Evidence for distinct sodium-, dopamine-, and cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine transporter. J Biol Chem (2003) 0.89

Design, synthesis, and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists. J Med Chem (2013) 0.88

Dissection of genetic mechanisms governing the expression of serum retroviral gp70 implicated in murine lupus nephritis. J Immunol (2008) 0.88

Probing dopamine transporter structure and function by Zn2+-site engineering. Eur J Pharmacol (2003) 0.88

Deciphering the kinetic binding mechanism of dimeric ligands using a potent plasma-stable dimeric inhibitor of postsynaptic density protein-95 as an example. J Biol Chem (2010) 0.87

Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists. J Med Chem (2003) 0.87

Rational design of alpha-conotoxin analogues targeting alpha7 nicotinic acetylcholine receptors: improved antagonistic activity by incorporation of proline derivatives. J Biol Chem (2009) 0.87

Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. J Med Chem (2011) 0.87

Side-chain interactions form late and cooperatively in the binding reaction between disordered peptides and PDZ domains. J Am Chem Soc (2011) 0.86

Energetic pathway sampling in a protein interaction domain. Structure (2013) 0.85