Published in Prostaglandins Other Lipid Mediat on July 03, 2011
Type 2 diabetes associated changes in the plasma non-esterified fatty acids, oxylipins and endocannabinoids. PLoS One (2012) 1.09
Calcium-independent phospholipases A2 and their roles in biological processes and diseases. J Lipid Res (2015) 0.97
Role of ceramide in diabetes mellitus: evidence and mechanisms. Lipids Health Dis (2013) 0.95
Epoxyeicosatrienoic acids mediate insulin-mediated augmentation in skeletal muscle perfusion and blood volume. Am J Physiol Endocrinol Metab (2014) 0.94
Eicosanoids in metabolic syndrome. Adv Pharmacol (2013) 0.87
Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes. Exp Mol Med (2014) 0.85
Systemic alterations in the metabolome of diabetic NOD mice delineate increased oxidative stress accompanied by reduced inflammation and hypertriglyceremia. Am J Physiol Endocrinol Metab (2015) 0.84
Beneficial effects of inhibition of soluble epoxide hydrolase on glucose homeostasis and islet damage in a streptozotocin-induced diabetic mouse model. Prostaglandins Other Lipid Mediat (2012) 0.84
Oxidative stress and heme oxygenase-1 regulated human mesenchymal stem cells differentiation. Int J Hypertens (2012) 0.84
Comparison of the efficacy of sitagliptin and glimepiride dose-up in Japanese patients with type 2 diabetes poorly controlled by sitagliptin and glimepiride in combination. J Diabetes Investig (2013) 0.81
Hepatoprotective Effects of Chinese Medicinal Herbs: A Focus on Anti-Inflammatory and Anti-Oxidative Activities. Int J Mol Sci (2016) 0.80
PTGS-2-PTGER2/4 signaling pathway partially protects from diabetogenic toxicity of streptozotocin in mice. Diabetes (2012) 0.79
Group X secretory phospholipase A2 regulates insulin secretion through a cyclooxygenase-2-dependent mechanism. J Biol Chem (2014) 0.79
Chemical genetics screening reveals KIAA1363 as a cytokine-lowering target. ACS Chem Biol (2014) 0.77
A diet containing a nonfat dry milk matrix significantly alters systemic oxylipins and the endocannabinoid 2-arachidonoylglycerol (2-AG) in diet-induced obese mice. Nutr Metab (Lond) (2014) 0.76
The Role of Cytochrome P450 Epoxygenases, Soluble Epoxide Hydrolase, and Epoxyeicosatrienoic Acids in Metabolic Diseases. Adv Nutr (2016) 0.75
Impact of Long-Term Poor and Good Glycemic Control on Metabolomics Alterations in Type 1 Diabetic People. J Clin Endocrinol Metab (2016) 0.75
Angiotensin type 1 receptor mediates renal production and conversion of prostaglandins E2 to F2α in conscious diabetic rats. J Renin Angiotensin Aldosterone Syst (2015) 0.75
Regulation of pancreatic β-cell function and mass dynamics by prostaglandin signaling. J Cell Commun Signal (2017) 0.75
The dual role of group V secretory phospholipase A2 in pancreatic β-cells. Endocrine (2017) 0.75
Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract (2009) 25.83
Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature (2006) 15.48
Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature (2007) 11.59
Oxidative stress and diabetic complications. Circ Res (2010) 9.37
Cyclooxygenases 1 and 2. Annu Rev Pharmacol Toxicol (1998) 7.22
Inducible cyclooxygenase may have anti-inflammatory properties. Nat Med (1999) 6.91
n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr (2006) 6.60
P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev (2002) 6.14
Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ Res (1996) 5.77
Genomics, type 2 diabetes, and obesity. N Engl J Med (2010) 5.58
Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes (2005) 5.54
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell (2001) 5.13
Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. J Clin Invest (2002) 4.96
Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate. J Biol Chem (1999) 4.39
The role of inflammation in insulitis and beta-cell loss in type 1 diabetes. Nat Rev Endocrinol (2009) 4.36
Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes (2000) 4.16
Insulin resistance--mechanisms, syndromes, and implications. N Engl J Med (1991) 3.58
Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases. Nat Rev Drug Discov (2009) 3.46
Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: a role for resolvins and protectins. FASEB J (2009) 2.83
Obesity, insulin resistance and free fatty acids. Curr Opin Endocrinol Diabetes Obes (2011) 2.67
Endothelial dysfunction and vascular disease. Acta Physiol (Oxf) (2009) 2.67
High glucose causes upregulation of cyclooxygenase-2 and alters prostanoid profile in human endothelial cells: role of protein kinase C and reactive oxygen species. Circulation (2003) 2.44
Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction. J Clin Invest (2003) 2.35
Regulation of insulin secretion: a matter of phase control and amplitude modulation. Diabetologia (2009) 2.15
The receptor RAGE as a progression factor amplifying arachidonate-dependent inflammatory and proteolytic response in human atherosclerotic plaques: role of glycemic control. Circulation (2003) 2.14
Epoxide hydrolase and epoxygenase metabolites as therapeutic targets for renal diseases. Am J Physiol Renal Physiol (2005) 2.10
In vivo chromatin remodeling events leading to inflammatory gene transcription under diabetic conditions. J Biol Chem (2004) 2.07
Inflammation-mediated dysfunction and apoptosis in pancreatic islet transplantation: implications for intrahepatic grafts. J Leukoc Biol (2005) 2.00
Arachidonic acid-metabolizing cytochrome P450 enzymes are targets of {omega}-3 fatty acids. J Biol Chem (2010) 1.83
Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice. FASEB J (2010) 1.82
Insulin resistance, defective insulin-mediated fatty acid suppression, and coronary artery calcification in subjects with and without type 1 diabetes: The CACTI study. Diabetes (2010) 1.80
Peroxisome proliferator-activated receptor alpha controls the hepatic CYP4A induction adaptive response to starvation and diabetes. J Biol Chem (1998) 1.76
Functional and pathological roles of the 12- and 15-lipoxygenases. Prog Lipid Res (2010) 1.72
Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity. Diabetes (2010) 1.71
Lipid inflammatory mediators in diabetic vascular disease. Arterioscler Thromb Vasc Biol (2004) 1.61
Cytochrome P-450 epoxygenases protect endothelial cells from apoptosis induced by tumor necrosis factor-alpha via MAPK and PI3K/Akt signaling pathways. Am J Physiol Heart Circ Physiol (2007) 1.55
20-hydroxyeicosatetraeonic acid: a new target for the treatment of hypertension. J Cardiovasc Pharmacol (2010) 1.55
12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet. Am J Physiol Endocrinol Metab (2008) 1.52
Epoxyeicosatrienoic acid agonist rescues the metabolic syndrome phenotype of HO-2-null mice. J Pharmacol Exp Ther (2009) 1.51
Actions of epoxygenase metabolites on the preglomerular vasculature. J Am Soc Nephrol (1996) 1.50
Autoimmune destruction of pancreatic beta cells. Am J Ther (2005) 1.49
12/15-lipoxygenase products induce inflammation and impair insulin signaling in 3T3-L1 adipocytes. Obesity (Silver Spring) (2009) 1.46
Essential role for hematopoietic prostaglandin D2 synthase in the control of delayed type hypersensitivity. Proc Natl Acad Sci U S A (2006) 1.43
Eicosanoids in inflammation: biosynthesis, pharmacology, and therapeutic frontiers. Curr Top Med Chem (2007) 1.42
Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia. J Biol Chem (2002) 1.41
Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis. J Pharmacol Exp Ther (2010) 1.38
Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids. Biochim Biophys Acta (2010) 1.36
Physiologic and pathophysiologic roles of lipid mediators in the kidney. Kidney Int (2007) 1.36
5-lipoxygenase activating protein signals adipose tissue inflammation and lipid dysfunction in experimental obesity. J Immunol (2010) 1.36
Characterization of epoxyeicosatrienoic acid binding site in U937 membranes using a novel radiolabeled agonist, 20-125i-14,15-epoxyeicosa-8(Z)-enoic acid. J Pharmacol Exp Ther (2008) 1.35
Regulation of cyclooxygenase-2 expression in monocytes by ligation of the receptor for advanced glycation end products. J Biol Chem (2003) 1.35
12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice. PLoS One (2009) 1.34
Arachidonic acid inhibits epithelial Na channel via cytochrome P450 (CYP) epoxygenase-dependent metabolic pathways. J Gen Physiol (2004) 1.33
A natural protective mechanism against hyperglycaemia in vascular endothelial and smooth-muscle cells: role of glucose and 12-hydroxyeicosatetraenoic acid. Biochem J (2002) 1.33
12-Lipoxygenase Products Reduce Insulin Secretion and {beta}-Cell Viability in Human Islets. J Clin Endocrinol Metab (2010) 1.31
Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice. J Clin Invest (1999) 1.30
Cytokines and nitric oxide in islet inflammation and diabetes. Proc Soc Exp Biol Med (1996) 1.29
Increased production of 12/15 lipoxygenase eicosanoids accelerates monocyte/endothelial interactions in diabetic db/db mice. J Biol Chem (2003) 1.28
Increased CYP2J3 expression reduces insulin resistance in fructose-treated rats and db/db mice. Diabetes (2010) 1.27
Activation of 12-lipoxygenase in proinflammatory cytokine-mediated beta cell toxicity. Diabetologia (2005) 1.26
The role of 12/15-lipoxygenase in the expression of interleukin-6 and tumor necrosis factor-alpha in macrophages. Endocrinology (2006) 1.26
Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages. Am J Physiol Heart Circ Physiol (2008) 1.25
Soluble epoxide inhibition is protective against cerebral ischemia via vascular and neural protection. Am J Pathol (2009) 1.23
The influence of dietary fat on insulin resistance. Curr Diab Rep (2002) 1.23
Increased prostaglandin production by glomeruli isolated from rats with streptozotocin-induced diabetes mellitus. J Clin Invest (1985) 1.21
Association of soluble epoxide hydrolase gene polymorphism with insulin resistance in type 2 diabetic patients. Biochem Biophys Res Commun (2005) 1.21
Pathways in beta-cell stimulus-secretion coupling as targets for therapeutic insulin secretagogues. Diabetes (2004) 1.21
Dietary fish as a major component of a weight-loss diet: effect on serum lipids, glucose, and insulin metabolism in overweight hypertensive subjects. Am J Clin Nutr (1999) 1.20
Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats. Am J Physiol Endocrinol Metab (2010) 1.20
Eicosanoid regulation of the renal vasculature. Am J Physiol Renal Physiol (2000) 1.19
Diabetes and inflammation: fundamental aspects and clinical implications. Diabetes Metab (2010) 1.19
Elevated glucose and angiotensin II increase 12-lipoxygenase activity and expression in porcine aortic smooth muscle cells. Proc Natl Acad Sci U S A (1993) 1.19
Obesity-associated insulin resistance in skeletal muscle: role of lipid accumulation and physical inactivity. Rev Endocr Metab Disord (2011) 1.18
Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets. Biochem Biophys Res Commun (1983) 1.18
The role of arachidonic acid and its metabolites in insulin secretion from human islets of langerhans. Diabetes (2007) 1.18
Cell-specific subcellular localization of soluble epoxide hydrolase in human tissues. J Histochem Cytochem (2005) 1.17
Lipoxygenase pathway in islet endocrine cells. Oxidative metabolism of arachidonic acid promotes insulin release. J Clin Invest (1983) 1.16
The 5-lipoxygenase/leukotriene pathway in preclinical models of cardiovascular disease. Cardiovasc Res (2010) 1.15
20-Hydroxyeicosa-tetraenoic acid (20 HETE) activates protein kinase C. Role in regulation of rat renal Na+,K+-ATPase. J Clin Invest (1997) 1.14
Inhibition of interleukin-1beta-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function. Diabetes (2002) 1.13
Decreased epoxygenase and increased epoxide hydrolase expression in the mesenteric artery of obese Zucker rats. Am J Physiol Regul Integr Comp Physiol (2004) 1.13
Structural determination and promoter analysis of the chicken mitogen-inducible prostaglandin G/H synthase gene and genetic mapping of the murine homolog. Arch Biochem Biophys (1993) 1.12
High pancreatic n-3 fatty acids prevent STZ-induced diabetes in fat-1 mice: inflammatory pathway inhibition. Diabetes (2011) 1.11
Dominance of cyclooxygenase-2 in the regulation of pancreatic islet prostaglandin synthesis. Diabetes (1998) 1.11
Predominant expression of an arachidonate epoxygenase in islets of Langerhans cells in human and rat pancreas. Endocrinology (1997) 1.11
Identification of ALOX5 as a gene regulating adiposity and pancreatic function. Diabetologia (2008) 1.10
Vasoconstrictor prostanoids. Pflugers Arch (2010) 1.09
Role of EDHF in type 2 diabetes-induced endothelial dysfunction. Am J Physiol Heart Circ Physiol (2008) 1.07
Basal expression of cyclooxygenase-2 and nuclear factor-interleukin 6 are dominant and coordinately regulated by interleukin 1 in the pancreatic islet. Proc Natl Acad Sci U S A (1998) 1.06
A 12-lipoxygenase product, 12-hydroxyeicosatetraenoic acid, is increased in diabetics with incipient and early renal disease. J Clin Endocrinol Metab (1996) 1.06
Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats. Biochem Biophys Res Commun (1999) 1.06
Prostanoid receptors of murine NIH 3T3 and RAW 264.7 cells. Structure and expression of the murine prostaglandin EP4 receptor gene. J Biol Chem (1996) 1.06
Profile of lipid and protein autacoids in diabetic vitreous correlates with the progression of diabetic retinopathy. Diabetes (2010) 1.05
Molecular mechanisms of high glucose-induced cyclooxygenase-2 expression in monocytes. Diabetes (2004) 1.05
Mediation of hyperglycemia-evoked gastric slow-wave dysrhythmias by endogenous prostaglandins. Gastroenterology (1995) 1.05
Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome. Int J Mol Med (2008) 1.05
Inhibition of soluble epoxide hydrolase attenuates endothelial dysfunction in animal models of diabetes, obesity and hypertension. Eur J Pharmacol (2010) 1.05
COX-2 and the kidney. J Cardiovasc Pharmacol (2006) 1.05
COX-2-mediated inflammation in fat is crucial for obesity-linked insulin resistance and fatty liver. Obesity (Silver Spring) (2009) 1.04
Loss of methyl-CpG-binding domain protein 2 enhances endothelial angiogenesis and protects mice against hind-limb ischemic injury. Circulation (2011) 1.74
Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis. J Pharmacol Exp Ther (2010) 1.38
Increasing or stabilizing renal epoxyeicosatrienoic acid production attenuates abnormal renal function and hypertension in obese rats. Am J Physiol Renal Physiol (2007) 1.24
Contributions of nucleus accumbens core and shell GluR1 containing AMPA receptors in AMPA- and cocaine-primed reinstatement of cocaine-seeking behavior. Brain Res (2008) 1.22
Bid deficiency ameliorates ischemic renal failure and delays animal death in C57BL/6 mice. Am J Physiol Renal Physiol (2005) 1.20
Extracellular high-mobility group box 1 acts as an innate immune mediator to enhance autoimmune progression and diabetes onset in NOD mice. Diabetes (2008) 1.17
Differential gender differences in ischemic and nephrotoxic acute renal failure. Am J Nephrol (2005) 1.15
Nitro-oleic acid protects the mouse kidney from ischemia and reperfusion injury. Am J Physiol Renal Physiol (2008) 1.14
Decreased epoxygenase and increased epoxide hydrolase expression in the mesenteric artery of obese Zucker rats. Am J Physiol Regul Integr Comp Physiol (2004) 1.13
Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress. Biochem Biophys Res Commun (2005) 1.13
Cytochrome P450-dependent eicosapentaenoic acid metabolites are novel BK channel activators. Hypertension (2002) 1.11
Cytoprotective effects of hypoxia against cisplatin-induced tubular cell apoptosis: involvement of mitochondrial inhibition and p53 suppression. J Am Soc Nephrol (2006) 1.11
Deletion of soluble epoxide hydrolase gene improves renal endothelial function and reduces renal inflammation and injury in streptozotocin-induced type 1 diabetes. Am J Physiol Regul Integr Comp Physiol (2011) 1.11
Differential regulation of natriuresis by 20-hydroxyeicosatetraenoic Acid in human salt-sensitive versus salt-resistant hypertension. Circulation (2003) 1.07
Prostaglandin E2 is a potent inhibitor of epithelial-to-mesenchymal transition: interaction with hepatocyte growth factor. Am J Physiol Renal Physiol (2006) 1.03
Microsomal prostaglandin synthase-1-derived prostaglandin E2 protects against angiotensin II-induced hypertension via inhibition of oxidative stress. Hypertension (2008) 1.03
Cytochrome P450 4A isoform inhibitory profile of N-hydroxy-N'-(4-butyl-2-methylphenyl)-formamidine (HET0016), a selective inhibitor of 20-HETE synthesis. Biol Pharm Bull (2005) 1.01
Colfibrate attenuates blood pressure and sodium retention in DOCA-salt hypertension. Kidney Int (2008) 0.94
Glomerular 20-HETE, EETs, and TGF-beta1 in diabetic nephropathy. Am J Physiol Renal Physiol (2009) 0.94
Physical interaction and functional coupling between ACDP4 and the intracellular ion chaperone COX11, an implication of the role of ACDP4 in essential metal ion transport and homeostasis. Mol Pain (2005) 0.92
Gender differences of renal CYP-derived eicosanoid synthesis in rats fed a high-fat diet. Am J Hypertens (2005) 0.92
mPGES-1 deletion impairs diuretic response to acute water loading. Am J Physiol Renal Physiol (2009) 0.91
Obesity-induced hypertension develops in young rats independently of the renin-angiotensin-aldosterone system. Exp Biol Med (Maywood) (2006) 0.90
PPAR-alpha activator fenofibrate increases renal CYP-derived eicosanoid synthesis and improves endothelial dilator function in obese Zucker rats. Am J Physiol Heart Circ Physiol (2006) 0.89
Cytochrome P-450 4A isoform expression and 20-HETE synthesis in renal preglomerular arteries. Am J Physiol Renal Physiol (2002) 0.89
Contribution of cytochrome P450 4A isoforms to renal functional response to inhibition of nitric oxide production in the rat. J Physiol (2003) 0.89
Transfection of CYP4A1 cDNA increases vascular reactivity in renal interlobar arteries. Am J Physiol Renal Physiol (2002) 0.87
Epoxyeicosatrienoic Acid inhibition alters renal hemodynamics during pregnancy. Exp Biol Med (Maywood) (2006) 0.87
A stress-dependent SUMO4 sumoylation of its substrate proteins. Biochem Biophys Res Commun (2008) 0.87
Induction of renal 20-hydroxyeicosatetraenoic acid by clofibrate attenuates high-fat diet-induced hypertension in rats. J Pharmacol Exp Ther (2005) 0.86
Differential effects of diet-induced dyslipidemia and hyperglycemia on mesenteric resistance artery structure and function in type 2 diabetes. J Pharmacol Exp Ther (2008) 0.86
Cytochrome P450 epoxygenases provide a novel mechanism for penile erection. FASEB J (2006) 0.85
Beneficial effects of inhibition of soluble epoxide hydrolase on glucose homeostasis and islet damage in a streptozotocin-induced diabetic mouse model. Prostaglandins Other Lipid Mediat (2012) 0.84
Bid activation in kidney cells following ATP depletion in vitro and ischemia in vivo. Am J Physiol Renal Physiol (2003) 0.84
20-HETE and furosemide-induced natriuresis in salt-sensitive essential hypertension. Hypertension (2003) 0.83
P2 receptor regulation of [Ca2+]i in cultured mouse mesangial cells. Am J Physiol Renal Physiol (2007) 0.81
Deletion of soluble epoxide hydrolase attenuates cardiac hypertrophy via down-regulation of cardiac fibroblasts-derived fibroblast growth factor-2. Crit Care Med (2014) 0.79
Renal epoxyeicosatrienoic acid synthesis during pregnancy. Am J Physiol Renal Physiol (2004) 0.79
Transfection of CYP4A1 cDNA decreases diameter and increases responsiveness of gracilis muscle arterioles to constrictor stimuli. Am J Physiol Heart Circ Physiol (2004) 0.78
Inhibition of apoptosis by Zn2+ in renal tubular cells following ATP depletion. Am J Physiol Renal Physiol (2004) 0.77
Transfection and functional expression of CYP4A1 and CYP4A2 using bicistronic vectors in vascular cells and tissues. J Pharmacol Exp Ther (2004) 0.76
Renal 20-HETE inhibition attenuates changes in renal hemodynamics induced by L-NAME treatment in pregnant rats. Am J Physiol Renal Physiol (2005) 0.75