The role of inflammation in insulitis and beta-cell loss in type 1 diabetes.

PubWeight™: 4.36‹?› | Rank: Top 1%

🔗 View Article (PMID 19352320)

Published in Nat Rev Endocrinol on April 01, 2009

Authors

Décio L Eizirik1, Maikel L Colli, Fernanda Ortis

Author Affiliations

1: Laboratory of Experimental Medicine, Medical Faculty, Université Libre de Bruxelles, 808 Route de Lennik, Brussels,Belgium. deizirik@ulb.ac.be

Articles citing this

(truncated to the top 100)

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature (2010) 2.88

EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals. Endocr Rev (2015) 2.51

Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. Cell Metab (2012) 2.39

Immune cell crosstalk in type 1 diabetes. Nat Rev Immunol (2010) 2.26

The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines. PLoS Genet (2012) 1.88

Pathogenesis of type 1 diabetes mellitus: interplay between enterovirus and host. Nat Rev Endocrinol (2010) 1.85

Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic beta-cells. Diabetes (2010) 1.80

GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes. Proc Natl Acad Sci U S A (2011) 1.69

Insulitis in human type 1 diabetes: The quest for an elusive lesion. Islets (2011) 1.61

Molecular signatures differentiate immune states in type 1 diabetic families. Diabetes (2014) 1.58

Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes. Sci Transl Med (2013) 1.55

STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation. J Biol Chem (2010) 1.49

The epigenetics of autoimmunity. Cell Mol Immunol (2011) 1.47

Combination therapy with an anti-IL-1β antibody and GAD65 DNA vaccine can reverse recent-onset diabetes in the RIP-GP mouse model. Diabetes (2014) 1.42

p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress. J Biol Chem (2010) 1.39

Immune therapy for type 1 diabetes mellitus-what is unique about anti-CD3 antibodies? Nat Rev Endocrinol (2010) 1.39

Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells. Diabetes (2009) 1.39

Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases? Pharmacol Rev (2010) 1.39

Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated β-cell death. Diabetes (2011) 1.33

Changes in microRNA expression contribute to pancreatic β-cell dysfunction in prediabetic NOD mice. Diabetes (2012) 1.32

Recent lessons learned from prevention and recent-onset type 1 diabetes immunotherapy trials. Diabetes (2013) 1.30

PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim. Diabetes (2011) 1.26

Diabetes: A virus-gene collaboration. Nature (2009) 1.25

MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA. Hum Mol Genet (2010) 1.25

Oxidative stress and beta-cell dysfunction. Pflugers Arch (2010) 1.22

The multiple faces of autoimmune-mediated bone loss. Nat Rev Endocrinol (2010) 1.22

Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation. J Biol Chem (2011) 1.20

ER stress as a trigger for β-cell dysfunction and autoimmunity in type 1 diabetes. Diabetes (2012) 1.19

GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim. PLoS Genet (2013) 1.19

Antigen targets of type 1 diabetes autoimmunity. Cold Spring Harb Perspect Med (2012) 1.18

Soluble factors secreted by T cells promote β-cell proliferation. Diabetes (2013) 1.14

Deconstructing pancreas development to reconstruct human islets from pluripotent stem cells. Cell Stem Cell (2010) 1.13

Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretion. J Biol Chem (2009) 1.13

Novel diabetes autoantibodies and prediction of type 1 diabetes. Curr Diab Rep (2013) 1.13

Expression and regulation of chemokines in murine and human type 1 diabetes. Diabetes (2011) 1.10

C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in β-cells. Cell Death Differ (2012) 1.10

Connexins protect mouse pancreatic β cells against apoptosis. J Clin Invest (2011) 1.08

Evidence that low-grade systemic inflammation can induce islet dysfunction as measured by impaired calcium handling. Cell Calcium (2010) 1.07

Metabolic regulation in progression to autoimmune diabetes. PLoS Comput Biol (2011) 1.06

Type 2 diabetes mellitus--an autoimmune disease? Nat Rev Endocrinol (2013) 1.06

Cesarean section and interferon-induced helicase gene polymorphisms combine to increase childhood type 1 diabetes risk. Diabetes (2011) 1.05

Treatment with recombinant tumor necrosis factor-related apoptosis-inducing ligand alleviates the severity of streptozotocin-induced diabetes. Diabetes (2010) 1.03

The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cells. PLoS One (2012) 1.03

Deficiency of Atf3, an adaptive-response gene, protects islets and ameliorates inflammation in a syngeneic mouse transplantation model. Diabetologia (2010) 1.03

The diabetes susceptibility gene Clec16a regulates mitophagy. Cell (2014) 1.02

Early life disease programming during the preconception and prenatal period: making the link between stressful life events and type-1 diabetes. PLoS One (2010) 1.02

Islet autoantigens: structure, function, localization, and regulation. Cold Spring Harb Perspect Med (2012) 1.02

Circulating levels of IL-1B+IL-6 cause ER stress and dysfunction in islets from prediabetic male mice. Endocrinology (2013) 1.01

Innate immunity and the pathogenesis of type 1 diabetes. Semin Immunopathol (2010) 0.99

USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis. Cell Death Dis (2012) 0.98

Comparative efficacy of 3 soluble epoxide hydrolase inhibitors in rat neuropathic and inflammatory pain models. Eur J Pharmacol (2012) 0.98

Approaching the in vitro clinical trial: engineering organs on chips. Lab Chip (2014) 0.98

Enhancement of 26S proteasome functionality connects oxidative stress and vascular endothelial inflammatory response in diabetes mellitus. Arterioscler Thromb Vasc Biol (2012) 0.98

ZnT8 is a major CD8+ T cell-recognized autoantigen in pediatric type 1 diabetes. Diabetes (2012) 0.97

Eicosanoids, β-cell function, and diabetes. Prostaglandins Other Lipid Mediat (2011) 0.97

Destruction of tissue, cells and organelles in type 1 diabetic rats presented at macromolecular resolution. Sci Rep (2013) 0.97

Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance. PLoS Pathog (2011) 0.96

Type 1 diabetes mellitus and multiple sclerosis: common etiological features. Nat Rev Endocrinol (2009) 0.95

Non-alcoholic fatty liver disease and type 2 diabetes mellitus: the liver disease of our age? World J Gastroenterol (2014) 0.93

Stem cell therapy to cure type 1 diabetes: from hype to hope. Stem Cells Transl Med (2013) 0.93

Immunology in the clinic review series; focus on type 1 diabetes and viruses: role of antibodies enhancing the infection with Coxsackievirus-B in the pathogenesis of type 1 diabetes. Clin Exp Immunol (2012) 0.93

Hyaluronan and hyaluronan-binding proteins accumulate in both human type 1 diabetic islets and lymphoid tissues and associate with inflammatory cells in insulitis. Diabetes (2014) 0.92

Sulfuretin protects against cytokine-induced beta-cell damage and prevents streptozotocin-induced diabetes. Exp Mol Med (2010) 0.92

Immunology in the clinic review series; focus on type 1 diabetes and viruses: how viral infections modulate beta cell function. Clin Exp Immunol (2012) 0.92

Epigenetics: deciphering how environmental factors may modify autoimmune type 1 diabetes. Mamm Genome (2009) 0.92

Role of the mitochondria in immune-mediated apoptotic death of the human pancreatic β cell line βLox5. PLoS One (2011) 0.91

CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients. Proc Natl Acad Sci U S A (2014) 0.91

ZnT8-Specific CD4+ T cells display distinct cytokine expression profiles between type 1 diabetes patients and healthy adults. PLoS One (2013) 0.91

Autophagy regulates inflammation following oxidative injury in diabetes. Autophagy (2013) 0.90

Children with islet autoimmunity and enterovirus infection demonstrate a distinct cytokine profile. Diabetes (2012) 0.90

Mechanisms of non-apoptotic programmed cell death in diabetes and heart failure. Cell Cycle (2010) 0.88

Regulation of the CCL2 gene in pancreatic β-cells by IL-1β and glucocorticoids: role of MKP-1. PLoS One (2012) 0.87

99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: immune therapies of type 1 diabetes: new opportunities based on the hygiene hypothesis. Clin Exp Immunol (2010) 0.87

Cytokine and chemokine production by human pancreatic islets upon enterovirus infection. Diabetes (2012) 0.87

A novel fluorescence imaging approach for comparative measurements of pancreatic islet function in vitro. Islets (2011) 0.87

Nardostachys jatamansi extract protects against cytokine-induced beta-cell damage and streptozotocin-induced diabetes. World J Gastroenterol (2010) 0.87

The pancreatic β cell and type 1 diabetes: innocent bystander or active participant? Trends Endocrinol Metab (2013) 0.86

Proinsulin and heat shock protein 90 as biomarkers of beta-cell stress in the early period after onset of type 1 diabetes. Transl Res (2015) 0.86

Altered immune regulation in type 1 diabetes. Clin Dev Immunol (2013) 0.85

99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: viruses, autoimmunity and immunoregulation. Clin Exp Immunol (2010) 0.85

Clinical immunologic interventions for the treatment of type 1 diabetes. Cold Spring Harb Perspect Med (2012) 0.85

Aspects of inflammation and oxidative stress in pediatric obesity and type 1 diabetes: an overview of ten years of studies. Exp Diabetes Res (2012) 0.85

Insulitis in human type 1 diabetes: a comparison between patients and animal models. Semin Immunopathol (2014) 0.85

Extracellular matrix components in the pathogenesis of type 1 diabetes. Curr Diab Rep (2014) 0.85

The role of endoplasmic reticulum stress in autoimmune-mediated beta-cell destruction in type 1 diabetes. Exp Diabetes Res (2012) 0.85

The role of innate immune pathways in type 1 diabetes pathogenesis. Curr Opin Endocrinol Diabetes Obes (2010) 0.85

The pancreatic beta cell surface proteome. Diabetologia (2012) 0.85

Oxysterol-EBI2 signaling in immune regulation and viral infection. Eur J Immunol (2014) 0.84

IFN-γ receptor deficiency prevents diabetes induction by diabetogenic CD4+, but not CD8+, T cells. Eur J Immunol (2012) 0.84

Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance. Cell Death Dis (2013) 0.84

Increased IFN-α-producing plasmacytoid dendritic cells (pDCs) in human Th1-mediated type 1 diabetes: pDCs augment Th1 responses through IFN-α production. J Immunol (2014) 0.84

Posttranslational modifications of proteins in type 1 diabetes: the next step in finding the cure? Diabetes (2012) 0.84

Influenza A viruses grow in human pancreatic cells and cause pancreatitis and diabetes in an animal model. J Virol (2012) 0.84

An enhanced immune response of Mclk1⁺/⁻ mutant mice is associated with partial protection from fibrosis, cancer and the development of biomarkers of aging. PLoS One (2012) 0.84

JNK3 maintains expression of the insulin receptor substrate 2 (IRS2) in insulin-secreting cells: functional consequences for insulin signaling. PLoS One (2012) 0.84

Mechanisms in the adaptation of maternal β-cells during pregnancy. Diabetes Manag (Lond) (2011) 0.84

Celastrol ameliorates cytokine toxicity and pro-inflammatory immune responses by suppressing NF-κB activation in RINm5F beta cells. BMB Rep (2015) 0.84

Macrophage migration inhibitory factor deficiency protects pancreatic islets from cytokine-induced apoptosis in vitro. Clin Exp Immunol (2012) 0.84

An immunohistochemical study of nitrotyrosine expression in pancreatic islets of cases with increasing duration of type 1 diabetes and without diabetes. Histochem Cell Biol (2017) 0.84

Viral infections in type 1 diabetes mellitus - why the β cells? Nat Rev Endocrinol (2016) 0.83

Articles cited by this

Pathogen recognition and innate immunity. Cell (2006) 44.14

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature (2001) 33.12

Recognition of microorganisms and activation of the immune response. Nature (2007) 12.99

Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature (2008) 12.45

Origin and physiological roles of inflammation. Nature (2008) 11.68

Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol (2008) 11.02

The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med (2006) 10.99

Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell (2008) 9.59

A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat Immunol (2005) 7.94

Induction and effector functions of T(H)17 cells. Nature (2008) 7.75

Intracellular NOD-like receptors in host defense and disease. Immunity (2007) 6.48

The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci U S A (2007) 6.44

Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes (2005) 5.54

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature (2005) 5.39

The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev (2007) 5.19

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Nature (2008) 4.42

MDA5/RIG-I and virus recognition. Curr Opin Immunol (2008) 4.05

Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature (2005) 3.62

A choice of death--the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia (2001) 3.60

The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes. Endocr Rev (2008) 3.56

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library. Nat Med (1999) 3.45

TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity. Nat Med (2007) 3.45

Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetes. Immunity (2007) 3.30

Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells. Diabetes (2005) 3.18

Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients. Proc Natl Acad Sci U S A (2007) 3.11

CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope. J Clin Invest (2008) 3.11

Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. Nat Med (2005) 3.10

Increased number of islet-associated macrophages in type 2 diabetes. Diabetes (2007) 3.01

Insulin secretion in type 1 diabetes. Diabetes (2004) 2.59

Effects of autoimmunity and immune therapy on beta-cell turnover in type 1 diabetes. Diabetes (2006) 2.52

Innocuous IFNgamma induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production. J Exp Med (2008) 2.28

Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse. Diabetes (1999) 2.27

Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis. Nat Med (2002) 2.17

Death-defying immunity: do apoptotic cells influence antigen processing and presentation? Nat Rev Immunol (2004) 2.03

Screening for insulitis in adult autoantibody-positive organ donors. Diabetes (2007) 2.02

Serum concentrations of the interferon-gamma-inducible chemokine IP-10/CXCL10 are augmented in both newly diagnosed Type I diabetes mellitus patients and subjects at risk of developing the disease. Diabetologia (2002) 1.93

Immunoreactive alpha-interferon in insulin-secreting beta cells in type 1 diabetes mellitus. Lancet (1987) 1.91

Conditional and specific NF-kappaB blockade protects pancreatic beta cells from diabetogenic agents. Proc Natl Acad Sci U S A (2006) 1.85

Human pancreatic islets produce and secrete MCP-1/CCL2: relevance in human islet transplantation. Diabetes (2002) 1.84

Among CXCR3 chemokines, IFN-gamma-inducible protein of 10 kDa (CXC chemokine ligand (CXCL) 10) but not monokine induced by IFN-gamma (CXCL9) imprints a pattern for the subsequent development of autoimmune disease. J Immunol (2003) 1.72

NOD1 variation, immunoglobulin E and asthma. Hum Mol Genet (2005) 1.66

Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells. Diabetes (2003) 1.63

A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells. J Biol Chem (2001) 1.60

A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes. J Clin Invest (2004) 1.51

Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-gamma-induced apoptosis in primary pancreatic beta-cells. J Biol Chem (2005) 1.50

A vitamin D analog down-regulates proinflammatory chemokine production by pancreatic islets inhibiting T cell recruitment and type 1 diabetes development. J Immunol (2004) 1.43

Identification of a molecular signature in human type 1 diabetes mellitus using serum and functional genomics. J Immunol (2008) 1.43

Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays. Diabetes (2001) 1.43

IL-1beta and IFN-gamma induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice. Diabetologia (2003) 1.41

Interferons induce an antiviral state in human pancreatic islet cells. Virology (2007) 1.41

Apoptotic cells deliver processed antigen to dendritic cells for cross-presentation. PLoS Biol (2005) 1.35

Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts. Proc Natl Acad Sci U S A (2007) 1.35

Viral trigger for type 1 diabetes: pros and cons. Diabetes (2008) 1.33

Increased expression of CCL2 in insulin-producing cells of transgenic mice promotes mobilization of myeloid cells from the bone marrow, marked insulitis, and diabetes. Diabetes (2008) 1.31

Islet-specific Th1, but not Th2, cells secrete multiple chemokines and promote rapid induction of autoimmune diabetes. J Immunol (1999) 1.31

Elevated serum IP-10 levels observed in type 1 diabetes. Diabetes Care (2001) 1.28

Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells. Diabetologia (2001) 1.28

Caspase-3-dependent beta-cell apoptosis in the initiation of autoimmune diabetes mellitus. Mol Cell Biol (2005) 1.26

Altered chemokine levels in individuals at risk of Type 1 diabetes mellitus. Diabet Med (2006) 1.23

Interferon-alpha as a mediator of polyinosinic:polycytidylic acid-induced type 1 diabetes. Diabetes (2005) 1.18

Differential expression of CC chemokines and the CCR5 receptor in the pancreas is associated with progression to type I diabetes. J Immunol (2000) 1.16

The effect of innate immunity on autoimmune diabetes and the expression of Toll-like receptors on pancreatic islets. J Immunol (2004) 1.15

Double-stranded RNA induces pancreatic beta-cell apoptosis by activation of the toll-like receptor 3 and interferon regulatory factor 3 pathways. Diabetes (2008) 1.14

Evidence of expression of endotoxin receptors CD14, toll-like receptors TLR4 and TLR2 and associated molecule MD-2 and of sensitivity to endotoxin (LPS) in islet beta cells. Clin Exp Immunol (2003) 1.13

Global profiling of coxsackievirus- and cytokine-induced gene expression in human pancreatic islets. Diabetologia (2005) 1.13

Toll-like receptor 4 suppression leads to islet allograft survival. FASEB J (2007) 1.12

Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells. Diabetes (2005) 1.09

Repair of pancreatic beta-cells. A relevant phenomenon in early IDDM? Diabetes (1993) 1.09

Pathogenesis of ankylosing spondylitis: current concepts. Best Pract Res Clin Rheumatol (2006) 1.09

Use of a systems biology approach to understand pancreatic beta-cell death in Type 1 diabetes. Biochem Soc Trans (2008) 1.08

Autoimmunity and beta cell regeneration in mouse and human type 1 diabetes: the peace is not enough. Ann N Y Acad Sci (2007) 1.08

Reversal of beta-cell suppression in vitro in pancreatic islets isolated from nonobese diabetic mice during the phase preceding insulin-dependent diabetes mellitus. J Clin Invest (1990) 1.07

Extent of beta cell destruction is important but insufficient to predict the onset of type 1 diabetes mellitus. PLoS One (2008) 1.05

The role of CC chemokine receptor 5 (CCR5) in islet allograft rejection. Diabetes (2002) 1.04

Double-stranded RNA cooperates with interferon-gamma and IL-1 beta to induce both chemokine expression and nuclear factor-kappa B-dependent apoptosis in pancreatic beta-cells: potential mechanisms for viral-induced insulitis and beta-cell death in type 1 diabetes mellitus. Endocrinology (2002) 1.02

Global profiling of double stranded RNA- and IFN-gamma-induced genes in rat pancreatic beta cells. Diabetologia (2003) 1.02

Use of microarray analysis to unveil transcription factor and gene networks contributing to Beta cell dysfunction and apoptosis. Ann N Y Acad Sci (2003) 1.01

Notch signaling: a mediator of beta-cell de-differentiation in diabetes? Biochem Biophys Res Commun (2005) 1.01

Beyond double-stranded RNA-type I IFN induction by 3pRNA and other viral nucleic acids. Curr Top Microbiol Immunol (2007) 1.00

Critical roles for macrophages in islet angiogenesis and maintenance during pancreatic degeneration. Diabetes (2008) 0.99

Chemokines in autoimmune diseases. Immunol Rev (2000) 0.98

JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells. PLoS One (2008) 0.96

Deletion of STAT-1 pancreatic islets protects against streptozotocin-induced diabetes and early graft failure but not against late rejection. Diabetes (2007) 0.96

Islet expression of M3 uncovers a key role for chemokines in the development and recruitment of diabetogenic cells in NOD mice. Diabetes (2007) 0.95

Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes. Clin Immunol (2008) 0.93

Innate immunity and its role in type 1 diabetes. Curr Opin Endocrinol Diabetes Obes (2008) 0.92

Double-stranded ribonucleic acid (RNA) induces beta-cell Fas messenger RNA expression and increases cytokine-induced beta-cell apoptosis. Endocrinology (2001) 0.90

Function of pancreatic islets isolated from a type 1 diabetic patient. Diabetes Care (2000) 0.89

Islet beta-cell death - fuel to sustain autoimmunity? Immunity (2007) 0.89

The CVB and etiology of type 1 diabetes. Curr Top Microbiol Immunol (2008) 0.89

Regeneration of pancreatic endocrine cells in interferon-gamma transgenic mice. Adv Exp Med Biol (1992) 0.85

Dual role of interferon-gamma signalling pathway in sensitivity of pancreatic beta cells to immune destruction. Diabetologia (2001) 0.84

Role of infiltrating T cells for impaired glucose metabolism in pancreatic islets isolated from non-obese diabetic mice. Diabetologia (1992) 0.83

Articles by these authors

Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells. Diabetes (2005) 3.18

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells. J Cell Sci (2008) 2.99

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis. J Biol Chem (2006) 2.26

The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines. PLoS Genet (2012) 1.88

PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis. Diabetes (2009) 1.63

Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB. Diabetes (2009) 1.50

STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation. J Biol Chem (2010) 1.49

Mild endoplasmic reticulum stress augments the proinflammatory effect of IL-1β in pancreatic rat β-cells via the IRE1α/XBP1s pathway. Endocrinology (2012) 1.49

p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress. J Biol Chem (2010) 1.39

Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells. Diabetes (2009) 1.39

PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim. Diabetes (2011) 1.26

MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA. Hum Mol Genet (2010) 1.25

Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells. Diabetes (2007) 1.22

GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim. PLoS Genet (2013) 1.19

Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue. J Nutr Biochem (2007) 1.13

Use of a systems biology approach to understand pancreatic beta-cell death in Type 1 diabetes. Biochem Soc Trans (2008) 1.08

Cell-permeable peptides induce dose- and length-dependent cytotoxic effects. Biochim Biophys Acta (2007) 1.00

JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells. PLoS One (2008) 0.96

Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and beta-cell apoptosis. Proc Natl Acad Sci U S A (2011) 0.91

Identification of new pancreatic beta cell targets for in vivo imaging by a systems biology approach. Curr Pharm Des (2010) 0.77