PubRank

David C Samuels

Author PubWeight™ 77.85‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Mitochondrial DNA mutations in human colonic crypt stem cells. J Clin Invest 2003 3.84
2 Pathogenic mitochondrial DNA mutations are common in the general population. Am J Hum Genet 2008 3.56
3 A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes. Nat Genet 2008 2.82
4 What causes mitochondrial DNA deletions in human cells? Nat Genet 2008 2.70
5 Universal heteroplasmy of human mitochondrial DNA. Hum Mol Genet 2012 2.39
6 Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission. Nat Genet 2012 1.94
7 Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations. Nat Genet 2011 1.92
8 The diversity present in 5140 human mitochondrial genomes. Am J Hum Genet 2009 1.90
9 Segregation of mtDNA throughout human embryofetal development: m.3243A>G as a model system. Hum Mutat 2011 1.83
10 Accumulation of mitochondrial DNA mutations in ageing, cancer, and mitochondrial disease: is there a common mechanism? Lancet 2002 1.65
11 Comparative study of exome copy number variation estimation tools using array comparative genomic hybridization as control. Biomed Res Int 2013 1.61
12 Large scale comparison of gene expression levels by microarrays and RNAseq using TCGA data. PLoS One 2013 1.61
13 Adult-onset spinocerebellar ataxia syndromes due to MTATP6 mutations. J Neurol Neurosurg Psychiatry 2012 1.46
14 Epigenetics, epidemiology and mitochondrial DNA diseases. Int J Epidemiol 2012 1.36
15 Depletion of mitochondrial DNA in leucocytes harbouring the 3243A->G mtDNA mutation. J Med Genet 2006 1.34
16 The effect of strand bias in Illumina short-read sequencing data. BMC Genomics 2012 1.34
17 Selection against pathogenic mtDNA mutations in a stem cell population leads to the loss of the 3243A-->G mutation in blood. Am J Hum Genet 2008 1.32
18 MitoSeek: extracting mitochondria information and performing high-throughput mitochondria sequencing analysis. Bioinformatics 2013 1.31
19 Three-stage quality control strategies for DNA re-sequencing data. Brief Bioinform 2013 1.30
20 Comparing phylogeny and the predicted pathogenicity of protein variations reveals equal purifying selection across the global human mtDNA diversity. Am J Hum Genet 2011 1.26
21 OPA1 mutations cause cytochrome c oxidase deficiency due to loss of wild-type mtDNA molecules. Hum Mol Genet 2010 1.22
22 The distribution of mitochondrial DNA heteroplasmy due to random genetic drift. Am J Hum Genet 2008 1.22
23 Previous estimates of mitochondrial DNA mutation level variance did not account for sampling error: comparing the mtDNA genetic bottleneck in mice and humans. Am J Hum Genet 2010 1.10
24 A computational model of mitochondrial deoxynucleotide metabolism and DNA replication. Am J Physiol Cell Physiol 2005 1.10
25 The use of next generation sequencing technology to study the effect of radiation therapy on mitochondrial DNA mutation. Mutat Res 2012 1.09
26 Detecting new neurodegenerative disease genes: does phenotype accuracy limit the horizon? Trends Genet 2009 1.07
27 A model of the nuclear control of mitochondrial DNA replication. J Theor Biol 2003 1.07
28 A review comparing deoxyribonucleoside triphosphate (dNTP) concentrations in the mitochondrial and cytoplasmic compartments of normal and transformed cells. Nucleosides Nucleotides Nucleic Acids 2011 1.05
29 Normal levels of wild-type mitochondrial DNA maintain cytochrome c oxidase activity for two pathogenic mitochondrial DNA mutations but not for m.3243A-->G. Am J Hum Genet 2007 1.05
30 Mitochondrial DNA deletions are associated with non-B DNA conformations. Nucleic Acids Res 2012 1.03
31 Evidence for variable selective pressures at a large secondary structure of the human mitochondrial DNA control region. Mol Biol Evol 2008 1.02
32 What is influencing the phenotype of the common homozygous polymerase-γ mutation p.Ala467Thr? Brain 2012 1.01
33 Mutation dependance of the mitochondrial DNA copy number in the first stages of human embryogenesis. Hum Mol Genet 2013 0.96
34 Somatic mitochondrial DNA mutations in cancer escape purifying selection and high pathogenicity mutations lead to the oncocytic phenotype: pathogenicity analysis of reported somatic mtDNA mutations in tumors. BMC Cancer 2012 0.96
35 Reassessing evidence for a postnatal mitochondrial genetic bottleneck. Nat Genet 2010 0.94
36 Mitochondrial DNA rearrangements in health and disease--a comprehensive study. Hum Mutat 2013 0.94
37 Poor correlations in the levels of pathogenic mitochondrial DNA mutations in polar bodies versus oocytes and blastomeres in humans. Am J Hum Genet 2011 0.90
38 The evidence that the DNC (SLC25A19) is not the mitochondrial deoxyribonucleotide carrier. Mitochondrion 2008 0.90
39 The length of cytochrome c oxidase-negative segments in muscle fibres in patients with mtDNA myopathy. Neuromuscul Disord 2002 0.89
40 Evaluation of allele frequency estimation using pooled sequencing data simulation. ScientificWorldJournal 2013 0.89
41 Discrete stochastic simulation methods for chemically reacting systems. Methods Enzymol 2009 0.88
42 POLG mutations cause decreased mitochondrial DNA repopulation rates following induced depletion in human fibroblasts. Biochim Biophys Acta 2010 0.87
43 No evidence of an association between mitochondrial DNA variants and osteoarthritis in 7393 cases and 5122 controls. Ann Rheum Dis 2012 0.86
44 Alternative applications for distinct RNA sequencing strategies. Brief Bioinform 2014 0.85
45 Mitochondrial DNA variation and HIV-associated sensory neuropathy in CHARTER. J Neurovirol 2012 0.85
46 Mitochondrial genomics and CD4 T-cell count recovery after antiretroviral therapy initiation in AIDS clinical trials group study 384. J Acquir Immune Defic Syndr 2011 0.85
47 Evaluating purifying selection in the mitochondrial DNA of various mammalian species. PLoS One 2013 0.85
48 Risk factors for symptomatic hyperlactatemia and lactic acidosis among combination antiretroviral therapy-treated adults in Botswana: results from a clinical trial. AIDS Res Hum Retroviruses 2012 0.85
49 Enzyme kinetics of the mitochondrial deoxyribonucleoside salvage pathway are not sufficient to support rapid mtDNA replication. PLoS Comput Biol 2011 0.84
50 The other genome: a systematic review of studies of mitochondrial DNA haplogroups and outcomes of HIV infection and antiretroviral therapy. AIDS Rev 2013 0.84
51 An analysis of enzyme kinetics data for mitochondrial DNA strand termination by nucleoside reverse transcription inhibitors. PLoS Comput Biol 2009 0.83
52 Mitochondrial genomics and antiretroviral therapy-associated metabolic complications in HIV-infected Black South Africans: a pilot study. AIDS Res Hum Retroviruses 2013 0.82
53 Mitochondria sequence mapping strategies and practicability of mitochondria variant detection from exome and RNA sequencing data. Brief Bioinform 2015 0.80
54 Non-random mtDNA segregation patterns indicate a metastable heteroplasmic segregation unit in m.3243A>G cybrid cells. PLoS One 2012 0.80
55 Epidermal nerve fiber density, oxidative stress, and mitochondrial haplogroups in HIV-infected Thais initiating therapy. AIDS 2014 0.80
56 Replication pauses of the wild-type and mutant mitochondrial DNA polymerase gamma: a simulation study. PLoS Comput Biol 2011 0.79
57 Polarization of superfluid turbulence. Phys Rev Lett 2002 0.79
58 T cell activation markers and African mitochondrial DNA haplogroups among non-Hispanic black participants in AIDS clinical trials group study 384. PLoS One 2012 0.77
59 Multi-perspective quality control of Illumina RNA sequencing data analysis. Brief Funct Genomics 2016 0.77
60 A computational model of mitochondrial AZT metabolism. Biochem J 2005 0.77
61 Analysis of enzyme kinetic data for mtDNA replication. Methods 2010 0.77
62 Unique mitochondrial DNA in highly inbred feral cattle. Mitochondrion 2012 0.76
63 Correlated tissue expression of genes of cytoplasmic and mitochondrial nucleotide metabolisms in normal tissues is disrupted in transformed tissues. Nucleosides Nucleotides Nucleic Acids 2012 0.75
64 STRATEGIES FOR EQUITABLE PHARMACOGENOMIC-GUIDED WARFARIN DOSING AMONG EUROPEAN AND AFRICAN AMERICAN INDIVIDUALS IN A CLINICAL POPULATION. Pac Symp Biocomput 2016 0.75
65 The effect of unhealthy β-cells on insulin secretion in pancreatic islets. BMC Med Genomics 2013 0.75
66 Mitochondrial-encoded membrane protein transcripts are pyrimidine-rich while soluble protein transcripts and ribosomal RNA are purine-rich. BMC Genomics 2005 0.75
67 Strategies for processing and quality control of Illumina genotyping arrays. Brief Bioinform 2017 0.75
68 Evaporation of a packet of quantized vorticity. Phys Rev Lett 2002 0.75
69 Power and sample size calculations for high-throughput sequencing-based experiments. Brief Bioinform 2017 0.75