Published in J Immunol on July 22, 2011
Tristetraprolin (TTP): interactions with mRNA and proteins, and current thoughts on mechanisms of action. Biochim Biophys Acta (2013) 1.90
Low ambient oxygen prevents atherosclerosis. J Mol Med (Berl) (2016) 1.38
miR-451 regulates dendritic cell cytokine responses to influenza infection. J Immunol (2012) 1.08
Tristetraprolin regulation of interleukin 23 mRNA stability prevents a spontaneous inflammatory disease. J Exp Med (2013) 0.99
Tristetraprolin expression and microRNA-mediated regulation during simian immunodeficiency virus infection of the central nervous system. Mol Brain (2013) 0.86
Translating the Untranslated Region. J Immunol (2015) 0.86
Apolipoprotein A-I inhibits LPS-induced atherosclerosis in ApoE(-/-) mice possibly via activated STAT3-mediated upregulation of tristetraprolin. Acta Pharmacol Sin (2013) 0.84
Tristetraprolin binding site atlas in the macrophage transcriptome reveals a switch for inflammation resolution. Mol Syst Biol (2016) 0.82
Enhanced LPS-induced peritonitis in mice deficiency of cullin 4B in macrophages. Genes Immun (2014) 0.80
Zinc finger protein 64 promotes Toll-like receptor-triggered proinflammatory and type I interferon production in macrophages by enhancing p65 subunit activation. J Biol Chem (2013) 0.79
Endothelial dysfunction in tristetraprolin-deficient mice is not caused by enhanced tumor necrosis factor-α expression. J Biol Chem (2014) 0.78
Hallmarks of cancer and AU-rich elements. Wiley Interdiscip Rev RNA (2016) 0.78
Tristetraprolin functions in cytoskeletal organization during mouse oocyte maturation. Oncotarget (2016) 0.77
Post-transcriptional Regulation of Immunological Responses through Riboclustering. Front Immunol (2016) 0.75
Post-transcriptional regulation of cytokine and growth factor signaling in cancer. Cytokine Growth Factor Rev (2016) 0.75
Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med (2005) 28.21
The significance of digital gene expression profiles. Genome Res (1997) 23.90
The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med (2006) 10.99
Using the transcriptome to annotate the genome. Nat Biotechnol (2002) 9.04
Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin. Science (1998) 8.55
The immune system in atherosclerosis. Nat Immunol (2011) 6.51
Inflammation in atherosclerosis: from pathophysiology to practice. J Am Coll Cardiol (2009) 6.11
A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. Immunity (1996) 5.64
Chemokines and disease. Nat Immunol (2001) 5.62
Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA. Mol Cell Biol (1999) 5.55
Sex differences in autoimmune disease. Nat Immunol (2001) 5.08
Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability. Blood (2000) 3.86
The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules. Nat Immunol (2009) 3.85
Macrophage inflammatory protein-1. Int J Biochem Cell Biol (2004) 3.15
Reduction of chemokine levels and leukocyte traffic to joints by tumor necrosis factor alpha blockade in patients with rheumatoid arthritis. Arthritis Rheum (2000) 3.06
Macrophage inflammatory protein-1. Cytokine Growth Factor Rev (2002) 2.93
ARED 2.0: an update of AU-rich element mRNA database. Nucleic Acids Res (2003) 2.39
Post-transcriptional regulons coordinate the initiation and resolution of inflammation. Nat Rev Immunol (2010) 2.08
The tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritis. Arthritis Res Ther (2004) 2.05
The lamina adventitia is the major site of immune cell accumulation in standard chow-fed apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol (2005) 1.81
Comparison of atherosclerotic lesions and HDL-lipid levels in male, female, and testosterone-treated female mice from strains C57BL/6, BALB/c, and C3H. Atherosclerosis (1987) 1.78
Mouse models of atherosclerosis. Am J Med Sci (2002) 1.78
Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients. FEBS J (2008) 1.78
Interferons limit inflammatory responses by induction of tristetraprolin. Blood (2006) 1.53
Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome. Blood (2001) 1.49
p53 improves aerobic exercise capacity and augments skeletal muscle mitochondrial DNA content. Circ Res (2009) 1.39
Mitogenic activation of human T cells induces two closely related genes which share structural similarities with a new family of secreted factors. J Immunol (1989) 1.37
The role of post-transcriptional regulation in chemokine gene expression in inflammation and allergy. Eur Respir J (2005) 1.29
Chemokine receptor CCR5: from AIDS to atherosclerosis. Br J Pharmacol (2011) 1.29
Differential regulation of ARE-mediated TNFalpha and IL-1beta mRNA stability by lipopolysaccharide in RAW264.7 cells. Biochem Biophys Res Commun (2006) 1.28
Rheumatoid arthritis: model of systemic inflammation driving atherosclerosis. Circ J (2009) 1.25
Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells. Arthritis Res Ther (2006) 1.10
Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice. Endocrinology (2004) 1.10
Human vascular smooth muscle cells express receptors for CC chemokines. Arterioscler Thromb Vasc Biol (1998) 1.09
CC chemokine ligand 3 overcomes the bacteriocidal and phagocytic defect of macrophages and hastens recovery from experimental otitis media in TNF-/- mice. J Immunol (2010) 0.98
An essential role for CCL3 in the development of collagen antibody-induced arthritis. Immunol Lett (2005) 0.96
CCR1 antagonists: what have we learned from clinical trials. Curr Top Med Chem (2010) 0.94
Atherosclerotic plaque macrophage transcriptional regulators are expressed in blood and modulated by tristetraprolin. Circ Res (2006) 0.93
Inflammation: cytokines and RNA-based regulation. Wiley Interdiscip Rev RNA (2010) 0.92
Blockage of TNF-α by infliximab reduces CCL2 and CCR2 levels in patients with rheumatoid arthritis. J Investig Med (2011) 0.87
Left-sided cardiac valvulitis in tristetraprolin-deficient mice: the role of tumor necrosis factor alpha. Am J Pathol (2010) 0.87
Atherosclerosis and the mouse: a decade of experience. Ann Med (1997) 0.83
FK506 is superior to methotrexate in therapeutic effects on advanced stage of rat adjuvant-induced arthritis. Inflamm Res (2001) 0.79
p53 regulates mitochondrial respiration. Science (2006) 9.06
MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat Cell Biol (2011) 8.21
The ClinSeq Project: piloting large-scale genome sequencing for research in genomic medicine. Genome Res (2009) 6.83
Augmented Wnt signaling in a mammalian model of accelerated aging. Science (2007) 5.62
Reversible inactivation of the tumor suppressor PTEN by H2O2. J Biol Chem (2002) 5.08
Association of loss-of-function mutations in the ABCA1 gene with high-density lipoprotein cholesterol levels and risk of ischemic heart disease. JAMA (2008) 4.41
Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport. Circulation (2012) 3.38
High-density lipoprotein reduces the human monocyte inflammatory response. Arterioscler Thromb Vasc Biol (2008) 3.09
Novel mRNA targets for tristetraprolin (TTP) identified by global analysis of stabilized transcripts in TTP-deficient fibroblasts. Mol Cell Biol (2006) 2.96
T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation. Nat Immunol (2004) 2.96
Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element. Mol Cell Biol (2006) 2.94
Tristetraprolin and its family members can promote the cell-free deadenylation of AU-rich element-containing mRNAs by poly(A) ribonuclease. Mol Cell Biol (2003) 2.61
Genome-wide analysis identifies interleukin-10 mRNA as target of tristetraprolin. J Biol Chem (2008) 2.38
HDL measures, particle heterogeneity, proposed nomenclature, and relation to atherosclerotic cardiovascular events. Clin Chem (2011) 2.33
HuR as a negative posttranscriptional modulator in inflammation. Mol Cell (2005) 2.27
Tristetraprolin down-regulates IL-2 gene expression through AU-rich element-mediated mRNA decay. J Immunol (2005) 2.24
Interactions of CCCH zinc finger proteins with mRNA: non-binding tristetraprolin mutants exert an inhibitory effect on degradation of AU-rich element-containing mRNAs. J Biol Chem (2002) 2.17
MicroRNA-27b is a regulatory hub in lipid metabolism and is altered in dyslipidemia. Hepatology (2012) 2.15
Seven direct methods for measuring HDL and LDL cholesterol compared with ultracentrifugation reference measurement procedures. Clin Chem (2010) 2.07
The tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritis. Arthritis Res Ther (2004) 2.05
Detection and quantitation of serum mesothelin, a tumor marker for patients with mesothelioma and ovarian cancer. Clin Cancer Res (2006) 1.99
Serum apolipoprotein A-I and large high-density lipoprotein particles are positively correlated with FEV1 in atopic asthma. Am J Respir Crit Care Med (2015) 1.97
Kruppel-like factor 2 (KLF2) regulates proinflammatory activation of monocytes. Proc Natl Acad Sci U S A (2006) 1.95
Tristetraprolin (TTP): interactions with mRNA and proteins, and current thoughts on mechanisms of action. Biochim Biophys Acta (2013) 1.90
The mRNA-destabilizing protein tristetraprolin is suppressed in many cancers, altering tumorigenic phenotypes and patient prognosis. Cancer Res (2009) 1.88
RNA sequence elements required for high affinity binding by the zinc finger domain of tristetraprolin: conformational changes coupled to the bipartite nature of Au-rich MRNA-destabilizing motifs. J Biol Chem (2004) 1.82
Elevated serum concentrations of insulin and glucose increase risk of recurrent colorectal adenomas. Gastroenterology (2007) 1.75
Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family. Mol Cell Biol (2004) 1.73
Lipid-based carriers of microRNAs and intercellular communication. Curr Opin Lipidol (2012) 1.73
Arthritis suppressor genes TIA-1 and TTP dampen the expression of tumor necrosis factor alpha, cyclooxygenase 2, and inflammatory arthritis. Proc Natl Acad Sci U S A (2004) 1.71
Should triglycerides and the triglycerides to high-density lipoprotein cholesterol ratio be used as surrogates for insulin resistance? Metabolism (2009) 1.69
Immunological characterization of tristetraprolin as a low abundance, inducible, stable cytosolic protein. J Biol Chem (2004) 1.65
The ATP binding cassette transporter A1 (ABCA1) modulates the development of aortic atherosclerosis in C57BL/6 and apoE-knockout mice. Proc Natl Acad Sci U S A (2001) 1.61
Class B scavenger receptor types I and II and CD36 targeting improves sepsis survival and acute outcomes in mice. J Immunol (2012) 1.61
Impact of blood collection devices on clinical chemistry assays. Clin Biochem (2009) 1.61
Human lecithin:cholesterol acyltransferase deficiency: in vivo kinetics of low-density lipoprotein and lipoprotein-X. Arterioscler Thromb Vasc Biol (2006) 1.56
Serum amyloid A binding to CLA-1 (CD36 and LIMPII analogous-1) mediates serum amyloid A protein-induced activation of ERK1/2 and p38 mitogen-activated protein kinases. J Biol Chem (2004) 1.55
Effect of sofosbuvir and ribavirin treatment on peripheral and hepatic lipid metabolism in chronic hepatitis C virus, genotype 1-infected patients. Hepatology (2015) 1.55
RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability. Mol Cell Biol (2006) 1.54
Interferons limit inflammatory responses by induction of tristetraprolin. Blood (2006) 1.53
Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells. J Clin Invest (2011) 1.52
Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling. J Biol Chem (2002) 1.51
Role of human CD36 in bacterial recognition, phagocytosis, and pathogen-induced JNK-mediated signaling. J Immunol (2008) 1.51
The prevalence of hypovitaminosis D and secondary hyperparathyroidism in obese Black Americans. Clin Endocrinol (Oxf) (2006) 1.50
The CCCH tandem zinc-finger protein Zfp36l2 is crucial for female fertility and early embryonic development. Development (2004) 1.50
Clinical utility of inflammatory markers and advanced lipoprotein testing: advice from an expert panel of lipid specialists. J Clin Lipidol (2011) 1.45
Effect of blood collection tubes on total triiodothyronine and other laboratory assays. Clin Chem (2004) 1.45
Structural basis for the recruitment of the human CCR4-NOT deadenylase complex by tristetraprolin. Nat Struct Mol Biol (2013) 1.45
Immunoassay interference by a commonly used blood collection tube additive, the organosilicone surfactant silwet L-720. Clin Chem (2005) 1.44
The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease. J Biol Chem (2004) 1.44
Asymmetry in the lipid affinity of bihelical amphipathic peptides. A structural determinant for the specificity of ABCA1-dependent cholesterol efflux by peptides. J Biol Chem (2008) 1.41
Lipopolysaccharide down regulates both scavenger receptor B1 and ATP binding cassette transporter A1 in RAW cells. Infect Immun (2002) 1.40
Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver. J Biol Chem (2010) 1.40
p53 improves aerobic exercise capacity and augments skeletal muscle mitochondrial DNA content. Circ Res (2009) 1.39
Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1, and -DQA1 allelic profiles distinguish European American patients with different myositis autoantibodies. Medicine (Baltimore) (2006) 1.39
Stimulation of polo-like kinase 3 mRNA decay by tristetraprolin. Mol Cell Biol (2009) 1.39
Inflammation and IGF-I activate the Akt pathway in breast cancer. Int J Cancer (2007) 1.38
Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10. J Immunol (2009) 1.37
T cell receptor stimulation, reactive oxygen species, and cell signaling. Free Radic Biol Med (2004) 1.36
Diverse range of small peptides associated with high-density lipoprotein. Biochem Biophys Res Commun (2005) 1.34
Targeted disruption of p53 attenuates doxorubicin-induced cardiac toxicity in mice. Mol Cell Biochem (2005) 1.34
5A apolipoprotein mimetic peptide promotes cholesterol efflux and reduces atherosclerosis in mice. J Pharmacol Exp Ther (2010) 1.34
Influence of nonameric AU-rich tristetraprolin-binding sites on mRNA deadenylation and turnover. J Biol Chem (2005) 1.33
Tristetraprolin mediates interferon-gamma mRNA decay. J Biol Chem (2009) 1.30
Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis. Blood (2009) 1.29
Tristetraprolin impairs myc-induced lymphoma and abolishes the malignant state. Cell (2012) 1.29
Lecithin: cholesterol acyltransferase--from biochemistry to role in cardiovascular disease. Curr Opin Endocrinol Diabetes Obes (2009) 1.29
The Arabidopsis tandem zinc finger protein AtTZF1 traffics between the nucleus and cytoplasmic foci and binds both DNA and RNA. Plant Physiol (2009) 1.27
Regulation of suppressor of cytokine signaling 3 (SOCS3) mRNA stability by TNF-alpha involves activation of the MKK6/p38MAPK/MK2 cascade. J Immunol (2007) 1.27
Circulating transcriptome reveals markers of atherosclerosis. Proc Natl Acad Sci U S A (2005) 1.27
Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis. Biochem J (2006) 1.26
Increased oxidative metabolism in the Li-Fraumeni syndrome. N Engl J Med (2013) 1.25
Myeloid-specific tristetraprolin deficiency in mice results in extreme lipopolysaccharide sensitivity in an otherwise minimal phenotype. J Immunol (2012) 1.24
Apolipoprotein AI mimetic peptides: possible new agents for the treatment of atherosclerosis. Curr Opin Investig Drugs (2007) 1.24
The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages. FEBS Lett (2009) 1.24
δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders. J Biol Chem (2012) 1.23
ABCA1 overexpression in the liver of LDLr-KO mice leads to accumulation of pro-atherogenic lipoproteins and enhanced atherosclerosis. J Biol Chem (2006) 1.23
Mitochondrial respiration protects against oxygen-associated DNA damage. Nat Commun (2010) 1.23
Predictors of acquired lipodystrophy in juvenile-onset dermatomyositis and a gradient of severity. Medicine (Baltimore) (2008) 1.22
Inverse log-linear relationship between thyroid-stimulating hormone and free thyroxine measured by direct analog immunoassay and tandem mass spectrometry. Clin Chem (2010) 1.21
A pivotal role for p53: balancing aerobic respiration and glycolysis. J Bioenerg Biomembr (2007) 1.21
High pre-beta1 HDL concentrations and low lecithin: cholesterol acyltransferase activities are strong positive risk markers for ischemic heart disease and independent of HDL-cholesterol. Clin Chem (2010) 1.19
Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1. J Biol Chem (2003) 1.19
The 5A apolipoprotein A-I mimetic peptide displays antiinflammatory and antioxidant properties in vivo and in vitro. Arterioscler Thromb Vasc Biol (2009) 1.19
Proteomic identification of altered apolipoprotein patterns in pulmonary hypertension and vasculopathy of sickle cell disease. Blood (2008) 1.18
The orphan nuclear receptor LRH-1 activates the ABCG5/ABCG8 intergenic promoter. J Lipid Res (2004) 1.18
The Environmental Polymorphisms Registry: a DNA resource to study genetic susceptibility loci. Hum Genet (2008) 1.18
Transmembrane TNF protects mutant mice against intracellular bacterial infections, chronic inflammation and autoimmunity. Eur J Immunol (2006) 1.17
Apolipoprotein E negatively regulates house dust mite-induced asthma via a low-density lipoprotein receptor-mediated pathway. Am J Respir Crit Care Med (2010) 1.16
Tristetraprolin, a negative regulator of mRNA stability, is increased in old B cells and is involved in the degradation of E47 mRNA. J Immunol (2007) 1.16
Expression and purification of recombinant tristetraprolin that can bind to tumor necrosis factor-alpha mRNA and serve as a substrate for mitogen-activated protein kinases. Arch Biochem Biophys (2003) 1.16
Antiatherogenic functionality of high density lipoprotein: how much versus how good. J Atheroscler Thromb (2008) 1.15
Global target mRNA specification and regulation by the RNA-binding protein ZFP36. Genome Biol (2014) 1.15
Structure/function relationships of apolipoprotein a-I mimetic peptides: implications for antiatherogenic activities of high-density lipoprotein. Circ Res (2010) 1.14
Lipid levels in sickle-cell disease associated with haemolytic severity, vascular dysfunction and pulmonary hypertension. Br J Haematol (2010) 1.13