Molecular determinants of U-type inactivation in Kv2.1 channels.

De novo KCNB1 mutations in infantile epilepsy inhibit repetitive neuronal firing. Sci Rep (2015) 0.91

Shab K (+) channel slow inactivation: a test for U-type inactivation and a hypothesis regarding K (+) -facilitated inactivation mechanisms. Channels (Austin) (2013) 0.79

Modulation of Closed-State Inactivation in Kv2.1/Kv6.4 Heterotetramers as Mechanism for 4-AP Induced Potentiation. PLoS One (2015) 0.77

The Inhibitory Effects of Ca2+ Channel Blocker Nifedipine on Rat Kv2.1 Potassium Channels. PLoS One (2015) 0.76

Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. Science (2005) 17.70

Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science (1990) 15.75

Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment. Nature (2007) 12.35

Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels. Receptors Channels (1993) 8.09

Two types of inactivation in Shaker K+ channels: effects of alterations in the carboxy-terminal region. Neuron (1991) 8.06

Tetraethylammonium blockade distinguishes two inactivation mechanisms in voltage-activated K+ channels. Proc Natl Acad Sci U S A (1991) 5.73

Dynamic rearrangement of the outer mouth of a K+ channel during gating. Neuron (1996) 5.52

Modulation of K+ current by frequency and external [K+]: a tale of two inactivation mechanisms. Neuron (1995) 4.62

Use-dependent blockers and exit rate of the last ion from the multi-ion pore of a K+ channel. Science (1996) 3.50

Energetics of pore opening in a voltage-gated K(+) channel. Cell (2002) 3.36

Exchange of conduction pathways between two related K+ channels. Science (1991) 3.09

C-type inactivation of a voltage-gated K+ channel occurs by a cooperative mechanism. Biophys J (1995) 2.97

Cooperative subunit interactions in C-type inactivation of K channels. Biophys J (1995) 2.84

TEA prevents inactivation while blocking open K+ channels in human T lymphocytes. Biophys J (1989) 2.82

Modulation of C-type inactivation by K+ at the potassium channel selectivity filter. Biophys J (1998) 2.51

Contribution of the selectivity filter to inactivation in potassium channels. Biophys J (1999) 2.50

alpha-helical structural elements within the voltage-sensing domains of a K(+) channel. J Gen Physiol (2000) 2.46

Inactivation determined by a single site in K+ pores. Pflugers Arch (1993) 2.37

A localized interaction surface for voltage-sensing domains on the pore domain of a K+ channel. Neuron (2000) 2.05

Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement. Proc Natl Acad Sci U S A (2010) 2.02

Inactivation of Kv2.1 potassium channels. Biophys J (1998) 2.02

A structural interpretation of voltage-gated potassium channel inactivation. Prog Biophys Mol Biol (2005) 1.86

Molecular coupling of S4 to a K(+) channel's slow inactivation gate. J Gen Physiol (2000) 1.72

Reconstructing voltage sensor-pore interaction from a fluorescence scan of a voltage-gated K+ channel. Neuron (2000) 1.71

S4 charges move close to residues in the pore domain during activation in a K channel. J Gen Physiol (2001) 1.65

Potassium-dependent changes in the conformation of the Kv2.1 potassium channel pore. J Gen Physiol (1999) 1.64

Structural dynamics of an isolated voltage-sensor domain in a lipid bilayer. Structure (2008) 1.64

Properties of Kv2.1 K+ channels expressed in transfected mammalian cells. J Biol Chem (1994) 1.56

Pore mutations in Shaker K+ channels distinguish between the sites of tetraethylammonium blockade and C-type inactivation. J Physiol (1997) 1.54

Role of transmembrane segment S5 on gating of voltage-dependent K+ channels. J Gen Physiol (1997) 1.32

U-type inactivation of Kv3.1 and Shaker potassium channels. Biophys J (2001) 1.25

Mechanisms of closed-state inactivation in voltage-gated ion channels. J Physiol (2010) 1.18

Heteromeric assembly of Kv2.1 with Kv9.3: effect on the state dependence of inactivation. Biophys J (1999) 1.17

Collapse of conductance is prevented by a glutamate residue conserved in voltage-dependent K(+) channels. J Gen Physiol (2000) 1.16

Functional analysis of Kv1.2 and paddle chimera Kv channels in planar lipid bilayers. J Mol Biol (2008) 1.15

A side chain in S6 influences both open-state stability and ion permeation in a voltage-gated K+ channel. Pflugers Arch (1998) 1.15

Structural determinants of the regulation of the voltage-gated potassium channel Kv2.1 by the modulatory α-subunit Kv9.3. J Biol Chem (2003) 1.08

Mutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels. Biophys J (2010) 1.08

Role of an invariant cysteine in gating and ion permeation of the voltage-sensitive K+ channel Kv2.1. Receptors Channels (1994) 1.07

Dynamic conformational changes of extracellular S5-P linkers in the hERG channel. J Physiol (2005) 1.07

Amino-terminal determinants of U-type inactivation of voltage-gated K+ channels. J Biol Chem (2002) 0.98

Depolarization induces intersubunit cross-linking in a S4 cysteine mutant of the Shaker potassium channel. J Biol Chem (2002) 0.97

Altered state dependence of c-type inactivation in the long and short forms of human Kv1.5. J Gen Physiol (2001) 0.94

Slow inactivation in Shaker K channels is delayed by intracellular tetraethylammonium. J Gen Physiol (2008) 0.92

Oxidation of an engineered pore cysteine locks a voltage-gated K+ channel in a nonconducting state. Biophys J (1996) 0.87

VAMP2 interacts directly with the N terminus of Kv2.1 to enhance channel inactivation. Pflugers Arch (2008) 0.86

Kinetic analysis of the effects of H+ or Ni2+ on Kv1.5 current shows that both ions enhance slow inactivation and induce resting inactivation. J Physiol (2010) 0.84

Separation of P/C- and U-type inactivation pathways in Kv1.5 potassium channels. J Physiol (2005) 0.83

Fast and slow voltage sensor rearrangements during activation gating in Kv1.2 channels detected using tetramethylrhodamine fluorescence. J Gen Physiol (2010) 0.79

Archaea predominate among ammonia-oxidizing prokaryotes in soils. Nature (2006) 9.25

Potential virulence determinants in terminal regions of variola smallpox virus genome. Nature (1994) 2.91

Analysis of the complete genome of smallpox variola major virus strain Bangladesh-1975. Virology (1994) 2.69

List-mode maximum-likelihood reconstruction applied to positron emission mammography (PEM) with irregular sampling. IEEE Trans Med Imaging (2000) 2.13

The relationship between marijuana initiation and dropping out of high school. Health Econ (2000) 1.74

p38 mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNF-alpha or FMLP stimulation. J Immunol (1998) 1.69

The effect of timing of ondansetron administration on its efficacy, cost-effectiveness, and cost-benefit as a prophylactic antiemetic in the ambulatory setting. Anesth Analg (1998) 1.60

Comparison of 3-D maximum a posteriori and filtered backprojection algorithms for high-resolution animal imaging with microPET. IEEE Trans Med Imaging (2000) 1.44

Activity of the multikinase inhibitor dasatinib against ovarian cancer cells. Br J Cancer (2009) 1.41

Dynactin regulates bidirectional transport of dense-core vesicles in the axon and dendrites of cultured hippocampal neurons. Neuroscience (2009) 1.23

Renal artery aneurysm: diagnosis and surveillance with multidetector-row computed tomography. Acta Radiol (2007) 1.18

Syntaxin 1A inhibits regulated CFTR trafficking in xenopus oocytes. Am J Physiol (1999) 1.09

Chemical profile of two types of oral snuff tobacco. Food Chem Toxicol (2002) 1.07

Cysteine-independent inhibition of the CFTR chloride channel by the cysteine-reactive reagent sodium (2-sulphonatoethyl) methanethiosulphonate. Br J Pharmacol (2009) 1.00

Role of snare proteins in CFTR and ENaC trafficking. Pflugers Arch (2001) 0.99

The effect of Employee Assistance Programs use on healthcare utilization. Health Serv Res (2000) 0.98

Sources of adult mesenchymal stem cells applicable for musculoskeletal applications - a systematic review of the literature. Open Orthop J (2011) 0.97

Ribosomal RNA as molecular barcodes: a simple correlation analysis without sequence alignment. Bioinformatics (2006) 0.96

Semiautomated volumetric measurement on postcontrast MR imaging for analysis of recurrent and residual disease in glioblastoma multiforme. AJNR Am J Neuroradiol (2013) 0.96

Pin1 modulates p63α protein stability in regulation of cell survival, proliferation and tumor formation. Cell Death Dis (2013) 0.93

Frequent methamphetamine injection predicts emergency department utilization among street-involved youth. Public Health (2011) 0.91

ROC and localization ROC analyses of lesion detection in whole-body FDG PET: effects of acquisition mode, attenuation correction and reconstruction algorithm. J Nucl Med (1999) 0.91

Imaging of primary adrenal lymphoma: case report and literature review. Acta Radiol (2006) 0.91

Fibrin induction of tissue factor expression in human vascular endothelial cells. Circulation (1997) 0.90

Effect of low dose radiation on intracellular calcium and protein kinase C in lymphocytes. Biomed Environ Sci (1994) 0.89

Internet2-based 3D PET image reconstruction using a PC cluster. Phys Med Biol (2002) 0.89

Contrast-enhanced ultrasonography for the detection and characterization of prostate cancer: correlation with microvessel density and Gleason score. Clin Radiol (2011) 0.88

Extracellular proton modulation of the cardiac voltage-gated sodium channel, Nav1.5. Biophys J (2011) 0.88

Factors influencing the degree of enhancement of prostate cancer on contrast-enhanced transrectal ultrasonography: correlation with biopsy and radical prostatectomy specimens. Br J Radiol (2012) 0.87

Detection of mRNA species in bulbospinal neurons isolated from the rostral ventrolateral medulla using single-cell RT-PCR. Brain Res Brain Res Protoc (1999) 0.86

Approximate maximum likelihood hyperparameter estimation for Gibbs priors. IEEE Trans Image Process (1997) 0.85

HIV knowledge and perceptions of risk in a young, urban, drug-using population. Public Health (2011) 0.84

Contribution of GM-CSF and IL-8 to the CD44-induced differentiation of acute monoblastic leukemia. Leukemia (2007) 0.84

Construction of circular oligodeoxyribonucleotides on the new structural basis of i-motif. J Am Chem Soc (2001) 0.83

Base of pore loop is important for rectification, activation, permeation, and block of Kir3.1/Kir3.4. Biophys J (2006) 0.83

Increased detectability of alpha brain glutamate/glutamine in neonatal hypoxic-ischemic encephalopathy. AJNR Am J Neuroradiol (2000) 0.82

Two cytotoxic pathways of natural killer cells in human cord blood: implications in cord blood transplantation. Br J Haematol (1997) 0.82

Congenital corneal opacification in De Barsy syndrome. Arch Ophthalmol (2001) 0.82

Noradrenaline transporter expression in the pons and medulla oblongata of the rat: localisation to noradrenergic and some C1 adrenergic neurones. Brain Res Mol Brain Res (1998) 0.82

Amantadine increases aromatic L-amino acid decarboxylase mRNA in PC12 cells. J Neurosci Res (1998) 0.81

Super-thin abdominal skin pedicle flap for the reconstruction of hypertrophic and contracted dorsal hand burn scars. Burns (2007) 0.81

L-deprenyl potentiates NGF-induced changes in superoxide dismutase mRNA in PC12 cells. J Neurosci Res (1998) 0.81

LeERF-1, a novel AP2/ERF family gene within the B3 subcluster, is down-regulated by light signals in Lithospermum erythrorhizon. Plant Biol (Stuttg) (2011) 0.81

Effects of cyanide and hypoxia on membrane currents in neurones acutely dissociated from the rostral ventrolateral medulla of the rat. Brain Res (1999) 0.80

Isolation and refined regional mapping of expressed sequences from human chromosome 21. Genomics (1994) 0.80

Dynamic gadolinium-enhanced MRI in early ischaemia of the proximal femoral epiphysis--a preliminary study. Clin Radiol (2008) 0.80

Role of internalization of M2 muscarinic receptor via clathrin-coated vesicles in desensitization of the muscarinic K+ current in heart. Am J Physiol Heart Circ Physiol (2006) 0.80

Reduction in glial fibrillary acidic protein mRNA abundance induced by (-)-deprenyl and other monoamine oxidase B inhibitors in C6 glioma cells. J Neurochem (1993) 0.80

Epidemiological comparison of clinical manifestations according to HLA-B*27 carrier status of Chinese ankylosing spondylitis patients. Tissue Antigens (2013) 0.79

Two dimensions and two States in DNA nanotechnology. J Biomol Struct Dyn (2000) 0.79

Cytokine-enhanced mixed lymphocyte reaction (MLR) in cord blood. Clin Exp Immunol (1998) 0.79

Differential effects of olanzapine on the gene expression of superoxide dismutase and the low affinity nerve growth factor receptor. J Neurosci Res (1999) 0.79

Pharmacokinetic interaction between acetaminophen and lansoprazole. J Clin Gastroenterol (1999) 0.78

Whole cell patch-clamp study of putative vasomotor neurons isolated from the rostral ventrolateral medulla. Am J Physiol (1998) 0.78

A region-specific microdissection library for human chromosome 2p23-p25 and the analysis of an interstitial deletion of 2p23.3-p25.1. Hum Genet (1994) 0.77

Mechanisms underlying regulated CFTR trafficking. Med Clin North Am (2000) 0.77

Isolation, polymorphism and expression study of two distinct major histocompatibility complex class II B genes from half-smooth tongue sole (Cynoglossus semilaevis). Int J Immunogenet (2010) 0.77

Beta-lapachone inhibits proliferation and induces apoptosis in retinoblastoma cell lines. Eye (Lond) (2007) 0.77

Cytotoxic T-lymphocytes recognizing P-glycoprotein in murine multidrug-resistant leukemias. Eur J Haematol (1997) 0.77

A region-specific microdissection library for human chromosome 2p23-->p21 and the analysis of an interstitial deletion of 2p21. Cytogenet Cell Genet (1995) 0.76

Baifuzi reduces transient ischemic brain damage through an interaction with the STREX domain of BKCa channels. Cell Death Dis (2010) 0.76

Reciprocal regulation of the content of aromatic L-amino acid decarboxylase and tyrosine hydroxylase mRNA by NGF in PC12 cells. J Neurosci Res (1997) 0.76

Identification of a novel allele HLA-DRB1*0114 in two Chinese marrow donors by sequence-based typing. Tissue Antigens (2007) 0.76

Identification of a novel HLA-B*48 allele, B*4814, in a Chinese marrow donor of Han descent. Tissue Antigens (2006) 0.76

Tunable face-centered-cubic photonic crystal formed in holographic polymer dispersed liquid crystals. Opt Lett (2003) 0.75

Extracellular protons inhibit charge immobilization in the cardiac voltage-gated sodium channel. Biophys J (2013) 0.75

Identification of an HLA-A*02 allele variant (A*0290) in a Chinese donor. Tissue Antigens (2006) 0.75

[Correlation between videodensity and iodine concentration in DSA--a prospective research]. Zhonghua Fang She Xue Za Zhi (1989) 0.75

The shine problem in hair: review of imaging methods and measures for luster. J Cosmet Sci (2009) 0.75

Photoassociative production and trapping of ultracold KRb molecules. Phys Rev Lett (2004) 0.75

[An investigation of the effect of rostral ventrolateral medulla lesion on pressor response induced by electrical stimulation of hypothalamic paraventricular nucleus in the cat]. Hua Xi Yi Ke Da Xue Xue Bao (1993) 0.75

Eltanolone as an alternative to propofol for ambulatory anesthesia. Anesth Analg (1997) 0.75

Surface magnetism in amine-capped ZnO nanoparticles. Nanotechnology (2009) 0.75

Total-internal-reflection mode in holographic polymer dispersed liquid crystals. Opt Lett (2003) 0.75

Measurement of the electronic transition dipole moment by Autler-Townes splitting: Comparison of three- and four-level excitation schemes for the Na2 A 1Sigma(u)+ - X 1Sigma(g)+ system. J Chem Phys (2006) 0.75

[Degradation of nitrobenzene in water by electrohydrodynamic DC discharge]. Huan Jing Ke Xue (2001) 0.75

Misinformation is prevalent in psoriasis-related YouTube videos. Dermatol Online J (2016) 0.75

Region-specific microdissection library and single-copy microclones for human chromosome 2p11-p13. Somat Cell Mol Genet (1994) 0.75

[Discovery of a novel reassortant H1N2 influenza virus]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi (1997) 0.75

Valsartan reduces AT1-AA-induced apoptosis through suppression oxidative stress mediated ER stress in endothelial progenitor cells. Eur Rev Med Pharmacol Sci (2017) 0.75

[Effects of cytokines on multidrug-resistance in K562/A02 cells]. Zhonghua Xue Ye Xue Za Zhi (1997) 0.75

Construction and characterization of region-specific microdissection libraries and single-copy microclones for short arm of human chromosome 2. Somat Cell Mol Genet (1994) 0.75

Quantum control of the spin-orbit interaction using the Autler-Townes effect. Phys Rev Lett (2011) 0.75

Selection of a high tanshinone-producing crown gall strain and production of tanshinone in the strain. Chin J Biotechnol (1997) 0.75

[Establishment of human amnion cell mutagenesis system by using a shuttle vector pS189]. Hua Xi Yi Ke Da Xue Xue Bao (1996) 0.75

[Simulation study of electrode configurations for cardiac stroke volume calculation by 3-dimensional finite element method]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi (2001) 0.75

[In vitro reversal of homoharringtonine resistance by the combination of tamoxifen and verapamil]. Zhonghua Xue Ye Xue Za Zhi (1997) 0.75

[T-cell subsets and lymphocyte proliferation in recurrent oral ulcers]. Zhonghua Kou Qiang Yi Xue Za Zhi (1995) 0.75

Selection of trypsin inhibitors in phage peptide library. Biochem Biophys Res Commun (1996) 0.75

Removal of titanium dioxide nanoparticles by coagulation: effects of coagulants, typical ions, alkalinity and natural organic matters. Water Sci Technol (2013) 0.75

Polymorphism of angiotensin I converting enzyme gene in the older Chinese: linked to ambulatory blood pressure levels and circadian blood pressure rhythm. Int J Cardiol (1996) 0.75

[A digital filter method for the elimination of 50 Hz interference from the ECG]. Zhongguo Yi Liao Qi Xie Za Zhi (1997) 0.75

[The plant regeneration of Salvia miltiorrhiza Bge. transformed by Agrobacterium]. Zhongguo Zhong Yao Za Zhi (1997) 0.75

16-Slice CT hepatic venography. Abdom Imaging (2006) 0.75

Genetics of osteoporosis and vitamin D receptor alleles. Calcif Tissue Int (1995) 0.75

[Comparative study on protein components of ouabain resistant mutant and wild cells of Chinese hamster V79 cell line by two-dimensional gel electrophoresis]. Hua Xi Yi Ke Da Xue Xue Bao (1989) 0.75

Genetics of osteoporosis and vitamin d receptor alleles. Calcif Tissue Int (2015) 0.75

[An overview of workplace violence in hospital]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi (2017) 0.75

[The predomination of rotavirus G3 serotype among children with diarrhea in Lulong County in 1998]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi (2001) 0.75

Experience with clinical use of Sandimmun Neoral in renal transplant patients. Transplant Proc (1996) 0.75